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Aileron Therapeutics Inc patents


Recent patent applications related to Aileron Therapeutics Inc. Aileron Therapeutics Inc is listed as an Agent/Assignee. Note: Aileron Therapeutics Inc may have other listings under different names/spellings. We're not affiliated with Aileron Therapeutics Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Aileron Therapeutics Inc-related inventors


Peptidomimetic macrocycles

The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.. . ... Aileron Therapeutics Inc

Peptidomimetic macrocycles and uses thereof

Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disorders, for example, for treatment of infectious diseases.. . ... Aileron Therapeutics Inc

Companion diagnostic tool for peptidomimetic macrocycles

The present invention provides diagnostic tools, systems, and methods for detecting wild type p53 and p53-associated mutations for the treatment of disease with peptidomimetic macrocycles.. . ... Aileron Therapeutics Inc

Peptidomimetic macrocycles

Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. ... Aileron Therapeutics Inc

Peptidomimetic macrocycles

Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an α,α-disubstituted amino acid, or may comprise a crosslinker linking the α-positions of at least two amino acids or at least one of said two amino acids may be an α,α-disubstituted amino acid. ... Aileron Therapeutics Inc

Peptidomimetic macrocycles

The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.. . ... Aileron Therapeutics Inc

Peptidomimetic macrocycles with improved properties

The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.. ... Aileron Therapeutics Inc

Peptidomimetic macrocycles and uses thereof

Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease. Also provided here in are methods of using such macrocycles in combination with at least one additional pharmaceutically active agent for treatment of disorders, for example for treatment of cancer.. ... Aileron Therapeutics Inc

Peptidomimetic macrocycles as modulators of mcl-1

The disclosed peptidomimetic macrocycles modulate the activity of mcl-1. Myeloid cell leukemia 1 (mcl-1) is a protein that inhibits cell death. ... Aileron Therapeutics Inc

Disubstituted amino acids and methods of preparation and use thereof

Provided are crystalline α, α-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the α, α-disubstituted amino acids and their salts; methods of making these, and methods of using these.. . ... Aileron Therapeutics Inc

Peptidomimetic macrocycles

The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.. . ... Aileron Therapeutics Inc

Peptidomimetic macrocycles with pth activity

The present invention provides peptidomimetic macrocycles capable of modulating parathyroid hormone levels and methods of using such macrocycles for the treatment of disease.. . ... Aileron Therapeutics Inc

Peptidomimetic macrocycles

The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.. . ... Aileron Therapeutics Inc








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