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Wayne State University patents


Recent patent applications related to Wayne State University. Wayne State University is listed as an Agent/Assignee. Note: Wayne State University may have other listings under different names/spellings. We're not affiliated with Wayne State University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "W" | Wayne State University-related inventors


Transgenic animal models for cystic fibrosis

This disclosure relates to transgenic rabbit models of cystic fibrosis, and methods of using these rabbits and their derivatives.. . ... Wayne State University

Electrochemical deposition of nanowires on nanoparticles, lithographical patterns and electronic devices and their use as chemical sensors

Materials and methods for generating nanowires are described. Krogmann salt potassium tetracyanoplatinate sesquihydrate (k(def)tcp) nanowires are synthesized as interconnects on metal lithographic patterns in which the k(def)tcp nanowires grow across the metal lines. ... Wayne State University

Protein-induced pluripotent cell technology and uses thereof

A method of generating protein-induced pluripotent stem cells by delivering bacterial!y expressed reprogramming proteins into nuclei of starting somatic cells using the qq-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous pips cells. Also provided are the pipcs cells formed using this method and uses thereof.. ... Wayne State University

Detectors of serum biomarkers for predicting ovarian cancer recurrence

Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at least one autoantibody marker. An antibody binding assay for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, and methods for performing the assay. ... Wayne State University

Detection of sleep disordered breathing using cardiac autonomic responses

A memory stores r-r interval (rri) data collected from a patient over a time interval and oxygen saturation (sao2) data collected from the patient over the time interval. A processor is programmed to analyze the sao2 data to identify desaturation events, analyze the rri data to identify dips, utilize the dips to construct a rri dip index measure of rri dips per unit time over the time interval, determine a number of desaturations above a predefined threshold, determine an oxygen desaturation index (odi), and utilize the rri dip index and the odi to provide results indicative of a risk of sleep-disordered breathing (sdb) for the patient.. ... Wayne State University

Ultrafast target detection based on microwave metamaterials

A system (100) for locating an object (114) includes a signal source (102) that generates a wideband signal (104) that includes a continuously variable frequency from a first frequency to a second frequency, a microwave metamaterial leaky wave antenna (106) that receives the wideband signal as an input and maps the wideband signal from the first frequency to the second frequency as electromagnetic radiation that increases as a function of an azimuthal direction (108,110,112), the microwave metamaterial leaky wave antenna (106) positionable to face toward an object that is within its field-of-view fov, wherein the transceiver assembly is positioned to receive the electromagnetic radiation that is reflected from the object and convert the reflected electromagnetic radiation to a reflected electrical signal, and an analyzer (118) configured to identify a main beam frequency of the reflected electrical signal and determine an azimuthal angle (108,110,112) and distance to the object based on the main beam frequency.. . ... Wayne State University

Augmented reality system and method for exposure therapy and motor skills training

An exemplary system may include an augmented reality device with a user interface, a processor and memory having a program communicatively connected to the processor. A transceiver may be communicatively connected to a practitioner device for real-time practitioner guidance. ... Wayne State University

Method of enhancing delivery of therapeutic compounds to the eye

The invention provides methods for enhancing the delivery of therapeutic compounds to the eye of a subject by administering plasmin or derivatives thereof and the therapeutic compounds to the eye.. . ... Wayne State University

Wayne State University

. . ... Wayne State University

Method of prevention and inhibition of preterm labor

Methods for preventing and/or inhibiting preterm labor in a pregnant subject, such as a human subject, are disclosed according to the invention including administering a therapeutically effective amount of a protein selected from the group consisting of: pibf1, a fragment or variant thereof; il-33, a fragment or variant thereof; and a combination of any two or more thereof. Pharmaceutical compositions for preventing and/or inhibiting preterm labor in a pregnant subject, such as a human subject, are disclosed according to the invention including a therapeutically effective amount of a protein selected from the group consisting of: pibf1, a fragment or variant thereof; il-33, a fragment or variant thereof; and a combination of any two or more thereof.. ... Wayne State University

Methods and compositions relating to treatment of nervous system injuries

Compositions are provided according to aspects of the present invention which include: a plurality of longitudinally extending fibers, each of the fibers having a longitudinal axis, wherein the longitudinal axis of each of a majority of the fibers is generally aligned; a plurality of stem cells capable of differentiation into a central or peripheral nervous system cell, a majority of the plurality of stem cells in contact with one or more of the plurality of longitudinally extending fibers; a biocompatible hydrogel, wherein the longitudinally extending fibers and stem cells are disposed in the matrix of a biocompatible hydrogel; a therapeutic amount of a neurotrophic factor disposed in the biocompatible hydrogel, wherein the neurotrophic factor is distributed as a gradient; a plurality of olfactory ensheathing cells disposed in the biocompatible hydrogel; and a therapeutic amount of a scar inhibitor disposed in the biocompatible hydrogel.. . ... Wayne State University

Detectors of serum biomarkers for predicting ovarian cancer recurrence

Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at least one autoantibody marker. An antibody binding assay for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, and methods for performing the assay. ... Wayne State University

Compositions and methods to diagnose diabetes and/or to treat negative effects of diabetes

The present disclosure describes a genome-wide transcriptional analysis of differentially expressed genes in diabetic, non-diabetic, normal and wounded tissue. The analysis allowed development of compositions and methods to diagnose diabetes and/or to treat negative effects of diabetes, including delayed wound healing and reduced vision.. ... Wayne State University

Method of making injectable cements

A discovery of the conversion of amorphous calcium polyphosphate (acpp) or/and other polyphosphate salts with various type of calcium phosphate to new calcium phosphate product (i.e. Dicalcium phosphate dihydrate (dcpd)) in a liquid environment. ... Wayne State University

01/11/18 / #20180012745

Mass spectrometry using laserspray ionization

Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (lsi). Lsi can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 daltons. ... Wayne State University

12/21/17 / #20170363612

Compositions and methods relating to proliferative disorders

Methods and compositions for drug discovery, analysis and treatment of a proliferative disorder characterized by abnormal cells in a mammalian subject are provided according to aspects of the present invention which include administering a pharmaceutically effective amount of a combination of: a cytotoxic agent, a set agonist and a set ribosome antagonist. Methods and compositions according aspect of the present invention incorporate agents effective to regulate and/or affect selective translation in a cell characterized by abnormal proliferation, such as a cancer cell, thereby promoting death of the cell.. ... Wayne State University

12/14/17 / #20170356043

Activity-dependent gene pairs as therapeutic targets and methods and devices to identify the same

Activity-dependent gene pairs as therapeutic targets and methods and devices to identify the same are provided. The methods and devices allow transcriptome-wide analysis of regulatory long non-coding rnas (incrnas), matched with differentially expressed protein-coding genes (mrnas) and/or with other incrnas. ... Wayne State University

12/07/17 / #20170348414

Novel synthetic anticancer, antifungal, and antibacterial vaccines

Described herein are compounds for use in vaccine compositions which contain natural or synthetic carbohydrate antigens. Such vaccines may be highly immunologically active due to the conjugation with an immune-stimulating protein or with a monophosphorylated lipid a derivative, and may be self-adjuvanting due to the presence of a monophosphorylated lipid a derivative. ... Wayne State University

11/09/17 / #20170319669

Method of enhancing viral-mediated gene delivery

The invention provides methods for enhancing the delivery of viral vectors to the eye of a subject by administering a proteasome inhibitor or and a viral vector ending a gene of interest to the eye.. . ... Wayne State University

10/05/17 / #20170285107

Battery state of charge estimator

A battery monitoring device includes a first coil positioned within a cell of a battery, a second coil positioned to be magnetically coupled to the first coil through active material that is contained within the cell, and a controller that is configured to apply an electrical current to one of the first and second coils, detect induced electrical current in the other of the first and second coils, and determine a state-of-charge (soc) of the battery based on the induced electrical current.. . ... Wayne State University

09/28/17 / #20170273924

Valproate as a topical anti-fungal treatment

Valproate is useful as an antifungal agent. The valproate compositions can be used to treat fungal infections. ... Wayne State University

09/14/17 / #this invention provides substituted pyrimidine compounds having the formula:

Wayne State University

. . ... Wayne State University

09/07/17 / #20170252376

Nucleic acid constructs including a txnip promoter for the treatment of disease

Nucleic acids for the treatment of diseases are described. The nucleic acids include a thioredoxin-interacting protein (txnip) promoter and a gene that encodes a therapeutic protein or an interfering nucleic acid sequence (e.g., interfering rna (irna sequence)).. ... Wayne State University

08/31/17 / #20170248599

Methods and compositions relating to assays of fetal extravillous trophoblast cells

Methods of isolating and assaying fetal extravillous trophoblast cells, including assays of rna of the fetal extravillous trophoblast cells according to aspects of the disclosure include obtaining a maternal endocervical sample containing fetal extravillous trophoblast cells from a pregnant subject; fixing the maternal endocervical sample in an aldehyde fixative, removing fetal extravillous trophoblast cells from the maternal endocervical sample thereby producing isolated extravillous trophoblast cells, isolating and assaying rna from the fetal extravillous trophoblast cells.. . ... Wayne State University

08/31/17 / #20170246238

Neurokinin 1 receptor agonist mediated protection of the eye

Neurokinin 1 receptor (nk1r) agonist mediated protection of the eye is described. The protection can reduce dry eye and ocular infections, particularly in individuals with reduced nk1r activity.. ... Wayne State University

08/03/17 / #20170217903

Anticancer drugs including the chemical structures of an androgen receptor ligand and a histone deacetylase inhibitor

A novel class of drugs for treating androgen receptor (ar) positive cancer including prostate cancer and breast cancer are described. The drugs include the chemical scaffolds of a high affinity androgen receptor ligand and a histone deacetylase inhibitor. ... Wayne State University

08/03/17 / #20170216445

Cxcr4 inhibiting carriers for nucleic acid delivery

The present invention generally relates to carriers including polymers and lipids that comprise a cxcr4 inhibiting moiety. More specifically, these carriers are biodegradable and can be bioreducible polymers that comprise a cxcr4 inhibiting moiety. ... Wayne State University

08/03/17 / #20170216200

Dendrimers for sustained release of compounds

Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.. . ... Wayne State University

07/27/17 / #20170214246

Balanced control strategies for interconnected heterogeneous battery systems in smart grid applications

A battery network includes a plurality of heterogeneous batteries coupled to at least one energy source and one energy load, a plurality of switches coupled to the heterogeneous batteries, and the switches controllable having a duty cycle between 0 and 1. A controller is configured to characterize each of the plurality of heterogeneous batteries characteristics, determine duty cycles for each of the plurality of switches based on the characterization such that a charge applied from the at least one energy source or a discharge to the at least one energy load converges to a balanced state for the plurality of heterogeneous batteries, and apply the determined duty cycles to the plurality of switches.. ... Wayne State University

06/29/17 / #20170183649

Method for identifying a subpopulation of mammalian cells with distinctive ribosome translation profiles

The present invention generally relates to subpopulations of mammalian cells with distinctive ribosome translational profiles, i.e. Translational activities. ... Wayne State University

05/04/17 / #20170121410

Compositions and methods to treat solid tumors

Compositions and methods that utilize anti-cd11b antibodies, anti-cd18 antibodies, anti-myeloperoxidase (mpo) antibodies, anti-integrin αv antibodies, anti-integrin β1 antibodies, abciximab, neutrophil inhibitory factor (nif) protein, and/or combinations thereof to treat solid tumor cancers are described.. . ... Wayne State University

04/27/17 / #fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general formula i:

Wayne State University

. . ... Wayne State University

04/27/17 / #20170112909

Her2 antigenic polypeptide compositions, and methods for their use in treatment and prevention of carcinomas

Antigenic polypeptides of the growth factor receptor her2, for breaking the tolerance of a host against self her2. The antigenic polypeptides include her2 polypeptides with single amino acid substitutions of lysine for glutamine, arginine for glutamine, or aspartic acid for asparagine. ... Wayne State University

04/20/17 / #20170109563

Palm vein-based low-cost mobile identification system for a wide age range

A system includes an infrared camera, an infrared light source, and a processor. The processor is programmed to receive, from the infrared camera, an image of a hand illuminated using the infrared light source, and send the image to a remote server to identify a user corresponding to the hand according to a vein pattern of the hand. ... Wayne State University

04/20/17 / #20170107253

Neuroprotective composition and method of use

A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines, and further comprising 1 or more terminal cysteines. The composition is administered in therapeutically effective dosages prophylactically or as soon as possible post-injury in treating neuronal injury.. ... Wayne State University

04/20/17 / #20170106007

Compositions and methods relating to treatment of infection

Microbial keratitis is a sight threatening disorder and infections result in ocular pain, stromal destruction, corneal thinning and/or perforation, leading to vision loss, if untreated and the need for transplantation. Methods of treating bacterial infection of the cornea prophylactically or therapeutically in a subject, are provided according to aspects of the present invention which include administering an effective dose of glycyrrhizin, or a pharmaceutically acceptable salt, hydrate, solvate, ester, amide, isomer or derivative thereof characterized by anti-bacterial activity, to the subject.. ... Wayne State University

03/09/17 / #20170067009

Cell culture devices for biomimetic and pathomimetic cell cultures

Cell culture devices and methods of their use are provided according to aspects of the present invention which include a base having a pair of spaced apart wells and at least one fluid port defined from an exterior of the base to each of the wells, each fluid port being spaced above the base sheet by a distance sufficient to introduce a material above a matrix deposited on the base sheet in the wells; and a cover having a pair of spaced apart well covering portions that are each disposed above a respective one of the one spaced apart wells of the base body when the cover is covering the upper surface of the base body and having a gas passage defined between the spaced apart well covering portions and at least one gas port defined from an exterior of the cover to each of the well covering portions.. . ... Wayne State University

02/09/17 / #20170035901

Iga fc-folate conjugates, pharmaceutical compositions and methods to treat cancer

Iga-based fc-folate conjugates as a treatment for cancer are provided. The conjugates utilize only the fc portion of iga to target its receptor on neutrophils (fcαr1) to elicit antibody-dependent cellular-cytotoxicity (adcc).. ... Wayne State University

02/02/17 / #20170028075

Injectable dendrimer hydrogel nanoparticles

Injectable hydrogels in the form of crosslinked nano beads or particle in the size range 5 nm to 10 μm, comprising pamam dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents are formed by reaction of the pamam dendrimer with asymmetrical end groups with linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The pamam dendrimer with asymmetrical terminal groups consists of a generation 2 and above pamam dendrimer with symmetrical end groups modified using the amino acids or their modified forms. ... Wayne State University

01/26/17 / #20170021038

A modified mglur6 promoter and methods of use

The invention provides nucleic acids and nucleic acid expression vectors containing optimized mglur6 promoters for expression of transgenes in the retina. The compositions and methods of the invention are useful for expression of gene products to preserve, improve, or restore phototransduction or vision.. ... Wayne State University

01/19/17 / #20170015672

Substituted pyrrolo[2,3-d]pyrimidines for selectively targeting tumor cells with fr-alpha and fr-beta type receptors

Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These compounds selectively target folate receptors (fr) of cancerous tumor cells and inhibit purine synthesis and hence, dna synthesis.. ... Wayne State University

01/19/17 / #20170015645

Substituted pyran derivatives

Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter systems and the corresponding relationships to various afflictions affecting the cns, or as a treatment for various cns-related disorders in which the monoamine transport and related systems are implicated.. ... Wayne State University

01/12/17 / #20170007678

Compositions and methods to promote wound healing

Compositions and methods to promote wound healing are described. The compositions and methods up-regulate x-box binding protein 1 (xbp1) and/or inositol-requiring enzyme-1 (ire-1). ... Wayne State University

01/05/17 / #20170002377

Compositions and methods for detecting and modulating cell death by a translation regulated gene expression system

The technology relates to a nucleic acid expression cassette comprising a tr element encoding an mrna molecule that is translated in stressed and/or dying cells, and a nucleotide sequence operably linked to the tr element, that is a first open reading frame (orf) sequence and encodes a polypeptide or a fragment thereof and is co-translated with the tr element. The technology further relates to mammalian cells and a transgenic animal comprising such expression cassette. ... Wayne State University








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