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Beth Israel Deaconess Medical Center patents


Recent patent applications related to Beth Israel Deaconess Medical Center. Beth Israel Deaconess Medical Center is listed as an Agent/Assignee. Note: Beth Israel Deaconess Medical Center may have other listings under different names/spellings. We're not affiliated with Beth Israel Deaconess Medical Center, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "B" | Beth Israel Deaconess Medical Center-related inventors


Methods for inducing protective immunity against human immunodeficiency virus infection

Compositions, vaccines and methods for inducing protective immunity against human immunodeficiency virus (hiv) infection are described. Heterologous vaccine combinations of one or more viral expression vectors and an isolated antigenic polypeptide induced strong protective immunity against infections by one or multiple clades of hiv.. ... Beth Israel Deaconess Medical Center

Methods for enhancing an immune response

Methods and compositions for enhancing an immune response in a subject (e.g., an immunocompromised subject or a subject with systemic lupus erythematosus (sle)) are described. In particular, methods of administering to the subject an effective amount of an anti-signaling lymphocytic activation molecule family member 7 (slamf7)-antibody or antigen binding fragment thereof are described.. ... Beth Israel Deaconess Medical Center

Compounds that target myc microrna responsive elements for the treatment of myc-associated cancer

Novel mir-330 agents and their methods of use are provided. Methods of treating myc-associated cancers are provided.. ... Beth Israel Deaconess Medical Center

Stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using same

The invention features stabilized human immunodeficiency virus (hiv) envelope (env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized hiv env trimers. ... Beth Israel Deaconess Medical Center

Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders

This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. ... Beth Israel Deaconess Medical Center

Methods and compositions for treating celiac disease

The invention features the treatment of gastrointestinal disorders associated with an innate immune response triggered by alpha amylase inhibitor cm3, alpha amylase inhibitor 0.19 (0.19), cm1, cm2, cma, cmd, cm 16, cmb, cmx1/cmx3, cmx2, and/or alpha amylase inhibitor 0.53 (0.53). To this end, the invention features pharmaceutical compositions including neutralizing antibodies to cm3, 0.19, cm1, cm2, cma, cmd, cm16, cmb, cmx1/cmx3, cmx2, and/or 0.53, food products containing reduced levels of cm3, 0.19, cm1, cm2, cma, cmd, cm1 6, cmb, cmx1/cmx3, cmx2, and/or 0.53 protein, the use of oral tlr4 inhibitors to block the effect of said alpha-amylase inhibitors, assays for identifying cm3, 0.19, cm1, cm2, cma, cmd, cm16, cmb, cmx1/cmx3, cmx2, and/or 0.53 content in food products, and assays for diagnosing subjects with a disorder related to cm3, 0.19, cm1, cm2, cma, cmd, cm 16, cmb, cmx1/cmx3, cmx2, and/or 0.53 triggered innate immune responses.. ... Beth Israel Deaconess Medical Center

Method and apparatus for managing photophobia and migraine photophobia

Apparatus and methods for producing narrow-band radiation in the green region of the visible spectrum are described. The narrow-band radiation may be used to aid subjects experiencing photophobia. ... Beth Israel Deaconess Medical Center

Cancer therapy targeting tetraspanin 33 (tspan33) in myeloid derived suppressor cells

Methods for treating cancer, e.g., in conjunction with anti-cancer therapy, like immunotherapy, and for identifying candidate therapeutic agents, by targeting myeloid derived suppressor cells expressing tspan33.. . ... Beth Israel Deaconess Medical Center

Substance p, mast cell degranulation inhibitors, and peripheral neuropathy

Described herein are methods of using substance p, mast cell degranulation inhibitors, or combinations thereof to delay the onset of, to reverse, or to reduce the risk of acquiring complications associated with diabetes. Also provided herein are methods for accelerating wound healing in diabetic subjects using substance p, mast cell degranulation inhibitors, or combinations thereof.. ... Beth Israel Deaconess Medical Center

Arsenic trioxide for treatment of pin1-associated disorders

The present invention relates to the treatment of pin1-associated disorders (e.g., disorders characterized by elevated pin1 activity) with arsenic trioxide, optionally in combination with a retinoic acid compound. Pin1-associated disorders may include, for example, proliferative disorders (e.g., cancers), inflammatory conditions, and autoimmune disorders associated with aberrant levels of pin1 activity.. ... Beth Israel Deaconess Medical Center

Targeting metabolic vulnerability in triple-negative breast cancer

Methods for treating cancer in a subject by administering a therapeutically effective amount of a pyrimidine synthesis inhibitor and a genotoxic chemotherapeutic agent. In some embodiments, the cancer is triple negative breast cancer.. ... Beth Israel Deaconess Medical Center

Treatment of cancers with micro-rna inhibitors

The invention relates to the treatment and prevention of cancers, including blood-based cancers and breast cancers, by administering agents that inhibit the activity of micrornas, including mir-22. Inhibitors can include oligonucleotides that are at least partially complementary to these mirnas. ... Beth Israel Deaconess Medical Center

Diabetes treatment

Methods and compositions for treating a patient who has recently developed diabetes are provided. The methods can include administering a tolerance-restoring agent to the patient and simultaneously administering intensive insulin therapy.. ... Beth Israel Deaconess Medical Center

Bacterial mediated thf alpha gene silencing

Methods are described for the delivery of one or more small interfering rnas (sirnas) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using rna interference, and methods for treating an inflammatory disease or disorder. ... Beth Israel Deaconess Medical Center

03/29/18 / #20180085398

Compositions and methods of treating cancer

The present invention provides compositions and methods for treating cancer.. . ... Beth Israel Deaconess Medical Center

03/29/18 / #20180085350

Compositions and methods of treating cancer

The present invention provides compositions and methods for treating cancer.. . ... Beth Israel Deaconess Medical Center

03/22/18 / #20180078650

Compositions and methods of treating acute myeloid leukemia

The present invention provides compositions and methods for treating acute myeloid leukemia.. . ... Beth Israel Deaconess Medical Center

03/22/18 / #20180078626

Compositions and methods of treating renal cell cancer

The present invention provides compositions and methods for treating renal cell carcinoma. . ... Beth Israel Deaconess Medical Center

03/15/18 / #20180075601

System and method for enhancing functional medical images

Systems and methods for generating a medical image of a subject that includes functional information. First, two medical images are acquired. ... Beth Israel Deaconess Medical Center

03/15/18 / #20180073025

Micro-rna inhibitors and their uses in disease

The invention relates to the treatment and prevention of cancer by administering agents that inhibit the activity of micrornas that modulate tumor suppressor genes, which can include pten, p53, and inpp4b, among others. Inhibitors can include oligonucleotides that are at least partially complementary to these mirnas. ... Beth Israel Deaconess Medical Center

03/15/18 / #20180072814

Methods and compositions for the generation and use of conformation-specific antibodies

The present invention features methods and compositions for the generation and use of conformation-specific antibodies or fragments thereof.. . ... Beth Israel Deaconess Medical Center

03/15/18 / #20180071340

Compositions and methods of treating multiple myeloma

The present invention provides compositions and methods for treating multiple myeloma.. . ... Beth Israel Deaconess Medical Center

03/15/18 / #20180071252

Methods of treating autoimmune and/or glomerulonephritis-associated diseases using shp2 inhibitors

Methods are disclosed herein for administering a oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (shp2) inhibitor for treating autoimmune and/or glomerulonephritis-associated diseases, and in particular, systemic lupus erythematosus (sle).. . ... Beth Israel Deaconess Medical Center

03/01/18 / #20180057610

Therapeutic use of mitochondria and combined mitochondrial agent

The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.. . ... Beth Israel Deaconess Medical Center

02/08/18 / #20180037614

Immunoassays for differential detection of clostridium difficile

Ultrasensitive and quantitative assays for detecting toxins of clostridium difficile, which may involve digital elisa, are provided. Also provided herein are differential detection assays that allow for distinguishing toxin b of highly virulent clostridium difficile strains from toxin b of less virulent strains.. ... Beth Israel Deaconess Medical Center

02/01/18 / #20180031660

Magnetic resonance imaging that nulls signals from two or more tissues to better delineate an interested tissue

A system and method for acquiring magnetic resonance imaging (mri) images with an mri system is provided. The system and method directs the mri system first to produce an inversion recovery radio frequency (rf) pulse, wait for a time period, produce a t2-preparation rf pulse, wait for another time period, and then acquire data of a part of a subject. ... Beth Israel Deaconess Medical Center

12/21/17 / #20170362661

Methods for detecting braf in cancer

The invention features compositions and methods for detecting and quantifying brafv600e in a sample of a subject. In particular embodiments, the invention provides a highly sensitive and precise quantitative method for diagnosis, post-operative surveillance, and monitoring evidence of disease over time in the adjuvant setting (i.e. ... Beth Israel Deaconess Medical Center

12/21/17 / #20170362320

Cancer therapy targeting intercellular adhesion molecule 4 (icam4)

Methods for treating cancer, e.g., in conjunction with anti-cancer therapy, like immunotherapy, and for identifying candidate therapeutic agents, by targeting icam4. While mdscs in mice have been extensively characterized, their human counterparts are not well defined, and cell markers present in mice are not always usable in humans. ... Beth Israel Deaconess Medical Center

11/30/17 / #20170343635

Reduced field-of-view perfusion imaging with high spatiotemporal resolution

Some aspects of the present disclosure relate a method for magnetic resonance imaging, which can include acquiring, by applying an imaging pulse sequence, magnetic resonance data associated with a region of interest of a subject. The imaging pulse sequence can include a plurality of rf pulses configured to generate a desired image contrast, and an outer-volume suppression (ovs) module to attenuate the signal outside the region of interest. ... Beth Israel Deaconess Medical Center

11/30/17 / #20170340882

Method and a system for optimizing the configuration of multisite transcranial current stimulation and a computer-readable medium

A system and a method for optimizing the configuration of multisite transcranial current stimulation, including providing an electric field characteristic target map on the brain's cortex, the target map including multiple cortical targets, the multiple cortical targets are localized and/or continuously varying and spatially extended, providing a weight map on the cortical surface prioritizing the important of areas in the target map for the purposes of optimization; and calculating, based on the target and weight maps, optimal currents and optimal locations for a plurality of electrodes intended for providing transcranial current stimulation to globally stimulate at once the multiple cortical targets with excitatory, inhibitory or neutral stimulation.. . ... Beth Israel Deaconess Medical Center

10/26/17 / #20170304248

Dietary emulsion formulations and methods for using the same

Disclosed herein is a formulation that can take the form of an emulsion which contains total enteral or parenteral nutrition for a recipient subject. The formulation includes as the sole fat components: (i) medium chain triglycerides; and (ii) very long chain fatty acids selected from (a) very long chain omega-3 polyunsaturated fatty acids; and (b) docosahexaenoic acid and arachidonic acid in a ratio of about 10:1 (v/v or w/w) to about 2000:1 (v/v or w/w). ... Beth Israel Deaconess Medical Center

08/10/17 / #20170226194

Poly-n-acetyl glucosamine (pnag/dpnag)-binding peptides and methods of use thereof

The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-n-acetyl glucosamine (pnag), such as staphylococcal pnag, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express pnag such as but not limited to staphylococci and e. ... Beth Israel Deaconess Medical Center

07/20/17 / #20170204466

Biomarkers for pin1-associated disorders

Biomarkers and driver mutations for diagnosis and prognosis of pin 1-associated diseases are disclosed. In one embodiment, the methods for diagnosis of pin 1-associated diseases may include detecting the level of pin1 to stage abnormal cell growth, such as breast or prostate cancer. ... Beth Israel Deaconess Medical Center

07/20/17 / #20170202799

Atra for modulating pin1 activity and stability

The present disclosure describes how all-retinoic acid (atra) binds and inhibits pin1 activity and induces degradation of the activated pin1 monomer selectively in cancer cells. Identification of the binding mechanism of atra with pin1 confirm atra binding specificity to pin1 residues in the ppiase active site, thus demonstrating that drug-induced pin1 ablation has potent anticancer activity, such as in acute promyelocytic leukemia (apl), by inducing pml-rara degradation, as well as against other types of cancer and diseases that are associated with pin1 overexpression, such as aggressive triple negative breast cancer, lupus, asthma, cocaine addiction, among others, due to their unique ability to simultaneously block numerous cancer-driving pathways, with relatively lower toxicity. ... Beth Israel Deaconess Medical Center

07/06/17 / #20170190762

Alpha1 -antitrypsin compositions and methods of treating autoimmune diseases

The specification provides compositions comprising chimeric proteins comprising aat conjugated to an fc region of an immunoglobulin. Methods for treating autoimmune disease, e.g., diabetes, e.g., type 1 and type 2 diabetes, are also provided.. ... Beth Israel Deaconess Medical Center

06/22/17 / #20170173218

Activation of antimicrobial agents

Post-operative infection in joint prostheses is a problem due to adverse consequences such as surgical debridement or implant removal. Embodiments create a coating that can be powered to release microbicidal agents to both ensure the prevention of infections, and avoid the development of antibiotic resistance. ... Beth Israel Deaconess Medical Center

05/04/17 / #20170121772

Biomarkers and treatments for heart failure

The invention features methods to predict the response to a cardiac therapy in a patient suffering from a cardiac disease, e.g., heart failure. The invention features measurement expression of biomarkers that help in this prediction. ... Beth Israel Deaconess Medical Center

05/04/17 / #20170120237

Products and methods to isolate mitochondria

Filtration apparatuses, kits, and methods for rapid isolation of intact, viable mitochondria from tissues are described with mitochondria isolated by differential filtration through nylon mesh filters. Mitochondria can be isolated in less than 30 minutes using the filtration apparatuses, kits, and methods described.. ... Beth Israel Deaconess Medical Center

04/27/17 / #20170112792

Enhanced atra-related compounds derived from structure-activity relationships and modeling for inhibiting pin1

The invention features all-trans retinoic acid (atra)-related compounds capable of associating with pin1 and methods of identifying the same. The invention also provides methods of treating a condition selected from the group consisting of a proliferative disorder, an autoimmune disease, and an addiction condition characterized by elevated pin1 marker levels, pin1 degradation, and/or reduced pin1 ser71 phosphorylation in a subject by administering a retinoic acid compound. ... Beth Israel Deaconess Medical Center

04/06/17 / #20170097363

Buccal cell diagnosis of arrhythmogenic cardiomyopathy (acm)

Described herein are, inter alia, methods for diagnosing and treating arrhythmogenic cardiomyopathy (acm) by detecting cardiac intercalated disk proteins, e.g., desmosomal proteins, mechanical and gap junction proteins, in buccal cells. Exemplary desmosomal and gap junction proteins that can be evaluated in the methods described herein include plakoglobin, plakophilin 1, desmoplakin, and cx43. ... Beth Israel Deaconess Medical Center

03/16/17 / #20170072018

Methods of diagnosing and treating complications of pregnancy

Disclosed herein are methods for diagnosing a pregnancy related hypertensive disorder or a predisposition to a pregnancy related hypertensive disorder by measuring the level or biological activity of soluble endoglin. Also disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that alter soluble endoglin levels or biological activity.. ... Beth Israel Deaconess Medical Center

02/23/17 / #20170049136

Methods for determination of bioactivity, removal, or inactivation cereal amylase trypsin inhibitors in cereals, flours and complex foods

The present invention features methods of extracting amylase trypsin inhibitors (atis) from processed and unprocessed foodstuff, determining bioactivity of atis, qualifying the amount of atis in a foodstuff, and reducing the content of atis in a foodstuff.. . ... Beth Israel Deaconess Medical Center

02/09/17 / #20170035319

Rapid 3d dynamic arterial spin labeling with a sparse model-based image reconstruction

Methods, systems, and computer-readable media for rapid 3d dynamic arterial spin labeling with a sparse model-based image reconstruction are disclosed. In one embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject. ... Beth Israel Deaconess Medical Center

02/02/17 / #20170027994

Differentiation of stem cells into thyroid tissue

Embodiments herein relate in vitro methods of stem cell differentiation into thyroid hormone producing cells and tissues, and methods of use of these cells.. . ... Beth Israel Deaconess Medical Center

01/12/17 / #20170007151

Electrical impedance myography

Electrical impedance myography (eim) can be used for assessment and diagnosis of muscular disorders. Eim includes applying an electrical signal to a region of tissue and measuring a resulting signal. ... Beth Israel Deaconess Medical Center








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