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Advanced Liquid Logic Inc patents (2015 archive)


Recent patent applications related to Advanced Liquid Logic Inc. Advanced Liquid Logic Inc is listed as an Agent/Assignee. Note: Advanced Liquid Logic Inc may have other listings under different names/spellings. We're not affiliated with Advanced Liquid Logic Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Advanced Liquid Logic Inc-related inventors


11/19/15 / #20150330943

Droplet-based particle sorting

The present invention relates to droplet-based particle sorting. According to one embodiment, a method of providing a droplet comprising a single cell is provided, wherein the method includes providing a droplet comprising a suspension of cells on an electrowetting droplet actuator surrounded by an oil medium, dispensing from the droplet to provide a dispensed droplet, determining whether the dispensed droplet on the electrowetting droplet actuator comprises a single cell, and sorting the dispensed droplet on the electrowetting droplet actuator based on the results of the determining step using electrowetting-mediated droplet operations.. ... Advanced Liquid Logic Inc

11/12/15 / #20150323496

Integrated droplet actuator for gel electrophoresis and molecular analysis

The invention is directed to a droplet actuator device and methods for integrating gel electrophoresis analysis with pre or post-analytical sample handling as well as other molecular analysis processes. Using digital microfluidics technology, the droplet actuator device and methods of the invention provide the ability to perform gel electrophoresis and liquid handling operations on a single integrated device. ... Advanced Liquid Logic Inc

11/05/15 / #20150314293

Droplet actuator devices and methods employing magnetic beads

A method of providing a droplet in contact with a magnetically responsive bead and having a reduced quantity of a substance. The method generally includes the steps of (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged for conducting droplet operations on a surface; (ii) a starting droplet comprising: (1) one or more magnetically responsive beads; (2) a starting quantity of the substance; and (3) a starting volume; (b) magnetically immobilizing the one or more magnetically responsive beads at a location which is at a distance from a target droplet splitting zone; (c) conducting one or more droplet operations comprising droplet dividing operations selected to divide the combined droplet to yield a set of droplets comprising: (i) a droplet comprising substantially all of the one or more magnetically responsive beads and having a decreased quantity of the substance relative to the starting concentration; and (ii) a droplet substantially lacking the magnetically responsive beads.. ... Advanced Liquid Logic Inc

09/24/15 / #20150268235

Bead incubation and washing on a droplet actuator

The invention relates to bead incubating and washing on a droplet actuator. Methods for incubating magnetically responsive beads that are labeled with primary antibody, a sample (i.e., analyte), and secondary reporter antibodies on a magnet, on and off a magnet, and completely off a magnet are provided. ... Advanced Liquid Logic Inc

09/24/15 / #20150267242

Acyl-coa dehydrogenase assays

A method for conducting medium-chain acyl-coa dehydrogenase (mcad) and very-long-chain acyl-coa dehydrogenase (vcad) enzymatic activity assays is provided. The method may include, but is not limited to, preparing a sample; preparing an enzyme-specific substrate/reagent mixture; mixing an aliquot of the prepared sample with an aliquot of the enzyme-specific substrate/reagent mixture; reading absorbance in the range of about 600 nm; incubating the prepared sample and enzyme-specific substrate/reagent mixture; and reading absorbance in the range of about 600 nm at various time intervals.. ... Advanced Liquid Logic Inc

09/10/15 / #20150253284

Droplet actuator and droplet-based techniques

The invention is directed to certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuator methods for detection of single nucleotide polymorphisms (snps) in a dna sequence using digital microfluidics, including droplet actuator-based sample preparation and snp analysis. ... Advanced Liquid Logic Inc

08/27/15 / #20150238975

Bead manipulation techniques

The invention provides a method of redistributing magnetically responsive beads in a droplet. The method may include conducting on a droplet operations surface one or more droplet operations using the droplet without removing the magnetically responsive beads from the region of the magnetic field. ... Advanced Liquid Logic Inc

07/30/15 / #20150212043

Digital microfluidics cartridge and system for operating a flow cell

A liquid handling system for supplying liquids to a flow cell (fc). The system may include a droplet actuator cartridge, wherein the droplet actuator and a flow cell are fluidly coupled to, or situated within, a droplet operations gap of the droplet actuator.. ... Advanced Liquid Logic Inc

07/23/15 / #20150205272

Droplet actuator with improved waste disposal capability

Methods, devices and systems for transporting a droplet along a droplet operations gap of a droplet actuator into contact with absorbent material to dispose of the droplet from the gap or from a region of the gap.. . ... Advanced Liquid Logic Inc

07/02/15 / #20150184219

Enzyme assays on a droplet actuator

The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties.. ... Advanced Liquid Logic Inc

06/25/15 / #20150174578

Droplet actuator configurations and methods of conducting droplet operations

A droplet actuator with a droplet formation electrode configuration associated with a droplet operations surface, wherein the electrode configuration comprises one or more electrodes configured to control volume of a droplet during formation of a sub-droplet on the droplet operations surface. Methods of making and using the droplet actuator are also provided.. ... Advanced Liquid Logic Inc

06/18/15 / #20150165763

Droplet actuator devices and methods

A microfluidic device having a substrate with an electrically conductive element made using a conductive ink layer underlying a hydrophobic layer.. . ... Advanced Liquid Logic Inc

04/23/15 / #20150111237

Biotinidase assays

The invention relates to methods for enzymatic detection of biotinidase activity. In certain aspects, the invention provides methods for bench-based enzymatic detection of biotinidase activity. ... Advanced Liquid Logic Inc

04/23/15 / #20150107995

Droplet actuator devices and methods for manipulating beads

The invention provides droplet actuators and droplet actuator techniques. Among other things, the droplet actuators and methods are useful for manipulating beads on a droplet actuator, such as conducting droplet operations using bead-containing droplets on a droplet actuator. ... Advanced Liquid Logic Inc

03/19/15 / #20150075991

Techniques and droplet actuator designs for reducing bubble formation

During droplet operations in a droplet actuator, bubbles often form in the filler fluid in the droplet operations gap and interrupt droplet operations. The present invention provides methods and systems for performing droplet operations on a droplet in a droplet actuator comprising maintaining substantially consistent contact between the droplet and an electrical ground while conducting multiple droplet operations on the droplet in the droplet operations gap and/or reducing the accumulation of electrical charges in the droplet operations gap during multiple droplet operations. ... Advanced Liquid Logic Inc

03/19/15 / #20150075986

Techniques and droplet actuator designs for reducing bubble formation

During droplet operations in a droplet actuator, bubbles often form in the filler fluid in the droplet operations gap and interrupt droplet operations. The present invention provides methods and systems for performing droplet operations on a droplet in a droplet actuator comprising maintaining substantially consistent contact between the droplet and an electrical ground while conducting multiple droplet operations on the droplet in the droplet operations gap and/or reducing the accumulation of electrical charges in the droplet operations gap during multiple droplet operations. ... Advanced Liquid Logic Inc

03/19/15 / #20150075985

Droplet dispensing device and methods

The invention provides nonlimiting examples of structures for and methods of dispensing droplets in a droplet actuator. The droplet actuator structures and methods of the invention exhibit numerous advantages over droplet actuators of the prior art. ... Advanced Liquid Logic Inc

03/12/15 / #20150072900

Sample processing droplet actuator, system and method

Sample processing droplet actuators, systems and methods are provided. According to one embodiment, a stamping device including a droplet microactuator is provided and includes: (a) a first plate including a path or network of control electrodes for transporting droplets on a surface thereof; (b) a second plate mounted in a substantially parallel orientation with respect to the first plate providing an interior volume between the plates, the second plate including one or more stamping ports for transporting some portion or all of a droplet from the interior volume to an exterior location; (c) a port for introducing fluid into the interior volume between the plates; and (d) a path or network of reference electrodes corresponding to the path or network of control electrodes. ... Advanced Liquid Logic Inc

03/12/15 / #20150068903

Droplet operations device

The invention provides droplet actuators with droplet operations surfaces for manipulating droplets, e.g., by conducting droplet operations. The droplet operations surfaces are typically exposed to a droplet operations gap. ... Advanced Liquid Logic Inc

03/05/15 / #20150065360

Systems for and methods of hybrid pyrosequencing

The systems and methods of the invention provide a guided approach to pyrosequencing (i.e., hybrid pyrosequencing). A de novo nucleic acid sequence may compared to a library of possible results and the next nucleotide to be dispensed is selected based on the comparison of the de novo sequence and the library of possible results. ... Advanced Liquid Logic Inc

02/26/15 / #20150053562

Droplet-based particle sorting

The present invention relates to droplet-based particle sorting. According to one embodiment, a droplet microactuator is provided and includes: (a) a suspension of particles; and (b) electrodes arranged for conducting droplet operations using droplets comprising particles. ... Advanced Liquid Logic Inc

02/19/15 / #20150050664

Enzyme concentration and assays

A method of preparing a sample for conducting an assay, the method including: providing an input sample including glycoproteins; capturing glycoproteins from the input sample on a solid support; and washing the sample support to remove unbound portions of the input sample.. . ... Advanced Liquid Logic Inc

02/05/15 / #20150038344

Method of preparing a nucleic acid library

A method of preparing a nucleic acid library in droplets in contact with oil, including: (a) blunt-ending nucleic acid fragments in a droplet in the oil to yield blunt-ended nucleic acid fragments; (b) phosphorylating the blunt-ended nucleic acid fragments in a droplet in the oil to yield phosphorylated nucleic acid fragments; coupling a-tails to the phosphorylated nucleic acid fragments in a droplet in the oil to yield a-tailed nucleic acid fragments; and (d) coupling nucleic acid adapters to the a-tailed nucleic acid fragments in a droplet in the oil to yield the nucleic acid library comprising adapter-ligated nucleic acid fragments.. . ... Advanced Liquid Logic Inc

02/05/15 / #20150034485

Bead incubation and washing on a droplet actuator

The present invention relates to bead incubating and washing on a droplet actuator. Methods for incubating magnetically responsive beads that are labeled with primary antibody, a sample (i.e., analyte), and secondary reporter antibodies on a magnet, on and off a magnet, and completely off a magnet are provided. ... Advanced Liquid Logic Inc

01/29/15 / #20150027889

Droplet actuator and method

The invention provides droplet actuators and droplet actuator cassettes including reagent storage capabilities, as well as methods of making and using the droplet actuators and cassettes. The invention also provides continuous flow channel elements and techniques for using electrodes to manipulate droplets in flowing streams. ... Advanced Liquid Logic Inc

01/22/15 / #20150021189

Multiplexed detection schemes for a droplet actuator

A droplet actuator configured to improve the throughput of droplet operations in a detection spot of the droplet actuator and/or to reduce carryover problems is provided. The droplet actuator may include electrodes configured for effecting droplet operations transporting droplets on a surface; a sensor arranged in proximity to one or more of the electrodes establishing a detection window on the surface for detection of one or more properties of one or more droplets on the surface; wherein the electrodes may establish at least two pathways for transport of droplets into the detection window.. ... Advanced Liquid Logic Inc

01/22/15 / #20150021182

Methods of maintaining droplet transport

The invention provides a method for reducing or preventing droplet pinning as the droplet is transported across a boundary between a ground electrode region and a non-ground electrode region on a droplet actuator. The invention also provides a method for reducing or preventing droplet super-movement as the droplet is transported across a boundary between a ground electrode region and a non-ground electrode region on a droplet actuator.. ... Advanced Liquid Logic Inc

01/08/15 / #20150008128

Bead manipulation techniques

The invention provides a method of redistributing magnetically responsive beads in a droplet. The method may include conducting on a droplet operations surface one or more droplet operations using the droplet without removing the magnetically responsive beads from the region of the magnetic field. ... Advanced Liquid Logic Inc








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