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Wake Forest University Health Sciences
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Wake Forest University patents


Recent patent applications related to Wake Forest University. Wake Forest University is listed as an Agent/Assignee. Note: Wake Forest University may have other listings under different names/spellings. We're not affiliated with Wake Forest University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "W" | Wake Forest University-related inventors


Methods for the identification, assessment, prevention, and treatment of neurological disorders and diseases

Described herein are methods of identifying a mammal having a neurological disease or disorder, such as AD or MCI, or at risk for developing a neurological disease or disorder, such as AD or MCI. Provided herein are also methods of monitoring the progression of a neurological disease or disorder in... Wake Forest University

Modified alginate hydrogels for therapeutic agents, their preparation and methods thereof

A novel chemically modified alginate hydrogel has been developed which combines an aromatic compound with a carbohydrate, where the aromatic compound is one or more amines combined with an alginate. The chemical structure of alginate is modified using different amines and different methods, including: (1) covalently bonding aminoethyl benzoic acid... Wake Forest University

Fas inhibitors and methods associated therewith

The present invention relates to compounds, compositions and methods comprising nanoparticles (NP) that are based on hyaluronic acid (HLA) that have been modified with hydrophobic moieties that can entrap FASN inhibitor compounds. In one embodiment, the FASN inhibitor compounds include Orlistat. In one embodiment, the hydrophobic moieties comprise 5-βCA, Pba,... Wake Forest University

Integrated compound discovery systems and methods

Methods, systems, devices and apparatus for use in screening and/or selecting a library of nucleic acid molecules and/or nucleic acid tagged or encoded molecules for binding to or interaction with a target molecule or substance (e.g., for use in new compound or drug discovery) are described. In some embodiments the... Wake Forest University

Use of nitrite salts for the treatment of cardiovascular conditions

It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood... Wake Forest University

Cleavable conjugates of functionalized platinum-acridine and platinum-benzacridine agents and methods thereof

The present invention relates to using a versatile synthetic approach to generate a new class of ester, amido, or carbamate prodrugs of highly potent, but systemically too toxic, platinum-acridine anticancer agents. The new hybrids contain a hydroxyl group, which has been masked with a cleavable lipophilic acyl moiety. Both butanoic... Wake Forest University

Hyaluronic acid-based nanoparticles as biosensors for imaging-guided surgery and drug delivery vehicles and methods associated therewith

In one embodiment, the present invention relates to a series of self-assembled nanoparticles using HLA (hyaluronic acid) as both a polymeric backbone as well as targeting ligand. In some embodiments, the present invention relates to the synthesis of HLA conjugates, and the effect of variation of the hydrophobic ligand structure... Wake Forest University

F10 inhibits growth of pc3 xenografts and enhances the effects of radiation therapy

Chemotherapy remains of limited use for the treatment of prostate cancer with only one drug, docetaxel, demonstrating a modest survival advantage for treatment of late-stage disease. Data from the NCI 60 cell line screen indicated that the castration-resistant prostate cancer cell lines PC3 and DU145 were more sensitive than average... Wake Forest University

Method for diagnosing renal diseases or predispositions

The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease... Wake Forest University

Nitrite and nitrite-metheme therapy to detoxify stroma-free hemoglobin based blood substitutes

This disclosure relates to methods of using nitrite to detoxify stroma-free hemoglobin based blood substitutes. In particular, methods are described for using a blood substitute comprised of about equimolar amounts of nitrite and hemoglobin (e.g., nitrite-metHb) to treat, prevent, or ameliorate diseases of the blood in a subject, or as... Wake Forest University

Method of making an organic thin film transistor

In one aspect, organic thin film transistors are described herein. In some embodiments, an organic thin film transistor comprises a source terminal, a drain terminal and a gate terminal; a dielectric layer positioned between the gate terminal and the source and drain terminals; and a vibrationally-assisted drop-cast organic film comprising... Wake Forest University

Functionalized tyrosine kinase inhibitors modified with precious metal electrophiles and methods associated therewith

Newly synthesized thiourea-modified 3-chloro-4-fluoroanilino-quinazoline derivatives have been studied as terminal carrier ligands in linear gold(I) complexes. The molecules mimic the tyrosine kinase inhibitor gefitinib (by computational docking experiments). Thiourea groups were either directly attached to quinazoline-C6 or linked to this position via a flexible ethylamino chain. One compound tested acts... Wake Forest University

Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith

wherein the various substituents are as defined herein. The compounds, solvates and salts thereof of Formula I are effective as anti-cancer compounds.... Wake Forest University

Composite polydots and applications thereof

The present invention relates to nanoparticle compositions and, in particular, to composite polymeric nanoparticle compositions. A composite nanoparticle described herein comprises a photoluminescent polymeric component and a photo-thermal polymeric component. The photoluminescent polymeric component and the photo-thermal polymeric component can each comprise a single polymeric species or multiple polymeric species.... Wake Forest University

Co-encapsulation of live cells with oxygen-generating particles

Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the... Wake Forest University

Modified alginate hydrogels for therapeutic agents, their preparation and methods thereof

A novel chemically modified alginate hydrogel has been developed which combines an aromatic compound with a carbohydrate, where the aromatic compound is one or more amines combined with an alginate. The chemical structure of alginate is modified using different amines and different methods, including: (1) covalently bonding aminoethyl benzoic acid... Wake Forest University

Hypdh inhibitors and methods of use for the treatment of kidney stones

Provided herein are compounds of Formula (I), Formula (II), and Formula (III), and compositions comprising the same, as well as methods of use thereof for controlling or inhibiting the formation of calcium oxalate kidney stones, inhibiting the production of glyoxylate and/or oxalate, and/or inhibiting hydroxyproline dehydrogenase (HYPDH).... Wake Forest University

Multi-level specific targeting of cancer cells

A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one... Wake Forest University

Devices and methods for treating spinal cord tissue

The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.... Wake Forest University

Integrated organ and tissue printing methods, system and apparatus

A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said... Wake Forest University

Co-encapsulation of live cells with oxygen-generating particles

Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the... Wake Forest University

Multi-layer skin substitute products and methods of making and using the same

Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics. Described herein is an artificial mammalian skin substitute... Wake Forest University

Bioreactor system and enhancing functionality of muscle cultured in vitro

A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c)... Wake Forest University

Vaccine compositions and methods of use to treat neonatal subjects

The presently disclosed subject matter relates to the fields of pharmacology and medicine, and provides vaccine compositions and methods of use, particularly influenza compositions and methods of use to treat neonatal subjects.... Wake Forest University

Tissue-mimicking hydrogel compositions for biofabrication

An extrudable hydrogel composition useful for making a three-dimensional organ construct includes a cross-linkable prepolymer, a post-deposition crosslinking group, optionally, an initiator that catalyzes the reaction between the prepolymer and said the crosslinking group; live cells (e.g., plant, animal, or microbial cells), optionally at least one one growth factor, and... Wake Forest University

Synthesis and use of poly(glycerol-sebacate) films in fibroblast growth regulation

Wound repair materials and methods of using the same to inhibit excess fibrosis are disclosed.... Wake Forest University

Subdural drainage catheter with self contained mechanism for restoration of flow following catheter obstruction

A subdural drainage device includes a subdural drainage housing defining a drainage passageway. The drainage passageway has a A subdural drainage device includes a subdural drainage housing defining a drainage passageway. The drainage passageway has a lower opening configured to connect to a subdural space of a patient and an... Wake Forest University

Regeneration of inner ear cells

The invention provides compositions and methods for treating or preventing hearing loss in a subject. The method comprises administering to the subject in need thereof, at least Myc or an agent that increases the expression of Myc in an inner ear organ, or associated neural structures, of the subject so... Wake Forest University

Compositions and methods for clearing a biological sample

The disclosure provides improved materials and methods for optically clearing biological tissue that is subsequently used for deep tissue imaging analysis. Also provided is a description of a microscopic image acquisition methodology in which imagery of intact tissues are acquired to rapidly acquire microscopy data on a whole-organ scale to... Wake Forest University

Amniotic membrane powder and its use in wound healing and tissue engineering constructs

The present invention includes compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane powder. The compositions of the present invention comprise amniotic membrane powder and a scaffold. The methods of the present invention comprises applying a composition of the present invention... Wake Forest University

Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer

The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of having or developing aggressive prostate cancer.... Wake Forest University

Methods and devices for improving cognitive function

The present invention provides methods and devices for improving cognitive function. In some embodiments, cognitive function is improved by detecting neuronal activity in the CA3 region of a patient's hippocampus and stimulating the CA3 region of the patient's hippocampus responsive to the neuronal activity detected.... Wake Forest University

Methods and compositions for determining indication for prostate biopsy

The present invention provides a method of identifying a subject for whom a prostate biopsy is indicated, comprising: a) determining, from a nucleic acid sample obtained from the subject, a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele... Wake Forest University

Systemic gene replacement therapy for treatment of x-linked myotubular myopathy (xlmtm)

The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces... Wake Forest University

Methods of treating incontinence and other sphincter deficiency disorders

A method of treating a sphincter deficiency disorder (e.g., incontinence; gastrointestinal disorders) is carried out by administering stromal cell-derived factor 1 (SDF-1) to a sphincter or sphincter complex, such as a urethral or gastrointestinal sphincter (e.g., a rectal sphincter) of the subject in a treatment-effective amount.... Wake Forest University

04/20/17 / #20170107483

Method of producing in vitro testicular constructs and uses thereof

A cell composition composed of spermatogonial stem cells, Sertoli cells, Leydig cells and optionally peritubular cells, is provided, as is a culture composition, artificial testicular construct, hydrogel composition, and device containing the same. A method for using the device as a physiologically relevant in vitro model of human testicular function... Wake Forest University

04/06/17 / #20170095204

Oral apparatus with rigid sensor capture component for strong coupling to upper jaw

An oral apparatus comprising a sensor or a plurality of sensors is provided for accurately measuring mechanical forces associated with concussive and sub-concussive impacts to the head, especially as in sports.... Wake Forest University

04/06/17 / #20170095540

Systemic gene replacement therapy for treatment of x-linked myotubular myopathy (xlmtm)

The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces... Wake Forest University

04/06/17 / #20170095630

Oxygen port nasal cannula

A device for use in delivering oxygen to a human patient while measuring carbon dioxide exhaled from that patient, comprises: (a) a base member having an oxygen delivery inlet port and a carbon dioxide detection outlet port formed therein separate from the oxygen delivery port; (b) a flexible cannula extending... Wake Forest University

04/06/17 / #20170096636

Methods and compounds for phototherapy with chalcogenorhodamine photosensitizers

A method of selectively depleting pathogenic T lymphocytes from a blood cell composition is carried out by (a) combining the cell composition ex vivo with an active compound in an effective amount, and then (b) irradiating the cells with light ex vivo for a time and at an intensity sufficient... Wake Forest University

03/30/17 / #20170087278

Methods for making a tissue engineered muscle repair (temr) construct in vitro for implantation in vivo

Provided herein are methods of culturing organized skeletal muscle tissue from precursor muscle cells by cyclically stretching and relaxing said muscle cells on a support in vitro for a time sufficient to produce said organized skeletal muscle tissue, including reseeding said organized skeletal muscle tissue by contacting additional precursor muscle... Wake Forest University

03/30/17 / #20170087548

Cell pathology tubes and associated cell processing methods

Cell tubes that can be used both for pathology collection and subsequent cell processing include a tube with a cell bed at a lower portion of the tube. The tube can include a base member that can be detachable from the tube body. The tubes can be used to form... Wake Forest University

03/23/17 / #20170082599

Selective analysis of modified biological molecules with solid-state nanopores

In one aspect, methods are described herein for the selective detection and quantitative analysis of biological molecule compositions. A method described herein comprises providing a mixture comprising biological molecules, such as DNA, RNA or proteins, complexed with a translocating agent, such as another DNA or protein, and non-complexed biological molecules.... Wake Forest University

03/23/17 / #20170082629

Diagnostic and prognostic markers for cancer

Compositions and methods useful for diagnosis and prognosis of cancer are provided.... Wake Forest University

03/16/17 / #20170071972

Method of treating peripheral neuropathies and motor neuron diseases

A composition comprising a molecule for use in the delivery of the molecule to the peripheral nervous system (PNS) and/or to the central nervous system (CNS), wherein the composition is administered by regional infusion.... Wake Forest University

03/16/17 / #20170072150

Halotherapy devices and methods

Devices and methods for administering halotherapy are provided for treating respiratory or skin conditions. Variations include a portable devices as well as stationary devices suitable for administering therapy in permanent settings (e.g., in the home).... Wake Forest University

03/09/17 / #20170067059

Methods and compositions for treatment of chlamydial infection and related diseases and disorders

The present invention provides compositions and methods of use in the treatment/prevention of chlamydial infection and/or diseases and disorders associated with chlamydial infection in a subject.... Wake Forest University

02/09/17 / #20170035551

Bioreactor system and enhancing functionality of muscle cultured in vitro

A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c)... Wake Forest University

01/19/17 / #20170014521

Pharmaceutical compositions for high-capacity targeted delivery

Provided herein are aptamers and pharmaceutical compositions comprising the same. In some embodiments, the aptamer selectively binds a protein of interest such as an extracellular receptor protein of interest (e.g., a cancer cell extracellular receptor protein, which may be differentially expressed in some embodiments). In some embodiments, the aptamer is... Wake Forest University

01/05/17 / #20170000373

Methods, systems, and devices for assessing neuromuscular status of ligamentous and soft tissues

Systems, devices, and methods for neuromuscular testing of ligamentous or soft tissue structures in mammals provide information (e.g., EMG feedback) about the status of neuromuscular function and reflex activity for, e.g., joint structures, in consideration of surgical or other procedures.... Wake Forest University








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