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Wisconsin Alumni Research Foundation patents


Recent patent applications related to Wisconsin Alumni Research Foundation. Wisconsin Alumni Research Foundation is listed as an Agent/Assignee. Note: Wisconsin Alumni Research Foundation may have other listings under different names/spellings. We're not affiliated with Wisconsin Alumni Research Foundation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "W" | Wisconsin Alumni Research Foundation-related inventors


Perivascular drug delivery system

The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly after perivascular surgery. The compositions include a hydrogel, unimolecular micelles dispersed within the hydrogel, and an effective amount of anti-stenotic drug dispersed... Wisconsin Alumni Research Foundation

Method of treating transplant rejection and autoimmune diseases

A method of treating autoimmune diseases and transplant rejection, comprising the step of treating the autoimmune or transplant patient with an effective amount of SU-5416 is disclosed.... Wisconsin Alumni Research Foundation

Pi3-kinase inhibition and lag-3 checkpoint blockade as a combination therapy for cancer

This disclosure provides methods of treating cancer comprising administering at least one PI3K inhibitor and at least one LAG-3 checkpoint inhibitor. Suitable compositions are also disclosed.... Wisconsin Alumni Research Foundation

Knife blade edge serrations and method therefor

Various aspects of the present disclosure are directed toward blades having serrations, and methods for forming the serrations. As may be implemented in accordance with one or more embodiments, laser light is scanned across a surface of a knife blade in which the laser light is intersected with an edge... Wisconsin Alumni Research Foundation

Compositions and methods for improving resistance to breakage and eggshell strength

Described herein are FGF-23 epitope peptides, methods of producing antibodies in laying hens by injecting the peptides, and methods of improving resistance to eggshell breakage and/or increasing eggshell strength by administering an FGF-23 epitope peptide to a laying hen.... Wisconsin Alumni Research Foundation

Methods and systems for transmission and detection of free radicals

The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from free radical interaction with a target molecule.... Wisconsin Alumni Research Foundation

Adaptor to allow electrogram visualization and pacing from temporary epicardial wires

A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ECG monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability... Wisconsin Alumni Research Foundation

Reagents and methods for esterification

where R is hydrogen, an alkyl, an alkenyl or an alkynyl, RA represents 1-5 substituents on the indicated phenyl ring and RM is an organic group, which includes a label, a cell penetrating group, a cell targeting group, or a reactive group or latent reactive group for reaction to bond... Wisconsin Alumni Research Foundation

Multi-color reporter cells for detecting hiv-1

Disclosed are methods to measure the extent of viral infection and methods to measure latent viral reservoir in cells harboring or suspected of harboring such a reservoir.... Wisconsin Alumni Research Foundation

Flexible compact nanogenerators based on mechanoradical-forming porous polymer films

Power generators that incorporate porous electric generation layers composed of mechanoradical-forming polymers are provided. Also provided are methods for using the generators to convert mechanical energy into and electrical signal to power electronic devices. The porous electric generation material includes an organic polymer that forms free radicals when covalent bonds... Wisconsin Alumni Research Foundation

Apparatus for augmenting human vision

The functional effect of having additional color-sensing cone types in the human eye is implemented by an encoding of some spectral information differently for the left and right eyes. This different encoding for identical features seen by the left and right eyes is interpreted as a perceptively different feature by... Wisconsin Alumni Research Foundation

Collagen mimics

Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly)n, where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix... Wisconsin Alumni Research Foundation

Targeted radiotherapy chelates for in situ immune modulated cancer vaccination

wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18,... Wisconsin Alumni Research Foundation

Radioactive phospholipid metal chelates for cancer imaging and therapy

R1 includes a chelating agent that is chelated to a metal atom, wherein the metal atom is a positron or single photon emitting metal isotope with a half life of greater than or equal to 4 hours, or an alpha, beta or Auger emitting metal isotope with a half life... Wisconsin Alumni Research Foundation

Cold spray chromium coating for nuclear fuel rods

A method is provided for coating the substrate of a component, such as a zirconium alloy cladding tube, for use in a water cooled nuclear reactor under normal operating conditions and under high temperature oxidation conditions. The method includes heating a pressurized carrier gas to a temperature between 200° C.... Wisconsin Alumni Research Foundation

Spray methods for coating nuclear fuel rods to add corrosion resistant barrier

A method is described herein for coating the substrate of a component for use in a water cooled nuclear reactor to provide a barrier against corrosion. The method includes providing a zirconium alloy substrate; and coating the substrate with particles selected from the group consisting of metal oxides, metal nitrides,... Wisconsin Alumni Research Foundation

High throughput semiconductor deposition system

A reactor for growing or depositing semiconductor films or devices. The reactor may be designed for inline production of III-V materials grown by hydride vapor phase epitaxy (HVPE). The operating principles of the HVPE reactor can be used to provide a completely or partially inline reactor for many different materials.... Wisconsin Alumni Research Foundation

Use of homosalate and octyl salicylate to treat multiple sclerosis

A method of treating an MS patient with homosalate, octyl salicylate, or a combination is disclosed.... Wisconsin Alumni Research Foundation

Phospholipid ether analogs for imaging and targeted treatment of pediatric solid tumors

or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+(CH3)3. The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, R1 includes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the... Wisconsin Alumni Research Foundation

Generation of uniform hepatocytes from human embryonic stem cells by inhibiting tgf-beta and methods of maintaining hepatic cultures

This disclosure relates generally to new methods of maintaining the expression of hepatic genes in human hepatocytes and method for maintaining the functional hepatic enzyme activity of primary hepatocytes in culture. The disclosure also encompasses new methods of deriving a population of pure hepatocytes without selecting or sorting the cells... Wisconsin Alumni Research Foundation

Radiohalogenated agents for in situ immune modulated cancer vaccination

wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.... Wisconsin Alumni Research Foundation

System and high-temporal resolution, time-resolved cone beam ct angiography

A system and method for reconstructing an image using a cone-beam computed tomography (CT) imaging system includes acquiring data from a subject with the CT imaging system using a limited scan range that is less than 360 degrees. The process also includes reconstructing at least one image of the subject... Wisconsin Alumni Research Foundation

Induction of hemogenic endothelium from pluripotent stem cells by forced expression of transcription factors

Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hPSCs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hPSCs of a combination of transcription factors as described herein.... Wisconsin Alumni Research Foundation

Compositions and methods to promote erythropoiesis

Described herein are compositions and methods for enhancing erythropoiesis in an individual in need thereof. Specifically agents that decrease the expression of Exosc10, such as inhibitory nucleic acid molecules, produce an increase in red blood cell production in the individual.... Wisconsin Alumni Research Foundation

Oxygen-responsive bacterial gene switch

The invention provided herein relates to sequence determinants that elicit certain levels of gene expression and methods for obtaining engineered ligand-responsive gene switches comprising these sequence determinants. More particularly, the invention provided herein relates to molecular building blocks (i.e., discrete nucleotide sequences), synthetic ligand-responsive gene switches comprising an assembly of... Wisconsin Alumni Research Foundation

Floating evaporative assembly of aligned carbon nanotubes

High density films of semiconducting single-walled carbon nanotubes having a high degree of nanotube alignment are provided. Also provided are methods of making the films and field effect transistors (FETs) that incorporate the films as conducting channel materials. The single-walled carbon nanotubes are deposited from a thin layer of organic... Wisconsin Alumni Research Foundation

Cellulose composite-structured triboelectric generator and method

A triboelectric generator and method are provided. The triboelectric generator includes a first electrode having an inner surface and an outer surface and a second electrode having an inner surface and an outer surface. A dielectric layer has a first surface and a second surface in engagement with the inner... Wisconsin Alumni Research Foundation

Fluoroscopy system resolving slowly evolving conditions

A fluoroscopy machine allows programming of a frame rate in the range of multiple seconds per frame and then displays the images at a higher rate in a loop in the radiological theater so as to impart an improved sense of motion to a human observer of a slow physiological... Wisconsin Alumni Research Foundation

Synthesis of cyclopropyl indoles and cyclohepta[b]indoles, pharmaceutical compositions containing them and using them

Methods of making indole analogs using a rhodium-containing catalyst are described, along with methods of using the compounds to treat hyperglycemic, hyperlipidemic, or autoimmune disorders in mammals, and corresponding pharmaceutical compositions. Disclosed herein is a method of making indoles. The method comprises contacting a reactant of formula I wherein E... Wisconsin Alumni Research Foundation

Single nucleotide polymorphisms associated with bull fertility

Single nucleotide polymorphic sites of the bovine MAP1B, PPP1R11, and DDX4 genes are associated with improved bull fertility as measured by e.g. sire conception rates. Nucleic acid molecules, arrays, kits, methods of genotyping and marker-assisted bovine breeding methods based on these SNPs are disclosed.... Wisconsin Alumni Research Foundation

Conductive textiles and related devices

A conductive textile is provided comprising a textile substrate comprising a network of one or more threads, each thread comprising one or more fibers, the one or more threads arranged to define a plurality of pores and a plurality of intersections distributed throughout the textile substrate, and a conductive polymer... Wisconsin Alumni Research Foundation

High power transfer through load-supporting bearings

A system for power transfer to a movable platform makes use of a capacitive interface in moving elements of load-supporting bearings for power transfer. Tank circuits associated with each bearing increase power transfer by reducing effective impedance of the small bearing capacitances.... Wisconsin Alumni Research Foundation

System and accelerated, time-resolved imaging

A system and method for reconstructing a series of images of a subject includes acquiring medical image data from the subject with a medical imaging system and reconstructing a series of images of the subject from the acquired medical image data set. The reconstructing includes enforcing general adherence to a... Wisconsin Alumni Research Foundation

Modulation of bacterial quorum sensing with synthetic ligands

The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural... Wisconsin Alumni Research Foundation

Gene construct encoding mutant thioesterase, mutant thioesterase encoded thereby, transformed host cell containing the gene construct, and using them to produce medium-chain fatty acids

Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ. ID. NO: 1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in... Wisconsin Alumni Research Foundation

12/21/17 / #20170360317

Wireless vibrometer with antenna array

A wireless vibrometer employs an antenna array to significantly boost the signal-to-noise ratio of faint received signals twin small objects vibrating at acoustic frequencies. This technique may be used to provide an improved physiological monitor (such as a pulse detector) or for long-range eavesdropping using the emitted power from a... Wisconsin Alumni Research Foundation

12/21/17 / #20170363513

Combustion gas sensor assembly for engine control

An optical sensor for sensing combustion products avoids fouling and damage to optical components by using a “windowless” design in which an air curtain through an orifice provides a constantly refreshing transparent shield protecting the optical components from corrosive combustion gases and resisting the accumulation of particulates that might otherwise... Wisconsin Alumni Research Foundation

12/14/17 / #20170354725

Combinatorial androgen deprivation with an androgen receptor vaccine

It is disclosed herein methods of treating prostate cancer comprising administering to the subject the combination of androgen deprivation therapy (ADT) and a vaccine directed against the androgen receptor or a fragment of the androgen receptor. Also disclosed are methods of increasing the efficacy of androgen deprivation therapy in a... Wisconsin Alumni Research Foundation

12/14/17 / #20170354964

Non-displasive pipette

A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid therefrom. The non-displasive pipette includes a body defining a chamber therethrough and having first and second opposite ends.... Wisconsin Alumni Research Foundation

12/14/17 / #20170355748

Method for the design of fibrillar collagen-mimetic peptide self-assemblies

Novel synthetic human scale collagen triple helices assemblies are disclosed. Methods of making self-assembling collagen mimetic peptides that self-assemble into human scale collagen are also disclosed.... Wisconsin Alumni Research Foundation

12/14/17 / #20170356829

Method and device for containing expanding droplets

A method and microfluidic device are provided for containing a droplet having an outer surface at a predetermined location. The microfluidic device includes a plate having an upper surface and a central region communicating with the upper surface. The central region is adapted for receiving a droplet of fluid thereon.... Wisconsin Alumni Research Foundation

12/14/17 / #20170356901

T cell-bound cytokine assay for antigen-specific tolerance

In vitro methods for detecting and measuring an antigen-specific regulatory T cell response are described. In particular, there is provided, for example, a method of detecting a change in surface expression of particular T cell markers in T cells obtained from the subject as a way to detect induced immune... Wisconsin Alumni Research Foundation

12/14/17 / #20170359001

Triboelectric nanogenerators based on chemically treated cellulose

Triboelectric nanogenerators that operate in a vertical contact separation mode and methods for fabricating the triboelectric generators are provided. Also provided are methods for using the triboelectric nanogenerators to harvest mechanical energy and convert it into electric energy. In the TENGs, one or both of the triboelectrically active layers comprises... Wisconsin Alumni Research Foundation

12/07/17 / #20170348118

Prosthetic manipulator and method therefor

Various aspects of the present disclosure characterize apparatuses and/or methods as may be implemented with a variety of prosthetic components and applications. As may be consistent with one or more embodiments described herein, respective manipulators are operable and/or operate to manipulate a prosthetic foot component about respective (e.g., separate) axes.... Wisconsin Alumni Research Foundation

12/07/17 / #20170348278

Ecteinamycin, compositions and uses thereof

An isolated or synthesized compound of Formula I and salts thereof are provided. A compound isolated from Actinomadura and having a chemical formula of C38H60O12 is also provided. Compositions including the compounds and methods of using the compounds to treat bacterial infections including gram positive infections such as C. difficile... Wisconsin Alumni Research Foundation

12/07/17 / #20170350951

System and chemical shift magnetic resonance imaging using magnetization transfer

A system and method is provided for producing a map of a static magnetic field (B0) of a magnetic resonance imaging system. The method includes forming a first dataset by acquiring, with the MRI system, a first plurality of different echo signals occurring at a respective plurality of different echo... Wisconsin Alumni Research Foundation

11/30/17 / #20170341300

Additive manufacturing process continuous reinforcement fibers and high fiber volume content

An additive printer dispenses filament having high volume content of axial reinforcing fibers impregnated with a partially cured thermoset material. Partial curing provides sufficient mechanical integrity for high-density fiber support and retention while maintaining tackiness necessary to allow layer by layer additive construction. The complete construction may then be heated... Wisconsin Alumni Research Foundation

11/30/17 / #20170342219

Polycarboxylated compounds and compositions containing same

Methods of selectively modifying lignin, polycarboxylated products thereof, and methods of deriving aromatic compounds therefrom. The methods comprise electrochemically oxidizing lignin using stable nitroxyl radicals to selectively oxidize primary hydroxyls on β-O-4 phenylpropanoid units to corresponding carboxylic acids while leaving the secondary hydroxyls unchanged. The oxidation results in polycarboxylated lignin... Wisconsin Alumni Research Foundation

11/30/17 / #20170342441

Hepatocyte based insulin gene therapy for diabetes

A method and vectors for controlling blood glucose levels in a mammal are disclosed. In one embodiment, the method comprises the steps of: treating the hepatocyte cells of a patient with a first, second or third vector, wherein the first vector comprises a promoter enhancer, glucose inducible regulatory elements, a... Wisconsin Alumni Research Foundation

11/30/17 / #20170342502

Biomarkers for breast cancer and methods of use thereof

Described herein is the use of Agouti Signaling Protein (ASIP), in addition to certain other melanocortin signaling network (MSN) genes, as prognostic and predictive biomarkers for the progression of breast cancer. In particular, the novel biomarkers can be used to determine if a female breast cancer patient is at risk... Wisconsin Alumni Research Foundation

11/30/17 / #20170342574

Nitroxyl-mediated oxidation of lignin and polycarboxylated products

Methods of selectively modifying lignin, polycarboxylated products thereof, and methods of deriving aromatic compounds therefrom. The methods comprise electrochemically oxidizing lignin using stable nitroxyl radicals to selectively oxidize primary hydroxyls on β-O-4 phenylpropanoid units to corresponding carboxylic acids while leaving the secondary hydroxyls unchanged. The oxidation results in polycarboxylated lignin... Wisconsin Alumni Research Foundation

11/30/17 / #20170346558

Spatial location indoors using standard fluorescent fixtures

A system for identifying the location of the mobile device uses standard fluorescent light fixtures commonly found in indoor environments and detects minor variations in the light output of those fixtures caused by normal manufacturing variation. These variations are catalogued as identifying fingerprints together with location of the light fixtures... Wisconsin Alumni Research Foundation

11/23/17 / #20170334835

Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing

where A is an acyclic aliphatic group, and HG is an optionally substituted phenyl group. Compounds include those where m and n are both 0, W is —NH—, Y is present and is —CO—CH2—CO—, and L1 and L2 independently are —[CH2]p1— and —[CH2]p2—, where p1 and p2, independently, are 0... Wisconsin Alumni Research Foundation

11/23/17 / #20170334953

Mosquitocidal xenorhabdus, lipopeptide and methods

Provided is a bacterial strain which produces a family of mosquitocidal toxins, Xenorhabdus MT, on deposit with the American Type Culture Collection, PTA-6826, insecticidal compositions comprising the mosquitocidal toxin(s) produced by Xenorhabdus MT, a mosquitocidal toxin preparation prepared from spent culture medium, whole culture or cells or a mixture thereof,... Wisconsin Alumni Research Foundation

11/23/17 / #20170335130

Azlactone based thermally crosslinkable polymer coating for controlling cell behavior

Random copolymers, crosslinked thin films of the random copolymers and cell culture substrates comprising the crosslinked thin films are provided. Also provided are methods of making and using the copolymers, thin films and substrates. The copolymers are polymerized from glycidyl methacrylate monomers and vinyl azlactone monomers. The crosslinked thin films... Wisconsin Alumni Research Foundation

11/23/17 / #20170335398

Method to predict likelihood of inherited peripheral neuropathy in mammals

Methods and kits for diagnosing propensity to exhibit acquired peripheral neuropathy in dogs are described. The methods and kits test dogs for presence of a single-nucleotide polymorphism (SNP) TIGRP2P18586_rs8746233. Presence of the SNP indicates an increased likelihood of the dog exhibiting an acquired peripheral neuropathy. This information can be used... Wisconsin Alumni Research Foundation

11/23/17 / #20170336390

Methods, systems, and compositions for studying solvent accessibility and three-dimensional structure of biological molecules

This disclosure provides methods, systems, and compositions of matter for studying solvent accessibility and three-dimensional structure of biological molecules. A plasma can be used to generate marker radicals, which can interact with a biological molecule and mark the solvent-accessible portions of the biological molecule.... Wisconsin Alumni Research Foundation

11/23/17 / #20170338750

Electrostatic rotating-machine employing dielectric substrates with surface conductors

An electrostatic rotating electrical machine employs axially extending electrically conductive electrodes on a rotor interacting with a corresponding set of axially extending electrodes on a stator, where the electrodes are supported at an outer surface of a dielectric sleeve which continues beneath the electrodes to provide a robust support and... Wisconsin Alumni Research Foundation

11/16/17 / #20170326159

Methods of use to orally and topically treat acne and other skin conditions by administering a 19-nor containing vitamin d analog with or without a retinoid

Oral and topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin D analogs as active pharmaceutical ingredients include 2-methylene-19-nor-20(S)-1α-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(S)-2-methylene-1α,25-dihydroxyvitamin D3, 2-methylene-1α,25-dihydroxy-(17E)-17(20)-dehydro-19-nor-vitamin D3, 2-methylene-19-nor-(24R)-1α,25-dihydroxyvitamin D2, 2-methylene-(20R,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, 2-methylene-19-nor-1α-hydroxy-pregnacalciferol, 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol, (20R)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, 2-methylene-19-nor-(20S)-1α-hydroxy-trishomopregnacalciferol, 2-methylene-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnancalciferol,... Wisconsin Alumni Research Foundation

11/16/17 / #20170327517

Boronic acid inhibitors of hiv protease

Protease inhibitors, particularly aspartyl protease inhibitors, and more particularly HIV protease inhibitors which are boronated to enhance activity or to enhance entry into cells. Compounds, prodrugs and salts thereof of this invention contain phenylboronate groups, in particular p-B(OH)2-phenyl groups, benzoxaborole groups or borono-pyridyl groups or analogous groups in which the... Wisconsin Alumni Research Foundation

11/16/17 / #20170329741

Graphic processor unit with improved energy efficiency

A GPU architecture employs a crossbar switch to preferentially store operand vectors in a compressed form allowing reduction in the number of memory circuits that must be activated during an operand fetch and to allow existing execution units to be used for scalar execution. Scalar execution can be performed during... Wisconsin Alumni Research Foundation

11/09/17 / #20170320928

Alpha/beta-polypeptide analogs of glucagon-like peptide 1

Described herein are peptide analogs of glucagon-like peptide 1 (GLP-1) that retain agonist activity, but are more resistant to proteolytic degradation than native GLP-1. In the analogs, at least one α-amino acid found in the native GLP-1 is replaced with a β-amino acid residue, which may or may not be... Wisconsin Alumni Research Foundation

11/02/17 / #20170312986

Systems and methods for controlling support structures in manufacturing

Systems and methods for controlling support structures in manufacturing are provided. In particular, the present disclosure provides systems and methods for characterizing the support volume in the design phase based on a perimeter length of a boundary with undercut, projected along a build direction, referred to as a projected undercut... Wisconsin Alumni Research Foundation

11/02/17 / #20170313635

Heterogeneous catalysts for the oxidative dehydrogenation of alkanes or oxidative coupling of methane

Improved methods of oxidative dehydrogenation (ODH) of short chain alkanes or ethylbenzene to the corresponding olefins, and improved methods of oxidative coupling of methane (OCM) to ethylene and/or ethane, are disclosed. The disclosed methods use boron- or nitride-containing catalysts, and result in improved selectivity and/or byproduct profiles than methods using... Wisconsin Alumni Research Foundation

11/02/17 / #20170317854

Differential mimo transceiver

A method of estimating a spatial filter matrix is provided. A conjugate of a received first signal defines a conjugate first signal. A Kronecker product of the defined first signal and a received second signal define a differential measurement signal. The computations are repeated for a plurality of first and... Wisconsin Alumni Research Foundation

Patent Packs
10/26/17 / #20170303887

Head mounted microphone array for tinnitus diagnosis

A three-dimensional, head mounted microphone array is employed to isolate and analyze intracranial sound sources such as may provide for objective tinnitus. The microphone array allows a region of interest within the patient's head to be isolated for the detection of sounds and allows episodic sounds to be automatically identified... Wisconsin Alumni Research Foundation

10/26/17 / #20170305973

Rhinovirus c immunogenic peptides

A peptide comprising the rhinovirus immunogen peptide of the rhinovirus structural protein 1 (VP1) of rhinovirus C and related vaccines and therapeutic compositions is disclosed.... Wisconsin Alumni Research Foundation

10/19/17 / #20170296490

Use of lignin-derived aldehydes as antifungal agents

Described herein is a method and corresponding composition of matter for inhibiting the growth of fungi and oomycetes. The method includes contacting fungi or oomycetes with a growth inhibitory effective amount of one or more compounds selected from p-hydroxycoumaryl aldehyde, coniferyl aldehyde, and sinapaldehyde, and salts and esters thereof.... Wisconsin Alumni Research Foundation

10/19/17 / #20170296558

Use of 2amd and 2md to treat fibrosis

The invention relates to using 2-methylene-19-nor-(20S)-1α,25-(OH)2D3 (2MD) or 2α-methyl-19-nor-(20S)-1α,25-(OH)2D3 (2AMD) to prevent nephrotoxicity and/or fibrosis in a patient, preferably without causing hypercalcemia in the patient.... Wisconsin Alumni Research Foundation

10/19/17 / #20170298458

Method to produce water-soluble sugars from biomass using solvents containing lactones

A process to produce an aqueous solution of carbohydrates that contains C6-sugar-containing oligomers, C6 sugar monomers, C5-sugar-containing oligomers, C5 sugar monomers, or any combination thereof is presented. The process includes the steps of reacting biomass or a biomass-derived reactant with a solvent system including a lactone and water, and an... Wisconsin Alumni Research Foundation

10/19/17 / #20170298534

Thermal diffusion doping of diamond

Boron-doped diamond and methods for making it are provided. The doped diamond is made using an ultra-thin film of heavily boron-doped silicon as a dopant carrying material in a low temperature thermal diffusion doping process.... Wisconsin Alumni Research Foundation

10/19/17 / #20170301432

Stretchable transmission lines and circuits for microwave and millimeter wave frequency wearable electronics

Stretchable high frequency transmission lines and high-frequency filters comprising the transmission lines are provided. The transmission lines provide low power loss, even at microwave and millimeter wave frequencies. The transmission lines are thin and flexible and can be stretched without a significant degradation of their scattering parameters. As a result,... Wisconsin Alumni Research Foundation

10/12/17 / #20170290852

Micelle formulations of amphotericin b

The present technology relates generally to micelle formulations of amphotericin B that optionally include 5-fluorocytosine and methods of preparing such formulations. Methods of treating fungal infections with the present compositions are also provided.... Wisconsin Alumni Research Foundation

10/12/17 / #20170290901

Global gene regulators (ggr) as vaccine candidates against paratuberculosis

Described herein is a mycobacterium mutant, comprising at least one mutation in at least one gene sequence encoding global gene regulators (GGRs) selected from the group consisting of sigH, sigL, sigE, ECF-1, and mixtures thereof, wherein the GGR gene is at least partially inactivated. Described herein also is a vaccine... Wisconsin Alumni Research Foundation

10/05/17 / #20170281643

Compounds and methods for modulating frataxin expression

The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker;... Wisconsin Alumni Research Foundation

10/05/17 / #20170281737

Universal platform for targeting therapies to treat neurological diseases

The present invention provides a universal delivery platform of functional, heterologous compounds to specific cells using toxins modified to include a heterologous compound. In one embodiment, the toxin is an AB5 toxin. In one embodiment, the AB5 toxin is a heat-labile enterotoxin from E. coli (LT), including LTI, LTII, LTIIa,... Wisconsin Alumni Research Foundation

10/05/17 / #20170281741

Peptide and reducing the phosphate requirement and excretiion from farm animals

Disclosed are methods of altering metabolism of phosphate in a livestock via an antibody. The methods involve the development of an antibody against FGF-23 for the purpose of reducing phosphate excretion by an animal.... Wisconsin Alumni Research Foundation

10/05/17 / #20170283437

Inhibitors of udp-galactopyranose mutase

Compounds and salts thereof which inhibit microbial growth or attenuate the virulence of pathogenic microorganisms and which inhibit UDP-galactopyranose mutase (UGM). Compounds of the invention include triazolothiadiazines, particularly 3, 6, 7-substituted-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, and 4-(1H-pyrrol-3-yl) thiazoles, particularly 4-(1,2,5-substituted-1H-pyrrol-3-yl)-2-substituted thiazoles, and salts thereof. Methods for inhibiting growth or attenuating virulence of microbial pathogens... Wisconsin Alumni Research Foundation

10/05/17 / #20170283772

Methods for differentiation of human pluripotent stem cells to brain microvascular endothelial cells

Methods for generating functional brain microvascular endothelial cells (BMECs) under chemically defined, serum-free conditions are provided. In particular, efficient and cost-effective methods for generating functional BMECs under chemically defined culture conditions are provided. BMECs obtained according to the methods provided herein are suitable for in vitro blood brain barrier (BBB)... Wisconsin Alumni Research Foundation

10/05/17 / #20170283774

Methods for efficient derivation of human motor neurons from diverse spinal regions

Described herein are chemically defined, adherent culture protocols for generating functional motor neurons characteristic of diverse hindbrain and spinal cord regions, with high efficiency.... Wisconsin Alumni Research Foundation

Patent Packs
10/05/17 / #20170283812

Method of creating industrial streptomyces with capability to grow on cellulosic polysaccharide substrates

A heterologous gene cassette useful for creating Streptomyces species with enhanced capability of growing on a cellulosic polysaccharide substrate, wherein the cassette comprises at least two members of the following categories: a) a GH6 gene, b) an AA10 gene, c) a GH48 gene, d) a GH5 gene and e) either... Wisconsin Alumni Research Foundation

10/05/17 / #20170285042

Gas-phase purification for accurate isobaric tag-based quantification

Described herein are mass spectrometry systems and methods which improve the accuracy of isobaric tag-based quantification by alleviating the pervasive problem of precursor interference and co-isolation of impurities through gas-phase purification. During the gas-phase purification, the mass-to-charge ratios of precursor ions within at least a selected range are selectively changed... Wisconsin Alumni Research Foundation

10/05/17 / #20170288586

Variable magnetization machine controller

A variable magnetization machine control system comprising a controller configured to adjust a d-axis current waveform and a q-axis current waveform in accordance with an operating condition of a variable magnetization machine to generate an adjusted d-axis current waveform and an adjusted q-axis current waveform that provide a driving voltage... Wisconsin Alumni Research Foundation

09/28/17 / #20170275643

Extending juvenility in grasses

The present invention relates to compositions and methods for modulating the juvenile to adult developmental growth transition in plants, such as grasses (e.g. maize). In particular, the invention provides methods for enhancing agronomic properties in plants by modulating expression of GRMZM2G362718, GRMZM2G096016, or homologs thereof. Modulation of expression of one... Wisconsin Alumni Research Foundation

09/28/17 / #20170279148

Charge transfer mediator based systems for electrocatalytic oxygen reduction

Disclosed are systems for the electrocatalytic reduction of oxygen, having redox mediator/redox catalyst pairs and an electrolyte solution in contact with an electrode. The redox mediator is included in the electrolyte solution, and the redox catalyst may be included in the electrolyte solution, or alternatively, may be in contact with... Wisconsin Alumni Research Foundation

09/28/17 / #20170279322

Permanent magnet synchronous motor

A permanent magnet synchronous motor includes a stator with a stator winding, a rotor with a rotor core rotatable relative to the stator, and a magnetic structure with at least one permanent magnet mounted to the rotor core. The magnetic structure produces a magnetic flux that flows between different magnetic... Wisconsin Alumni Research Foundation

09/28/17 / #20170279392

Variable magnetization machine controller

A variable magnetization machine control system comprising a controller configured to generate a reversely rotating d-axis/q-axis current vector trajectory during a change in a magnetization state of a variable magnetization machine to drive the variable magnetization machine at a predetermined speed while maintaining the driving voltage below a predetermined maximum... Wisconsin Alumni Research Foundation

09/21/17 / #20170266318

Hydrogel microspheres containing peptide ligands for growth factor regulation in blood products

Vascular endothelial growth factor VEGF-sequestering hydrogel microspheres that have been prepared to selectively bind VEGF from blood products are disclosed herein. In one particular embodiment, the microspheres bind VEGF as part of an intra-operative process such that the growth factor can be removed from the blood products before the products... Wisconsin Alumni Research Foundation

09/21/17 / #20170269089

Methods for detection and treatment of colorectal cancer

This invention provides methods, reagents, and diagnostic and prognostic markers useful for minimally invasive identification, diagnosis, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.... Wisconsin Alumni Research Foundation

09/21/17 / #20170269179

System and controlling undesired magnetic field effects in magnetic resonance imaging

A system and method are provided for determining a spatial distribution of susceptibility in a subject using a magnetic resonance imaging (MRI) system. The method includes directing the MRI system to acquire imaging data from an imaging volume within a subject, wherein the imaging volume is subject to both background... Wisconsin Alumni Research Foundation

09/21/17 / #20170270424

Method of estimating program speed-up in highly parallel architectures using static analysis

The amount of speed-up that can be obtained by optimizing the program to run on a different architecture is determined by static measurements of the program. Multiple such static measurements are processed by a machine learning system after being discretized to alter their accuracy vs precision. Static analysis requires less... Wisconsin Alumni Research Foundation

09/14/17 / #20170258805

Inhibitors of udp-galactopyranose mutase

Compounds and salts thereof which are acyl-sulfonamides or certain carboxylic acids and which inhibit microbial growth or attenuate the virulence of pathogenic microorganisms and which inhibit UDP-galactopyranose mutase (UGM). Compounds of the invention include 2-aminothiazoles and triazolothiadiazines, particularly 3,6,7-substituted-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, and 2-amino and salts thereof. Methods for inhibiting growth or attenuating... Wisconsin Alumni Research Foundation

09/14/17 / #20170258898

Versikine for inducing and potentiating an immune response

Disclosed are methods, kits, polypeptides, and pharmaceutical compositions for inducing an immune response in a subject, which may include a T-cell mediated immune response. The methods comprise administering to the subject, or to explanted cells of the subject, a pharmaceutical composition comprising an effective amount of versikine or a variant... Wisconsin Alumni Research Foundation

09/14/17 / #20170260506

Methods of t cell expansion and activation

The present disclosure relates to methods, cells, and compositions for preparing T cell populations and compositions for adoptive cell therapy. In particular, provided herein are methods for efficiently expanding and activating T cell populations for genetic engineering and adoptive T cell immunotherapies. Also provided are cells and compositions produced by... Wisconsin Alumni Research Foundation

09/07/17 / #20170252360

Use of 2-methylene-19-nor-(20s)-1alpha,25-dihydroxyvitamin d3 to treat secondary hyperparathyroidism

Disclosed are methods of administering 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 to treat and/or prevent secondary hyperparathyroidism and/or its accompanying symptoms in a subject having or at risk for developing secondary hyperparathyroidism.... Wisconsin Alumni Research Foundation

09/07/17 / #20170253546

Synthesis and biological activity of 2-methylene analogs of calcitriol and related compounds

Disclosed are 2-methylene analogs of vitamin D3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1α-hydroxy-2-methylene-vitamin D3, (20S)-1α-hydroxy-2-methylene-vitamin D3, and (5E)-1α,25-dihydroxy-2-methylene-vitamin D3, their biological activities, and various pharmaceutical uses for these compounds including methods of treating and/or preventing bone diseases and disorders.... Wisconsin Alumni Research Foundation

09/07/17 / #20170257300

Secure wireless network using radiometric signatures

A network security system for wireless devices derives a fingerprint from the modulation imperfections of the analog circuitry of the wireless transceivers. These fingerprints may be compared to templates obtained when the wireless devices are initially commissioned in a secure setting and used to augment passwords or other security tools... Wisconsin Alumni Research Foundation

08/31/17 / #20170246206

Calcium formate for use as a dietary supplement

A calcium formate composition for oral administration to an individual for the purpose of supplementary dietary calcium is disclosed.... Wisconsin Alumni Research Foundation

08/31/17 / #20170246357

Hydrogel compositions for use in cell expansion and differentiation

Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiation of various cells.... Wisconsin Alumni Research Foundation

08/31/17 / #20170249758

System and resolving artifacts in four-dimensional angiographic data

A system and method are provided for medical imaging that includes acquiring, during a common imaging acquisition process, rotational, x-ray volume image data and x-ray tomosynthesis image data from a subject. The method includes reconstructing a time-resolved three-dimensional (3D) image volume from the rotational, x-ray volume image data and producing... Wisconsin Alumni Research Foundation

08/31/17 / #20170249759

Systems and methods for artifact removal for computed tomography imaging

An imaging system includes a computed tomography (CT) acquisition unit and at least one processor. The CT acquisition unit includes an X-ray source and a CT detector configured to collect CT imaging data of an object. The at least one processor is operably coupled to the CT acquisition unit, and... Wisconsin Alumni Research Foundation

08/31/17 / #20170250800

Encrypted digital circuit description allowing signal delay simulation

A system for creating protected functional descriptions of integrated circuits provides encrypted gate delay information preventing deduction of gate function from gate delay but allowing simulation of the integrated circuit with accurate propagation delay calculation. Individual gate delay values may be modified so that they obscure actual gate delays but... Wisconsin Alumni Research Foundation








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