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Zymeworks Inc patents

Recent patent applications related to Zymeworks Inc. Zymeworks Inc is listed as an Agent/Assignee. Note: Zymeworks Inc may have other listings under different names/spellings. We're not affiliated with Zymeworks Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "Z" | Zymeworks Inc-related inventors

Systems and methods for making two dimensional graphs of complex molecules

Systems and methods for two-dimensional visualization of a molecule, comprising the set of particles {p1, . . ... Zymeworks Inc

Crystal structures of heterodimeric fc domains

Disclosed are the atomic coordinates of compositions comprising fc heterodimer proteins in crystalline form derived from high resolution x-ray diffraction. Further disclosed are systems and methods for using all or a portion of these atomic coordinates to identify and design improved fc heterodimer proteins. ... Zymeworks Inc

Stable heterodimeric antibody design with mutations in the fc domain

The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. Ch2 and ch3) to accomplish selectivity between the various fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) fc molecule, and increased stability and purity of the resulting variant fc heterodimers. ... Zymeworks Inc

Methods of using bispecific antigen-binding constructs targeting her2

Described herein methods of using antigen-binding constructs to treat her2+ tumors in a subject such as breast, lung, or head and neck tumors. In some aspects, the tumor volume in the subject after receiving at least seven doses of the antigen binding construct is less than the tumor volume of a control subject receiving an equivalent amount of trastuzumab. ... Zymeworks Inc

Cytotoxic and anti-mitotic compounds, and methods of using the same

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. ... Zymeworks Inc

Modified antigen binding polypeptide constructs and uses thereof

The present invention provides heterodimer pairs that can comprise a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain or fragment thereof. At least one of the heterodimers can comprise one or more amino acid modifications in the ch1 and/or cl domains, one or more amino acid modifications in the vh and/or vl domains, or a combination thereof. ... Zymeworks Inc

Single-arm monovalent antibody constructs and uses thereof

Provided herein are monovalent antibody constructs. In specific embodiments is a monovalent antibody construct comprising: an antigen-binding polypeptide construct which monovalently binds an antigen; and a dimeric fc polypeptide construct comprising a ch3 domain, said construct comprising two monomeric fc polypeptides, wherein one said monomeric fc polypeptide is fused to at least one polypeptide from the antigen-binding polypeptide construct. ... Zymeworks Inc

Multivalent heteromultimer scaffold design and constructs

Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at least one cargo polypeptide, attached to a transporter polypeptide, such that said monomeric proteins associate to form the heteromultimer. ... Zymeworks Inc

Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells

The present invention provides a process and methods for producing asymmetric antibodies in a mammalian expression system. The asymmetric antibodies are transiently or stably expressed and in cells that stably express the asymmetric antibody, following a rapid 2-step process of stable pool to clone, a highly pure asymmetric antibody expressing clone can be identified at a success frequency that permits for screening of tens of clones rather than thousands. ... Zymeworks Inc

Methods for determining correlated residues in a protein or other biopolymer using molecular dynamics

The invention provides methods and systems of determining biopolymer profiles and correlations between structural units (residues) of a biopolymer based on sampling of the conformational space available to the molecule. The correlations between these structural units can further be used to find networks within a biopolymer such as the coupled residue networks in a protein. ... Zymeworks Inc

Sulfonamide-containing linkage systems for drug conjugates

Sulfonamide-containing linkage systems for release of payload compounds from an attached targeting moiety in drug conjugates. The conjugates have the formula of [(p)-(l)]m-(t), wherein (p) is a payload compound, (l) is a linker, (t) is a targeting moiety and m is an integer from 1- to 10. ... Zymeworks Inc

Antibodies comprising c-terminal light chain polypeptide extensions and conjugates and methods of use thereof

The present disclosure provides light chain polypeptides that include a c-terminal extension, as well as antibodies and antibody conjugates containing such modified light chain polypeptides, where the c-terminal extension includes one or more cysteine residues. Conjugates that include an antibody of the present disclosure conjugated to an agent via the cysteine residue of the c-terminal amino acid extension are also provided. ... Zymeworks Inc

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