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Yale University patents


Recent patent applications related to Yale University. Yale University is listed as an Agent/Assignee. Note: Yale University may have other listings under different names/spellings. We're not affiliated with Yale University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "Y" | Yale University-related inventors


Josephson junction-based circulators and related systems and methods

According to some aspects, a circuit is provided comprising a plurality of Josephson junctions arranged in series in a loop, at least one magnetic element producing magnetic flux through the loop, a plurality of superconducting resonators, each resonator coupled to the loop between a different neighboring pair of Josephson junctions... Yale University

Myc g-quadruplex stabilizing small molecules and their use

Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of... Yale University

Compositions and methods for identifying secretory antibody-bound microbes

The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression of inflammatory diseases and disorders. Thus, the invention relates to compositions and methods for detecting and identifying the constituents of a subject's microbiota, methods of modifying the constituents... Yale University

Techniques for universal quantum control of quantum coherent states and related systems and methods

Some aspects are directed to a method of operating an apparatus, the apparatus comprising a first quantum system having a plurality of coherent quantum states, the first quantum system being coupled to a second quantum system, the method comprising providing an input energy signal to the second quantum system that... Yale University

Genetically modified non-human animals and methods of use thereof

The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.... Yale University

Compositions and methods for treating nlrp3 inflammasome-related diseases and disorders

The present invention provides compositions and methods for treating or preventing an NLRP3 immunosome-related disorder. In one embodiment, the method includes administering a therapeutically effective amount of a composition comprising at least one NLRP3 inflammasome inhibitor to a subject in need thereof.... Yale University

Compositions and methods of increasing longevity or treating cellular stress

The present invention includes methods and compositions for increasing longevity of a cell and increasing cellular resistance to stress. In certain embodiments, the invention includes a method to induce gene expression of a homolog of Pachytene Checkpoint 2 (pch-2) or bmk-1 gene. The present invention also includes methods to treat... Yale University

Use of mif and mif pathway agonists

The present invention relates to novel methods and compositions for increasing AMPK activity and glucose uptake comprising administering a macrophage migration inhibitory factor (MIF) pathway agonist in a subject in need thereof. The invention also relates to methods for selecting a subject for treatment with an agonist of MIF, identifying... Yale University

Integrated painless bone marrow biopsy device

An apparatus and method for performing painless bone marrow biopsy that requires only a single procedural pass to the biopsy bone site is disclosed. The biopsy device combines dermatotomy, anesthesia and marrow specimen extraction functionality and inherently aligns the bone drilling site with the site of anesthetic delivery by incorporating... Yale University

Mosquito saliva protein malaria vaccine

The invention provides compositions and methods for preventing and treating infection by Plasmodium sporozoites.... Yale University

Methods of preventing neurodegeneration of association cortex in a mammal

The present invention provides methods of preventing and/or reducing risk of neurodegeneration of association cortex, and/or inhibiting or reversing formation of phosphorylated tau or COXIV in the prefrontal cortex of a mammal in need thereof. In certain embodiments, the method comprises administering to the mammal a therapeutically effective amount of... Yale University

Glutamate agents in the treatment of mental disorders

Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. Also provided are methods of enhancing the activity of a serotonin reuptake inhibitor (SRI) comprising co-administering a glutamate modulator... Yale University

Formulations for targeted release of agents under low ph conditions and methods of use thereof

Poly(amine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic,... Yale University

Compositions and methods for treating pathological calcification and ossification

The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.... Yale University

Compositions and methods for modulating salm5 and hvem

The invention provides compositions and methods for regulating immune responses. In one embodiment, compositions of the invention include one or more SALM5-HVEM antagonists that are able to induce inflammation in the CNS or an immune privileged tissue. In another embodiment, compositions of the invention include one or more SALM5-HVEM agonists... Yale University

Methods and kits for detecting misfolded proteins

Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.... Yale University

Compositions for treating pathological calcification conditions, and methods using same

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament... Yale University

Compositions for treating pathological calcification conditions, and methods using same

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament... Yale University

Cavo-arterial pump

The present invention provides an intravascular right ventricular assist device, i.e., the cavo-arterial pump (CAP). Two prototypes of the CAP were developed, including a direct drive CAP and a magnetic drive CAP, demonstrating the feasibility of providing adequate pulmonary support and the feasibility of using axial magnetic couplings for contactless... Yale University

Novel ulk1 inhibitors and methods using same

In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.... Yale University

Drug therapy to inhibit chemotherapy-induced adverse effects and related pharmaceutical compositions, diagnostics, scrreening techniques and kits

The invention provides a method of treatment comprising reducing therapy-induced adverse effects (TIAE), including chemotherapy-induced adverse effects (CIAE), such as chemotherapy-induced peripheral neuropathy (CIPN) and/or chemotherapy-induced cardiovascular adverse effects (CICAE) in a subject being treated with a CIAE-inducing anti-cancer active ingredient by co-administering to the subject a pharmaceutically effective amount... Yale University

Compositions and methods for treating pathological calcification and ossification

The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.... Yale University

Cell-penetrating anti-dna antibodies and uses thereof inhibit dna repair

Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA... Yale University

Novel methods and devices for high-throughput quantification, detection and temporal profiling of cellular secretions, and compositions identified using same

The present invention relates to the unexpected discovery of methods and devices that can be used for high-throughput precise quantification, detection and/or temporal profiling of cellular secretions. In various embodiments, the methods of the invention allow for high-throughput absolute detection of secretions of cells, identification of the nature of the... Yale University

Endovascular graft defining internal lumens

An endovascular graft is provided that includes a stent structure adapted to move between a collapsed and a deployed configuration. An endovascular graft material is mounted with respect to the stent structure. At least one lumen- or chute-forming structure is associated with the stent structure internal to the endovascular graft... Yale University

Cd4 t cells provide antibody access to immunoprivileged tissue

The present disclosure relates to compositions and methods for treating or preventing a disease or disorder of immunoprivileged tissue. It is described herein that an immunogenic composition which induces production of memory CD4 T cells allows for the access of a therapeutic antibody to the immunoprivileged tissue.... Yale University

Methods, computer-readable media, and systems for measuring brain activity

One aspect of the invention provides a method including: obtaining neural activity data for a first subject and a second subject during verbal interaction between the first subject and the second subject; and calculating coherence between the neural activity data for the first subject and the neural activity data for... Yale University

Novel precatalyst scaffolds for cross-coupling reactions, and methods of making and using same

The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable and moisture-stable. The present invention further provides methods of making and using the precatalysts of the invention.... Yale University

Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same

The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal... Yale University

Loss of function mutations in kcnj10 cause sesame, a human syndrome with sensory, neurological, and renal deficits

The invention includes a method of identifying a human subject at-risk of developing SeSAME syndrome. The invention also includes a method of diagnosing a human subject afflicted with SeSAME syndrome. The invention further includes a method of identifying a therapeutic agent that modulates a given KCNJ10 mediated K+ current in... Yale University

Multivalent fragments of antibody 3e10 and methods of use thereof

Antigen binding molecules that bind to the epitope of 3E10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain variable fragments (scFv) of monoclonal antibody 3E10, wherein the variant scFv has one or more insertions, deletions, or substitutions... Yale University

Compositions and methods for treating epithelial cancer

The present invention provides the eutomeric isomer of the compound of formula (I), or a salt or solvate thereof, which can be used to treat epithelial cancer in a subject. In certain embodiments, the compound of formula (I) can be used in combination with AICAR and/or cisplatin.... Yale University

Compositions for enhancing targeted gene editing and methods of use thereof

Compositions and methods for enhancing targeted gene editing and methods of use thereof are disclosed. In the most preferred embodiments, gene editing is carried out utilizing a gene editing composition such as triplex-forming oligonucleotides, CRISPR, zinc finger nucleases, TALENS, or others, in combination with a gene modification potentiating agent such... Yale University

Humanized m-csf mice

Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice.... Yale University

Assemblies and methodologies for the repair of hernias

An assembly for the repair of a hernia. The assembly includes an elongated shaft having a first end; a first holding member at least mostly positionable in the elongated shaft and a second holding member positionable in the elongated shaft; a coupler assembly having (i) a coupler for coupling the... Yale University

09/28/17 / #20170274001

Compositions and methods for increasing red blood cells

The invention relates generally to a composition and method for increasing the frequency, amount, or presence of red blood cells in peripheral blood. In one embodiment, the invention comprises the inhibition of, or genetic modification of the genes encoding, one or more scavenger receptors. In one aspect, the invention relates... Yale University

09/28/17 / #20170274041

Reactivation of axon growth and recovery in chronic spinal cord injury

Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides, Nogo receptor-1 antibodies and antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, and polynucleotides. Also disclosed are methods of noninvasively monitoring axonal growth... Yale University

09/28/17 / #20170274054

Compositions and methods for modulating coagulation

The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of NPP4.... Yale University

09/21/17 / #20170266119

Hyperbranched polyglycerol-coated particles and methods of making and using thereof

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the... Yale University

09/21/17 / #20170266325

Compositions for nanoconfinement induced contrast enhancement and methods of making and using thereof

Multivalent CT or MR contrast agents and methods of making and using thereof are described herein. The agents contain a moiety, such as a polymer, that provides multivalent attachment of CT or MR contrast agents. Examples include, but are not limited to, multivalent linear polymers, branched polymers, or hyperbranched polymers,... Yale University

09/07/17 / #20170252414

Compositions and methods for treating pathological calcification and ossification

The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.... Yale University

08/31/17 / #20170248611

Method and panel for determining acute kidney injury

A method for determining the risk of acute kidney injury (AKI) in a mammal following cardiac surgery is provided. The method comprises determining the sample value of IL-6 or hFABP concentration, or the ratio of IL-6 to IL-10, in a biological sample from the mammal, either prior to cardiac surgery... Yale University

08/31/17 / #20170251191

Systems, methods, and computer-readable media for ultra-high resolution 3d imaging of whole cells

One aspect of the invention provides a method for drift correction to correct a 3D point collection dataset to compensate for drift over time. The method includes: (a) separating the 3D dataset into n segments, wherein n>1; (b) for each of the n segments, reconstructing a volume image as a... Yale University

08/24/17 / #20170240648

Anti-erbb antibodies and methods of use thereof

Provided herein are compositions, methods and uses involving antibodies that bind to ErbB, a receptor tyrosine kinase, and modulate the activity of ErbB. Also provided are uses and methods for treating disorders, such as cancer, by administering to subject an antibody that binds to ErbB.... Yale University

08/24/17 / #20170240908

Compositions and methods for biocontainment of microorganisms

Methods and strategies for introducing genetic safeguards into microorganisms, genetically modified organisms (GMO) including the safeguards, and methods of use thereof are provided. The genetic safeguards generally impart a low escape frequency, are robust, and are modular. Safeguards with low escape frequency prevent the rise of mutants escaping defined media... Yale University

08/24/17 / #20170242000

Calibration of nanostructure sensors

The present invention relates to uniform nanostructure biosensors and methods of calibrating the response of nanostructure biosensors. The invention overcomes device to device variability that has made quantitative detection difficult. The described biosensors have uniform characteristics that allow for more reliable comparison across devices. The methods of the invention comprise... Yale University

08/17/17 / #20170232027

Novel compositions and methods useful for treating or preventing liver diseases or disorders, and promoting weight loss

The invention includes a method of preventing or treating a toxic liver disease or disorder, such as but not limited to non-alcoholic steatohepatitis (NASH), liver injury associated with or caused by alcohol consumption in a mammal afflicted with NASH, alcoholic hepatitis, drug induced liver injury, primary sclerosing cholangitis, viral hepatitis,... Yale University

08/17/17 / #20170233749

Site-specific incorporation of phosphoserine into proteins in escherichia coli

Nucleic acids encoding mutant elongation factor proteins (EF-Sep), phosphoseryl-tRNA synthetase (SepRS), and phosphoseryl-tRNA (tRNASep) and methods of use in site specific incorporation of phosphoserine into a protein or polypeptide are described. Typically, SepRS preferentially aminoacrylates tRNASep with O-phosphoserine and the tRNASep recognizes at least one codon such as a stop... Yale University

08/17/17 / #20170237234

A gan vertical microcavity surface emitting laser (vcsel)

Structures and methods for forming highly uniform and high-porosity gallium-nitride layers with sub-100-nm pore sizes are described. Electrochemical etching of heavily-doped gallium nitride at low bias voltages in concentrated nitric acid is used to form the porous gallium nitride. The porous layers may be used in reflective structures for integrated... Yale University

08/10/17 / #20170224617

Methods of treating inflammatory and autoimmune diseases and disorders

Compositions and methods for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder are described herein. The compositions contain a nanolipogel for sustained delivery of an effective amount of one or more active agents of choice, preferably a drug for treating or ameliorating the symptoms of inflammatory... Yale University

08/10/17 / #20170226228

Compositions and methods to regulate renalase in the treatment of diseases and disorders

The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.... Yale University

08/03/17 / #20170216244

Methods for treating diabetic nephropathy

The present invention provides methods for treating or preventing diabetic nephropathy and its related pathologies by inhibiting podocyte Semaphorin3a (Sema3a). The invention also provides a method for identifying or characterizing a compound useful for treating or preventing diabetic nephropathy.... Yale University

08/03/17 / #20170216416

Pigment epithelium-derived factor (pedf) and peptide derivatives thereof for use in osteoblast differentiation and bone growth

The present invention provides compositions and methods for differentiating a stem cell into an osteoblast or osteoblast progenitor cell. In certain embodiments, the invention may be used for promoting bone formation and increasing bone mass. In one embodiment, the composition comprises an agent which increases PEDF expression, PEDF activity, or... Yale University

08/03/17 / #20170218036

Innate immune system modification for anticancer therapy

The present invention relates to the discovery of a role of the nuclear receptor retinoid-related orphan receptor gamma (RORgamma) in tumor suppression. The introduction and expression of RORgamma result in genes activation within innate immune cells that trigger recognition and suppression of tumor cells. Thus, in various embodiments described herein,... Yale University

07/27/17 / #20170209079

Nanopatterned biosensor electrode for enhanced sensor signal and sensitivity

An electrode structure, which can be used as a biosensor, is provided that has non-random topography located on one surface of an electrode base substrate. The non-random topography of the electrode structure and the electrode base substrate of the electrode structure are of unitary construction and unitary composition and thus... Yale University

07/27/17 / #20170209489

Fast acting inhibitor of gastric acid secretion with enhanced activity

The present invention relates to the discovery that a hydrated salt form of zinc exhibits enhanced activity in reducing the acidity of gastric juice in a subject in need when compared to typical zinc salts. According to the invention, a zinc salt hydrate may be used alone or in combination... Yale University

07/27/17 / #20170209570

Carbon nanotube compositions and methods of use thereof

Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or antigens. The CNT compositions function as artificial antigen-presenting cells (aAPCs) or as modular vaccines. The disclosed CNT aAPCs are efficient at activating T... Yale University

06/29/17 / #20170181966

Intranasal administration of ketamine to treat depression

Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent... Yale University

06/22/17 / #20170172121

Genetically modified mice and engraftment

A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mll2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/ll2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic... Yale University

06/22/17 / #20170173039

Compositions and methods to treat addiction

The present invention provides compositions and methods comprising talampanel and/or perampanel for treating or preventing an addictive disease or disorder, such as alcoholism, in a subject in need thereof. AMPA receptor (AMPA-Rs) antagonists (i.e., blockers), such as perampanel and talampanel, reduce drug and alcohol seeking behaviors in mammals since activation... Yale University

06/22/17 / #20170174763

Nogo receptor-mediated blockade of axonal growth

Disclosed are NgR proteins and biologically active Nogo (ligand) protein fragments. Also disclosed are compositions and methods for modulating the expression or activity of the Nogo and NgR protein. Also disclosed are peptides which block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in... Yale University

06/22/17 / #20170175190

Circulating microrna as biomarkers for endometriosis

The invention includes compositions and methods useful for the diagnosis, assessment, and characterization of endometriosis in a subject in need thereof, based upon the expression level of at least one miRNA that is associated with endometriosis.... Yale University

06/01/17 / #20170151191

Intranasal administration of ketamine to treat depression

Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent... Yale University

06/01/17 / #20170152558
06/01/17 / #20170154759

Mass spectrometry imaging of benign melanocytic nevi and malignant melanomas

A method of differentiating benign melanocytic nevi from malignant melanomas is disclosed. The method generally includes subjecting a skin lesion sample from a patient to mass spectrometry to obtain a mass spectrometry protein profile. This profile is compared to mass spectrometry protein profiles of reference samples, which include known normal,... Yale University

Patent Packs
05/25/17 / #20170146576

Consumption breakdown monitoring through power state sensing

Systems and methods are provided for estimating power breakdowns for a set of one or more appliances inside a building by exploiting a small number of power meters and data indicative of binary power states of individual appliances of such set. In one aspect, a breakdown estimation problem is solved... Yale University

05/18/17 / #20170138950

Identification of cancer protein biomarkers using proteomic techniques

The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein.... Yale University

05/18/17 / #20170140807

Circuitry for ferroelectric fet-based dynamic random access memory and non-violatile memory

Exemplary embodiments of the present disclosure are directed to circuitry for effective operation of Ferroelectric-gated FET (FeFET) memories. Exemplary embodiment of the present disclosure includes circuits and/or circuit blocks to facilitate memory refresh, error checking and correcting (ECC), reading and sensing memory cells, program and erase operations, and other control... Yale University

05/11/17 / #20170128490

Method for obtaining globally activated monocytes

The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer.... Yale University

05/11/17 / #20170130228

Compositions and methods to activate or inhibit toll-like receptor signaling

The present invention includes compositions and methods of inhibiting or activating TLR7 signaling. In one aspect, a composition includes an inhibitor of TLR7 signaling is described, where the inhibitor of TLR7 signaling is a TLR7 inhibitory oligonucleotide, a TLR7 antibody, or a TLR7 antagonist. In another aspect, a composition and... Yale University

05/11/17 / #20170133826

Lateral electrochemical etching of iii-nitride materials for microfabrication

Conductivity-selective lateral etching of III-nitride materials is described. Methods and structures for making vertical cavity surface emitting lasers with distributed Bragg reflectors via electrochemical etching are described. Layer-selective, lateral electrochemical etching of multi-layer stacks is employed to form semiconductor/air DBR structures adjacent active multiple quantum well regions of the lasers.... Yale University

05/04/17 / #20170120198

In situ formation of biocidal metal nanoparticles on thin-film composite reverse osmosis membranes for biofouling mitigation

The present invention relates to a method including reacting a solution of a salt of a biocidal metal with an active layer of water purification membrane, discarding the biocidal metal salt solution such that a thin layer of the biocidal metal salt solution remains on the membrane surface, reacting a... Yale University

05/04/17 / #20170121321

Proteolysis targeting chimera compounds and methods of preparing and using same

The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase in a subject in need thereof. In certain embodiments, the compounds of the present invention comprise a tyrosine kinase inhibitor, a linker and a... Yale University

05/04/17 / #20170121454

Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery

Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more... Yale University

05/04/17 / #20170121773

Methods for the diagnosis and treatment of pulmonary fibrosis in subjects with hermansky pudlak syndrome

Described herein are methods, assays, and systems related to the prognosis, diagnosis, and treatment of Hermansky Pudlak Syndrome (HPS) and, e.g., pulmonary fibrosis in a subject. As described herein, subjects with HPS who have, will develop, Cor are most at risk or developing pulmonary fibrosis have elevated levels of CHI3L1.... Yale University

04/20/17 / #20170105956

Novel methods of treating or preventing fibrotic lung diseases

The invention includes a method of preventing or treating a fibrotic lung disease in a subject, comprising administering to the subject a thyroid hormone by inhalation and/or aerosolization. The invention further comprises compositions and kits comprising compositions useful within the invention.... Yale University

04/20/17 / #20170106070

Uses of parasite macrophage migration inhibitory factors

This invention relates to compositions (e.g. vaccine compositions) which can be used to provide a subject with protective immunity against a parasite infection. The compositions comprise: (i) an immunologically effective amount of a nucleic acid (e.g. a nucleic acid-based vaccine) comprising a sequence which encodes a parasite macrophage migration inhibitory... Yale University

04/20/17 / #20170107499

Compositions and methods for treating and preventing pancreatitis, renal injury and cancer

The present invention includes compositions and methods for detecting, treating and preventing renal and pancreatic diseases and disorders.... Yale University

04/20/17 / #20170111046

Bootstrapping circuit and unipolar logic circuits using the same

Exemplary embodiments of the present disclosure are directed to a bootstrapping module and logic circuits utilizing the bootstrapping module to compensate for a weak high condition. The bootstrapping module can be implemented using transistors have a single channel type that is the same as the channel type of transistors utilized... Yale University

04/13/17 / #20170100428

Regulators of anaplastic lymphoma kinase and uses thereof

Provided herein are ALK regulators for the treatment of diseases and disorders. For example, presented herein are ALK regulators, e.g., ALK activators, and methods of treatment and/or prevention of diseases, including neurodegenerative, neuromuscular and cognitive diseases or disorders, and methods of enhancing cognitive abilities using ALK regulators, e.g., ALK activators.... Yale University

Patent Packs
04/06/17 / #20170096415

Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus

The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It... Yale University

03/30/17 / #20170087148

Tlr-agonist-conjugated antibody recruiting molecules (tlr-arms)

The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and... Yale University

03/16/17 / #20170073429

Cell penetrating anti-guanosine antibody based therapy for cancers with ras mutations

It has been established that cancer cells with oncogenic mutants in the small GTPase K-Ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells can be challenging. A subset of lupus autoantibodies is associated with anti-guanosine activity, and is capable of cellular penetration. These antibodies... Yale University

03/16/17 / #20170073676

Treatment for conditions associated with fibrosis and collagen deposition

Methods, compositions, devices, and kits for treating and/or reducing the risk of developing a condition associated with fibrosis and/or collagen deposition are provided. The method of treating and/or reducing the risk of developing a condition associated with fibrosis and/or collagen deposition in a subject includes administering an effective amount a... Yale University

03/09/17 / #20170065719

Compounds and methods for the targeted degradation of bromodomain-containing proteins

The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain... Yale University

03/09/17 / #20170067109

Assays for detecting wdr62 mutations

The present invention relates to compositions and methods for detecting mutations in WD repeat domain 62 (WDR62).... Yale University

03/09/17 / #20170067874

Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same

The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal... Yale University

03/09/17 / #20170067887

System, device and high-throughput multi-plexed detection

The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture... Yale University

03/02/17 / #20170056493

Virus like vesicles (vlvs) based vaccines to prevent or treat chronic hepatitis b virus (hbv) infection

The present invention relates to the discovery of compositions and methods for therapeutic immunization for treatment of chronic hepatitis B. Methods of the invention include a method generating an evolved high titer hybrid-hepatitis B virus (HBV) vector, methods of treating and/or preventing HBV, and methods of inducing a memory T... Yale University

02/23/17 / #20170049583

Multi-grasp prosthetic hand

The present invention provides a prosthetic hand capable of multiple grasp types. The prosthetic finger units are underactuated both within and between the finger units using a differential mechanism arrangement. The locking movement of the prosthetic thumb unit is coupled to the differential mechanism. As the user repositions the prosthetic... Yale University

02/23/17 / #20170051307

Evolution of high-titer virus-like vesicles for vaccine applications

The present invention relates to the discovery of a high titer hybrid-virus vector that gives rise to high titer virus like vesicles (VLVs) that can be used as a vaccine. The invention includes compositions and methods of generating an evolved hybrid-virus vector vaccine and selecting high titer VLVs, methods of... Yale University

02/16/17 / #20170047220

Nitrogen-polar semipolar gan layers and devices on sapphire substrates

Methods and structures for forming epitaxial layers of semipolar III-nitride materials on patterned sapphire substrates are described. Semi-nitrogen-polar GaN may be grown from inclined c-plane facets of sapphire and coalesced to form a continuous layer of (2021) GaN over the sapphire substrate. Nitridation of the sapphire and a low-temperature GaN... Yale University

02/02/17 / #20170027140

Human sirpa transgenic animals and their methods of use

The invention relates generally to compositions and methods of using transgenic non-human animals expressing human SIRPα that are engrafted with a human hematopoietic system. In various embodiments, the human hematopoietic system engrafted, human SIRPα transgenic non-human animals of the invention are useful as systems for the in vivo evaluation of... Yale University

02/02/17 / #20170027926

Compositions and methods of inhibiting histone deacetylases

The present invention provides compositions and methods for treating pulmonary hypertension. In one aspect, a method is included for increasing myocyte enhancer factor 2 (MEF2) activity in an endothelial cell comprising exposing the cell to a class IIa histone deacetylase inhibitor. In another aspect, a method is included for treating... Yale University

02/02/17 / #20170029858

Compositions and methods for making selenocysteine containing polypeptides

Non-naturally occurring tRNASec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring tRNASec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the requirement of an SECIS element. In some embodiments,... Yale University

02/02/17 / #20170033186

Method of obtaining planar semipolar gallium nitride surfaces

Methods and structures for forming flat, continuous, planar, epitaxial layers of semipolar III-nitride materials on patterned sapphire substrates are described. Semipolar GaN may be grown from inclined c-plane facets on a patterned sapphire substrate, and coalesced to form a continuous layer of semipolar III-nitride semiconductor over the sapphire substrate. Planarization... Yale University

01/26/17 / #20170020508

Assemblies and methodologies for internal transfascial mesh fixation

An assembly for securing a mesh patch to a surface of a peritoneum layer of an abdominal wall. The assembly includes first and second holding members coupled by a suture. After the two holding members are deployed from a shaft, tension on the coupler pulls the first holding member and... Yale University

01/26/17 / #20170021005

Compositions and methods for using salmonella typhi toxin to induce or enhance an immune response

The invention provides compositions and methods for using PltA, PltB, CdtB, or a mutant thereof, in inducing or enhancing an immune response.... Yale University

01/26/17 / #20170022337

Multiblock copolymer films, methods of making same, and uses thereof

A method for forming an isoporous graded film comprising multiblock copolymers and isoporous graded films. The films have a surface layer and a bulk layer. The surface layer can have at least 1×1014 pores/m2 and a pore size distribution (dmax/dmin)) of less than 3. The bulk layer has an asymmetric... Yale University

01/19/17 / #20170014500

Compositions and methods of preparing leptospira

The present invention includes compositions and methods of preparing flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. In one aspect, the invention includes an isolated, flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. Another aspect includes a composition comprising a flagellar-coiling protein 1 (Fcp1) deficient Leptospira bacterium. Yet another aspect includes a method of... Yale University

01/12/17 / #20170007685

Tumors expressing igg1 fc induce robust cd8 t cell responses

A lymphoma cell line was engineered to express surface IgG1 Fc. These tumor cells were taken up rapidly by DCs, leading to enhanced cross-presentation of tumor-derived antigen to CD8 T cells. IgG1-Fc tumors failed to grow in vivo and prophylactic vaccination in an animal model resulted in rejection of unmanipulated... Yale University

01/12/17 / #20170007717

Duocarmycin adcs for use in treatment of endometrial cancer

The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumours expressing HER2, wherein the human solid tumour expressing HER2 is endometrial cancer, in particular uterine serous carcinoma (USC). In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment... Yale University








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