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Whitehead Institute For Biomedical Research
Whitehead Institute For Biomedical Research Nine Cambrideg Center

Whitehead Institute For Biomedical Research patents


Recent patent applications related to Whitehead Institute For Biomedical Research. Whitehead Institute For Biomedical Research is listed as an Agent/Assignee. Note: Whitehead Institute For Biomedical Research may have other listings under different names/spellings. We're not affiliated with Whitehead Institute For Biomedical Research, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "W" | Whitehead Institute For Biomedical Research-related inventors


Hic: identifying interactions between genomic loci

The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be... Whitehead Institute For Biomedical Research

Reprogramming of somatic cells

The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to... Whitehead Institute For Biomedical Research

Rna interference mediating small rna molecules

Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like... Whitehead Institute For Biomedical Research

Core transcriptional circuitry in human cells and methods of use thereof

Disclosed are methods for identifying the core regulatory circuitry or cell identity program of a cell or tissue, and related methods of diagnoses, screening, and treatment involving the core regulatory circuitry and/or cell identity programs identified using the methods.... Whitehead Institute For Biomedical Research

Yeast cells expressing tar dna-binding protein 43 and uses therefor

Disclosed are yeast cells expressing TAR DNA-binding protein 43 (TDP-43) and methods of screening yeast cells to identify compounds that prevent or suppress TDP-43-induced toxicity, compounds that inhibit the formation or maintenance of cytoplasmic inclusions of TDP-43, genetic suppressors or enhancers of TDP-43-induced toxicity, and genetic suppressors or enhancers of... Whitehead Institute For Biomedical Research

Methods of identifying modulators of sestrin-gator-2 interaction and use of same to modulate mtorc1

The present invention provides methods of identifying modulators of mTORC1 based upon their effect on GATOR2-Sestrin binding or Sestrin-leucine binding; and the use of such modulators to alter mTORC1 activity in a cell and to treat disease and conditions that are effected by mTORC1 activity.... Whitehead Institute For Biomedical Research

Three-dimensional hydrogels that support growth of physiologically relevant tissue and methods of use thereof

The presently disclosed subject matter provides hydrogel precursor compositions (e.g., solutions) for forming three-dimensional hydrogels that support growth of physiologically relevant tissue when at least one cell is cultured in the three-dimensional hydrogel, kits comprising the hydrogel precursor composition, three-dimensional hydrogels, methods of forming the three-dimensional hydrogels, methods of growing... Whitehead Institute For Biomedical Research

Compositions and methods for promoting intestinal stem cell and/or non-stem progenitor cell function

Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful for stimulating the proliferation of and/or self-renewal of intestinal stem cells, as well as for minimizing, preventing, or ameliorating cellular damage resulting from incidental or accidental exposure to radiation... Whitehead Institute For Biomedical Research

Methods for reprogramming somatic cells

The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated... Whitehead Institute For Biomedical Research

Wnt pathway stimulation in reprogramming somatic cells with nuclear reprogramming factors

The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including... Whitehead Institute For Biomedical Research

Compositions and methods for genetically modifying yeast

The present invention provides compositions and methods for genetically modifying yeast cells using a Candida-compatible CRISPR/Cas9 nuclease system. Also provided are yeast cells that have been genetically modified using such compositions and methods.... Whitehead Institute For Biomedical Research

Cellular discovery platform for neurodegenerative diseases

... Whitehead Institute For Biomedical Research

Compositions and methods for altering gene expression

Provided herein are improved compositions and methods for the directed control of gene expression.... Whitehead Institute For Biomedical Research

Uses of kinase inhibitors for inducing and maintaining pluripotency

The present disclosure provides compounds of any one of Formulae (A) to (L). The present disclosure also provides compositions, uses, and methods that include or involve a compound described herein, a serine/threonine-protein kinase B-Raf (BRAF) inhibitor, an epidermal growth factor receptor (EGFR) inhibitor, a vascular endothelial growth factor 1 (VEGFR1)... Whitehead Institute For Biomedical Research

Compositions and methods for modified dendrimer nanoparticle delivery

Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to... Whitehead Institute For Biomedical Research

Compositions and methods for modulating mtorc1

The invention relates to methods of identifying compounds that modulate mTORC1 activity in a cell by modulating the activity of SLC38A9 (NCBI Gene ID: 153129), as well as to the use of such identified compounds in the modulation of mTORC 1 and the treatment of diseases and conditions characterized by... Whitehead Institute For Biomedical Research

Withaferin a analogs and uses thereof

The present invention provides a novel class of withanolides that have been isolated from W. somnifera under aeroponic conditions or produced semi-synthetically from withanolide natural products. The invention also provides pharmaceutical compositions thereof and methods for using the same in proliferative diseases, neurodegenerative diseases, autoimmune, and inflammatory diseases.... Whitehead Institute For Biomedical Research

Nucleic acid constructs encoding reprogramming factors linked by self-cleaving peptides

The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to... Whitehead Institute For Biomedical Research

Methods and compositions for targeting cancer stem cells

Aspects of the disclosure relate to methods that involve activating the Protein Kinase A (PKA) pathway to induce cancer stem cells (CSCs) to undergo a mesenchymal to epithelial transition. Methods provided herein are useful, in some embodiments, because they render CSCs amenable to treatment with conventional cancer therapies. In some... Whitehead Institute For Biomedical Research

Hsf1 in tumor stroma

In some aspects, the invention relates to Heat Shock Protein-1 (HSF1) gene and HSF1 gene products in tumor stroma. In some aspects, the invention provides methods of tumor prognosis, treatment-specific prediction, or treatment selection, the methods comprising measuring the level of HSF1 expression or HSF1 activation in a sample obtained... Whitehead Institute For Biomedical Research

Mtorc1 modulation by amino acids and uses thereof

Disclosed herein are methods for modulating mTORC1 activation in cells or a subject, and related compositions, kits, and agents for use in those methods. Also disclosed is the treatment of diseases and conditions characterized by decreased mTORC1 activation.... Whitehead Institute For Biomedical Research

Crispr-mediated genome engineering for protein depletion

The present invention provides compositions and methods for tagging a target gene with a degron (e.g., auxin-inducible degron) in a variety of eukaryotic cells using the CRISPR genome-editing technology. Also provided are cells that have been genetically modified using such compositions and methods.... Whitehead Institute For Biomedical Research

Master transcription factors identification and use thereof

Provided herein are methods for identifying master transcription factors (TFs) in a cell type of interest and for transdifferentiation of a somatic cell, e.g., a fibroblast to the cell type of interest. Also provided herein are induced retinal pigment epithelium (iRPE) cell, master TFs therefor, methods for making iRPE cell,... Whitehead Institute For Biomedical Research








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