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Adaptive Biotechnologies Corp patents


Recent patent applications related to Adaptive Biotechnologies Corp. Adaptive Biotechnologies Corp is listed as an Agent/Assignee. Note: Adaptive Biotechnologies Corp may have other listings under different names/spellings. We're not affiliated with Adaptive Biotechnologies Corp, we're just tracking patents.

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Determining antigen-specific t-cells

The invention is directed to methods for determining antigen-specific t cells. In some embodiments, methods of the invention may be implemented by the steps of reacting under interaction conditions one or more antigens with t cells in a plurality of subsets of a tissue sample, such as peripheral blood; sorting antigen-interacting t cells from other t cells; separately sequencing for each subset recombined nucleic acid encoding a segment of a tcr chain from a sample of t cells prior to exposure to antigen and from a sample of t cells isolated based on their interaction with antigen, thereby forming a clonotype profile for the former sample and the latter sample for each subset; and identifying as antigen-specific t cells those t cells associated with a clonotype whose frequency increases in the latter sample relative to its frequency in the former sample.. ... Adaptive Biotechnologies Corp

Monitoring health and disease status using clonotype profiles

There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using dna sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions. ... Adaptive Biotechnologies Corp

Method for studying v(d)j combinatory diversity

The invention relates to a method for analyzing the diversity of the catalogue of t and/or b lymphocytes in an individual, based on the amplification, from a sample, of genomic dna fragments by pcr multi-n-plexes, with n≧2, carried out with a combination of at least 3 primers defining at least 2 primer couples, each of which includes a primer specifically hybridizing upstream and/or in a given v or d gene and a primer specifically hybridizing downstream and/or in a given j gene, in order to obtain the amplification of at least two fragments characteristic of two distinct v-j or d-j rearrangements from each primer couple. The invention also relates to the applications of this method, in particular in the treatment follow-up or in the diagnosis and/or prognosis of certain diseases.. ... Adaptive Biotechnologies Corp

Monitoring health and disease status using clonotype profiles

There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using dna sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions. ... Adaptive Biotechnologies Corp

Method for genotyping clonotype profiles using sequence tags

The invention is directed to sequence-based profiling of populations of nucleic acids by multiplex amplification and attachment of one or more sequence tags to target nucleic acids and/or copies thereof followed by high-throughput sequencing of the amplification product. In some embodiments, the invention includes successive steps of primer extension, removal of unextended primers and addition of new primers either for amplification (for example by pcr) or for additional primer extensions. ... Adaptive Biotechnologies Corp

Methods using randomer-containing synthetic molecules

Methods are provided for correction of amplification bias and quantitation of adaptive immune cells in a sample using synthetic templates that include random oligonucleotide sequences.. . ... Adaptive Biotechnologies Corp

T-cell receptor clonotypes shared among ankylosing spondylitis patients

The invention includes a method for determining the disease status of an individual suffering from ankylosing spondylitis by monitoring the individual's t-cell repertoire for the presence and/or level of clonotypes encoding t-cell receptor chains with segments identical to ant or related to the peptide lcassleasgssyneqffgpgtrltv (seq id no: 1) or the peptide vyfcassdssgstdtqyfgpgtrltv (seq id no: 2). The invention also includes therapeutic antibodies specific for these peptides for ameliorating the effects ankylosing spondylitis.. ... Adaptive Biotechnologies Corp

Quantification of adaptive immune cell genomes in a complex mixture of cells

A relative representation of adaptive immune cells in a biological sample is quantified using multiplex pcr and sequencing of adaptive immune cells, control genes, and synthetic template molecules. Disclosed herein are methods for quantifying a number of adaptive immune cells in a biological sample, and methods for quantifying a relative representation of adaptive immune cells in a biological sample that comprises a mixture of cells comprising adaptive immune cells and cells that are not adaptive immune cells. ... Adaptive Biotechnologies Corp








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