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Allergan Inc patents (2018 archive)


Recent patent applications related to Allergan Inc. Allergan Inc is listed as an Agent/Assignee. Note: Allergan Inc may have other listings under different names/spellings. We're not affiliated with Allergan Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Allergan Inc-related inventors


Sustained release poloxamer containing pharmaceutical compositions

A thermo-reversible thermoplastic pharmaceutical composition, comprising a botulinum toxin and a biocompatible poloxamer which provides thermoreversibility to the composition and additionally stabilizes the botulinum toxin, is described. The pharmaceutical composition can be administered to a patient as a liquid, and gels after administration into a sustained release drug delivery system from which the biologically active botulinum toxin is released over a multi-day period thereby localizing the drug as a depot and controlling release to enhance the therapeutic effect per dose.. ... Allergan Inc

Prostamide-containing intraocular implants and methods of use thereof

Prostamide-containing intraocular implants that biodegrade in the eye and that are effective for reducing intraocular pressure in an eye for a sustained period. The implants generally contain a prostamide, such as bimatoprost, and at least three distinct biodegradable polymers selected from polylactide and poly(lactide-co-glycolide) polymers and are optimized for placement in and compatibility with the anterior chamber of the eye, particularly the anterior chamber angle. ... Allergan Inc

Needle array device

A needle injection array can comprise a plurality of needles that are fluidly interconnected via a fluid manifold. The fluid manifold can be configured to direct fluid from a syringe to arrive at tips of the needles approximately simultaneously. ... Allergan Inc

Artificial tears and therapeutic uses

The present invention provides ophthalmic compositions, e.g. Artificial tears, suitable for treating dry eye syndrome in a human or other mammal suffering there from, e.g. ... Allergan Inc

Stabilized oxymetazoline formulations and their uses

The present invention provides stabilized cream formulations of oxymetazoline and uses thereof. The present invention also provides a method of treating facial erythema associated with rosacea in a patient in need of such treatment, comprising topically administering once or twice daily to the site of erythema on the face of the patient a pharmaceutical composition comprising 0.5%, 1.0% or 1.5% oxymetazoline or a pharmaceutically acceptable salt thereof as the sole active ingredient.. ... Allergan Inc

Topical dapsone and dapsone/adaplene compositions and methods for use thereof

Dapsone and dapsone/adapalene compositions can be useful for treating a variety of dermatological conditions. The compositions of this disclosure include dapsone and/or adapalene in a polymeric viscosity builder. ... Allergan Inc

Microneedle array with active ingredient

Microneedle arrays for introducing an active ingredient through a skin surface of a subject can include a base layer, a plurality of microneedles projecting from the base layer, and an active ingredient. Each of the microneedles comprises an elongate body having a proximal portion and a distal portion, in which the proximal portion is attached to the base layer. ... Allergan Inc

Implants for sculpting, augmenting or correcting facial features such as the chin

An injectable device, comprising a hyaluronic acid-based composition, useful for long lasting facial sculpting and correction of facial features, for example, for augmenting and shaping the profile, including for example, the chin, jawline or the nose, in a human being is provided. Methods of treatment are also provided.. ... Allergan Inc

Dissolvable microneedles for skin treatment

A skin treatment device is provided including bioerodible polymeric microneedles which are designed to more effectively deliver beneficial agents to the skin. The device includes a flexible substrate and an arrangement, for example, an array, of microneedles projecting from the substrate.. ... Allergan Inc

Substance delivery device

A substance delivery device that includes a hypodermic needle with a tube for receiving and containing a volume of a substance. The substance delivery device includes a rod, a portion of which is of a size and shape to fit within the tube of the hypodermic needle. ... Allergan Inc

Compositions & methods for lowering intraocular pressure

Disclosed herein are compositions for lowering intraocular pressure (iop) of an eye comprising a combination iop-lowering agents bimatoprost, brimonidine, and timolol. Further disclosed are methods for reducing iop in the eye of a subject.. ... Allergan Inc

Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators

The present invention relates to novel amide derivatives of n-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the n-formyl peptide receptor like-1 (fprl-1) receptor.. . ... Allergan Inc

Non-irritating testosterone emulsions

Disclosed herein are emulsions comprising testosterone or related androgens, castor oil, cyclodextrin, pemulen tr-2, polyoxyl 40, and other ingredients. The compositions are useful for treating keratoconjunctivitis sicca and meibomian gland disease.. ... Allergan Inc

Dermal filler compositions including antioxidants

Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin c derivatives. The compositions provide for extended release of active vitamin c into tissue, promoting collagenesis and other benefits to skin.. ... Allergan Inc

07/26/18 / #20180207230

Autoclavable suspensions of cyclosporin a form 2

Disclosed herein are autoclavable formulations of cyclosporin a form 2, methods of making such formulations, and methods of treating diseases of the eye with such formulations.. . ... Allergan Inc

07/26/18 / #20180207174

Hypotensive lipid-containing biodegradable intraocular implants and related methods

Biocompatible intraocular implants include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. ... Allergan Inc

07/26/18 / #20180206967

Thread insertion devices

Devices and methods for inserting an implant into skin or other tissue of a patient can include an insertion device having moveable portions that can retain, move, or otherwise control engagement and injection of a hyaluronic thread. The device can include a tubular member and a handle. ... Allergan Inc

07/26/18 / #20180206966

Thread insertion devices

Devices and methods for inserting an implant into skin or other tissue of a patient can include an insertion device having moveable portions that can retain, move, or otherwise control engagement and injection of a hyaluronic thread. The device can include a tubular member and a handle. ... Allergan Inc

07/26/18 / #20180206965

Thread insertion devices

Devices and methods for inserting an implant into skin or other tissue of a patient can include a hyaluronic thread that is coupled at along distal portion with an insertion device. The insertion device can include a cover member and a piston that can collectively facilitate engagement with or disengagement of the distal portion of the thread with the device. ... Allergan Inc

07/26/18 / #20180206964

Thread insertion devices

Devices and methods for inserting an implant into skin or other tissue of a patient can include a hyaluronic thread coupled with an insertion device that can provide a supportive enclosure for the thread as it is injected into a patient's skin or other tissue. The device can include a cover member, a base, and a thread. ... Allergan Inc

07/26/18 / #20180206963

Thread insertion devices

Devices and methods for inserting an implant into skin or other tissue of a patient can include an insertion device that can enclose and support a hyaluronic thread as it is injected into a patient's skin or other tissue. The device can include a cover member, a non-tubular support member, and the thread. ... Allergan Inc

07/19/18 / #20180200045

Soft filled prosthesis shell with discrete fixation surfaces

A soft prosthetic implant shell, such as a silicone breast implant shell, that has discrete fixation surfaces thereon for tissue adhesion. The fixation surfaces may be provided on the posterior face of the shell, as well as either on the periphery or at discrete areas on the anterior face. ... Allergan Inc

07/12/18 / #20180193523

Dermal filler compositions for fine line treatment

The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.. . ... Allergan Inc

07/05/18 / #20180185460

Method for treating premature ejaculation with a botulinum neurotoxin

Methods for prolongation of climax time in a patient in need thereof are presented, as are methods for treating premature ejaculation by local administration of a clostridial neurotoxin, such as botulinum neurotoxin, to the patient, are provided.. . ... Allergan Inc

07/05/18 / #20180185385

Preservative free bimatoprost and timolol solutions

The present invention is directed to preservative-free solutions of bimatoprost and timolol for lowering intraocular pressure and treatment of glaucoma.. . ... Allergan Inc

06/28/18 / #20180177718

Implant for treatment of an ocular condition

. . The present disclosure relates to the field of pharmaceutical compositions, ocular implants, and systems and methods for treating an ocular condition. In certain aspects, the disclosure provides ocular implant systems for treating post-operative inflammation. ... Allergan Inc

06/21/18 / #20180170858

Novel ep4 agonists as therapeutic compounds

Described herein are compounds that are ep4 agonists and antagonists which are useful for treating a variety of pathological conditions associated with activity of ep4 receptors.. . ... Allergan Inc

06/21/18 / #20180169086

Compositions containing aromatic aldehydes and their use in treatments

Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. ... Allergan Inc

06/14/18 / #20180161342

Prostamide-containing intraocular implant

Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.. . ... Allergan Inc

06/07/18 / #20180153903

Oil-in-water method for making polymeric implants containing a hypotensive lipid

Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. ... Allergan Inc

05/31/18 / #20180147307

Methods for sterilizing compositions and resulting compositions

Method for sterilizing a hydrogel composition include subjecting the composition to pulsed light comprising broadband spectrum radiation, the pulsed light being at a dose effective to sterilize the composition without causing significant change in rheology of the composition.. . ... Allergan Inc

05/31/18 / #20180147217

Pharmaceutical compositions and methods of use of 4-pregenen-11beta-17-21-triol-3,20-dione derivatives

The present invention relates to pharmaceutical compositions comprising 4-pregenen-11β-17-21-triol-3,20-dione derivatives, and their use as pharmaceuticals as modulators of the glucocorticoid receptors (gr) and/or the mineralocorticoid receptors (mr). The invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat ocular conditions associated with the glucocorticoid receptors (gr) and/or the mineralocorticoid receptors (mr).. ... Allergan Inc

05/17/18 / #20180133401

Adipose tissue combinations, devices, and uses therof

Described are devices, systems, and methods for processing adipose tissue for reintroduction into a body. In some embodiments, adipose tissue is mixed with an additive prior to reintroduction.. ... Allergan Inc

05/10/18 / #20180125951

Methods for alleviating histamine-independent pruritus using neurotoxins

Methods for treating, reducing the occurrence or preventing a histamine-independent pruritic itch using a clostridial toxin derivative are provided herein. In some aspects, the clostridial toxin derivative reduces the itch intensity or duration without affecting thermal or pain sensitivity.. ... Allergan Inc

05/10/18 / #20180125861

Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues

Ophthalmically therapeutic materials, such as liquid-containing compositions and polymeric drug delivery systems, include a therapeutic component that includes an glucocorticoid derivative which, upon delivery to the posterior segment of a mammalian eye, does not significantly diffuse to the anterior segment of said eye. Methods of making and using the present materials are also described.. ... Allergan Inc

05/03/18 / #20180119126

Degradable clostridial toxins

The specification discloses clostridial toxins or clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.. . ... Allergan Inc

04/19/18 / #20180105515

Pyridyl benzothiophenes as kinase inhibitors

This invention is directed to compounds, which are useful as protein kinase (pk) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders, metabolic diseases inflammatory disorders and neurodegenerative disorders.. . ... Allergan Inc

04/05/18 / #20180094031

Cyclosporin derivatives wherein the mebmt sidechain has been cyclized

The present invention relates to cyclosporin analogs that are potent inhibitors of cyclophilin d and have low immunosuppressive activity; processes for preparing them; pharmaceutical compositions containing them; and methods for using these analogs and compositions containing them for the treatment of medical conditions, including but not limited to ischemic conditions, such as ischemia-reperfusion (i/r) injury, including myocardial fr injury, cerebral i/r injury, and ocular or retinal i/r injury.. . ... Allergan Inc

04/05/18 / #20180092726

Dual plane breast implant

A soft breast prosthesis is provided, the prosthesis having a surface configuration advantageous for dual plane placement of the prosthesis in a breast.. . ... Allergan Inc

03/29/18 / #20180086774

Compounds as tyrosine kinase modulators

The present invention is directed to novel compounds of formula i. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors.. ... Allergan Inc

03/22/18 / #20180078674

Heat stable hyaluronic acid compositions for dermatological use

The disclosure provides hyaluronic acid (ha) gel formulations and methods for treating the appearance of the skin. The formulations contain hyaluronic acid and at least one additional ingredient. ... Allergan Inc

03/22/18 / #20180078622

Suture line administration technique using botulinum toxins

The present invention utilizes patient-specific landmarks in order to treat headache pain. In one aspect, the present invention relates to the administration of clostridial toxins, such as a botulinum neurotoxin, to a patient suffering from a headache pain, where the location of administration of the botulinum toxin is based upon at least one suture line of the patient's skull.. ... Allergan Inc

03/22/18 / #20180078606

Methods of providing therapeutic effects using cyclosporin components

Methods of treating an eye of a human or animal include administering to an eye of a human or animal a composition in the form of an emulsion including water, a hydrophobic component and a cyclosporin component in a therapeutically effective amount of less than 0.1% by weight of the composition. The weight ratio of the cyclosporin component to the hydrophobic component is less than 0.8.. ... Allergan Inc

03/22/18 / #20180078500

Fixed dose combination of brimonidine and timolol

Embodiments disclosed herein are directed to fixed compositions comprising brimonidine and timolol for lowering intraocular pressure and treating glaucoma.. . ... Allergan Inc

03/15/18 / #20180071361

Non-protein clostridial toxin compositions

Pharmaceutical compositions that stabilize a clostridial toxin active ingredient are described. The compositions can be liquid or solid compositions, and comprise a surfactant and an antioxidant. ... Allergan Inc

03/15/18 / #20180071308

Methods for fat reduction

Disclosed herein are methods, compounds, and compositions for fat reduction, and in particular fat reduction without significant hair growth and/or additional hair growth.. . ... Allergan Inc

03/15/18 / #20180071260

Methods of treating alpha adrenergic mediated conditions

Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, acute, neuropathic and chronic.. ... Allergan Inc

03/15/18 / #20180071259

Method of activating regulatory t cells with alpha-2b adrenergic receptor agonists

Disclosed herein is a method of upregulating regulatory t-cells, and treating diseases that would benefit from such upregulation, by administering an alpha-2 receptor agonist.. . ... Allergan Inc

03/08/18 / #20180064721

Combination of brimonidine and timolol for topical ophthalmic use

Disclosed are pharmaceutical compositions comprising brimonidine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans.. . ... Allergan Inc

03/08/18 / #20180064720

Combination of brimonidine and timolol for topical ophthalmic use

Disclosed are pharmaceutical compositions comprising brimonidine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans.. . ... Allergan Inc

03/01/18 / #20180057576

Complement factor bb antibodies

The present disclosure relates to antibodies and polynucleotides encoding the same, which may be used to prevent, control, or reduce the activity of the complement pathway. In addition, the disclosure is directed to compositions and methods for diagnosing and treating diseases mediated by or involving complement factor bb. ... Allergan Inc

03/01/18 / #20180056261

Method of manufacturing coated beads

The present specification discloses methods of making porogen compositions, methods of making polymer-coated beads, and methods of making implantable devices that use polymer-coated beads.. . ... Allergan Inc

03/01/18 / #20180055971

Co-crosslinked hyaluronic acid-silk fibroin hydrogels for improving tissue graft viability and for soft tissue augmentation

Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a silk fibroin component.. ... Allergan Inc

02/15/18 / #20180043032

Stabilization of therapeutic agents to facilitate administration

The present invention provides for a carrier complex for administration of therapeutic agents. In one aspect, an isolated c. ... Allergan Inc

02/15/18 / #20180042932

Combination of brimonidine and timolol for topical ophthalmic use

Disclosed are pharmaceutical compositions comprising brimonidine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans.. . ... Allergan Inc

02/08/18 / #20180036252

Pharmaceutical soft gelatin capsule dosage form with modified guar gum

. . A pharmaceutical soft gelatin capsule dosage form that includes (a) a shell that includes gelatin; and (b) a fill that includes at least one active ingredient, one or more polyethylene glycol, and a modified guar gum. The pharmaceutical soft gelatin capsule dosage form maintains its shell integrity (hardness) and fill viscosity after storage.. ... Allergan Inc

02/08/18 / #20180036233

Self-emulsifying drug delivery (sedds) for ophthalmic drug delivery

Provided herein are topical ophthalmic preparations which comprise a non-aqueous, self-emulsifying system which can spontaneously give rise to either nanosized emulsions upon contact with an aqueous phase. Also provided herein are methods for the preparation of the same and their use in formulating and delivering poorly water soluble drugs.. ... Allergan Inc

02/01/18 / #20180029994

Process for the preparation of intermediates useful in the synthesis of eluxadoline

The invention relates to an improved process for preparing [(s)-1-(4-phenyl-1-h-imidazol-2-yl)-ethyl]-amine. The process involves formation of the novel intermediate crystalline compound [(s)-1-(4-phenyl-1-h-imidazol-2-yl)-ethyl]-carbamic acid tert-butyl ester oxalate.. ... Allergan Inc

02/01/18 / #20180028719

Hyaluronic acid-collagen matrices for dermal filling and volumizing applications

Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.. ... Allergan Inc

02/01/18 / #20180028624

Injection paradigm for administration of botulinum toxins

Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.. ... Allergan Inc

01/25/18 / #20180021352

Implants and methods for treating inflammation-mediated conditions of the eye

Methods for treating inflammation-mediated conditions of the eye are described, comprising: implanting into the vitreous of the eye of an individual a bioerodible implant comprising a steroidal anti-inflammatory agent and a bioerodihle polymer, wherein the implant delivers the agent to the vitreous in an amount sufficient to reach a concentration equivalent to at least about 0.05 μg/ml dexamethasone within about 48 hours and maintains a concentration equivalent to at least about 0.03 μg/ml dexamethasone for at least about three weeks.. . ... Allergan Inc

01/25/18 / #20180021348

Hypotensive lipid-containing biodegradable intraocular implants and related implants

Biocompatible intraocular implants include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. ... Allergan Inc

01/25/18 / #20180021282

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.. . ... Allergan Inc

01/25/18 / #20180021254

Compositions containing alpha-2-adrenergic agonist components

Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. ... Allergan Inc

01/04/18 / #20180000992

Hyaluronic acid-based gels including lidocaine

Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. ... Allergan Inc

01/04/18 / #20180000909

Treatment of psychological trauma

The present specification discloses methods of treating a psychological trauma in an individual using botulinum toxins and/or a targeted exocytosis modulator, and compositions thereof.. . ... Allergan Inc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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