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Washington University patents


Recent patent applications related to Washington University. Washington University is listed as an Agent/Assignee. Note: Washington University may have other listings under different names/spellings. We're not affiliated with Washington University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "W" | Washington University-related inventors


Fast, continuous psychometric estimation system utilizing machine learning and associated use

A method and system for of computerized psychometric testing of sensory information that includes selecting stimulus parameters for a first stimulus to be applied with a stimulus inducer, applying a first stimulus on a subject with the stimulus inducer upon command of a processor, calculating a posterior probability function and... Washington University

Bilayered structures for solar steam generation

The present disclosure is directed to steam generation through the efficient harvesting of solar energy. In particular, the present disclosure is directed to bilayered structures that are cost-effective, scalable and/or biodegradable that provide high steam-generation efficiency.... Washington University

Antibodies to tau

This invention relates to antibodies to tau and methods of use thereof.... Washington University

Tumor targeted tnf-related apoptosis inducing ligand fusion polypeptide, methods and uses therefor

Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds MUC16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. A sequence that binds MUC 16 can be mesothelin or a... Washington University

Homing agents

The present disclosure provides peptide constructs for diagnostic imaging and therapeutic applications, using pegylated peptides which exhibit specific binding for a target molecule of interest, such as a biomarker of a disease or disorder.... Washington University

Self-cleaning endoscope

A self-cleaning endoscope and methods of using the same are described. The self-cleaning endoscope includes a housing having a distal end and a proximal end opposite the distal end, a lens positioned at the distal end of the housing, and a lens protector coupled to the distal end of the... Washington University

Discectomy instrument

A discectomy instrument for use with a cutting tool including a flexible shaft and an implement extending from the shaft generally includes a guard including a shaft and a foot extending therefrom, wherein the foot has a port and a plurality of teeth. The instrument also includes a guide including... Washington University

Anti-tau constructs

The present invention provides anti-tau constructs. Anti-tau constructs of the invention are polynucleotide sequences encoding a polypeptide comprising at least one tau binding moiety and optionally comprising a signal peptide and/or a purification moiety. The present invention also provides isolated polypeptides encoded by anti-tau constructs, vectors comprising anti-tau constructs, and... Washington University

Toolkit for the production of post-translationally modified proteins

The present disclosure provides a system to produce soluble, folded, and post-translationally modified proteins. The system includes a fusion protein comprising a catalytic domain of an enzyme involved in post-translational protein modification and a targeting domain, and a substrate protein comprising a protein of interest and a sequence that interacts... Washington University

Vaccine compositions for use against enterotoxigenic escherichia coli

The present disclosure provides vaccine compositions for use against enterotoxigenic Escherichia coli (ETEC) comprising EtpA and EatA. EtpA and EatA are prevalent amount diverse ETEC isolates and display significant sequence conservation. In an aspect, the disclosure encompasses a vaccine composition comprising EtpA and EatA. In another aspect, the disclosure encompasses... Washington University

Detection of rare sequence variants, methods and compositions therefor

The present disclosure encompasses methods of error corrected sequencing (ECS) that enable detection of very rare mutations well below the error rate of convention next generation sequencing (NGS). Further, the methods disclosed herein enable multiplex targeting of genomic DNA.... Washington University

Blood substitute composition and use

The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.... Washington University

Induction of tolerance in lung allograft transplantation

The present disclosure relates to methods of inducing tolerance to lung allograft transplantation. These methods comprise increasing suppressor CD8+ T cells and/or suppressing deleterious CD8+ and CD4+ T cells.... Washington University

Inhibition and diagnostics of emerging tetracycline resistance enzymes

The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that binds a FAD-dependent flavoenzyme and a tetracycline, analog, derivative, or pharmaceutically acceptable salt thereof.... Washington University

Tunable add-drop filter with an active resonator

An add-drop filter for transmitting at least one signal is provided. The add-drop filter includes at least two optical waveguides capable of carrying the at least one signal, and at least one active resonator coupled between the optical waveguides, wherein the at least one active resonator provides gain that counteracts... Washington University

Compostions and methods for tissue repair

Provided herein are compositions and methods for treating a subject with damaged tissue, such as an injury associated with a tissue to tissue (e.g., a connective tissue-to-connective tissue or tissue to bone) interface. One aspect provides an adhesive film or adhesive layer, optionally comprising a biomaterial, tissue growth factors, including... Washington University

Radiant boiler for pressurized oxy-combustion and radiant trapping to control heat flux in high temperature particle-laden flows at elevated pressure

A boiler has a shell surrounding a vertical centerline. The shell defines an inner surface having an inner diameter and an inner length extending between an upper upstream end and a lower downstream end. The inner surface defines a hollow interior, the boiler having a pre-combustion zone, a combustion zone... Washington University

Sulfur-containing compounds targeting vesicular acetylcholine transporter

The present invention generally relates to various compounds that are useful as vesicular acetylcholine transporter (VAChT) ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of neurodegenerative diseases including Parkinson's disease (PD), and Alzheimer's disease (AD).... Washington University

Compositions and methods for detecting ccr2 receptors

Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in detecting, monitoring, and evaluating CCR2 associated diseases, disorders, and conditions.... Washington University

Systems and methods for point-of-care positron emission tomography

A positron emission tomography (PET) system is provided. The system includes a first detector panel including a first array of detectors, a second detector panel including a second array of detectors, said second detector panel being moveable relative to a point between the first detector panel and the second detector... Washington University

Ddr2 inhibitors and methods of using

Compounds that inhibit activation of Discoidin Domain Receptor 2 (DDR2) and methods of using the compounds to inhibit DDR2 activation, inhibit migration of cells expressing DDR2, and treat diseases or disorders associated with DDR2 dysfunction.... Washington University

Neuroactive 19-alkoxy-17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same

The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.... Washington University

Biomedical patches with aligned fibers

A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a... Washington University

Method for the use of slurries in spray pyrolysis for the production of non-hollow, porous particles

A process for preparing a metal oxide-containing powder that comprises conducting spray pyrolysis that comprises aerosolizing a slurry that comprises solid-phase particles in a liquid that comprises at least one precursor compound, which comprises one or more metallic elements of at least one metal oxide, to form droplets of said... Washington University

Methods and systems for controlling body parts and devices using ipsilateral motor cortex and motor related cortex

A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere... Washington University

Treatment of cardiovascular disease using actrii ligand traps

Provided herein are methods of treating diseases associated with vascular calcification and/or cardiovascular disease in a subject by using the level of a biomarker, in particular, snail homolog 1 (Snai1), phosphosmad2, phosphosmad3, urinary protein, dickkopf homolog 1 (Dkk1), collagen type 1 alpha 1 (Col1a1), activin (e.g., free activin), runt-related transcription... Washington University

Tau kinetic measurements

The invention relates to in vitro methods for measuring the in vivo metabolism of tau in a subject.... Washington University

Antibodies to tip-1 and grp78

The present invention is directed towards isolated antibodies that bind to GRP78.... Washington University

Bile acid biomarkers for niemann-pick diseases, methods and uses therefor

Methods for identification and quantification of bile acids are disclosed. Bile acids in plasma, serum and/or blood such as a dried blood spot are used to identify subjects with a Niemann-Pick disease. The methods include measuring levels of a bile acid, such as 3β,5α,6β-trihydroxycholanic acid, N-(3β,5α,6β-trihydroxy-cholan-24-oyl)glycine, N-(3β,5α,6β-trihydroxy-cholan-24-oyl)taurine, or a combination... Washington University

Compositions and methods for treatment of pre-cancerous skin lesions

The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.... Washington University

Compounds and methods for treating bacterial infections

The present invention encompasses compounds and methods for treating urinary tract infections.... Washington University

Developing predictive dose-voume relationships for a radiotherapy treatment

Embodiments develop a predictive dose-volume relationships for a radiation therapy treatment is provided. A system includes a memory area for storing data corresponding to a plurality of patients, wherein the data comprises a three-dimensional representation of the planning target volume and one or more organs-at-risk. The data further comprises an... Washington University

08/17/17 / #20170231501

Super-pixel detection for wearable diffuse optical tomography

A system includes a wearable head apparatus and an electronic console. The head apparatus is configured to receive resultant light from the head of a subject. The electronic console includes a fiber array, a detector, and a computing device. The fiber array includes a plurality of fibers configured to transport... Washington University

08/17/17 / #20170232006

Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same

The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.... Washington University

08/17/17 / #20170232092

Methods and compositions for t cell generation and uses thereof

Among the various aspects of the present disclosure is the provision of a method of treating an inflammatory bowel disease. Another aspect provides the provision of a screening method for therapeutic agents. Another aspect provides a method of detecting Treg cells to determine if a subject has an inflammatory disease.... Washington University

08/17/17 / #20170232146

3d tissue-engineered bone marrow for personalized therapy and drug development

A tissue-engineered bone marrow for personalized therapy of a patient is described. The tissue-engineered bone marrow includes an autologous fibrin scaffold and a plurality of patient-derived cells isolated from the patient's bone marrow. The autologous fibrin scaffold is made using fibrinogen isolated from the patient's bone marrow. The plurality of... Washington University

08/17/17 / #20170233356

Neuroactive substituted cyclopent[a]anthracenes as modulators for gaba type-a receptors

The present disclosure is generally directed to neuroactive substituted cyclopent[a]anthracenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.... Washington University

08/17/17 / #20170237398

Phase-selective entrainment of nonlinear oscillator ensembles

A system for entraining an oscillator ensemble is disclosed that includes a plurality of oscillators in an entrained phase pattern. The system includes an entrainment device operatively coupled to each non-linear oscillator of the oscillator ensemble, and the entrainment control device is configured to deliver a 2π-periodic control signal v(θ)... Washington University

08/03/17 / #20170218465

Compositions and methods for detecting viruses in a sample

The present disclosure provides a composition comprising a panel of probes for detecting one or more viruses in a sample. The panel of probes may be used to detect viruses in a biological sample obtained from a subject.... Washington University

07/27/17 / #20170209603

Compositions targeting radiation-induced molecules and methods of use thereof

The present invention is directed towards the compositions of peptide constructs that bind to GRP78 and the methods of use thereof.... Washington University

07/27/17 / #20170209606

Hydrogels for localized radiotherapy

Radioactive hydrogels for the delivery of localized radiotherapy, methods of making the radioactive hydrogels, and methods of using the radioactive hydrogels are disclosed. A radioisotope may be conjugated to a high molecular weight molecule, which may be encapsulated in a microparticle, where the microparticle is then dispersed within a hydrogel.... Washington University

07/27/17 / #20170211155

Method for predicting risk of metastasis

The invention encompasses methods and compositions for predicting the risk of metastasis. In particular, the invention encompasses a method for correlating the level of expression of one or more nucleic acid sequences with a risk of metastasis.... Washington University

07/20/17 / #20170202475

Depression brain computer interface for the quantitative assessment of mood state and for biofeedback for mood alteration

A brain computer interface (BCI) system includes an electroencephalogram (EEG) headset and a computing device communicatively coupled to the EEG headset. The computing device includes a memory, a processor and a display device. The memory stores instructions that, when executed by the processor, cause the processor to monitor, using the... Washington University

07/20/17 / #20170202939

Personalized cancer vaccines and methods therefor

Methods of cane r treatment based, on personalized vaccines are disclosed. Individual amino acid substitutions from tumors are revealed using whole genome sequencing, and identified as neoantigens silico. Peptide sequences are then tested in vitro for ability to bind HLA molecules and to be presented to CD8+ T-cells. A vaccine... Washington University

07/20/17 / #20170203113

Method for low-voltage termination of cardiac arrhythmias by effectively unpinning anatomical reentries

A method for extinguishing a cardiac arrhythmia utilizes destructive interference of the passing of the reentry wave tip of an anatomical reentry through a depolarized region created by a relatively low voltage electric field in such a way as to effectively unpin the anatomical reentry. Preferably, the relatively low voltage... Washington University

07/13/17 / #20170197912

Synthesizing pet tracers using [f-18]sulfonyl fluoride as a source of [f-18]fluoride

The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic evaporation step by the use of anion exchange resin and sulfonyl chloride, and its applications in the manufacturing of PET radiopharmaceuticals.... Washington University

07/13/17 / #20170199971

Acceptance, commissioning, and ongoing benchmarking of a linear accelerator (linac) using an electronic portal imaging device (epid)

The present invention is a method or system for acceptance testing and commissioning of a LINAC and treatment planning system (TPS). For a LINAC commissioning, the present invention collects reference data from a fully calibrated LINAC and compares the reference data with machine performance data collected from a testing LINAC.... Washington University

07/06/17 / #20170188571

Systems and methods for normothermic extracorporeal organ perfusion

A system and method for perfusing an organ with a normothermic extracorporeal perfusion system is disclosed. The perfusion system is an active flow system using a centrifugal pump to aid in circulation. The system includes a dialyzer that removes excess fluid and impurities, while maintaining the pH, which allows the... Washington University

07/06/17 / #20170189566

Alpha-synuclein ligands

The present invention generally relates to various compounds that are useful as α-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of synucleinopathies, including Parkinson's disease (PD).... Washington University

07/06/17 / #20170190732

Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same

The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.... Washington University

06/29/17 / #20170181424

Blood substitute composition and use

The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.... Washington University

06/29/17 / #20170183385

Methods and compositions for red-shifted chromophore substitution for optogenetic applications

The present disclosure provides compositions and methods used for optogenetics, wherein the composition comprises an optogenetic device and a retinoid processing enzyme.... Washington University

06/22/17 / #20170176563

Methods for simultaneous multi-angular relaxometry and rf mapping of tissue using magnetic resonance imaging

Methods of obtaining quantitative MRI images of a subject that includes fitting a theoretical model that accounts for tissue-specific relaxation properties and magnetization transfer effects to MRI measured data is disclosed.... Washington University

06/08/17 / #20170159072
06/08/17 / #20170163971

Multiple-view compressed-sensing ultrafast photography (mv-cup)

On the basis of compressed sensing (CS), CUP may encode the spatial domain with a pseudo-random binary pattern, followed by a shearing operation in the temporal domain, performed using a streak camera with a fully opened entrance slit. This encoded, sheared three-dimensional (3D) x, y, t scene may then be... Washington University

06/01/17 / #20170153243

Methods of polypeptide identification, and compositions therefor

Methods are disclosed for identifying one or more proteins or polypeptides comprised by a sample. The methods comprise determining binding of each polypeptide with respect to each binding pool of a plurality of binding pools, wherein each binding pool comprises one or more probes which bind a structure comprised by... Washington University

05/25/17 / #20170146557

Methods of determining amyloid beta turnover in blood

The present invention encompasses a method for determining Aβ turnover in blood.... Washington University

05/25/17 / #20170146628

Diagnosis of central nervous system white matter pathology using diffusion mri

A method of performing diffusion basis spectrum imaging (DBSI) within a tissue of a patient using diffusion magnetic resonance data acquired from a portion of the tissue is disclosed. The diffusion magnetic resonance data includes a plurality of diffusion MR signals associated with one voxel and the one voxel represents... Washington University

05/18/17 / #20170135656

Insert device for enhancing pet and mri images

Insert devices that include a RF surface coil and gamma-ray photon detector array for enhancing PET and MRI images produced from integrated PET-MRI scanners are disclosed. Integrated PET-MRI scanners that include such insert devices as well of methods for scanning an object by use of such devices are also disclosed.... Washington University

05/18/17 / #20170136030

Treatment of malaria using inhibitors of the ispd enzyme in the non-mevalonate pathway

Compounds are disclosed that inhibit the methylerythritol cytidyltransferase (IspD) enzyme in the non-mevalonate pathway (MEP pathway), which is present in many organisms including the P. falciparum parasite. Inhibitors of the IspD enzyme in the non-mevalonate pathway of the P. falciparum parasite are useful for treating malaria.... Washington University

Patent Packs
05/04/17 / #20170119467

Thermoablation probe

A thermoablation probe for performing an interstitial thermal therapy (ITT) procedure on a brain lesion generally includes a rigid sheath and a flexible treatment device telescopically slidable within the sheath. The treatment device has a substantially continuous covering and a shape-memory wire enveloped by the covering.... Washington University

05/04/17 / #20170124255

Method and performing similarity searching

A system and method for performing similarity searching is disclosed wherein programmable logic devices such as field programmable gate arrays (FPGAs) can be used to implement Bloom filters for identifying possible matches between a query and data. The Bloom filters can be implemented in a parallel architecture where the different... Washington University

04/20/17 / #20170105636

Photoacoustic flowmetry systems and methods

Methods for measuring blood flow speed within blood vessels using a PA imaging system are disclosed. The methods include position a field of view of a PA imaging system along a section of a blood vessel, introducing a PA discontinuity into the blood flow within the blood vessel upstream of... Washington University

04/20/17 / #20170108515

Antibodies to disulfated heparin disaccharide in the diagnosis of neuropathy

Methods aiding in the diagnosis of certain neuropathies are disclosed, in which the titer of antibodies to a disulfated heparin disaccharide is assessed in a test sample from a subject. Also disclosed are apparatus and kits that can be used in the methods of the invention.... Washington University

04/13/17 / #20170101624

Methods of enhancing t-cell longevity and uses thereof

The present disclosure encompasses methods of enhancing T cell longevity and/or T cell function by promoting mitochondrial fusion and/or mitochondrial structural remodeling including cristae. Compositions comprising the enhanced T cells may be used in adoptive cellular immunotherapy.... Washington University

04/13/17 / #20170101642

Methods of inhibiting viral replication comprising the signal peptidase complex

The present invention is directed to compositions targeting the signal peptidase complex and methods of use in treating and preventing flavivirus infection.... Washington University

04/06/17 / #20170095577

Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography

The present disclosure provides compositions comprising an oligopeptide comprising a fragment of a natriuretic peptide, wherein the fragment comprises the sequence Arg-Ile-Asp-Arg-Ile (SEQ ID NO:1), and a detectable label. Further disclosed are methods of imaging atherosclerotic plaque by optical imaging using a peptide composition.... Washington University

03/30/17 / #20170087519

Composite nanostructures having a crumpled graphene oxide shell

Composite nanostructures having a crumpled graphene oxide shell and a nanoparticle selected from titanium dioxide, silver and magnetite within the shell are disclosed. The nanostructures may be incorporated into a filtration membrane suitable for purifying water for targeted separations and for human consumption.... Washington University

03/30/17 / #20170089689

System and quantifying deformation, disruption, and development in a sample

A computer-implemented method for determining a quantification of the deformation of the sample is implemented using a computer device in communication with a memory. The method includes receiving, by the computer device, a first image of the sample and a second image of the sample. The method also includes registering... Washington University

03/30/17 / #20170089897

Distinguishing flavivirus infection using a recombinant mutant envelope protein

The present invention relates to mutant peptides of the E protein of the West Nile virus and other flaviviruses useful for discriminating flaviviral infections, as well as kits, methods and uses related thereto.... Washington University

03/16/17 / #20170071889

Dna methyltransferases for the treatment and prevention of arthritis

The present disclosure is directed to compositions and methods for treating osteoarthritis comprising increasing the expression of Dnmt3b and/or inhibiting aminobutyrate aminotransferase.... Washington University

03/16/17 / #20170074811

Integrated epr nmr with frequency agile gyrotron

A frequency agile gyrotron for use in combination with an NMR system is disclosed. The frequency agile gyrotron combined with EPR-NMR magic angle spinning resonators and cryogenic sample cooling may increase the sensitivity of solid state NMR with DNP.... Washington University

03/09/17 / #20170065182

Reversibly switchable photoacoustic imaging systems and methods

Reversibly switchable photoacoustic tomography (RS-PAT), a photoacoustic technique with enhanced sensitivity and resolution, is disclosed. RS-PAT utilizes a subtractive process for the formation of a photoacoustic image of a region containing a plurality of switchable photoacoustic probes. In various aspects, the photoacoustic detection in RS-PAT imaging occurs minimally twice: a... Washington University

03/09/17 / #20170065669

Antithrombotic nanoparticle

The present invention encompasses an antithrombotic nanoparticle and use thereof.... Washington University

03/09/17 / #20170067112

Sequences associated with tdp-43 proteinopathies and methods of using the same

The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.... Washington University

Patent Packs
03/09/17 / #20170067920

Methods of determining efficacy of therapy for niemann-pick c disease and related disorders

A method for identifying and screening subjects for cholesterol storage or trafficking diseases using an oxysterol as a biomarker. More particularly, subjects are screened and can be identified as having Niemann-Pick C disease, the method comprising the steps quantifying the concentration of an oxysterol in a biological sample taken from... Washington University

03/02/17 / #20170056240

Methods and devices for brain cooling for treatment and/or prevention of epileptic seizures

Passive prosthetic devices for focally cooling a brain and methods for inhibiting seizures are disclosed. The prosthetic devices replace a thermally insulating bone flap with a thermally conductive insert having an inner surface that contacts the relatively warm meninges or brain and an outer surface that contacts the relatively cool... Washington University

03/02/17 / #20170058297

Compositions and methods for site specific recombination at asymmetric sites

The present invention relates to enzymes, compositions and methods for catalyzing site specific recombination at asymmetric sites.... Washington University

02/23/17 / #20170052194

Molecules and methods for iterative polypeptide analysis and processing

Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the N-terminal amino acid or N-terminal phosphorylated amino acid of a polypeptide. Also, an enzyme for use in the cleavage step of the Edman degradation reaction and a method for... Washington University

02/16/17 / #20170044269

Adenoviral targeting, compositions and methods therefor

Polypeptides are disclosed comprising, in N-terminal-to-C-terminal order: an N-terminal segment of Ad5 fiber tail sequence; at least 2 pseudorepeats of an Ad5 fiber shaft domain sequence; a portion of a third Ad5 fiber shaft domain sequence; a carboxy-terminal segment of a 14 fibritin bacteriophage trimerization domain sequence; a linker sequence;... Washington University

02/16/17 / #20170044618

Methods and compositions involving intrinsic genes

Disclosed are compositions and methods related intrinsic gene sets and methods and compositions related to detecting and classifying cancer.... Washington University

02/09/17 / #20170035759

Treatment of parasitic diseases using kdac inhibitor compounds

Methods of using KDAC inhibitor compounds for the treatment of various parasitic diseases are described.... Washington University

02/09/17 / #20170037079

Neuroactive 13, 17-substituted steroids as modulators for gaba type-a receptors

The present disclosure is generally directed to neuroactive 13, 17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.... Washington University

02/02/17 / #20170028034

Mutant huntingtin-mediated protein dysfunction

The present invention relates to methods of inhibiting neurodegeneration in a subject suffering from or genetically at risk and/or destined to develop Huntington's Disease comprising increasing, in neurons of the subject, the activity of the TIM23 mitochondrial protein import complex.... Washington University

01/26/17 / #20170020402

Implantable and bioresorbable sensors

Provided herein are implantable and bioresorbable sensors that are specifically designed to be implanted, function for an operational lifetime, and at some point after the operational lifetime to be resorbed by the body in such a manner so as to avoid having to remove any part of the sensor. This... Washington University

01/26/17 / #20170022263

Tumor targeted tnf-related apoptosis inducing ligand fusion polypeptide, methods and uses therefor

Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds MUC16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. A sequence that binds MUC 16 can be mesothelin or a... Washington University

01/19/17 / #20170014066

Task-less optical mapping of brain function using resting state functional connectivity

A method for utilizing an optical system for taskless mapping of brain function includes determining a time series of dynamic light measurements for a plurality of spatially distributed source-detector pairs, receiving the dynamic light measurements over a period of time using the source-detector pairs without dependence on either a task... Washington University

01/19/17 / #20170015660

Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof

Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC50 value below 5 μM against human pancreatic cancer cells in vitro. Administration of this... Washington University

01/12/17 / #20170007196

Automated apparatus to improve image quality in x-ray and associated use

A system or method for improving quality in projection and tomographic x-ray, which includes a depth sensing device to measure a depth of at least one body part of a patient from the depth sensing device and a control unit to calculate a thickness and/or circumference of the body part... Washington University

01/12/17 / #20170007724

Imaging and treatment of pathophysiologic conditions by cerenkov radiation

The present disclosure discloses methods and compositions for A administering Cerenkov radiation-induced therapy (GRIT). In an aspect, the invention encompasses a composition comprising at least two radiation-sensitive molecules. In another aspect, the invention encompasses a composition comprising a radiation-sensitive molecule and a targeting agent. In still another aspect, the invention... Washington University

02/01/18 / #20180031483

Bioplasmonic detection of biomarkers in body fluids using peptide recognition elements

Plasmonic nanotransducers and methods for label-free detection of biomarkers are disclosed. The plasmonic nanotransducers include nanostructure cores and peptide aptamers. The plasmonic nanotransducers are exposed to a biological sample that can contain the specific biomarkers and can be analyzed with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance... Washington University

01/18/18 / #20180014971

Thermally conductive graft

The present disclosure provides thermally conductive grafts and methods of passively cooling a hyperthermic region and preventing epilepsy, neural inflammation, and other neurological abnormalities using a thermally conductive graft including a thermally conductive matrix disposed between two opposed surfaces.... Washington University

11/30/17 / #20170342436

Transgenic plants exhibiting enhanced phytochelatin-based heavy metal tolerance and methods of use thereof

Transgenic plants exhibiting phytochelatin-based heavy metal tolerance and methods of use thereof for bioremediation are disclosed.... Washington University

10/26/17 / #20170307590

Inhibitors of malarial and human glucose transporters and methods for identifying the inhibitors

Inhibitors of glucose transporter Plasmodium falciparum hexose transporter (PfHT) are provided herein. Further, a cell-based, high-throughput assay that directly measures the ability of a compound to inhibit glucose transport by PfHT is provided.... Washington University








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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