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Bi Incorporated patents


Recent patent applications related to Bi Incorporated. Bi Incorporated is listed as an Agent/Assignee. Note: Bi Incorporated may have other listings under different names/spellings. We're not affiliated with Bi Incorporated, we're just tracking patents.

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Optical communication systems, devices, and methods including high performance optical receivers

. . . . . . The present invention relates to communication systems, devices, and methods for providing for a wide bandwidth optical receiver including amplification through optical beating from a local oscillator laser operating without a phase-locked loop at frequency near the receiver optical signal and decreasing the system-performances dependence on optical polarization alignment between the signal and the local oscillator. Systems, devices, and methods including a local oscillator providing a local oscillator signal having a local oscillator frequency that may be controlled based on a frequency offset from the signal center frequency through the use of monitoring signals representative of the frequency offset. ... Bi Incorporated

Predictive test for patient benefit from antibody drug blocking ligand activation of the t-cell programmed cell death 1 (pd-1) checkpoint protein and classifier development methods

A method is disclosed of predicting cancer patient response to immune checkpoint inhibitors, e.g., an antibody drug blocking ligand activation of programmed cell death 1 (pd-1) or ctla4. The method includes obtaining mass spectrometry data from a blood-based sample of the patient, obtaining integrated intensity values in the mass spectrometry data of a multitude of pre-determined mass-spectral features; and operating on the mass spectral data with a programmed computer implementing a classifier. ... Bi Incorporated

Medical monitoring system, method of displaying monitoring data, and monitoring data display device

A medical monitoring system includes: one or more signal sampling devices to detect parameter data corresponding to at least one physiological parameter; memory to store the parameter data corresponding to the at least one physiological parameter; a display to display parameter data obtained by at least one sensor; and a processor to obtain, according to the parameter data, abnormal event indications having a plurality of different attributes and transmit the abnormal event indications to the display; wherein the abnormal event indications are shown as anomalies identifiers on a timeline.. . ... Bi Incorporated

Skin product fitting method and electronic apparatus therefor

A skin product fitting method and an electronic apparatus therefor are provided. The method includes following steps: capturing a skin image of a current user by using an image capturing device and analyzing the skin image to determine a skin concern; obtaining a skin type of the current user; and sorting a plurality of skin products stored in a product database at least according to the skin concern and the skin type so as to provide product information fitting a skin condition of the current user.. ... Bi Incorporated

System and method for algorithmic extracellular vesicle population discovery and characterization

Methods and systems for extracellular vesicle characterization are provided herein. Embodiments of the methods include inputting measured physical, biological, or chemical aspects of extracted extracellular vesicles. ... Bi Incorporated

Inclusion of protocol conditions within search engine results

Taught is a search engine for science tools which dynamically evaluates search rank of said science tools through natural language processing and machine learning. The search engine accepts into a corpus of public and private materials, which references individual science tools. ... Bi Incorporated

Real-time focusing in line scan imaging

System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. ... Bi Incorporated

Composition for diagnosing infectious dieases or infectious complications by using tryptophanyl-trna synthetase and method for detecting diagnostic marker

The present invention relates to a composition for diagnosing infectious diseases by using a tryptophanyl-trna synthase (wrs) and a method for detecting a diagnostic marker and, more specifically, to: a composition for diagnosing infectious diseases, containing a preparation measuring the wrs protein or mrna expression level; a diagnostic kit; a method for detecting the wrs for providing information required for the diagnosis of infectious diseases, and a method for determining the infectious disease mortality risk by using the wrs. According to the present invention, the wrs is increased only in infection-induced infectious diseases, differentiating non-infectious diseases therefrom, and is rapidly increased in the early stage of infection. ... Bi Incorporated

Analyte detection with multiple substrates

The present disclosure provides methods and/or kits for detecting an analyte in a sample. Some embodiments provide an analyte detection system, kit, and method of using the same, comprising: a first agent comprising at least one tag and capable of binding to the analyte; a second agent covalently bound to a plurality of peptide tags and capable of binding to the analyte; a first bead comprising a binder capable of binding with the tagged first agent; and a second bead comprising an anti-peptide agent capable of binding with at least one of the plurality of covalently bound peptide tags.. ... Bi Incorporated

A chromatography system and a method therefor

The present invention relates to a chromatography system and a method therefor. The chromatography system comprising an inlet port (102) for receiving a sample, an outlet port (106) for delivering the sample, a detector (201), a column (104), and a valve (202) in fluid communication with the inlet port, the outlet port, the detector, and the column. ... Bi Incorporated

Hydrogel particles with tunable optical properties and methods for using the same

Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to the at least one optical property of a target cell. ... Bi Incorporated

Expandable mat-based sun shelter

A collapsible sun shelter that includes an arch support and a rollable flat mat that is configured to expand to include a canopy section and further includes a floor area portion, an upwardly deployable area portion at least two mat anchor points and at least two arch support openings. The rollable mat has an upwardly deployable area portion defined by an outer perimeter passing through at least one layer of the rollable flat mat such that the upwardly deployable area portion remains connected with the floor area portion when the upwardly deployable area portion is extended upwardly in a deployed configuration.. ... Bi Incorporated

Expandable structure and vendor space

An expandable structure that includes front and rear structural units having inside-facing surfaces parallel to one another, a retractable top that spans the front and rear structural units, and first and second retractable partitions each of which spans and connects the front and rear structural units. The front structural unit is fixably attached to a substrate and the rear structural unit is mounted on a rolling mechanism so that the rear structural unit may be moved away from the front structural unit in an orientation perpendicular to the face of the first structural unit to a distance equivalent to a deployed depth of the first retractable partition, the second retractable partition and the retractable top.. ... Bi Incorporated

Expandable kiosk structure with public service element

An expanded kiosk and kiosk system that is collapsible and deployable by expansion and contraction. The kiosk includes a lighting system adapted to provide a light characteristic to the kiosk and represent a lamp post or light post for public or private spaces. ... Bi Incorporated

09/27/18 / #20180274235

Wall framing system

The present invention relates to an engineered lumber framing system of pre-fabricated components for construction of structures comprising: a first top plate comprising an end, the end including corners at variable angles forming a first stepped construct; and a second top plate comprising an end, the end including corners at variable angles forming a second stepped construct; wherein the first stepped construct fits into the second stepped construct forming a corner connection; and wherein the first top plate and the second top plate each comprise of a plurality of sheet layers. The corner connection comprises a haunched stub tenon-like corner joint.. ... Bi Incorporated

09/27/18 / #20180274226

Expandable shade and shelter system

An expandable shade and shelter system that includes an expandable grid structure of reversibly expandable cells in a two-dimensional grid configured to collapse to a rectangular cuboid with a top surface, an anchored bottom, an anchored first end, an expandable second end, and two expandable sides. The system includes a connecting device fixed at corners of the top surface and/or the expandable second end of the structure, a vertically oriented support structure having a top and bottom ends, where the expandable grid structure is configured to expand upwardly from the second end and inwardly towards the top of the vertically oriented support structure, while the anchored first end remains anchored, to connect the connecting device to the top of the vertically oriented support structure to form a three dimensional shelter.. ... Bi Incorporated

09/27/18 / #20180274044

Methods for detection of anti-cytomegalovirus neutralizing antibodies

The present disclosure provides methods useful for determining levels of hcmv infection in host cells and, by extension, determining levels of neutralizing antibodies present in a sample. The present disclosure encompasses the recognition that hcmv viruses that have a fluorescent moiety permit detection of viral infection (e.g., by assessing fluorescence in cells after contacting the host cell with the virus). ... Bi Incorporated

09/27/18 / #20180274029

Universal hairpin primers

The present invention relates to methods of target nucleic acid amplification and uses thereof in methods of sequencing, or other down-stream applications such a genotyping or cloning. More specifically, the methods relate to methods of target nucleic acid amplification through the use of a universal hairpin primer.. ... Bi Incorporated

09/27/18 / #20180274028

Sequencing and high resolution imaging

Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.. ... Bi Incorporated

09/27/18 / #20180274025

Methods of using nucleotide analogues

The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-o position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to sequencing by synthesis.. ... Bi Incorporated

09/27/18 / #20180274015

Detection processes using sites of chromosome interaction

A process for analysing epigenetically active regions of the genome.. . ... Bi Incorporated

09/27/18 / #20180274014

Nucleic acid sample preparation

The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.. ... Bi Incorporated

09/27/18 / #20180274006

Method for detecting molecular interactions using an immobilized nucleic acid

The present invention relates to a method for detecting and/or characterizing molecular interactions between two molecules, in particular two proteins and most particular between an antigen and an antibody by using an immobilized single-stranded nucleic acid molecule to which single-stranded nucleic acid molecules having a ligand attached thereto are hybridized.. . ... Bi Incorporated

09/27/18 / #20180274005

Cord blood therapy to treat chronic disease caused by l-form bacteria

The present disclosure describes screening cord blood for antibacterial activity against l-form bacteria, methods of treating a patient having an l-form bacterial infection using a cord blood agent, and methods of killing or inhibiting l-form bacteria in an in vitro or ex vivo setting. L-form bacteria underlying an l-form bacterial infection are isolated from a subject having an infection and are altered to a culturable morphology. ... Bi Incorporated

09/27/18 / #20180273996

Fermentation process for producing monosaccharides in free form from nucleotide-activated sugars

The present invention relates to a process for producing a monosaccharide, e.g. L-fucose, in free form using a microbial fermentation process. ... Bi Incorporated

09/27/18 / #20180273986

Novel organic acid pathway

The invention relates to the use of a cytosolic citric acid synthase for the heterologous production of citrate outside the mitochondrion of a micro-organism or algae, wherein the protein is selected from a. Niger an08g10920, an01g09940, an09g03570 ,or an ortholog of these genes. ... Bi Incorporated

09/27/18 / #20180273971

Reduced gluten grains and compositions thereof

Plants with reduced gluten grains and compositions thereof are disclosed herein.. . ... Bi Incorporated

09/27/18 / #20180273961

A crispr/cas9 system for high efficient site-directed altering of plant genomes

Cassettes comprising a yao promoter operably linked to at least one nucleotide sequence encoding a nuclease, vectors comprising the same are provided. A system for altering a plant genome comprising a nucleotide sequence encoding a nuclease operably linked to a yao promoter and a method to alter the target nucleic acid molecule by using the system are provided. ... Bi Incorporated

09/27/18 / #20180273940

Treating and preventing microbial infections

The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, sirs or septic shock. ... Bi Incorporated

09/27/18 / #20180273936

Variant libraries of the immunological synapse and synthesis thereof

Disclosed herein are methods for the generation of highly accurate nucleic acid libraries encoding for predetermined variants of a nucleic acid sequence. The nucleic acid sequence may encode for all or part of a reference domain of a car. ... Bi Incorporated

09/27/18 / #20180273909

Purification of respiratory syncytial virus

Disclosed herein are methods for the purification of respiratory syncytial virus (rsv) particles from a host cell culture comprising treating the host cell culture with an endonuclease, filtering the material to remove cellular debris and/or aggregated material, applying the material to a core bead chromatography resin, and recovering the purified rsv particles. Also disclosed herein are pharmaceutical compositions comprising purified rsv.. ... Bi Incorporated

09/27/18 / #20180273907

Method for producing non-enveloped viral particles

Provided is a method for producing non-enveloped viral particles, comprising a step for obtaining a fraction containing non-enveloped viral particles by removing precipitates which are produced in a step for adding a substance which reduces the solubility of proteins under acidic conditions and/or a substance which precipitates under acidic conditions to a neutral or basic sample containing non-enveloped viral particles, and acidifying the sample after the addition of the substance.. . ... Bi Incorporated

09/27/18 / #20180273900

Cell culture support

There is provided an adherent cell-culture support comprising gold nanoparticles on the surface where the cells attach to, wherein the size of the nanoparticles is from 5 nm to 2 microns, the distance between the nanoparticles is from 2 nm to 30 nm and the anisotropy aspect ratio is greater than 1. These substrates have improved properties for allowing the culturing and subsequent detachment of cells, with potential applications in a wide range of fields such as stem cell research and tissue engineering. ... Bi Incorporated

09/27/18 / #20180273895

Lactic acid bacteria and their use for the treatment of mastitis

The present invention relates to novel lactic acid bacteria strains lactobacillus reuteri selected from the group comprising lactobacillus reuteri dsm 32229, lactobacillus reuteri dsm 32230, lactobacillus reuteri dsm 32231 and lactobacillus reuteri dsm 32232 and products comprising these strains. The present invention also relates to a use of one or more lactic acid bacteria strains as a probiotic for the treatment of an inflammation and infection, such as mastitis and/or thrush, especially after topical administration of said strains.. ... Bi Incorporated

09/27/18 / #20180273894

Method for preparing a degradable material

The disclosure relates to the biotechnology field, and a method for preparing degradable materials, which comprises: inoculating ceriporia lacerata into a culture medium containing lignocellulose debris for solid-state fermentation. The accession number of the c. ... Bi Incorporated

09/27/18 / #20180273629

Glucagon receptor binding proteins and methods of use thereof

The present disclosure provides binding proteins, such as antibodies, that bind glucagon receptors, including a human glucagon receptor, and methods of their use.. . ... Bi Incorporated

09/27/18 / #20180273621

Humanized anti-cd19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease

The present invention provides chimeric and humanized versions of anti-cd19 mouse monoclonal antibodies. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human cd19 antigen and that may mediate adcc, cdc, and/or apoptosis for the treatment of b cell diseases and disorders, such as, but not limited to, b cell malignancies, for the treatment and prevention of autoimmune disease, and for the treatment and prevention of graft-versus-host disease (gvhd), humoral rejection, and post-transplantation lymphoproliferative disorder in human transplant recipients.. ... Bi Incorporated

09/27/18 / #20180273620

Antibody molecules which bind cd22

The present disclosure relates to antibody molecules comprising a binding domain specific to cd22, said binding domain comprising seq id no: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.. ... Bi Incorporated

09/27/18 / #20180273602

T cell receptors and immune therapy using the same against prame positive cancers

The present invention pertains to antigen recognizing constructs against tumor associated antigens (taa), in particular against preferentially expressed antigen of melanoma (prame). The invention in particular provides novel t cell receptor (tcr) based molecules which are selective and specific for the tumor expressed antigen of the invention. ... Bi Incorporated

09/27/18 / #20180273576

Compositions and methods for synthesizing 5'-capped rnas

Provided herein are methods and compositions for synthesizing 5′capped rnas wherein the initiating capped oligonucleotide primers have the general form m7gppp[n2′ome]n[n]m wherein m7g is n7-methylated guanosine or any guanosine analog, n is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.. . ... Bi Incorporated

09/27/18 / #20180273560

Phospholipidation of imidazoquinolines and oxoadenines

The present invention relates to a process for phospholipidation of imidazoquinolines and oxoadenines. More particularly, the present invention relates to a high-yielding and scalable procedure for the phospholipidation of imidazoquinolines and oxoadenines which obviates the need to isolate unstable phosphoramidite intermediates. ... Bi Incorporated

09/27/18 / #20180273544

Compounds that participate in cooperative binding and uses thereof

The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the fkbp family, a member of the cyclophilin family, or pin1) and a target protein such as cep250. These compounds bind endogenous intracellular presenter proteins, such as the fkbps or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. ... Bi Incorporated

09/27/18 / #20180273521

Hepatitis b core protein allosteric modulators

The present disclosure provides, in part, compounds having allosteric effector properties against hepatitis b virus cp. Also provided herein are methods of treating viral infections, such as hepatitis b, comprising administering to a patient in need thereof a disclosed compound.. ... Bi Incorporated

09/27/18 / #20180273486

Method for the preparation of 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid

The present invention relates to method for the preparation of 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid, wherein it comprises the following steps: step 1, fluoroacetyl fluoride derivative shown in formula i undergoes condensation with dimethylamino vinyl methyl ketone, as a result, 3-dimethylamino methylene-fluoro-2,4-pentanedione derivative shown in formula ii is formed; step 2, ring closing reaction takes place between said 3-dimethylamino methylene-fluoro-2,4-pentanedione shown in formula ii and methylhydrazine, in this way, 3-fluoroalkyl-1-methyl-4-acetyl pyrazol derivative shown in formula iii is obtained; step 3, the said 3-fluoroalkyl-1-methyl-4-acetyl pyrazol derivative shown in formula iii is oxidized in the presence of alkali, and then acidified, in this way, 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid shown in formula iv is formed. Preparing method of present invention, wherein the required preparing route is simple, the raw material cost is low, the resulting yield of each step is high, and it is suitable for industrialization.. ... Bi Incorporated

09/27/18 / #20180273437

Methods and compositions for improving plant traits

Disclosed herein are methods of increasing nitrogen fixation in a non-leguminous plant. The methods can comprise exposing the plant to a plurality of bacteria. ... Bi Incorporated

09/27/18 / #20180273366

Electric personnel lift device

An electric personnel lift device that includes a base assembly having two columns that are laterally spaced apart. Each of the two columns has a lift cylinder device mounted in the respective column and extending upward. ... Bi Incorporated

09/27/18 / #20180273353

Tower crane

The invention relates to a tower crane with a crane tower and a jib mounted thereon as well as a counter-jib, wherein the length of the counter-jib is defined by the number of the counterweights received.. . ... Bi Incorporated

09/27/18 / #20180272914

Mobile kiosk with shade structure

An expandable kiosk structure with a front face, a rear face, a first side structural unit and a second side structural unit arranged such that the front face and rear face are parallel and connect the first and second side structural units to form a box shaped structure that is expandable from a collapsed form an expanded form in which the front face, the rear face, and the first and second side structural units define an interior workspace in the box shaped structure. The front and rear faces each have an outwardly extendable portion that is hingeably or pivotally foldable onto a remaining portion of the front or rear face. ... Bi Incorporated

09/27/18 / #20180272688

Sleeve station

A sleeve station dedicated to the assembly of a sleeve and a mandrel for a flexographic press. The sleeve station can be loaded manually, and assembles the sleeve with the mandrel in a vertical orientation when both are in a vertical orientation with aligned axes, avoiding problems caused by the bending of the sleeves during assembly. ... Bi Incorporated

09/27/18 / #20180272337

Detection apparatus for detecting analyte in a liquid sample and method thereof

The present invention discloses a detection apparatus, comprising a base layer, wherein the base layer comprises a groove for containing a testing element and a sample chamber for collecting a fluid sample. The detection apparatus can achieve fast, efficient and accurate detection of analytes in liquid samples, make operators to perform testing conveniently and freely, without causing incorrect results. ... Bi Incorporated

09/27/18 / #20180272251

Wastesolution treatment systems

Wastesolution treatment systems and methods are provided which may remove particulates and hydrocarbons from wastesolution. Embodiments may be used to treat scrubber wastesolution from exhaust gas cleaning (“egc”) systems. ... Bi Incorporated

09/27/18 / #20180272133

Device and method for multi-modality spinal cord stimulation therapy

A device for neurostimulation includes a pulse generator for generating current having pulses and at least one first pair of electrodes connected to the pulse generator. The device provides a user-programmable therapy strength parameter configuration and at least two current parameter configurations for neurostimulation stored in the pulse generator. ... Bi Incorporated

09/27/18 / #20180272124

Multi-electrode stimulation therapy with reduced energy

A device for neurostimulation has a number n of electrodes. N is equal to or larger than 3. ... Bi Incorporated

09/27/18 / #20180272108

Catheter with improved loop contraction and greater contraction displacement

A catheter with a variable circular loop is responsive to a contraction wire for increasing the coiling of the circular loop. The shape of the loop is supported by an elongated member, wherein a radially constrictive sleeve confines the contraction wire to extends immediately alongside the length of elongated member so as to improve uniformity and minimize misshaping of the loop during contraction.. ... Bi Incorporated

09/27/18 / #20180272005

Biodegradable lipids for delivery of nucleic acids

The present invention provides, in part, a biodegradable compound of formula i, and sub-formulas thereof: formula (i) or a pharmaceutically acceptable salt thereof, where each x independently is o or s, each y independently is o or s, and each r1 independently is defined herein; and a liposome composition comprising the cationic lipid of formula i or a sub-formula thereof, and methods of delivering agents, such as nucleic acids including mrna, in vivo, by administering to a subject the liposome comprising the cationic lipid of formula i or a sub-formula thereof, where the agent is encapsulated within the liposome.. . ... Bi Incorporated

09/27/18 / #20180272004

Biodegradable lipids for delivery of nucleic acids

The present invention provides, in part, a biodegradable compound of formula i, and sub-formulas thereof: formula (i) or a pharmaceutically acceptable salt thereof, where each x independently is o or s, each y independently is o or s, and each r1 independently is defined herein; and a liposome composition comprising the cationic lipid of formula i or a sub-formula thereof, and methods of delivering agents, such as nucleic acids including mrna, in vivo, by administering to a subject the liposome comprising the cationic lipid of formula i or a sub-formula thereof, where the agent is encapsulated within the liposome.. . ... Bi Incorporated

09/27/18 / #20180272003

Biodegradable lipids for delivery of nucleic acids

The present invention provides, in part, a biodegradable compound of formula i, and sub-formulas thereof: formula (i) or a pharmaceutically acceptable salt thereof, where each x independently is o or s, each y independently is o or s, and each r1 independently is defined herein; and a liposome composition comprising the cationic lipid of formula i or a sub-formula thereof, and methods of delivering agents, such as nucleic acids including mrna, in vivo, by administering to a subject the liposome comprising the cationic lipid of formula i or a sub-formula thereof, where the agent is encapsulated within the liposome.. . ... Bi Incorporated

09/27/18 / #20180272002

Biodegradable lipids for delivery of nucleic acids

The present invention provides, in part, a biodegradable compound of formula i, and sub-formulas thereof: formula (i) or a pharmaceutically acceptable salt thereof, where each x independently is o or s, each y independently is o or s, and each r1 independently is defined herein; and a liposome composition comprising the cationic lipid of formula i or a sub-formula thereof, and methods of delivering agents, such as nucleic acids including mrna, in vivo, by to a subject the liposome comprising the cationic lipid of formula i or a sub-formula thereof, where the agent is encapsulated within the liposome.. . ... Bi Incorporated

09/27/18 / #20180271960

Method to treat cancer using arginine delpetor and ornithine decarboxylase (odc) inhibitor

One example embodiment is a method of treating lung carcinoma in a subject in need thereof. The method includes administering to the subject a therapeutically effective amount of an arginine reducing compound and a therapeutically effective amount of an ornithine decarboxylase (odc) inhibitor to provide a combination therapy that has a synergistic therapeutic effect compared to an effect of the arginine reducing compound and an effect of the odc inhibitor, in which each of the arginine reducing compound and the odc inhibitor is administered alone.. ... Bi Incorporated

09/27/18 / #20180271951

Methods and products for nucleic acid production and delivery

The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the dna sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic rna molecules, including cells present in vivo. ... Bi Incorporated

09/27/18 / #20180271943

Methods for treating inflammation with tgf-beta

Provided wherein are methods for treating inflammation. In one embodiment, the method includes administering an effective amount of a composition to a subject having or at risk of having a condition that includes inflammation. ... Bi Incorporated

09/27/18 / #20180271916

Treatment of diseases and conditions caused by increased vascular permeability

The invention is directed to methods for the treatment of diseases and conditions caused by increased vascular permeability. The invention is also directed to methods for returning vascular permeability that is a symptom of a disease or condition to a homeostatic state. ... Bi Incorporated

09/27/18 / #20180271914

Methods for reducing the extent of light-induced tissue inflammation and injury

The invention is directed to methods for reducing the extent of light-induced tissue injury. The method comprises applying a therapeutically effective amount of amnion-derived cellular cytokine solution (accs) to the tissue prior to or as soon as possible following exposure to the light. ... Bi Incorporated

09/27/18 / #20180271912

Spinal disc regenerative composition and method of manufacture and use

The present invention provides a novel way to replenish the disc using retooled disc compositions to repair degenerative discs. There is no better source of proteoglycans than the actual disc material (6) itself. ... Bi Incorporated

09/27/18 / #20180271887

Dosage forms for oral administration of zoledronic acid or related compounds for treating disease

Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form, can be used to treat or alleviate pain or related conditions, such as arthritis.. . ... Bi Incorporated

09/27/18 / #20180271873

Methods for treating viral infections

Described herein are methods for treating a viral infection comprising administering to an individual in need thereof a therapeutically effective amount of a compound of formula i: formula (i).. . ... Bi Incorporated

09/27/18 / #20180271849

Pharmaceutical composition and application thereof

Disclosed are a pharmaceutical composition and an application thereof. The pharmaceutical composition includes one or more of a benzoheterocyclic compound as shown in formula (i), a pharmaceutically acceptable salt thereof, a solvate thereof, a crystalline form thereof, a co-crystal thereof, a stereoisomer thereof, an isotope compound thereof, a metabolite thereof and a pro-drug thereof, and an androgen receptor pathway modulator. ... Bi Incorporated

09/27/18 / #20180271840

Compositions and methods for treating amyotrophic lateral sclerosis in responders

A method for treating amyotrophic lateral sclerosis (als) in a subject in need thereof comprising administering to said subject an effective amount of (6r)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole or pharmaceutically acceptable salt thereof, wherein said subject is a treatment responder. In certain embodiments, said subject is a subject with definite amyotrophic lateral sclerosis, a subject with amyotrophic lateral sclerosis symptom onset duration of less than about 18 months, a subject with a high level of serum creatinine, a subject with concomitant riluzole administration and combinations thereof.. ... Bi Incorporated

09/27/18 / #20180271839

Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils

Disclosed herein are methods of treating conditions, which may be associated with elevated levels of eosinophils and/or basophils, with a therapeutically effective amount of dexpramipexole or pharmaceutical acceptable salt thereof.. . ... Bi Incorporated

09/27/18 / #20180271822

Compositions and methods of use of phorbol esters for the treatment of stroke

Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.. ... Bi Incorporated

09/27/18 / #20180271821

Neuroprotection in demyelinating diseases

Methods of treating neurological disorders characterized by extensive demyelination and/or axonal loss are provided. Examples of such disorders include secondary progressive multiple sclerosis and devic's disease. ... Bi Incorporated

09/27/18 / #20180271814

Method for treating cancer with low molecular weight components of aurin tricarboxylic acid complex

A method of preventing and/or treating cancer in a subject is provided. The method includes administering to the subject a composition comprising an effective amount of an active agent selected from the group consisting of aurin tricarboxylic acid (ata), aurin quadracarboxylic acid (aqa), aurin hexacarboxylic acid (aha), aurin tricarboxylic acid complex (atac), and pharmaceutically acceptable salts thereof. ... Bi Incorporated

09/27/18 / #20180271812

Calcium based clinical material with antimicrobial properties and method of forming for prevention or treatment of infection

Disclosed is an absorbable, calcium based, clinical material with antimicrobial properties and a method of forming for the prevention or treatment of infection within hard and soft tissue within or on a patient's body.. . ... Bi Incorporated

09/27/18 / #20180271811

Treatment of alzheimer's disease using compounds that reduce the activity of non-selective ca++ activated atp-sensitive cation channels regulated by sur1 receptors

Nsc antagonists are disclosed as useful in the treatment of dementia, in delaying the onset of dementia, and in the prevention of dementia. Dementia so treated may be, for example, alzheimer's disease (ad). ... Bi Incorporated

09/27/18 / #20180271810

Compounds for use in the treatment of conditions associated with nadph oxidase

A compound of formula (i) or a pharmaceutically acceptable salt thereof, for use in the treatment of a condition or disorder associated with nicotinamide adenine dinucleotide phosphate oxidase.. . ... Bi Incorporated

09/27/18 / #20180271806

Nicotinic receptor non-competitive antagonists

The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.. . ... Bi Incorporated

09/27/18 / #20180271803

Compositions and methods for treatment or prevention of oral mucositis

Radiation therapy or chemotherapy may cause oral mucositis. Compositions are disclosed here which prevent and/or treat oral mucositis caused by radiation therapy or chemotherapy. ... Bi Incorporated

09/27/18 / #20180271794

Encapsulated cells producing cytochrome p450 and methods of use thereof

Disclosed herein are methods and compositions to treat solid tumors. In one embodiment, the method of treating a solid tumor in a patient includes administering at the tumor site a therapeutically effective amount of cytochrome p450 producing cells encapsulated in a capsule and administering a prodrug which is activated by cytochrome p450, wherein the prodrug is administered at least three or more cycles, and wherein each cycle comprises three consecutive daily administration.. ... Bi Incorporated

09/27/18 / #20180271676

Adjustable interbody fusion devices and methods of use

Interbody fusion devices, insertion tools, methods for assembling an interbody fusion device, and methods for inserting a medical device between two vertebral bodies are disclosed. The interbody fusion device includes a base member, a top member, and at least one movement mechanism. ... Bi Incorporated

09/27/18 / #20180271625

Dental implant with cushion

An dental implant has a substantially cylindrical hollow base member; an abutment; an implant-abutment junction (iaj) portion at one end of the base member to retain the abutment to the base member, so that the abutment is able to move within a predetermined distance alone an axial direction of the base member, and a first cushion adapted to be mounted between the abutment and the base member for providing a resistance force when the abutment is pressed to move relatively toward the base member and providing a bouncing back force when the abutment is released from the pressing.. . ... Bi Incorporated

09/27/18 / #20180271601

Method for implanting a hip prosthesis and related system

A method of implanting a hip joint prosthesis into a patient can include obtaining image data of hip joint anatomy of the patient. Physical activities that the patient desires to participate in subsequent to implanting the hip prosthesis can be determined. ... Bi Incorporated

09/27/18 / #20180271590

Catheter with deformable distal electrode

A catheter probe configured with a capability to present a larger tissue contact area or “footprint” for larger, deeper lesions, without increasing the french size of the catheter, especially its distal section, includes an elastically deformable electrode configured to adopt a neutral configuration and a tissue contact configuration. The deformable electrode comprising a hollow porous tube with a distal portion having a closed distal end, and a proximal portion defining an opening to an interior of the tube, where the distal tip end is received in the tube through the opening and the distal section is generally surrounded by tube, with the proximal portion being affixed to an outer surface of the distal section. ... Bi Incorporated

09/27/18 / #20180271583

Touch free operation of ablator workstation by use of depth sensors

An inventive system and method for touch free operation of an ablation workstation is presented. The system can comprise a depth sensor for detecting a movement, motion software to receive the detected movement from the depth sensor, deduce a gesture based on the detected movement, and filter the gesture to accept an applicable gesture, and client software to receive the applicable gesture at a client computer in an ablation workstation for performing a task in accordance with client logic based on the applicable gesture. ... Bi Incorporated

09/27/18 / #20180271580

Safe ablation of eustachian tube epithelum

Described embodiments include a method that includes inserting an ablation catheter into a eustachian tube of a subject, and, using the ablation catheter, while the subject is awake, passing an ablating signal, which is audible to the subject, through epithelial cells that line the eustachian tube, while controlling an amplitude of the ablating signal responsively to a loudness of the ablating signal as perceived by the subject. Other embodiments are also described.. ... Bi Incorporated

09/27/18 / #20180271402

Sensor for facilitating catheter visualization

Described embodiments include apparatus for use with a catheter. The apparatus includes a sheath configured for insertion into a body of a subject, and a sensor, coupled to the sheath, configured to detect an electric current passing through the catheter, when the catheter passes through the sheath and into the body of the subject. ... Bi Incorporated

09/20/18 / #20180270292

Network transfer of large files in unstable network environments

. . . . A file with a unique filename is transferred from a client computer to a server computer in chunks, which can be packaged into packets including metadata. The server computer can record indices of received chunks in a local metadata file associated with the file. ... Bi Incorporated

09/20/18 / #20180270206

Content management system

Disclosed is a content management system comprising: a server; a content database, configured within the server, within which are stored one or more channels, each channel comprising one or more stories, each story comprising a title and one or more files; and one or more user devices connected to the network, each user device being associated with a user, each user device being configured to allow the associated user to view one or more stories from a channel to which the associated user has viewing rights. The title of each story and the names of the files contained in the story are stored obfuscated in the content database, and the files are stored encrypted in the content database.. ... Bi Incorporated

09/20/18 / #20180269596

Method and structure for positioning and wrapping wire leads

A method and a structure for positioning and wrapping wire leads involve providing two leads of a transmission wire for transmitting power and/or signal with appropriate orientational limit therebetween by: wrapping a predetermined range of the two leads extending from a predetermined object with one or more segments of strip-shaped net for orientational limit that maintain independent extension and juxtaposition of the two leads, so as to prevent the leads of the transmission wire from entwining with each other after frequent orientational change caused by an external force.. . ... Bi Incorporated

09/20/18 / #20180269353

Optical element and electronic device including the same

An optical element includes a plurality of nanowires disposed in the form of an array and a light emitting material disposed on the nanowires, where the nanowires are longitudinally aligned in the array to linearly polarize at least a portion of light emitted from the light emitting material, and an electronic device includes the optical element.. . ... Bi Incorporated

09/20/18 / #20180269047

Pseudo internal standard method, device and application for mass spectrometry quantitative analysis

A pseudo internal standard method, device and application for mass spectrometry quantitative analysis is disclosed.. . ... Bi Incorporated

09/20/18 / #20180268475

Enabling a personalized conversation between retailer and customer at scale

The invention relates to the gathering of information from multiple sources: customer, retailer, and third parties with information affecting commerce. The invention further establishes communication that allows the offering to each customer an instantaneous dynamic price (idp), reflecting constantly changing conditions in the market and the customer's profile and the retailer's business imperatives and allowing the customer to place bids in lieu or in addition to purchase at the idp. ... Bi Incorporated

09/20/18 / #20180268372

Visualization of microflows or processes

A process management tool (pmt) brings together the functionalities of rigid, system-enforced workflow orchestration and user-driven, task-centric collaboration space. The pmt allows a user to store their work artifact in their preferred repositories or file sharing services. ... Bi Incorporated

09/20/18 / #20180268338

Management of microflows or processes

A process management tool (pmt) brings together the functionalities of rigid, system-enforced workflow orchestration and user-driven, task-centric collaboration space. The pmt allows a user to store their work artifact in their preferred repositories or file sharing services. ... Bi Incorporated

09/20/18 / #20180268038

Systems and methods for similarity and context measures for trademark and service mark analysis and repository searches

Exemplary embodiments of the present disclosure provide for identifying similar trademarks from one or more repositories and providing an interactive graphical user interface in which selectable graphical segments corresponding to the trademarks in a graphical user interface are grouped based on similarity measures associated with one or more characters of the trademarks and arranged radially and circumferentially in the graphical user interface about a central circle representing the trademark input string of an electronic search order. Retrieval of the trademarks in the set can include a subset of possible trademarks available for retrieval that would satisfy one or more of the similarity measures and a color of each of the selectable graphical segments depends on whether the trademarks retrieved corresponding to the selectable graphical segments represent a complete set of the possible trademarks available, a subset of the possible trademarks available, or a null set of the possible trademarks available. ... Bi Incorporated

09/20/18 / #20180267700

User interface for medical information

A user interface for medical information includes a timeline that can be highlighted or selected by a time window with a time duration, and the information plots of biomarkers displayed in subsystem displays can update to display the biomarker information for the time duration highlighted by the time window. The trendline, baseline, and data points shown on the information plot(s) can also be adjusted to display only information during the time duration highlighted or selected by the time window.. ... Bi Incorporated

09/20/18 / #20180267331

Contact lens containing a photonic crystal

A contact lens containing a photonic crystal which is configured to change color depending on a concentration of an analyte in the tears of a subject. The change in color is reversible. ... Bi Incorporated

09/20/18 / #20180267059

Compositions and methods for treating age-related diabetes and related disorders

The invention features compositions and methods treating or preventing for age-related insulin resistance, type 2 diabetes and related disorders. The method involves depleting ftreg cells with an anti-st2 antibody to decrease age-related ftreg accumulation and restore insulin sensitivity, thereby treating age-related insulin resistance, type 2 diabetes and related disorders.. ... Bi Incorporated

09/20/18 / #20180267048

Method and composition using a quaternary ammonium compound

A method (e.g. High resolution melting analysis) of determining of the presence or absence of a target nucleic acid in a sample, e.g. ... Bi Incorporated

09/20/18 / #20180267037

Method for the noninvasive detection of activated bifidobacteria

Some embodiments of the invention include a kit and a device for detecting activated bifidobacteria. Methods of making and using the kit and/or device are also described herein.. ... Bi Incorporated

09/20/18 / #20180267025

Cancer analysis system

The invention provides for detecting target subpopulations of cells that have high proliferative and renewal properties in animals, including circulating tumor cells, cancer stem cells, hematopoietic stem cells and endothelial progenitor cells. The invention utilizes a defined substrate and media of known property to enrich target cell subpopulations which can be used for future genetic, proteomic and morphological analyses. ... Bi Incorporated

09/20/18 / #20180267024

Composition for determination of cell-mediated immune responsiveness

The present invention relates to a composition comprising (i) a first substance which is capable to stimulate t cells, (ii) a second substance which is capable to stimulate nk cells (natural killer cells), and (iii) lipopolysaccharide (lps) and wherein the second substance is a double stranded nucleic acid, single stranded nucleic acid, unmethylated cpg oligodeoxynucleotide, tlr agonist except lipopolysaccharide (lps), arabinoxylan (biobran® mgn-3), an immunoglobulin, a murine cytomegalovirus (mcmv)-encoded protein, ccl5 (chemokine (c—c motif) ligand 5), a ul-16-binding protein (ulbp), cd48, cd70, cd155, cd112, necl-1, b7-h6, icam-1, rae-1 (retinoic acid early inducible 1), h60, mult1 and/or hemagglutinin, to a method for measuring, determining and/or detecting the status of cell-mediated immune responsiveness of a subject, to a kit comprising the composition according to the invention, to the use of the composition for measuring, determining and/or detecting of cell-mediated immunity (cmi) and/or for detecting, diagnosing, monitoring an immunosuppression condition in a subject.. . ... Bi Incorporated

09/20/18 / #20180266977

Odor sensor and odor measurement system

According to various embodiments, there is provided an odor sensor including at least two sensor elements each having a substance adsorbing membrane for adsorbing one or more odor substances included in air; and an electrical signal conversion unit for measuring the electrical characteristics of the substance adsorbing membrane after adsorption of the substance, in which the substance adsorbing membrane has a main skeleton containing an electroconductive polymer and contains a dopant for modifying the main skeleton of the electroconductive polymer, and the at least two sensor elements are respectively provided with substance adsorbing membranes having different proportions of the main skeleton and the dopant. Also provided is an odor measurement system using the sensor.. ... Bi Incorporated

09/20/18 / #20180266713

Method of operating a humidifying module, humidifying module, and incubator or climatic chamber with humidifying module

A method of operating a humidifying module for an incubator, the humidifying module having a container with a water inlet and a steam outlet, a heating device which is arranged in the interior of the container, and a temperature sensor and a control circuit for controlling or regulating a water supply through the water inlet and/or for controlling or regulating a heat output of the heating device, wherein container is filled with water, at a maximum, so that a steam volume remains, in which there is steam generated when heating with the heating device, wherein part of the heating device protrudes from the water and projects into the steam volume, so that the steam can be superheated, and wherein the temperature sensor is arranged to directly or indirectly measure the temperature of the steam, the measured temperature being used as a control parameter by the control circuit, a humidifying module for an incubator for carrying out such a method, and an incubator with such a humidifying module.. . ... Bi Incorporated

09/20/18 / #20180266681

Safety device for catalytic converter

Safety devices prevent packaged catalytic converters from being expelled from stacks, or at least reduce the velocity with which such a package may be expelled, in case of an explosion in a bio-fueled appliance, such as a wood-burning stove.. . ... Bi Incorporated

09/20/18 / #20180266600

Connection clamping device

A connection clamping device (21; 61; 81; 131; 151) arranged for connecting a flexible tube (1) to a barbed end (5b) of a connection means (5), whereby the barbed end (5b) comprises a barb (9) and the connection means during connection is arranged to protrude into an end of the flexible tube (1), characterized in that said connection clamping device comprises two halves (23a, 23b) which, during connection when the connection means protrudes into an end of the flexible tube, are arranged to be connected and locked to each other by a locking mechanism (33a,33b,34a,34b; 63a, 63b, 64a, 64b) around the connection means (5) and the flexible tube (1), such that the flexible tube (1) is compressed against the connection means (5) by a rib (41a, 41b) provided on the inner circumference of the connection clamping device.. . ... Bi Incorporated

09/20/18 / #20180266172

Garage door systems and methods

Provided are door systems having a plurality of door panels and a frame, the door panels being movable between an extended position closing an opening in a building structure, and a folded retracted position. When in the extended position, the door panels interlock with each other forming a barrier to wind, dirt, dust and insects. ... Bi Incorporated

09/20/18 / #20180266169

Garage door systems and methods

Provided are door systems having a plurality of door panels and a frame, the door panels being movable horizontally between an extended position closing an opening in a building structure, and a folded retracted position opening the opening in the building structure. When in the extended position, the door panels interlock with each other forming a barrier to wind, dirt, dust and insects. ... Bi Incorporated

09/20/18 / #20180265925

Molecular signatures for use in diagnosis and response to treatment analysis of autoimmune diseases

The present invention relates to molecular signatures that can be used to identify patients diagnosed with an autoimmune disease, in particular with systemic lupus erythematosus for treatment with a cd40 or cd40l antagonist such as anti-cd40 antibody, anti-cd40l antibody or a binding fragment thereof. The signatures can also be used to monitor target engagement and response to treatment.. ... Bi Incorporated

09/20/18 / #20180265915

Transcription factor decoys

Methods and compositions for altering prokaryotic cellular viability phenotypes, including antibiotic susceptibility.. . ... Bi Incorporated

09/20/18 / #20180265910

Cleavage of fucose in n-glycans

Provided herein is an α-fucosidase that can cleave a conjugate comprising an n-glycan and a label where the label is added by amine reactive chemistry. The α-fucosidase also has an accelerated reaction time using schiff base labeled n-glycans compared with bkf. ... Bi Incorporated

09/20/18 / #20180265903

Process for the production of malate

The present invention relates to the microbial production of malate. Fungal cells belonging to a species of the family of ustilaginaceae were found to be an excellent host for the production of malate from glycerol. ... Bi Incorporated

09/20/18 / #20180265900

Process and method for simultaneous saccharification and fermentation using microalgae

The present invention generally relates to the production of biofuels and, in particular, to a process for simultaneous saccharification and fermentation using a microalgae substrate. According to one aspect of the present invention, a process is provided in which the temperature and ph of a broth mixture are adjusted to slow the rate of glucose conversion and to match the glucose metabolizing rate of the microalgae.. ... Bi Incorporated

09/20/18 / #20180265896

Fungal production of fdca

The invention relates to fungal cells for the production of fdca. The fungal cell is genetically modified to have at least one of a) a genetic modification that confers to or increases in the cell the ability to oxidize 5-hydroxymethyl-2-furancarboxylic acid to 5-formyl-2-furoic acid; and, b) a genetic modification that reduces catabolism of 2,5-furandicarboxylic acid in the cell. ... Bi Incorporated

09/20/18 / #20180265884

Wheat with reduced lipoxygenase activity

A series of independent human-induced non-transgenic mutations found at one or more of the lpx genes of wheat; wheat plants having these mutations in one or more of their lpx genes; and a method of creating and finding similar and/or additional mutations of lpx by screening pooled and/or individual wheat plants. The wheat plants disclosed herein exhibit decreased lipoxygenase activity without having the inclusion of foreign nucleic acids in their genomes. ... Bi Incorporated

09/20/18 / #20180265883

Wheat with increased resistant starch levels

A series of independent human-induced non-transgenic mutations found at one or more of the sbeii genes of wheat; wheat plants having these mutations in one or more of their sbeii genes; and a method of creating and finding similar and/or additional mutations of sbeii by screening pooled and/or individual wheat plants. The seeds and flour from the wheat plants of the present invention exhibit an increase in amylose and resistant starch without having the inclusion of foreign nucleic acids in their genomes. ... Bi Incorporated

09/20/18 / #20180265882

Plants with increased seed size

The invention relates to genetically modified plants with an altered seed phenotype, in particular increased seed size. The invention relates to a plant that does not produce a functional ngal2 polypeptide or functional ngal2 and ngal3 polypeptides. ... Bi Incorporated

09/20/18 / #20180265862

The method of synthesis and purification of a nucleoside and/or a nucleotide, a modified nucleoside and/or nucleotide, a dna molecule and an oligonucleotide library comprising said modified nucleoside and/or nucleotide and the use of said oligonucleotide library

The object of the invention is a method of synthesis and purification of a nucleoside and/or a nucleotide being a mono-, di- or triphosphate, wherein a huisgen's azide-alkyne cycloaddition reaction is being performed using a compound of structure (1) with a compound chosen from the group of structures (2) to (5). The object of the invention is also a modified nucleoside and/or nucleotide of structure (10), a dna molecule and an oligonucleotide library comprising one or more modified nucleotides and the use of said oligonucleotide library for aptamers selection.. ... Bi Incorporated

09/20/18 / #20180265857

Recombinant batroxobin mixed composition and a hemostatic powder or hemostatic pad comprising same

The present invention relates to a novel recombinant batroxobin mixture, a hemostatic composition comprising the same, and a method for preparing the same. According to the present invention, the hemostatic composition of the present invention has an excellent hemostatic effect by suppressing rebleeding, and maintains activity thereof even when prepared in a solid form, and thus, the composition of the present invention can be easily used by being applied as a topical hemostatic agent.. ... Bi Incorporated

09/20/18 / #20180265854

Cleavage of fucose in n-glycans

Provided herein is an α-fucosidase that can cleave a conjugate comprising an n-glycan and a label where the label is added by amine reactive chemistry. The α-fucosidase also has an accelerated reaction time using schiff base labeled n-glycans compared with bovine kidney fucosidase. ... Bi Incorporated

09/20/18 / #20180265852

Compositions and methods comprising the use of exiguobacterium acetylicum and bacillus coagluans alpha-glucanotransferase enzymes

An isolated and/or purified α-glucanotransferase from exiguobacterium acetylicum, recombinantly engineered variants thereof, active fragments thereof, synthetic nucleic acids encoding the α-glucanotransferase and variants thereof, host cells comprising the synthetic nucleic acids, and compositions comprising the α-glucanotransferase are provided. Methods of using the compositions include the manufacture of oligosaccharides.. ... Bi Incorporated

09/20/18 / #20180265845

Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene

Disclosed herein is a genetically-modified cell comprising in its genome a modified human t cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous t cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.. ... Bi Incorporated

09/20/18 / #20180265842

Pluripotent stem cell culture on micro-carriers

The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on micro-carriers.. . ... Bi Incorporated

09/20/18 / #20180265652

Cross-linked biopolymer macroscopic systems and method of making same

Disclosed are macroscopic systems of highly concentrated, cross-linked biopolymers. The macroscopic system is created by combining a biopolymer with a cross-linking agent, submerging the resulting product in an aqueous solution which contains additional cross-linking agents, to allow the biopolymer to undergo a second cross-linking process. ... Bi Incorporated

09/20/18 / #20180265596

Binding molecules with modified j-chain

The present invention concerns binding molecules that comprise an igm, iga, igg/igm or igg/iga antibody with a j-chain modified to include an ad-me-modulating moiety, and their uses.. . ... Bi Incorporated

09/20/18 / #20180265583

Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer

This invention relates to humanized antibodies that selectively bind the 31.1 epitope on the a33 protein differentially expressed in cancers including, lung cancer, ovarian cancer, pancreas cancer, breast cancer, and colon cancer, and diagnostic and therapeutic usages.. . ... Bi Incorporated

09/20/18 / #20180265580

Novel p2x7 epitopes

The invention relates to purinergic (p2x) receptors, more specifically to p2x7 receptors, the generation of antibodies and the use of antibodies and immunogens that are capable of selectively binding to a non atp-binding p2x7 receptor but not to an atp-binding p2x7 receptor, for the detection and treatment of disease conditions, especially cancer.. . ... Bi Incorporated

09/20/18 / #20180265575

Anti-phf-tau antibodies and uses thereof

Monoclonal anti-phf-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.. ... Bi Incorporated

09/20/18 / #20180265574

Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection

The present invention relates to compositions and methods for the treatment of infection caused by streptococcus pneumonia. In particular, the invention provides human hyperimmune globulin and compositions thereof for preventing or treating pneumococcal infection. ... Bi Incorporated

09/20/18 / #20180265551

Cytomegalovirus antigens

The invention generally relates to recombinant human cytomegalovirus (cmv) gb proteins and immunogenic fragments thereof, which do not comprise a transmembrane (tm) domain; and comprise one or more mutations that reduce the aggregation between the monomeric trimers of gb, and/or adhesion of the monomeric trimer of gb to the host cell.. . ... Bi Incorporated

09/20/18 / #20180265540

Synthesis of estetrol via estrone derived steroids

A process is provided for the making of estetrol starting from a 3-a-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein a is an c1-c5 alkyl group, preferably a methyl group, or a c7-c12 benzylic group, preferably a benzyl group. This process is particularly suitable to industry.. ... Bi Incorporated

09/20/18 / #20180265523

Antibacterial therapeutics and prophylactics

The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.. . ... Bi Incorporated

09/20/18 / #20180265511

Compounds and compositions for treating chemical warfare agent-induced injuries

Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.. . ... Bi Incorporated

09/20/18 / #20180265490

Methods for producing beraprost and its derivatives

The present invention is directed to methods for preparing beraprost and novel synthetic intermediates for beraprost.. . ... Bi Incorporated

09/20/18 / #20180264666

Shaving aid adaptor for a shaving cartridge

An adaptor for a shaving cartridge is provided. The adaptor is provided with at least one shaving aid. ... Bi Incorporated

09/20/18 / #20180264642

Ensuring operator engagement in an exoskeleton bionic device

An operator supervising a wearer of an exoskeleton is verified by performing a verification routine on the operator using the exoskeleton. If the verification routine is unsuccessful, the exoskeleton is caused to follow a pre-established response routine. ... Bi Incorporated

09/20/18 / #20180264464

Nitrocellulose extrusion for porous film strips

Methods and systems are provided making a porous nitrocellulose strip for use in a lateral flow test. The strip may be formed from a liquid polymer mixture dispensed onto the planar surface via a dispensing device positioned vertically above the planar surface. ... Bi Incorporated

09/20/18 / #20180264428

De novo synthesized gene libraries

De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. ... Bi Incorporated

09/20/18 / #20180264247

Minimally invasive methods and systems for hemostasis in a bleeding closed tissue volume

Disclosed herein are improved methods and apparatuses for providing hemostasis within a cavity defined by an internal surface of a bleeding tissue space. A catheter comprising a proximal end and a distal end may be advanced into the cavity through a proximal opening of the tissue space into the cavity. ... Bi Incorporated

09/20/18 / #20180264243

System for integrating an antibacterial-element receptacle into an autoinjector cap

A system for integrating an antibacterial-element receptacle into an autoinjector cap facilitates the pre-injection treatment, the post-injection treatment, and prevents the accidental delivery of the injection. The system includes a cap assembly, an autoinjector body, and an antiseptic-soaked dressing. ... Bi Incorporated

09/20/18 / #20180264205

Reducing pain of skin piercing using vibration

An instrument is applied to body tissue of a body part to produce vibration to thereby reduce pain of injection or other pain producing stimulus. The device has a frame, and a source of vibration connected to the frame. ... Bi Incorporated

09/20/18 / #20180264199

Apparatus and method for the preparation and administration of blood components

A dual chambered syringe includes: an inner barrel defining a first inner chamber, the inner barrel having an apertured stopper at its distal end, the inner barrel being open at its proximal end; a shaft adapted to fit within the inner barrel, the shaft having a distal end which is engageable with the aperture of the stopper; a device for controlling engaging and disengaging of the distal end of the shaft with the aperture of the stopper; an outer barrel concentric with the inner barrel defining a second inner chamber, the outer barrel having a distal end for receiving and dispensing fluids and a proximal end into which the distal end of the inner barrel is insertable into the second inner chamber; the apertured stopper engages the second inner chamber of the outer barrel and selectively prevents or permits the passage of fluids between the outer barrel second chamber and the inner barrel first chamber; the inner barrel having an engageable surface on its outside surface; and, the outer barrel having operatively associated therewith an engaging device for selective engagement and disengagement with the engageable surface on the inner barrel.. . ... Bi Incorporated

09/20/18 / #20180264179

Biodegrading implantable ocular sustained release drug delivery system

An ocular implant is provided for an intraocular delivery of a therapeutic biologic agent. The implant may be used intracamerally or intravitreally. ... Bi Incorporated

09/20/18 / #20180264148

Tissue allograft sterilization method

The invention is a novel method of sterilizing bone and soft tissues intended for human transplantation. In one embodiment the process includes steps of subjecting transplants to high hydrostatic pressures of aqueous fluid to which chlorhexidine gluconate or similar sterilizing chemicals have been added.. ... Bi Incorporated

09/20/18 / #20180264140

Motor neuron-specific expression vectors

The present disclosure relates to nucleic acid promoter sequences that are able to specifically express genes operatively linked to the promoter in brainstem and spinal motor neuron cells, and to methods for using such promoters to selectively express genes in motor neurons in vitro and in vivo. It is based, at least in part, on the discovery that the nucleic acid of seq id no: 1 functioned as a motor neuron-specific promoter and was successful in expressing transgenes in motor neuron cells in vivo. ... Bi Incorporated

09/20/18 / #20180264137

Thymidine kinase diagnostic assay for gene therapy applications

Nucleic acid sequences encoding improved herpes simplex virus thymidine kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. ... Bi Incorporated

09/20/18 / #20180264134

A composition of gold nanoparticles having antimicrobial peptides bound on their surface for use the treatment of wound healing or in the treatment of ischemic or vascular diseases or in the treatment of skin disorders

The present disclosure relates to an antimicrobial peptide conjugated with nanoparticles, in particular the antimicrobial peptide ll37-conjugated gold nanoparticles for use in medicine or cosmetic, for human or animals, namely in the treatment of wound healing or in the treatment of ischemic or vascular diseases, comprising a gold nanoparticle and a plurality of ll-37 peptides, wherein the plurality of ll-37 peptides is bound to the gold nanoparticle surface.. . ... Bi Incorporated

09/20/18 / #20180264128

Compounds for medicinal applications

The present invention provides compounds for use in treating and/or preventing influenza. The compound comprises a first and second domain in which the first domain comprises at least one anchoring group which binds to the surface of influenza viruses and the second domain comprises at least one anionic group. ... Bi Incorporated

09/20/18 / #20180264122

Cannabinoid glycoside prodrugs and methods of synthesis

The present invention relates to cannabinoid glycoside prodrugs suitable for site- and tissue-specific delivery of cannabinoid molecules. The present invention also relates to methods of forming the cannabinoid glycoside prodrugs through glycosyltransferase mediated glycosylation of cannabinoid molecules.. ... Bi Incorporated

09/20/18 / #20180264112

Anti-cd40 antibody formulations

Provided herein, in some aspects, are low viscosity, low aggregation propensity, high anti-cd40 antibody concentration formulations.. . ... Bi Incorporated

09/20/18 / #20180264108

Immunoglobulin-like molecules directed against fibronectin-eda

The present invention is concerned with immunoglobulin (ig)-like molecules or fragments thereof for use in treatment, prevention, or prevention of progression of adverse cardiac remodelling and conditions resulting from or relating to pressure-overload, such as heart failure, aneurysm formation and remote myocardial fibrosis and for use in improving angiogenesis, preferably after ischemic injury. The invention also provides nucleic acid molecules encoding said ig-like molecules, vectors comprising same, and host cells comprising same.. ... Bi Incorporated








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