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Affymetrix Inc patents


Recent patent applications related to Affymetrix Inc. Affymetrix Inc is listed as an Agent/Assignee. Note: Affymetrix Inc may have other listings under different names/spellings. We're not affiliated with Affymetrix Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Affymetrix Inc-related inventors


Array-based translocation and rearrangement assays

Methods for detecting genomic rearrangements are provided. In one embodiment, methods are provided for the use of paired end tags from restriction fragments to detect genomic rearrangements. ... Affymetrix Inc

Analysis of methylation using nucleic acid arrays

Arrays for genome-wide analysis of methylation are disclosed. In a preferred aspect arrays comprising a plurality of probes complementary to a plurality of identified cpg islands in the human, mouse and rat genome are disclosed. ... Affymetrix Inc

Methods, systems and apparatuses for testing and calibrating fluorescent scanners

Disclosed are calibration apparatuses for fluorescent microscopy instruments and methods of making and using them. Specifically, disclosed are calibration apparatuses with a fluorescent layer, such as photoresist, deposited on a substrate, with an optional layer of a reflective material, such as chrome. ... Affymetrix Inc

Complexity management of genomic dna

The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. ... Affymetrix Inc

Dna ligation on rna template

Disclosed are methods and compositions for detection and amplification of nucleic acids, wherein two dna strands hybridized to an rna strand are ligated. In one aspect, the disclosed methods include removal of an energy source, such as atp, upon charging a ligase to form an enzyme-amp intermediate, and then adding substrate, which results in one complete round of rna-templated dna ligation. ... Affymetrix Inc

Multiplex amplification methods

Compositions and methods for amplifying selected polynucleotides, including dna and rna, particularly in multiplex amplification reactions using common primers amplification. Generally, methods of the invention employ multiple steps such as template-specific hybridization, a linear amplification, partial degradation of nucleic acid, and ligation. ... Affymetrix Inc

Enzymatic methods for genotyping on arrays

The invention relates to methods for enzymatic, genotyping of polymorphisms on solid supports. In some aspects the methods include ligation of allele or base specific interrogation probes to an array probe. ... Affymetrix Inc

Polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection

The invention provides for polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection.. . ... Affymetrix Inc

Methods and devices for reading microarrays

In one embodiment of the invention, a method to image a probe array is described that includes focusing on a plurality of fiducials on a surface of an array. The method utilizes obtaining the best z position of the fiducials and using a surface fitting algorithm to produce a surface fit profile. ... Affymetrix Inc

System, method, and computer software product for genotype determination using probe array data

An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate.. . ... Affymetrix Inc

Differential filtering of genetic data

Computer software products, methods, and systems are described which provide functionality to a user conducting experiments designed to detect and/or identify genetic sequences and other characteristics of a genetic sample, such as, for instance, gene copy number and aberrations thereof. The presently described software allows the user to interact with a graphical user interface which depicts the genetic information obtained from the experiment. ... Affymetrix Inc

Polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection

The invention provides for polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection.. . ... Affymetrix Inc

Methods, systems and apparatuses for testing and calibrating fluorescent scanners

Disclosed are calibration apparatuses for fluorescent microscopy instruments and methods of making and using them. Specifically, disclosed are calibration apparatuses with a fluorescent layer, such as photoresist, deposited on a substrate, with an optional layer of a reflective material, such as chrome. ... Affymetrix Inc

Silane mixtures

Silanation compositions containing a mixture of two or more silanation reagents, where at least one silanation reagent includes a functional group capable of supporting polymer synthesis and at least one silanation reagent includes no functional group capable of supporting polymer synthesis are useful in modulating the active site density and hydrolytic stability of a surface. These compositions are particularly useful in silanating a surface prior to preparation of a polymer array and provide for increased hybridization results.. ... Affymetrix Inc

03/23/17 / #20170081703

Methods of analysis of methylation

Methods for determining the methylation status of a plurality of cytosines are disclosed. In some aspects genomic dna target sequences containing cpgs are targeted for analysis by multiplex amplification using target specific probes that can be specifically degraded prior to amplification. ... Affymetrix Inc

03/16/17 / #20170073731

Multiplex targeted amplification using flap nuclease

Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed. In one aspect targets are circularized using a single circularization probe that is complementary to two regions in the target that flank a region to be amplified. ... Affymetrix Inc

03/09/17 / #20170067099

Multiplex targeted amplification using flap nuclease

Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed. In one aspect targets are circularized using a single circularization probe that is complementary to two regions in the target that flank a region to be amplified. ... Affymetrix Inc

02/23/17 / #20170051339

Locus specific amplification using array probes

Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets. In preferred aspects the amplification and analysis take place on the same solid support and preferably in a localized area such as a bead or a feature of an array. ... Affymetrix Inc

01/19/17 / #20170016057

Complexity management of genomic dna

The presently claimed invention provides for novel methods and kits for reducing the complexity of a nucleic acid sample by providing non-gel based methods for amplification of a subset of the sequences in a sample. In a preferred embodiment, amplification of a subset can be accomplished by digesting a sample with two or more restriction enzymes and ligating adaptors to the fragments so that only a subset of the fragments can be amplified. ... Affymetrix Inc








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