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Agilent Technologies Inc patents

Recent patent applications related to Agilent Technologies Inc. Agilent Technologies Inc is listed as an Agent/Assignee. Note: Agilent Technologies Inc may have other listings under different names/spellings. We're not affiliated with Agilent Technologies Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Agilent Technologies Inc-related inventors

Electron ionization (ei) utilizing different ei energies

Mass spectrometry is performed utilizing an electron ionization (ei) source. The ei source ionizes a sample at different electron energies, including below and above 70 ev. ... Agilent Technologies Inc

Chambers for microwave plasma generation

. . A microwave chamber for plasma generation. The microwave chamber comprises a launch structure at a first end of the microwave chamber to accommodate a microwave source for producing microwave energy and a termination section at a second end of the microwave chamber opposite the first end. ... Agilent Technologies Inc

Method and device for calibration of biological flux

An apparatus for calibrating a flux analyzer comprises a first frame; a second frame; and a permeable membrane. The first frame and the second frame are connected or integrally formed. ... Agilent Technologies Inc

System and methodology for the analysis of genomic data obtained from a subject

The present teachings describe a method for determining the presence or absence of a fetal chromosomal aneuploidy in a pregnant female, the method comprising the calculation of a parameter p from sequences obtained from a biological sample from said pregnant female. The present teachings equally provide a method for determining the fetal fraction of said sample.. ... Agilent Technologies Inc

Method for making an asymmetrically-tagged sequencing library

A method for making an asymmetrically-tagged sequencing library is provided. In some embodiments, the method may comprise: obtaining a symmetrically-tagged library of cdna or genomic dna fragments, hybridizing a tailed first primer to the 3′ sequence tag of the library and extending the same to produce primer extension products, and amplifying the primer extension products using a prior of tailed primers to produce asymmetrically-tagged library.. ... Agilent Technologies Inc

Mixer bypass sample injection for liquid chromatography

In a liquid chromatography system, a sample is injected into a column by flowing a solvent mixture from a mixer into the column along a solvent mixture flow path; and injecting a sample into the solvent mixture flow path downstream of the mixer. In another liquid chromatography system, a sample is injected into a column by loading an isolator fluid into a sample loop, loading a sample into the sample loop, and flowing the sample into the column as a plug in front of the isolator fluid.. ... Agilent Technologies Inc

Protected monomer and method of final deprotection for rna synthesis

A method of deprotecting a solid support bound polynucleotide comprising at least one 2′-protected ribonucleotide in which a step of contacting the polynucleotide with a composition comprising a diamine is performed under conditions sufficient to deprotect and cleave the polynucleotide which remains retained on the solid support.. . ... Agilent Technologies Inc

Quadrupole rod assembly

A quadrupole rod assembly includes a plurality of electrically conductive rods, electrically insulating rings coaxially surrounding the rods, and clamping systems. The rods are arranged about a longitudinal axis. ... Agilent Technologies Inc

Microfluidic check valve and related devices and systems

A microfluidic check valve includes an inlet bore, an internal chamber, an outlet bore, and a disk freely movable in the chamber between an open position and a closed position. At the open position, the disk permits fluid to flow from the inlet bore, through the chamber, and to the outlet bore. ... Agilent Technologies Inc

Method for unsupervised stain separation in pathological whole slide images

A method of operating a data processing system to automatically process a color digital image of a specimen that has been stained with a first dye and a second different dye is disclosed. The method includes receiving a color image that includes a plurality of pixels, each pixel being characterized by a pixel vector having components determined by the intensity of light in each of a corresponding number of wavelength bands. ... Agilent Technologies Inc

Composition and method for improving signal-to-noise in hybridization to oligonucleotide arrays

Provided herein, among other things, are compositions for improving signal-to-noise in hybridization to oligonucleotide arrays. In some embodiments, the composition may comprise a population of indexing oligonucleotides of formula x-y, where the sequences of region x hybridize to an array and the sequences of region y hybridize to distinct sites within a genomic region, transcript, set of transcripts, or complement of the same. ... Agilent Technologies Inc

Deparaffinization of tissue by electric field generation and ionization

Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. ... Agilent Technologies Inc

Chemically modified guide rnas for crispr/cas-mediated gene regulation

Provided herein are methods for inducing crispr/cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target dna or target rna) in a cell. The methods include using modified single guide rnas (sgrnas) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. ... Agilent Technologies Inc

On-array ligation assembly

Provided herein, among other things, is a method for producing a ligation product on a support. In some embodiments, the method may comprise hybridizing a first double-stranded oligonucleotides and a second double-stranded oligonucleotide to a substrate comprising surface-tethered oligonucleotides and ligating the distal ends of the first and second double-stranded oligonucleotides together, thereby producing a first ligation product that is tethered to the support at both ends.. ... Agilent Technologies Inc

03/22/18 / #20180080858

Functionalized support for analytical sample preparation

Aspects of the present disclosure include a solid phase sorbent for preparation of analytical samples. The solid phase sorbent includes particles that are surface modified with an α-cyclodextrin moiety. ... Agilent Technologies Inc

03/15/18 / #20180073068

Hairpin-mediated amplification method

In some embodiments, the amplification method may comprise producing a reaction mix comprising: a nucleic acid sample, a polymerase, nucleotides, a forward primer that hybridizes to a sequence in the bottom strand of a fragment in the sample, and a reverse primer. The reverse primer has a hairpin structure comprising a loop, a stem and a 3′ overhang of at least 8 nucleotides, wherein the 3′ overhang hybridizes to a sequence in the top strand of the fragment. ... Agilent Technologies Inc

03/08/18 / #20180068840

Ion transfer device for mass spectrometry

An ion transfer device for transferring ions from one chamber to another, reduced-pressure chamber includes an inlet section and a main capillary section. The inlet section has a lumen and the main capillary section has a bore communicating with the lumen. ... Agilent Technologies Inc

03/01/18 / #20180059073

Quick lock connector for connecting a capillary to a fluidic conduit of a fluidic component

A fitting for providing a fluid connection between a capillary and a fluidic conduit of a fluidic component, wherein the fitting comprises a capillary reception configured for receiving the capillary, a force applicator configured for being operable to apply a fixing force for fixing the capillary within the fitting, a force limitation mechanism configured for limiting the fixing force being applicable by the force applicator to the capillary, a force splitter configured for splitting the fixing force into an advance force component for advancing the capillary received in the capillary reception towards the fluidic component and into a clamping force component for clamping the capillary received in the capillary reception within the fitting, and a biasing mechanism particularly arranged between the force applicator and the force splitter and configured for biasing the force splitter against the capillary.. . ... Agilent Technologies Inc

03/01/18 / #20180058453

Hermetic vacuum pump isolation valve

A vacuum pump isolation (vpi) valve is interposed between a vacuum pump and a vacuum chamber. During normal operation of the vacuum pump, the vpi valve is open, allowing fluid communication between the vacuum pump and the vacuum chamber. ... Agilent Technologies Inc

02/22/18 / #20180053640

In-source collision-induced heating and activation of gas-phase ions for spectrometry

An electrode assembly is provided in a high sub-atmospheric pressure region of an ion source, between an ionization chamber and a vacuum region of a spectrometer, such as a mass spectrometer, an ion mobility spectrometer, or an ion mobility-mass spectrometer. The electrode assembly is spaced at a distance from an outlet of an ion transfer device. ... Agilent Technologies Inc

02/22/18 / #20180052141

Artifact compensation due to different properties of fluid accommodation volumes in sample separation apparatus

A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus including at least two fluid accommodation volumes having different flow through properties and each being configured for temporarily accommodating fluidic sample, wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts resulting from the different flow through properties of the fluid accommodation volumes.. . ... Agilent Technologies Inc

02/22/18 / #20180051281

Guide rna with chemical modifications

The present invention relates to modified guide rnas and their use in clustered, regularly interspaced, short palindromic repeats (crispr)/crispr-associated (cas) systems.. . ... Agilent Technologies Inc

02/22/18 / #20180050370

System and method for facilitating manual sorting of objects

An apparatus that facilitates the manual sorting of objects is disclosed. The apparatus includes a display surface having a surface that can be selectively illuminated and that is adapted for receiving the objects. ... Agilent Technologies Inc

02/15/18 / #20180044722

Tri-color probes for detecting multiple gene rearrangements in a fish assay

A probe system is provided. In some embodiments, the probe system may comprise: a first labeled probe that hybridizes to one side of a potential translocation breakpoint in a first locus; a second labeled probe that hybridizes to the other side of the potential translocation breakpoint in the first locus; a third labeled probe that hybridizes to one side of a potential translocation breakpoint in a second locus; a fourth labeled probe that hybridizes to the other side of the potential translocation breakpoint in the second locus; and a fifth labeled probe that hybridizes to both sides of the potential translocation breakpoint in either the first locus or the second locus, but not both. ... Agilent Technologies Inc

01/18/18 / #20180015390

Impact centrifugal separator and associated methods for fraction collection in supercritical fluid systems

A separator (e.g. An impact centrifugal separator) is for use in collection of liquid portions of a bi-phasic flowstream in a supercritical fluid system. ... Agilent Technologies Inc

12/14/17 / #20170355985

High specificity genome editing using chemically modified guide rnas

The present invention relates to guide rnas having chemical modifications and their use in crispr-cas systems. The chemically modified guide rnas have enhanced specificity for target polynucleotide sequences. ... Agilent Technologies Inc

12/07/17 / #20170349612

Functionalized particles having modified phases

Modified silica particles are provided. Aspects of the particles include an outer layer that is composed of organically-modified silica comprising a siloxane-linked hydrophilic group, such as a charged functional group or a polar neutral functional group. ... Agilent Technologies Inc

11/30/17 / #20170347443

Ion throughput pump and method

An ion throughput pump (itp) includes a pump inlet configured to communicate with a vacuum chamber; an ionization source fluidly communicating with the vacuum chamber via the pump inlet and configured for ionizing gas species received from the vacuum chamber; a pump outlet; ion optics configured for accelerating ions produced by the ionization source toward the pump outlet; and a roughing pump stage configured for receiving the ions from the ionization source, producing neutral species from the ions, and pumping the neutral species through the pump outlet.. . ... Agilent Technologies Inc

11/30/17 / #20170343520

Branching off fluidic sample with low influence on source flow path

A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured to adjust a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.. . ... Agilent Technologies Inc

11/30/17 / #20170343518

Sample injection with fluidic connection between fluid drive unit and sample accommodation volume

An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. ... Agilent Technologies Inc

11/30/17 / #20170343414

Optical emission system including dichroic beam combiner

An optical emission spectrometer system includes a light source and a dichroic beam combiner. The light source emits first light in a first direction and second light in a second direction different from the first direction. ... Agilent Technologies Inc

11/30/17 / #20170343405

Flow meters, flow meter cartridges, and related methods

A flow meter for measuring a flow rate of a fluid may include a cartridge containing certain components such as a flow sensor. The cartridge is removable from the flow meter such that it may be replaced with a new cartridge, allowing calibration of the flow meter while enabling the flow meter to continue to be operated with another cartridge in the place of the removed cartridge. ... Agilent Technologies Inc

11/30/17 / #20170342483

Transposase-random priming dna sample preparation

Provided herein, among other things, are a variety of methods for transposase-mediated tagging and amplification of short dna fragments, e.g., between about 150 bp and 1.5 kb in length. In some aspects, the method includes tagging the dna fragments with a first primer sequence using barcoded transposases followed by a primer extension reaction to introduce a second primer sequence, e.g., using random or gene-specific primers. ... Agilent Technologies Inc

11/16/17 / #20170328928

Systems and methods for transferring liquids

One or more liquids are transferred from a source array to one or more remotely positioned destination sites such as chambers by utilizing one or more movable transfer elements, such as contact pins or capillaries. The source array may include a predetermined organization of addresses at which materials are positioned. ... Agilent Technologies Inc

11/09/17 / #20170322187

Metering device with defined enabled flow direction

A sample injector configured to introduce a sample fluid into a mobile phase, wherein the mobile phase is to be driven by a mobile phase drive through a separation unit for separating compounds of the sample fluid in the mobile phase, wherein the sample injector comprises a metering device being operable for displacing fluid and for intaking a metered amount of the sample fluid into the sample injector, an injector valve being switchable for operating the sample injector selectively in a sample intake mode in which the metering device is operable to intake the sample fluid from a sample container, or a separation mode in which intaken sample fluid is driven between the mobile phase drive and the separation unit for separating the compounds, and a flow direction controller configured for defining an enabled flow direction of fluid displaced by the metering device and for defining a disabled flow direction.. . ... Agilent Technologies Inc

10/05/17 / #20170285037

Scoring methods for anti-pd therapy eligibility and compositions for performing same

Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-pd therapeutic agent based on a combined positive score (cps) for a tumor tissue sample from the subject. Compositions and kits or performing the disclosed methods are also provided.. ... Agilent Technologies Inc

10/05/17 / #20170285029

Immunohistochemistry scoring methods and compositions

Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-pd therapeutic agent. In certain embodiments, the method includes determining, by immunohistochemistry, the number of pd-l1 positive malignant cells in a tumor tissue section as well as the number of infiltrating non-malignant cells and/or non-malignant cells of the stromal interface area. ... Agilent Technologies Inc

10/05/17 / #20170284979

Sample injector with metering device balancing pressure differences in an intermediate valve state

A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.. . ... Agilent Technologies Inc

10/05/17 / #20170284904

Apparatus and methods for transferring a tissue section

This invention relates to apparatus and methods for automated tissue sectioning, including slicing and transferring a tissue section from a microtome. The invention also relates to automated systems and methods for slicing and transferring a tissue section onto a slide.. ... Agilent Technologies Inc

10/05/17 / #20170283864

Use of transposase and y adapters to fragment and tag dna

Described herein, among other things, is an adapter comprising a population of first oligonucleotides, a second oligonucleotide and a third oligonucleotide, wherein the first oligonucleotides, the second oligonucleotide and the third oligonucleotide are hybridized together to produce a complex that comprises: (i) a first end comprising a transposase recognition sequence, (ii) a central single-stranded region of variable sequence and (iii) a second end comprising sequences that are non-complementary. A method, as well as a kit for practicing the method, are also provided.. ... Agilent Technologies Inc

10/05/17 / #20170282155

Superficially porous particles with dual pore structure and methods for making the same

Superficially porous particles are provided. Aspects of the superficially porous particles include a non-porous inner core and a porous outer shell that includes inner and outer porous regions. ... Agilent Technologies Inc

09/14/17 / #20170263435

Filament assembly for generating electrons, and related devices, systems and methods

A filament assembly includes a core and a filament. At least a central portion of the filament is disposed on the core. ... Agilent Technologies Inc

08/31/17 / #20170247671

Methods and compositions for blocking off-target nucleic acids from cleavage by crispr proteins

This invention relates to reagents and methods for increasing specificity and efficiency of genome editing by crispr associated (cas) protein systems, more particularly by cas:guide rna complexes, by blocking off-target nucleic acids from cleavage by cas:guide rna complexes.. . ... Agilent Technologies Inc

08/03/17 / #20170221688

Method for supplying gas for plasma based analytical instrument

To achieve an effective gas filtering in a plasma spectrometric apparatus using a gas of a comparatively high consumption flow rate, and to improve the analytical ability, there is provided a plasma spectrometric apparatus containing a sample introducer for producing and delivering an injector gas containing an analyte sample, a plasma generator for generating plasma into which the injector gas is introduced, and an analyzer disposed subsequent to the plasma generator for analyzing the analyte sample. The plasma spectrometric apparatus contains a first gas line for supplying gas to the sample introducer, a second gas line for supplying gas to the plasma generator, and a filter located in the first gas line for removing impurities contained in the gas.. ... Agilent Technologies Inc

08/03/17 / #20170219540

Temporary storage of sample portions for artefact-preventing fluid processing

In a method for processing successive fluidic sample portions provided by a sample source, sample reception volumes are filled successively temporarily with at least a respective one of the sample sections, and the sample sections are emptied successively out of the sample reception volumes in such a way, that, while emptying, it is avoided to bring two respective ones of the sample sections, which have not left the sample source directly adjacent to one another, in contact with one another.. . ... Agilent Technologies Inc

08/03/17 / #20170218358

One-pot multiplex gene synthesis

The present invention provides methods for generating a library of synthetic polynucleotides. The present invention also provides methods for generating proteins encoded by the library of synthetic polynucleotides. ... Agilent Technologies Inc

06/22/17 / #20170175182

Transposase-mediated barcoding of fragmented dna

Provided herein, among other things, are a variety of methods that comprise inserting a plurality of barcoded transposons into a population of dna fragments that comprise dna fragments of less than 1 kb in length, to produce transposon-tagged fragments that each comprise a barcoded transposon. Kits for performing this method are also provided.. ... Agilent Technologies Inc

05/18/17 / #20170138913

Sealing moving with piston in a high-pressure pump

A piston member for a high-pressure pump for pumping fluid in a sample separation apparatus, wherein the piston member comprises a piston configured for being mountable to reciprocate in a piston chamber for displacing fluid, and a sealing for sealing between the piston member and the piston chamber when the piston member is mounted in the piston chamber to reciprocate, wherein the sealing is mounted on the piston so as to reciprocate together with the piston.. . ... Agilent Technologies Inc

05/11/17 / #20170131245

Secondary stage fluid separation device connectable with primary stage fluid separation device

A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a fluidic coupling between a primary stage sample separation device and the secondary separation device, so that the fluidic sample separated by the primary stage sample separation device is fluidically suppliable to the secondary stage sample separation device via the fluidic interface for further separation, and a pressure reduction mechanism configured for reducing pressure at the fluidic interface at least in the event of an overpressure or of an excessive pressure increase.. . ... Agilent Technologies Inc

05/11/17 / #20170131244

Secondary stage fluid separation device detachably connectable with primary stage fluid separation device

A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a detachable fluidic coupling between a primary stage sample separation device and the secondary separation device so that the fluidic sample separated by the primary stage sample separation device is fluidically supplyable to the secondary stage sample separation device via the fluidic interface for further separation, wherein the secondary stage sample separation device is further configured for separating at least a portion of the supplied fluidic sample independent of a flow rate of the fluidic sample supplied from the primary stage sample separation device at the fluidic interface.. . ... Agilent Technologies Inc

05/11/17 / #20170130258

Multiplex on-array droplet pcr and quantitative pcr

This present disclosure provides methods and compositions for multiplex amplification, e.g., pcr, of dna samples compartmentalized on the surface of an array. In certain aspects, the method includes providing a solid substrate having features of immobilized forward and reverse primer pair constructs therein for amplifying a target polynucleotide sequence, contacting the plurality of features with a corresponding nucleic acid sample, and incubating the contacted features under conditions to allow release of the forward and reverse primer constructs and amplification of the desire target polynucleotide. ... Agilent Technologies Inc

04/20/17 / #20170108140

Fluidic valve with contactless force transmission for pressing together stator and rotor

A fluidic valve for switching between different fluid coupling states includes a stator having at least one fluidic stator interface, a rotor having at least one fluidic rotor interface, wherein the rotor is rotatable relative to the stator to thereby switch the fluidic valve between a plurality of different fluid coupling states between the at least one fluidic stator interface and the at least one fluidic rotor interface, and a force transmission mechanism configured for pressing the stator and the rotor together by a contactless force transmission to provide for a fluid tight sealing between the stator and the rotor.. . ... Agilent Technologies Inc

04/20/17 / #20170107560

Nucleic acid enrichment using cas9

A method of enriching for a fragment of a genome, as well as corresponding compositions and kits, are provided. In certain embodiments, the method comprises: (a) contacting a sample comprising fragmented dna with a cas9-grna complex comprising mutant cas9 protein that has inactivated nuclease activity and a cas9-associated guide rna that is complementary to a site in the dna, to produce a cas9-fragment complex that comprises a fragment of the fragmented dna; and (b) isolating the complex. ... Agilent Technologies Inc

04/13/17 / #20170105247

Conical heater assembly for a gas chromatography column

A heating apparatus for a gas chromatography column is described. The gc column heating apparatus includes a conical heater assembly comprising a heating element between an inner layer and an outer layer. ... Agilent Technologies Inc

04/13/17 / #20170100682

Apparatus and method for introducing a sample into a separation unit of a chromatography system

An apparatus introduces a sample into a separation unit of a chromatography system with a mobile phase, including first and second mobile phase components. The apparatus includes first and second pump systems, and an injection unit. ... Agilent Technologies Inc

04/06/17 / #20170096999

High pressure seal for a pump system for pumping liquid under high pressure

A system for pumping liquid under high pressure includes a housing and a high pressure seal. The housing houses a pump assembly and a chamber assembly that includes a chamber for containing high pressure liquid. ... Agilent Technologies Inc

03/30/17 / #20170090439

Interlock system

An implementation of an interlock system disclosed herein provides an interlock system for remotely tracking and controlling usage of a number of equipment. The interlock system disclosed herein includes an interlock module communicatively connected to the equipment and is configured to control the status and monitor usage of such equipment. ... Agilent Technologies Inc

03/30/17 / #20170089915

Methods of analyte derivatization and enhanced soft ionization

Methods of analyte derivatization and soft ionization are provided. The methods include contacting a sample including an analyte with a derivatization agent to produce a modified analyte including a pseudo-molecular analyte group and a leaving group connected via a fragmentable bond; and selectively breaking the fragmentable bond under soft ionization conditions to produce a predominant first fragmentation product including the pseudo-molecular analyte group and a second fragmentation product including the leaving group. ... Agilent Technologies Inc

03/23/17 / #20170085810

Apparatus and method for three-dimensional infrared imaging of surfaces

A scanner and method for using the same are disclosed. The scanner includes a stage, a mir light source, an imaging system, and a controller. ... Agilent Technologies Inc

03/23/17 / #20170082538

Infrared spectrometer and scanner utilizing attenuated total reflection

A scanner and an attenuated total reflection (atr) objective for use in such scanners are disclosed the atr objective includes first and second optical elements and an input port. The input port receives an input collimated light beam that is focused to a point on a planar face of the first optical element by the second optical element such that substantially all of that portion is reflected by the planar face and no portion of the input beam strikes the planar face at an angle greater than the critical angle. ... Agilent Technologies Inc

03/23/17 / #20170082490

High dynamic range infrared imaging spectroscopy

An imaging scanner and a method for using the same are disclosed. The scanner includes a variable attenuator adapted to receive a light beam generated by a mir laser and that generates an attenuated light beam therefrom characterized by an attenuation level. ... Agilent Technologies Inc

03/09/17 / #20170067103

Polymerase idling method for single molecule dna sequencing

A method for sequencing a nucleic acid is provided. In certain embodiments the method comprises obtaining a duplex comprising a nucleic acid and a primer, wherein the primer has a nuclease resistant 3′ end, combining the duplex with a chain terminator nucleotide and a proof-reading polymerase to produce a reaction in which the polymerase idles on the added chain terminator nucleotide, identifying the chain terminator nucleotide added to the end of the primer; and adding a nuclease-resistant nucleotide to the end of the primer after the polymerase has idled on and removed the added chain terminator nucleotide, thereby producing a duplex comprising the template and an extended primer that has a nuclease resistant 3′ end.. ... Agilent Technologies Inc

03/02/17 / #20170058326

Immobilized transposase complexes for dna fragmentation and tagging

The present invention provides a simple and rapid method for preparing purified transposase complexes that are highly suited for fragmenting dna. The method includes forming transposase complexes with oligonucleotide adapters in cell lysate, then purifying the complexes from the other substance in the cell lysate. ... Agilent Technologies Inc

03/02/17 / #20170058298

Compounds and methods for crispr/cas-based genome editing by homologous recombination

The present invention relates to guide rnas comprising adaptor segments having one or more modifications, and their use in homologous recombination by crispr:cas systems. The modified adaptor segments are resistant to degradation by rnaseh. ... Agilent Technologies Inc

02/16/17 / #20170045165

Fitting element with bio-compatible sealing

A fitting element is configured for coupling tubing to a fluidic device having a receiving cavity configured for receiving the fitting element, where the tubing has an inner contact surface of a biocompatible material, the inner contact surface being configured to contact a fluid to be conducted by the tubing, and the receiving cavity having a receiving contact surface of a bio-compatible material. The fitting element includes a first sealing element of a bio-compatible material configured for sealing to the bio-compatible material of the inner contact surface of the tubing, and a second sealing element configured for sealing against a pressure ambient to a pressure of the fluid in the tubing. ... Agilent Technologies Inc

02/16/17 / #20170044592

Method for fragmenting genomic dna using cas9

A method for fragmenting a genome is provided. In certain embodiments, the method comprises: (a) combining a genomic sample containing genomic dna with a plurality of cas9-grna complexes, wherein the cas9-grna complexes comprise a cas9 protein and a set of at least 10 cas9-associated guide rnas that are complementary to different, pre-defined, sites in a genome, to produce a reaction mixture; and (b) incubating the reaction mixture to produce at least 5 fragments of the genomic dna. ... Agilent Technologies Inc

02/02/17 / #20170033532

Quantum cascade laser with serially configured gain sections

An apparatus that includes a gain chip assembly, an external cavity, and a controller is disclosed. The gain chip assembly includes first and second gain chips that are coupled optically such that light travels serially between the first gain chip and the second gain chip, each gain chip is electrically biased. ... Agilent Technologies Inc

01/12/17 / #20170009766

Rigid piston-actuator-assembly supported for performing a pendulum-type tolerance compensation motion

A pump for pumping fluid, wherein the pump includes a working chamber, a piston assembly configured for reciprocating within the working chamber to thereby displace fluid, a piston actuator being rigidly assembled with the piston assembly at least in a working mode of the pump to thereby transmit drive energy to the piston assembly to reciprocate along a common rigid axis of the piston-actuator-assembly, and a bearing arrangement bearing the piston assembly and the piston actuator in the pump so that the piston-actuator-assembly provided by the piston assembly and the piston actuator is capable of performing a pendulum-type compensation motion around a pendulum point at the piston actuator on the common rigid axis.. . ... Agilent Technologies Inc

01/05/17 / #20170003256

Esd protected tubing for removing charge from lumen

An electrostatic discharge protected device for conducting a fluid through at least one lumen includes a tubing having a hollow interior defining the at least one lumen. The tubing includes an electrically conductive section configured for conducting electric charge, generated within the at least one lumen when the fluid flows through the at least one lumen, away from the at least one lumen.. ... Agilent Technologies Inc

01/05/17 / #20170003170

Light source with controllable linear polarization

A light source having first and second wire-grid polarizers and a laser that emits a beam of linearly polarized light that is characterized by a propagation direction is disclosed. The first wire-grid polarization filter is characterized by a first linear polarization pass direction and a first actuator for causing the first linear polarization pass direction to rotate relative to the beam of linearly polarized light. ... Agilent Technologies Inc

01/05/17 / #20170003166

Infrared imaging system with automatic referencing

A method and apparatus for obtaining reference samples during the generation of a mid-infrared (mw) image without requiring that the sample being imaged be removed is disclosed. A tunable mir laser generates a light beam that is focused onto a specimen on a specimen stage that moves the specimen in a first direction. ... Agilent Technologies Inc

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