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Applied Biosystems Llc patents


Recent patent applications related to Applied Biosystems Llc. Applied Biosystems Llc is listed as an Agent/Assignee. Note: Applied Biosystems Llc may have other listings under different names/spellings. We're not affiliated with Applied Biosystems Llc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Applied Biosystems Llc-related inventors


Method and system for genotyping samples in a normalized allelic space

Aspects of the present invention describe an apparatus and method for generating genotype calls for a sample. The genotyping initially models allelic signal response into an allelic model having one or more model parameters for an identified one or more sources of systematic variation. ... Applied Biosystems Llc

Methods and compositions for sorting and/or determining organisms

This invention is directed to methods and compositions for sorting and/or determining microscopic organisms or cells. The methods and compositions are directed to the use of molecular probes to selectively stain the organisms or cells in combination with the use of binding partners to selectively immobilize the stained organisms or cells to a solid carrier. ... Applied Biosystems Llc

Methods for producing a paired tag from a nucleic acid sequence and methods of use thereof

Methods for producing a paired tag from a nucleic acid sequence are provided in which the paired tag comprises the 5′ end tag and 3′ end tag of the nucleic acid sequence. In one embodiment, the nucleic acid sequence comprises two restriction endonuclease recognition sites specific for a restriction endonuclease that cleaves the nucleic acid sequence distally to the restriction endonuclease recognition sites. ... Applied Biosystems Llc

Multiplex amplification of polynucleotides

The present invention provides methods, reagents and kits for carrying out a variety of assays suitable for analyzing polynucleotides or samples that include an amplification step performed in a multiplex fashion. Also provided are methods for analyzing and improving the efficiency of amplification and for carrying out gene expression analysis.. ... Applied Biosystems Llc

Electrowetting dispensing devices and related methods

A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. ... Applied Biosystems Llc

Method and system for multiplex genetic analysis

The present disclosure provides apparatus, systems and method for detecting separately and substantially simultaneously light emissions from a plurality of localized light-emitting analytes. A system according to exemplary embodiments of the present disclosure comprises a sample holder having structures formed thereon for spatially separating and constraining a plurality of light-emitting analytes each having a single nucleic acid molecule or a single nucleic acid polymerizing enzyme, a light source configured to illuminate the sample holder, an optical assembly configured to collect and detect separately and substantially simultaneously light emissions associated with the plurality of light emitting analytes. ... Applied Biosystems Llc

Calibrating the positions of a rotating and translating two-dimensional scanner

Systems and methods are provided that comprise calibration techniques and associated systems that identify the two-dimensional position, or other alignment or positioning, of sample wells or other calibration objects located in a sample well plate, or other surface or area of interest. In some embodiments, calibration of the plate and/or positioning and/or alignment with respect to detection optics can be performed in multiple stages for two or more dimensions.. ... Applied Biosystems Llc

Sirna sequence-independent modification formats for reducing off-target phenotypic effects in rnai, and stabilized forms thereof

Modification formats having modified nucleotides are provided for sirna. Short interfering rna having modification formats and modified nucleotides provided herein reduce off-target effects in rna interference of endogenous genes. ... Applied Biosystems Llc

Reagents useful for synthesizing rhodamine-labeled oligonucleotides

The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.. . ... Applied Biosystems Llc

Systems and methods for multiple analyte detection

Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. ... Applied Biosystems Llc

Pna probes, probe sets, methods and kits pertaining to the detection of candida

This invention is related to novel pna probes, probe sets, methods and kits pertaining to the detection of one or more species of candida yeast. Non-limiting examples of probing nucleobase sequences that can be used for the probes of this invention can be selected from the group consisting of: aga-gag-cag-cat-gca (seq. ... Applied Biosystems Llc

Poly and copoly(n-vinylamide)s and their use in capillary electrophoresis

The invention relates generally to polymers and copolymers comprising n-vinylamide-type monomers, their preparation, and compositions, such as electrophoresis separation media, containing the same; to supports, such as capillaries, containing these polymers; and methods for separating a mixture of biomolecules, especially polynucleotides, using capillary electrophoresis. Separation media comprising such polymers yield advantageous performance in the analysis and separation of biomolecules by capillary electrophoresis.. ... Applied Biosystems Llc

Methods, compositions, and kits comprising linker probes for quantifying polynucleotides

The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. ... Applied Biosystems Llc

Signal noise reduction for imaging in biological analysis

A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods of the present teachings and used for signal correction by systems of the present teachings.. ... Applied Biosystems Llc

09/28/17 / #20170275678

Methods of detecting target nucleic acids

The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. ... Applied Biosystems Llc

09/21/17 / #20170269031

High speed, high resolution compositions, methods and kits for capillary electrophoresis

The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. ... Applied Biosystems Llc

09/21/17 / #20170268051

Methods for placing, accepting, and filling orders for products and services

Methods and systems for ordering assays which detect snps or gene expression are provided. The methods use pcr and rt-pcr procedures. ... Applied Biosystems Llc

08/10/17 / #20170226580

Method of making a paired tag library for nucleic acid sequencing

The present disclosure relates to methods and compositions for making paired tags and paired tag libraries.. . ... Applied Biosystems Llc

08/10/17 / #20170225162

Multi-material microplate and method

A microplate assembly for performing an analytical method on an assay, comprising a microplate base structure having a plurality of apertures formed therethrough, and a plurality of well inserts coupled to the microplate base structure adjacent the apertures. Each of the plurality of well inserts has an open top portion and is adapted to receive an assay. ... Applied Biosystems Llc

08/03/17 / #20170218359

Crude biological derivatives competent for nucleic acid detection

The invention relates to methods for the detection of a specific sequence of rna in a cell or tissue sample. The invention also relates to methods to enzymatically manipulate the rna in a crude cell lysate in a number of applications.. ... Applied Biosystems Llc

07/20/17 / #20170204385

Thermus scotoductus nucleic acid polymerases

The invention provides nucleic acids and polypeptides for a nucleic acid polymerase from a thermophilic organism, thermus scotoductus. The invention also provides methods for using these nucleic acids and polypeptides.. ... Applied Biosystems Llc

06/22/17 / #20170175185

Nanowire-based system for analysis of nucleic acids

A method for sequencing a nucleic acid template includes forming a nanowire assembly including a semiconductor nanowire and a probe covalently bound to the semiconductor nanowire; contacting the nanowire assembly with a template nucleic acid; contacting the nucleic acid duplexes with an extension nucleic acid, the extension nucleic acid joined to the probe; disrupting the nucleic acid duplexes; and measuring an electrical characteristic of a nanowire assembly of the set of nanowire assemblies.. . ... Applied Biosystems Llc

06/22/17 / #20170175093

Thermus brockianus nucleic acid polymerases

The invention provides nucleic acids and polypeptides for nucleic acid polymerases from a thermophilic organism, thermus brockianus. The invention also provides methods for using these nucleic acids and polypeptides.. ... Applied Biosystems Llc

06/01/17 / #20170153229

Reagents, kits and methods, for detecting biological molecules by energy transfer from an activated chemiluminescent substrate to an energy acceptor dye

Reagents, kits and methods for detecting biological molecules by energy transfer from an activated chemiluminescent substrate to an energy acceptor dye such as a j-aggregated dye are described.. . ... Applied Biosystems Llc

06/01/17 / #20170153203

Sequencing system with memory

The present teachings provide a device including a memory. According to various embodiments, the memory is readable, writable, and rewritable. ... Applied Biosystems Llc

05/11/17 / #20170130259

Methods for multiplexing amplification reactions

A two-step multiplex amplification reaction includes a first step which truncates the standard initial multiplex amplification round to “boost” the sample copy number by only a 100-1000 fold increase in the target. Following the first step the product is divided into optimized secondary single amplification reactions, each containing one of the primer sets that were used previously in the first or multiplexed booster step. ... Applied Biosystems Llc

03/30/17 / #20170087556

Cooling in a thermal cycler using heat pipes

A device for amplifying a nucleic acid sample may include a sample holder configured to receive a nucleic acid sample, a heating system configured to raise the temperature of the sample, a cooling system configured to lower the temperature of the sample, and a controller configured to operably control the heating system and the cooling system to cycle the device through a desired time-temperature profile. The cooling system may include at least one heat pipe and a heat sink and the at least one heat pipe may include a first portion disposed proximate to the sample holder and a second portion disposed proximate to the heat sink.. ... Applied Biosystems Llc

03/30/17 / #20170087555

Methods and systems for using rfid in biological field

Biological reagent carrier devices and methods are disclosed, which employ rfid techniques to associate information with biological reagents.. . ... Applied Biosystems Llc

03/23/17 / #20170081717

Reagents, methods, and libraries for bead-based sequencing

The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. ... Applied Biosystems Llc

03/16/17 / #20170076231

Information system for biological and life sciences research

An online life science research environment and virtual community with a focus on design and analysis of biological experiments includes a life sciences laboratory system employing at least one networked computer system that defines a virtual research environment. Users access the system through a portal associated with the networked computer system(s). ... Applied Biosystems Llc








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