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Adaptimmune Limited patents


Recent patent applications related to Adaptimmune Limited. Adaptimmune Limited is listed as an Agent/Assignee. Note: Adaptimmune Limited may have other listings under different names/spellings. We're not affiliated with Adaptimmune Limited, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Adaptimmune Limited-related inventors


High affinity ny-eso t cell receptors

The present invention provides t cell receptors (tcrs) having the property of binding to sllmwitqc-hla-a*0201, the sllmwitqc seq id no:126 peptide being derived from the ny-eso-1 protein which is expressed by a range of tumour cells. The tcrs have a kd for the said peptide-hla complex of less than or equal to 1 μm and/or have an off-rate (koff) of 1×10−3s−1 or slower.. ... Adaptimmune Limited

T cells with increased immunosuppression resistance

This invention relates to the treatment of cancer in an individual by administration of a population of modified t cells that express a recombinant camp phosphodiesterase (pde) or a fragment thereof and an antigen receptor which binds specifically to cancer cells in the individual. Populations of modified t cells and methods of producing populations of modified t cells are provided, along with pharmaceutical compositions and methods of treatment. ... Adaptimmune Limited

T cell receptors

The present invention relates to t cell receptors (tcrs) which bind the hla-a*02 restricted peptide glydgmehl (seq id no: 1) derived from the mage-a10 protein. The tcrs of the invention demonstrate excellent specificity profiles for this mage epitope. ... Adaptimmune Limited

High affinity ny-eso t cell receptors

The present invention provides t cell receptors (tcrs) having the property of binding to sllmwitqc-hla-a*0201, the sllmwitqc seq id no:126 peptide being derived from the ny-eso-1 protein which is expressed by a range of tumour cells. The tcrs have a kd for the said peptide-hla complex of less than or equal to 1 μm and/or have an off-rate (koff) of 1×10−3 s−1 or slower.. ... Adaptimmune Limited

Tcr libraries

The present invention relates to a library of particles, the library displaying a plurality of different t cell receptors (tcrs), wherein the plurality of tcrs may consist essentially of tcrs which may comprise an alpha chain variable domain from a natural repertoire and a beta chain variable domain from a natural repertoire, wherein the alpha chain variable domain may comprise a trav12-2 or a trav21 gene product and the beta chain variable domain may comprise a trbv6 gene product.. . ... Adaptimmune Limited








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