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Berkeley Lights Inc patents


Recent patent applications related to Berkeley Lights Inc. Berkeley Lights Inc is listed as an Agent/Assignee. Note: Berkeley Lights Inc may have other listings under different names/spellings. We're not affiliated with Berkeley Lights Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "B" | Berkeley Lights Inc-related inventors


Micro-fluidic devices for assaying biological activity

Biological activity in holding pens in a micro-fluidic device can be assayed by placing in the holding pens capture objects that bind a particular material of interest produced by the biological activity. The biological material of interest that binds to each capture object can then be assessed, either in the micro-fluidic device or after exporting the capture object from the micro-fluidic device. ... Berkeley Lights Inc

Lateral/vertical transistor structures and process of making and using same

A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium. The base can include an array of individually controllable transistor structures each of which can comprise both a lateral transistor and a vertical transistor. ... Berkeley Lights Inc

Methods, systems and devices for selection and generation of genome edited clones

Methods are described herein for isolating clonal populations of cells having a defined genetic modification. The methods are performed, at least in part, in a microfluidic device comprising one or more sequestration pens. ... Berkeley Lights Inc

Selection and cloning of t lymphocytes in a microfluidic device

Methods of expanding t lymphocytes in a microfluidic device are provided. The methods can include introducing one or more t lymphocytes into a microfluidic device; contacting the one or more t lymphocytes with an activating agent; and perfusing culture medium through the microfluidic device for a period of time sufficient to allow the one or more t lymphocytes to undergo at least one round of mitotic cell division. ... Berkeley Lights Inc

Providing dep manipulation devices and controllable electrowetting devices in the same microfluidic apparatus

A structure for providing a boundary for a chamber in a microfluidic apparatus can comprise dielectrophoresis (dep) configurations each having an outer surface and electrowetting (ew) configurations each having an electrowetting surface. The dep configurations can facilitate generating net dep forces with respect to the outer surfaces of the dep configurations to move micro-objects on the outer surfaces, and the ew configurations can facilitate changing wetting properties of the electrowetting surfaces to move droplets of liquid medium on the electrowetting surfaces.. ... Berkeley Lights Inc

Movement and selection of micro-objects in a microfluidic apparatus

A microfluidic apparatus is provided having one or more sequestration pens configured to isolate one or more target micro-objects by changing the orientation of the microfluidic apparatus with respect to a globally active force, such as gravity. Methods of selectively directing the movements of micro-objects in such a microfluidic apparatus using gravitational forces are also provided. ... Berkeley Lights Inc

Single-sided light-actuated microfluidic device with integrated mesh ground

Single-sided optoelectrowetting (ssoew)-configured substrates are provided, as well as microfluidic devices that include such substrates. The substrates can include a planar electrode, a photoconductive (or photosensitive) layer, a dielectric layer (single-layer or composite), a mesh electrode, and a hydrophobic coating. ... Berkeley Lights Inc

Exporting a selected group of micro-objects from a micro-fluidic device

A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device. The micro-fluidic device can have a plurality of holding pens, and each holding pen can isolate micro-objects located in the holding pen from micro-objects located in the other holding pens or elsewhere in the micro-fluidic device. ... Berkeley Lights Inc

Light sequencing and patterns for dielectrophoretic transport

Optically-actuated microfluidic devices permit the use of spatially-modulated light to manipulate micro-objects such as biological cells. Systems and methods are described for providing sequences of light patterns to move and direct a plurality of micro-objects within the environment of a microfluidic device. ... Berkeley Lights Inc

Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor

A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one b cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated b cell; and (d) using the microfluidic device to identify at least one b cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. ... Berkeley Lights Inc

Tumor infiltrating cells engineered to express a pro-inflammatory polypeptide

The present disclosure provides methods of preparing tumor infiltrating cells engineered to express a pro-inflammatory polypeptide. The pro-inflammatory polypeptide is expressed from the tumor infiltrating cell to counter a generally immunosuppressive state in and around tumors resulting from an imbalance between the number and activation state of immune effector cells versus those of suppressor cells. ... Berkeley Lights Inc

In situ-generated microfluidic assay structures, related kits, and methods of use thereof

In situ-generated microfluidic capture structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described. Microfluidic capture structures may be advantageously used for assays performed within the microfluidic environment, providing flexibility in assaying micro-objects such as biological cells. ... Berkeley Lights Inc

Microfluidic apparatus having an optimized electrowetting surface and related systems and methods

Microfluidic devices having an electrowetting configuration and an optimized droplet actuation surface are provided. The devices include a conductive substrate having a dielectric layer, a hydrophobic layer covalently bonded to the dielectric layer, and a first electrode electrically coupled to the dielectric layer and configured to be connected to a voltage source. ... Berkeley Lights Inc

In situ-generated microfluidic isolation structures, kits and methods of use thereof

In situ-generated microfluidic isolation structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described. The ability to introduce in real time, a variety of isolating structures including pens and barriers offers improved methods of micro-object manipulation in microfluidic devices. ... Berkeley Lights Inc

04/27/17 / #20170114316

Well plate incubator

Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed. The enclosure includes a plurality of openings configured to allow access to the wells. ... Berkeley Lights Inc

02/16/17 / #20170043343

Dep force control and electrowetting control in different sections of the same microfluidic apparatus

A microfluidic apparatus can comprise a dielectrophoresis (dep) configured section for holding a first liquid medium and selectively inducing net dep forces in the first liquid medium. The microfluidic apparatus can also comprise an electrowetting (ew) configured section for holding a second liquid medium on an electrowetting surface and selectively changing an effective wetting property of the electrowetting surface. ... Berkeley Lights Inc

01/26/17 / #20170021366

Capturing specific nucleic acid materials from individual biological cells in a micro-fluidic device

Individual biological cells can be selected in a micro-fluidic device and moved into isolation pens in the device. The cells can then be lysed in the pens, releasing nucleic acid material, which can be captured by one or more capture objects in the pens. ... Berkeley Lights Inc








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