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Advaxis Inc patents


Recent patent applications related to Advaxis Inc. Advaxis Inc is listed as an Agent/Assignee. Note: Advaxis Inc may have other listings under different names/spellings. We're not affiliated with Advaxis Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Advaxis Inc-related inventors


Combination therapies with recombinant listeria strains

The disclosure is directed to compositions comprising an oncolytic virus, chimeric antigen receptor t cells (car t cells), a therapeutic or immunomodulating monoclonal antibody, a targeting thymidine kinase inhibitor (tki), or an adoptively transferred cells incorporating engineered t cell receptors, and a live attenuated recombinant listeria strain comprising a fusion protein of a truncated llo, a truncated acta or a pest-sequence peptide fused to a tumor-associated antigen. The disclosure is further directed to methods of treating, protecting against, and inducing an immune response against a tumor, comprising the step of administering the same, with or without an additional radiation therapy treatment.. ... Advaxis Inc

Immunogenic listeria-based compositions comprising truncated acta-antigen fusions and methods of use thereof

The present invention relates to compositions comprising a recombinant attenuated listeria strain expressing a truncated acta and fusion proteins thereof and methods of using the same for inducing anti-disease immune responses, and treatment of the same, including a tumor growth or cancer. In particular, the invention relates to the treatment of a tumor growth or cancer using a live attenuated recombinant listeria strain that expresses a fusion protein of a truncated acta fused to an antigen.. ... Advaxis Inc

Manufacturing device and process for personalized delivery vector-based immunotherapy

This invention provides a system of providing and a process of creating personalized immunotherapeutic compositions for a subject having a disease or condition, including therapeutic vaccine delivery vectors comprising gene expression constructs expressing peptides associated with one or more neo-epitopes or peptides containing mutations that are specific to an subject's cancer or unhealthy tissue. The invention further provides a scalable fully enclosed single use cell growth system, wherein the entire process of manufacturing of personalized immunotherapeutic compositions, up to and including dispensing said composition into containers for patient delivery is carried out within a single enclosed fluid flow path.. ... Advaxis Inc

Biomarker directed multi-target immunotherapy

This invention provides methods and compositions for using evaluating biomarker expression in a disease and providing a multi-targeted listeria-based immunotherapeutic approach against said disease. In a related aspect, the invention relates to a method of treating a disease in a subject, the method comprising the steps of: a. ... Advaxis Inc

Compositions and methods comprising klk3 or folh1 antigen

The present invention provides klk3 peptides, folh1 peptides, recombinant polypeptides comprising same, recombinant nucleotide molecules encoding same, recombinant listeria strains comprising same, and immunogenic and therapeutic methods utilizing same.. . ... Advaxis Inc

Recombinant listeria vaccine strains and methods of producing the same

The present invention provides methods of treating, protecting against and inducing an immune response against a tumor or cancer, comprising the step of administering to a subject a recombinant listeria strain. In one embodiment the present invention relates to a recombinant listeria strain, said recombinant listeria strain comprising a recombinant nucleic add, said nucleic add comprising a first open reading frame encoding a recombinant polypeptide comprising a first n-terminal fragment of an llo protein fused to a heterologous antigen or fragment thereof, and wherein said recombinant nucleic add further comprises a second open reading frame encoding a mutant prfa protein.. ... Advaxis Inc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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