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Augusta University Research Institute Inc patents


Recent patent applications related to Augusta University Research Institute Inc. Augusta University Research Institute Inc is listed as an Agent/Assignee. Note: Augusta University Research Institute Inc may have other listings under different names/spellings. We're not affiliated with Augusta University Research Institute Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Augusta University Research Institute Inc-related inventors


Compositions for modulating pd-1 signal transduction

Several compounds have been discovered that modulate signal transduction through the pd-1 receptor. In certain embodiments, the compounds promote or induce an activating signal through the pd-1 receptor that activates a t cell. ... Augusta University Research Institute Inc

Method and compositions for enhancing immunotherapeutic treatment of a cancer

Provided are methods and compositions for enhancing treatment of a cancer by administering a therapeutic agent for the treatment of a cancer together with a second agent that elevates the level of protein p53. The second agent generates in the tumor a population of dendritic cells expressing at least one of batf3, irf5, cd103, and xcr1. ... Augusta University Research Institute Inc

Combination of listeria-based vaccine with anti-ox40 or anti-gitr antibodies

Disclosed herein are compositions comprising use of compositions comprising a live attenuated recombinant listeria strain comprising a fusion protein of a truncated listeriolysin o (llo) protein, a truncated acta protein, or a pest amino acid sequence fused to a heterologous antigen, including a tumor-associated antigen, wherein the compositions further comprise or are co-administered with an antibody or fragment thereof. Also disclosed are combination therapies comprising use of these compositions comprising live attenuated recombinant listeria strains, in conjunction with an antibody or fragment thereof for use in treating, protecting against, and/or inducing an immune response against a tumor, especially wherein the treating, protection against and/or inducing an immune response increases percent survival in a subject.. ... Augusta University Research Institute Inc

Methods of treating sickle cell disease and related disorders using fumaric acid esters

Methods of using one or more fumaric acid esters or pharmacologically active salts, derivatives, analogues, or prodrugs thereof to increase expression of fetal hemoglobin (hbf) are disclosed. The methods typically include administering to a subject an effective amount of one or more fumaric acid esters optionally in combination or alternation with hydroxyurea to induce hbf expression in the subject in an effective amount to reduce one or more symptoms of a sickle cell disorder, a hemoglobinopathy, or a beta-thalassemia, or so compensate for a genetic mutation is the human beta-globin gene (hbb) or an expression control sequence thereof. ... Augusta University Research Institute Inc

Protein-coupled red blood cell compositions and methods of their use

Methods and compositions for using n-hydroxysuccinimide and n-hydroxysulfosuccinimide to covalently couple protein(s) to the surface of red blood cells universally, rapidly and conveniently are provided. In one embodiment, the compositions promote immune tolerance in a subject. ... Augusta University Research Institute Inc

Ceramide analogs

Ceramide analogs and methods of their use are provided.. . ... Augusta University Research Institute Inc

Methods and compositions for treating ovarian failure

Methods and compositions for treating ovarian failure are provided. In one embodiment, the method includes administering stem cells into the ovary of a female subject in need of such treatment. ... Augusta University Research Institute Inc

Methods and compositions for enhancing t cell function and survival

It has been discovered that the inhibition of pi3k-δ, but not pi3k-α or pi3k-β, delays the terminal differentiation of cd8 t cell and maintains the tcm phenotype thus enhancing their proliferative ability and survival while maintaining their cytokine and granzyme b production ability. Methods and compositions for delaying or inhibiting terminal differentiation of cd8 t cells are provided.. ... Augusta University Research Institute Inc

Methods and compositions for inhibiting akt3

Compounds and compositions for selectively inhibiting akt3 are provided. Methods of using the compounds are also provided. ... Augusta University Research Institute Inc

Materials and methods of treating dyslipidemia

Described herein are materials and methods for treating dyslipidemia in a mammalian subject in need thereof comprising administering a growth hormone-releasing hormone (ghrh) antagonist or variant thereof to the subject.. . ... Augusta University Research Institute Inc

Specific akt3 inhibitor and uses thereof cross-reference to related applications

Methods of selectively inhibiting akt3 are provided. It has been discovered that 4-[(6-nitroquinolin-4-yl)amino]-n-[4-(pyridin-4-ylamino)phenyl]benzamide selectively inhibits akt3. ... Augusta University Research Institute Inc

Methods for enhancing the efficacy of a tumor-directed immune response

As described below, the present invention features methods for enhancing the efficacy of a tumor antigen in inducing an anti-cancer immune response in a subject by administering an ox40 agonist and an indoleamine 2,3-dioxygenase (ido) inhibitor with the tumor antigen.. . ... Augusta University Research Institute Inc

Compositions and methods for the detection or treatment of uterine leiomyosarcoma

Compositions and methods for the detection and treatment of cancer are provided. It has been discovered that uterine cancer cells selectively induce the survivin promoter to express a gene product. ... Augusta University Research Institute Inc

Flavonoid compositions for the treatment of cancer

Compositions containing luteolin, quercetin, and kaempferol are provided. The compositions are useful killing cancer cells and treating cancer. ... Augusta University Research Institute Inc

02/23/17 / #20170049422

Cell collection devices

In some embodiments, a cell collection device includes a sample brush including a proximal end, a distal end, and outwardly extending bristles provided at the distal end, and an outer sleeve adapted to receive the sample brush, the sleeve including a proximal end and a distal end, wherein the sleeve can be linearly slid along the length of the brush to encapsulate the bristles after they have been used to collect cells from a patient.. . ... Augusta University Research Institute Inc

02/02/17 / #20170029782

Devices and methods for separating particles

Devices for non-invasive, label-free separation of particles in liquid, including circulating tumors cells in blood, are provided. Embodiments of the disclosure provide for devices employing magnetic fluids and magnets for separation of circulating tumor cells from blood. ... Augusta University Research Institute Inc








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