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Wayne State University
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Wayne State University patents


Recent patent applications related to Wayne State University. Wayne State University is listed as an Agent/Assignee. Note: Wayne State University may have other listings under different names/spellings. We're not affiliated with Wayne State University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "W" | Wayne State University-related inventors


Methods and compositions relating to treatment of nervous system injuries

Compositions are provided according to aspects of the present invention which include: a plurality of longitudinally extending fibers, each of the fibers having a longitudinal axis, wherein the longitudinal axis of each of a majority of the fibers is generally aligned; a plurality of stem cells capable of differentiation into... Wayne State University

Compositions and methods to diagnose diabetes and/or to treat negative effects of diabetes

The present disclosure describes a genome-wide transcriptional analysis of differentially expressed genes in diabetic, non-diabetic, normal and wounded tissue. The analysis allowed development of compositions and methods to diagnose diabetes and/or to treat negative effects of diabetes, including delayed wound healing and reduced vision.... Wayne State University

Detectors of serum biomarkers for predicting ovarian cancer recurrence

Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at least one autoantibody marker. An antibody binding assay for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, and methods for performing the... Wayne State University

Methods of treating hearing disorders

The present disclosure provides methods for treating a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in central gain, and/or changes in neural sensitivity in a subject by inhibiting the function and/or production of tumor necrosis factor alpha (TNF-α) in the subject. The present... Wayne State University

Method of making injectable cements

A discovery of the conversion of amorphous calcium polyphosphate (ACPP) or/and other polyphosphate salts with various type of calcium phosphate to new calcium phosphate product (i.e. dicalcium phosphate dihydrate (DCPD)) in a liquid environment. The discovery includes mixing a various type of calcium phosphate with an aqueous ACPP or/and other... Wayne State University

Mass spectrometry using laserspray ionization

Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 Daltons. The analysis can be solvent-based or solvent-free. Solvent-free analysis following LSI allows for... Wayne State University

Compositions and methods relating to proliferative disorders

Methods and compositions for drug discovery, analysis and treatment of a proliferative disorder characterized by abnormal cells in a mammalian subject are provided according to aspects of the present invention which include administering a pharmaceutically effective amount of a combination of: a cytotoxic agent, a SET agonist and a SET... Wayne State University

Activity-dependent gene pairs as therapeutic targets and methods and devices to identify the same

Activity-dependent gene pairs as therapeutic targets and methods and devices to identify the same are provided. The methods and devices allow transcriptome-wide analysis of regulatory long non-coding RNAs (IncRNAs), matched with differentially expressed protein-coding genes (mRNAs) and/or with other IncRNAs. The described methods and devices allow analysis of these activity-dependent... Wayne State University

Novel synthetic anticancer, antifungal, and antibacterial vaccines

Described herein are compounds for use in vaccine compositions which contain natural or synthetic carbohydrate antigens. Such vaccines may be highly immunologically active due to the conjugation with an immune-stimulating protein or with a monophosphorylated lipid A derivative, and may be self-adjuvanting due to the presence of a monophosphorylated lipid... Wayne State University

Compounds and methods for activating the apoptotic arm of the unfolded protein response

N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.... Wayne State University

Method of enhancing viral-mediated gene delivery

The invention provides methods for enhancing the delivery of viral vectors to the eye of a subject by administering a proteasome inhibitor or and a viral vector ending a gene of interest to the eye.... Wayne State University

Method and composition for a protein transduction technology and its applications

A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection from degradation of the delivered proteins from cellular proteases. A composition for treat proteins has cation reagents, lipids and enhancers in a carrier. The... Wayne State University

Systems and methods to detect stem cell stress and uses thereof

Systems and methods (S/M) to detect stress in stem cells are described. The S/M, including modified stem cells, assays and high throughput screens, can be used to identify compounds or other potential stressors that can negatively affect development potential.... Wayne State University

Battery state of charge estimator

A battery monitoring device includes a first coil positioned within a cell of a battery, a second coil positioned to be magnetically coupled to the first coil through active material that is contained within the cell, and a controller that is configured to apply an electrical current to one of... Wayne State University

Valproate as a topical anti-fungal treatment

Valproate is useful as an antifungal agent. The valproate compositions can be used to treat fungal infections. The valproate compositions can be formulated as topical antifungals.... Wayne State University

Substituted pyrimidine compounds and methods of use and manufacture

wherein X is absent, CH2, S, or O, and R is an alkyl group having from one to ten carbon atoms, and optionally salts, hydrates, or solvates thereof, that are useful in treating a patient having a disease or cancer. The compounds of this invention are useful as multi-enzyme antifolates... Wayne State University

Nucleic acid constructs including a txnip promoter for the treatment of disease

Nucleic acids for the treatment of diseases are described. The nucleic acids include a thioredoxin-interacting protein (TXNIP) promoter and a gene that encodes a therapeutic protein or an interfering nucleic acid sequence (e.g., interfering RNA (iRNA sequence)).... Wayne State University

Neurokinin 1 receptor agonist mediated protection of the eye

Neurokinin 1 receptor (NK1R) agonist mediated protection of the eye is described. The protection can reduce dry eye and ocular infections, particularly in individuals with reduced NK1R activity.... Wayne State University

Methods and compositions relating to assays of fetal extravillous trophoblast cells

Methods of isolating and assaying fetal extravillous trophoblast cells, including assays of RNA of the fetal extravillous trophoblast cells according to aspects of the disclosure include obtaining a maternal endocervical sample containing fetal extravillous trophoblast cells from a pregnant subject; fixing the maternal endocervical sample in an aldehyde fixative, removing... Wayne State University

Systems and methods to identify and treat subjects at risk for obstetrical complications

Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.... Wayne State University

Dendrimers for sustained release of compounds

Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.... Wayne State University

Compositions and methods for treatment of sickle cell disease

This invention relates to methods of treating sickle cell disease with VLA-4 antagonists and methods for evaluating the responsiveness of patients having sickle cell disease to treatment with VLA-4 antagonists.... Wayne State University

Cxcr4 inhibiting carriers for nucleic acid delivery

The present invention generally relates to carriers including polymers and lipids that comprise a CXCR4 inhibiting moiety. More specifically, these carriers are biodegradable and can be bioreducible polymers that comprise a CXCR4 inhibiting moiety. These carriers can be suitable for delivery of nucleic acids to cells. These carriers and pharmaceutical... Wayne State University

Anticancer drugs including the chemical structures of an androgen receptor ligand and a histone deacetylase inhibitor

A novel class of drugs for treating androgen receptor (AR) positive cancer including prostate cancer and breast cancer are described. The drugs include the chemical scaffolds of a high affinity androgen receptor ligand and a histone deacetylase inhibitor. Also described are compositions including the novel drugs and methods of treating... Wayne State University

Balanced control strategies for interconnected heterogeneous battery systems in smart grid applications

A battery network includes a plurality of heterogeneous batteries coupled to at least one energy source and one energy load, a plurality of switches coupled to the heterogeneous batteries, and the switches controllable having a duty cycle between 0 and 1. A controller is configured to characterize each of the... Wayne State University

Method for identifying a subpopulation of mammalian cells with distinctive ribosome translation profiles

The present invention generally relates to subpopulations of mammalian cells with distinctive ribosome translational profiles, i.e. translational activities. The present invention further relates to methods for identifying and isolating such cells, kits comprising the same, or methods which utilize different translational activities of these subpopulations of mammalian cells.... Wayne State University

System and ionization of molecules for mass spectrometry and ion mobility spectrometry

An ionizing system includes a channel and a heater coupled to the channel. The channel has an inlet disposed in a first pressure region having a first pressure and an outlet disposed in a second pressure region having a second pressure. The first pressure is greater than the second pressure.... Wayne State University

Compositions and methods to treat solid tumors

Compositions and methods that utilize anti-CD11b antibodies, anti-CD18 antibodies, anti-myeloperoxidase (MPO) antibodies, anti-integrin αV antibodies, anti-integrin β1 antibodies, Abciximab, neutrophil inhibitory factor (NIF) protein, and/or combinations thereof to treat solid tumor cancers are described.... Wayne State University

Her2 antigenic polypeptide compositions, and methods for their use in treatment and prevention of carcinomas

Antigenic polypeptides of the growth factor receptor HER2, for breaking the tolerance of a host against self HER2. The antigenic polypeptides include HER2 polypeptides with single amino acid substitutions of lysine for glutamine, arginine for glutamine, or aspartic acid for asparagine. Gene expression constructs, vaccine compositions, and immunization methods including... Wayne State University

Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same

These compounds are useful in methods for treating cancer, selectively targeting cancerous cells via the proton coupled folate transporter, folate receptor alpha, and/or folate receptor beta pathways, inhibiting GARFTase in cancerous cells, and selectively targeting activated macrophages in a patient having an autoimmune disease, such as rheumatoid arthritis.... Wayne State University

Compositions and methods relating to treatment of infection

Microbial keratitis is a sight threatening disorder and infections result in ocular pain, stromal destruction, corneal thinning and/or perforation, leading to vision loss, if untreated and the need for transplantation. Methods of treating bacterial infection of the cornea prophylactically or therapeutically in a subject, are provided according to aspects of... Wayne State University

Neuroprotective composition and use

A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines, and further comprising 1 or more terminal cysteines. The composition is administered in therapeutically effective dosages prophylactically or as soon as possible post-injury in treating neuronal injury.... Wayne State University

Palm vein-based low-cost mobile identification system for a wide age range

A system includes an infrared camera, an infrared light source, and a processor. The processor is programmed to receive, from the infrared camera, an image of a hand illuminated using the infrared light source, and send the image to a remote server to identify a user corresponding to the hand... Wayne State University

Cell culture devices for biomimetic and pathomimetic cell cultures

Cell culture devices and methods of their use are provided according to aspects of the present invention which include a base having a pair of spaced apart wells and at least one fluid port defined from an exterior of the base to each of the wells, each fluid port being... Wayne State University

02/09/17 / #20170035901

Iga fc-folate conjugates, pharmaceutical compositions and methods to treat cancer

IgA-based Fc-folate conjugates as a treatment for cancer are provided. The conjugates utilize only the Fc portion of IgA to target its receptor on neutrophils (FcαR1) to elicit antibody-dependent cellular-cytotoxicity (ADCC).... Wayne State University

02/02/17 / #20170028075

Injectable dendrimer hydrogel nanoparticles

Injectable hydrogels in the form of crosslinked nano beads or particle in the size range 5 nm to 10 μm, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of... Wayne State University

01/26/17 / #20170021038

A modified mglur6 promoter and methods of use

The invention provides nucleic acids and nucleic acid expression vectors containing optimized mGluR6 promoters for expression of transgenes in the retina. The compositions and methods of the invention are useful for expression of gene products to preserve, improve, or restore phototransduction or vision.... Wayne State University

01/19/17 / #20170015645

Substituted pyran derivatives

Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter systems and the corresponding relationships to various afflictions affecting the CNS, or... Wayne State University

01/19/17 / #20170015672

Substituted pyrrolo[2,3-d]pyrimidines for selectively targeting tumor cells with fr-alpha and fr-beta type receptors

Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These compounds selectively target folate receptors (FR) of cancerous tumor cells and inhibit purine synthesis and hence, DNA synthesis.... Wayne State University

01/12/17 / #20170007678

Compositions and methods to promote wound healing

Compositions and methods to promote wound healing are described. The compositions and methods up-regulate X-box binding protein 1 (XBP1) and/or inositol-requiring enzyme-1 (IRE-1). In various embodiments, the compositions and methods can be used to promote wound healing in diabetic subjects.... Wayne State University

01/05/17 / #20170002377

Compositions and methods for detecting and modulating cell death by a translation regulated gene expression system

The technology relates to a nucleic acid expression cassette comprising a TR element encoding an mRNA molecule that is translated in stressed and/or dying cells, and a nucleotide sequence operably linked to the TR element, that is a first open reading frame (ORF) sequence and encodes a polypeptide or a... Wayne State University








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