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Virginia Commonwealth University
Virginia Commonwealth University Intellectual Property Foundation

Virginia Commonwealth University patents


Recent patent applications related to Virginia Commonwealth University. Virginia Commonwealth University is listed as an Agent/Assignee. Note: Virginia Commonwealth University may have other listings under different names/spellings. We're not affiliated with Virginia Commonwealth University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "V" | Virginia Commonwealth University-related inventors


Three-dimensional pre-vascularized scaffold for bone regeneration

The present invention provides scaffolds comprising dual structural organization for bone and regeneration. Methods for fabricating and using the scaffold are also disclosed.... Virginia Commonwealth University

Chelation directed c-h activation reactions catalyzed by solid-supported palladium(ii) catalysts

Chelation directed C—H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or graphene are provided. The reactions are used to directly and regioselectively or regiospecifically functionalize specific C—H bonds, e.g. to build complexity into small molecules. Features and advantages of the present... Virginia Commonwealth University

Use of hemoglobin effectors to increase the bioavailability of therapeutic gases

Methods which increase the bioavailability of beneficial gases in the circulatory system are provided. The methods involve administering agents that changes the binding affinity of a medicinal gas such as NO, CO, H2S, N2O, SO, SO2 and O2 for IIb and/or hemoglobin based oxygen carriers (HBOCs). The change results in... Virginia Commonwealth University

In situ-forming of dendrimer hydrogels using michael-addition reaction

A method of forming a dendrimer hydrogel, the method comprising providing one or more amine end-functioned polyamidoamine (PAMAM) as a first reactant; providing one or more small molecule, polymer, hyperbranched molecule, or dendrimer as a second reactant, wherein the second reactant comprises one or more acrylate groups; and reacting the... Virginia Commonwealth University

Portable alcohol tester

A portable electronic alcohol-testing device is provided that uses vaporization and sensitive pressure guages to approximate the alcohol content of a solution. The device may be used, for example, to determine the relative alcohol content of a mixed beverage.... Virginia Commonwealth University

Ompa in vaccine compositions and as diagnostic targets

Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. OmpA proteins or peptide fragments may be used in combination with other Anaplasmatacaea surface proteins to elicit an... Virginia Commonwealth University

A convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction

Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.... Virginia Commonwealth University

Oxygenated cholesterol sulfates for therapy of disorders caused by at least one of attenuated leptin activity and a lipid storage disorder

Methods and compositions are provided for the prevention and/or treatment of symptoms associated with lipid accumulation disorders caused by attenuated leptin activity and by lipid storage disorders. The methods involve administering at least one oxygenated cholesterol sulfate (OCS) to a subject with the disorder. The disorder may be acquired or... Virginia Commonwealth University

Stage specific diagnostic antigens, assay and vaccine for lyme disease

Stage-specific Borrelia antigens for diagnosing, treating and/or preventing Lyme disease are provided. The antigens include chimeric Borrelia antigen constructs and mutant recombinant proteins comprising OspC and OspE epitopes, respectively. The antigens are used in multiprotein assays that differentiate early, middle and late stage infection, and/or in vaccine preparations.... Virginia Commonwealth University

Compositions and methods for prophylaxis and/or therapy of disorders that correlate with dennd1a variant 2

Pharmaceutical compositions and methods for the treatment of DENND1A.V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse monoclonal antibodies specific for DENND1A.V2 and methods for using the same are provided.... Virginia Commonwealth University

Halogen-free electrolytes

Compounds (salts) for use as electrolytes, e.g. in batteries such as Li ion, Na ion and Mg ion batteries are provided. The negative ions (anions) of the compounds are complex molecules which do not contain halogens, and thus exhibit improved safety, and yet have electron affinities that are equal to... Virginia Commonwealth University

Induction of tumor hypoxia for cancer therapy

Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region.... Virginia Commonwealth University

Method for one-step synthesis, cross-linking and drying of aerogels

A method of synthesizing aerogels and cross-linked aerogels in a single step and in a single pot without requiring any solvent exchange is described. Porous matrices are synthesized through a modification of hydrolysis condensation of alkoxides in which addition of water is minimized. The reaction occurs in an ethanol-water azeotrope... Virginia Commonwealth University

Compositions and methods for modulating cardiac conditions

Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin... Virginia Commonwealth University

Ompa and asp14 in vaccine compositions and as diagnostic targets

Anaplasma phagocytophilum surface proteins Asp14 and OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. Asp14 and/or OmpA proteins or peptide fragments may be used in combination with other Anaplasmatacaea surface... Virginia Commonwealth University

Aipa, ompa, and asp14 in vaccine compositions and diagnostic targets for anaplasma phagocytophilum infection

Anaplasma phagocytophilum surface protein AipA and/or fragments thereof which comprise an invasin domain are used in compositions suitable to elicit an immune response to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. AipA proteins and protein fragments or antibodies directed to AipA proteins and protein fragments... Virginia Commonwealth University

Organ protection solutions and use

An organ protectant solution which is intravenously administered includes at least one oncotic agent and optionally a high concentration of cell-impermeant molecules. Together, they promote transfer of water from cells to interstitium and into the capillaries, thereby preventing or reducing cell swelling, maintaining blood circulation and oxygenation of tissues, and... Virginia Commonwealth University

Sulfated-oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver tissue regeneration

Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase... Virginia Commonwealth University

Lyme disease vaccine

Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are useful as vaccines against Lyme disease, and as diagnostics for detecting Borrelia infections. The OspA and OspC antigenic polypeptides typically comprise a plurality of peptides representing epitope containing regions... Virginia Commonwealth University

Wireless implantable taste system

The system includes various embodiments of components, including (1) a sensor array, (2) a processor, (3) a transmitter, (4) a receiver-stimulator, and (5) an implantable electrode array. The gustatory implant system generates tastant fingerprints by detecting tastants with an array of chemical sensors and then transmitting variable spatiotemporal stimulation patterns... Virginia Commonwealth University

Nanosensor for assessing thrombin inhibitors

Constructs and monitoring systems to assess the level of molecules that bind to thrombin (e.g. thrombin regulators and inhibitors) are provided. The constructs are nanosensors comprising i) a thrombin molecule to which is bound a reporter ligand comprising a fluorescent label, ii) a fluorescence-quenching metal nanoparticle, and, optionally iii) a... Virginia Commonwealth University

Antimicrobial polymeric compositions

wherein n, y, R1 and R2 are defined herein, and others, methods of making of and using, and compositions made thereby which have an antimicrobial resistance effect are described.... Virginia Commonwealth University

Target for firmicutes and related bacteria: the prp protease

L27 in Staphylococcus aureus and other Firmicutes is encoded with an N-terminal extension that is not present in most Gram-negative organisms and is absent from mature ribosomes. We have identified a cysteine protease, conserved among bacteria containing the L27 N-terminal extension, which performs post-translational cleavage of L27. The provided methods... Virginia Commonwealth University

2-substituted-5-hydroxy-4h-chromen-4-ones as novel ligands for the serotonin receptor 2b (5-ht2b)

A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT2B) is identified. Some of the compounds are synthetic non-natural ligands which have a relatively strong interaction with 5-HT2B compared to naturally occurring compounds (some of which are identified for the first time herein as ligands... Virginia Commonwealth University

Uses of oxygenated cholesterol sulfates (ocs)

Methods of preventing and/or treating ischemia, organ dysfunction and/or organ failure, including multiple organ dysfunction syndrome (MODS), and necrosis and apoptosis associated with organ dysfunction/failure, are provided. For instance, the methods involve contacting organ(s) with an oxygenated cholesterol sulfate (OCS), e.g. 5-cholesten-3,25-diol, 3-sulfate (25HC3S). The organ(s) may be in vivo... Virginia Commonwealth University

Application permission recommendation and control

In one example implementation, a method includes receiving, at a computing device, a request to grant a set of requested permissions to an application installed on the computing device, and sending, from the computing device, a permission query request to a recommendation server, where the permission query request includes an... Virginia Commonwealth University








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