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Bi Incorporated patents


Recent patent applications related to Bi Incorporated. Bi Incorporated is listed as an Agent/Assignee. Note: Bi Incorporated may have other listings under different names/spellings. We're not affiliated with Bi Incorporated, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "B" | Bi Incorporated-related inventors


Mobile device security lock

. . . . . . Management of a mobile device security lock is described herein. A method as described herein includes connecting, by a system comprising a processor, to a trusted device via a first wireless communication link, receiving, by the system, a lock command from the trusted device, in response to receiving the lock command, transitioning from an open access mode of the system to a limited access mode, connecting, by the system, to a non-trusted device via a second wireless communication link while in the limited access mode, attempting, by the system, to obtain an authorization for communication by the system with the non-trusted device, and in response to the attempting to obtain the authorization being determined to be unsuccessful, preventing the communication with the non-trusted device.. ... Bi Incorporated

Second opinion network

Systems and methods are provided to facilitate consultations between a referral source (e.g., labs, pathologists and patients) and a consultant (e.g., pathologist, radiologist, or other digital image analyst). Links between the various referral sources and consultants are established through a scanning center via a data communication network such as the internet. ... Bi Incorporated

Systems and methods for selective enhancement of a region of interest in an image

The present disclosure provides systems and methods for receiving ultrasound image data corresponding to an ultrasound image with a master dynamic range and displaying a globally tone-mapped version of the ultrasound image on an electronic display. A region of interest (roi) within the ultrasound image may be regionally tone mapped to provide an enhanced, optimized, and/or otherwise improved image of the roi. ... Bi Incorporated

System and method for generating antibody libraries

The invention relates to system and method for generating an antibody library. Specifically, the invention relates to a computer-implemented system and method for generating a library of antibodies based on a predetermined epitope.. ... Bi Incorporated

Device and method for generating a model of an object with superposition image data in a virtual environment

A device for generating a model of an object with superposition image data in a virtual environment includes an image capturing element configured to generate an image data stream of the object as well as a calculating unit configured to extract, from the image data stream, a model of the object from a real environment, to insert the extracted model into the virtual environment, and to superpose at least part of the model with superposition image data so as to generate the model of the object with superposition image data in the virtual environment, and a display element configured to display the model of the object with superposition image data in the virtual environment.. . ... Bi Incorporated

Microscope module for a microscope arrangement for imaging a sample

A microscope module (300) for imaging a sample (270) is disclosed. The microscope module (300) includes at least one illumination objective (210) for producing an illumination beam along an illumination beam path (215) arranged to illuminate lower surface of the sample (270) and at least one detection objective (220) having a detection path (225). ... Bi Incorporated

Materials and methods for performing histochemical assays for human pro-epiregulin and amphiregulin

The invention provides anti-human pro-epiregulin and anti-human amphiregulin antibodies and methods of using the same. Anti-ereg antibodies raised against amino acids 148-169 and 156-169 of the human ereg protein, and anti-areg antibodies raised against amino acids 238-252 of the human areg protein are disclosed. ... Bi Incorporated

Predictive baseline biomarkers for use of vascular disrupting agents

The present disclosure relates to the biological markers ferritin and il-8 that are predictive for patient response to treatment with a vascular disrupting agent. In particular, the present disclosure relates to biological markers predictive for cancer patient response to treatment with a vascular disrupting agent, as well as methods of treating a cancer patient with a vascular disrupting agent.. ... Bi Incorporated

Pd-l1 antibodies and uses thereof

Provided herein are pd-l1 antibodies and methods for using the same for detecting human pd-l1 protein in biological samples. The pd-l1 antibodies and methods may be useful for diagnosing a medical condition associated with elevated pd-l1 levels (e.g., cancer) in subjects in need thereof and in evaluating the efficacy of a particular therapeutic regime in a subject diagnosed as having a pd-l1-related medical condition, among other uses.. ... Bi Incorporated

Predictive biomarkers

The present disclosure relates to the biological markers sap, shbg, myoglobin, mmp-9, and scf that are predictive for patient response to treatment with a vascular disrupting agent. In particular, the present disclosure relates to biological markers predictive for cancer patient response to treatment with a vascular disrupting agent, as well as methods of treating a cancer patient with a vascular disrupting agent.. ... Bi Incorporated

Method and kit for determining the probability that a patient will develop a severe case of dengue

A kit for determining whether a patient will develop severe dengue includes a binding partner for platelet factor 4 and a binding partner for at least one member selected from the group consisting of dengue virus ns1 protein, olfactomedin 4, and α2-macroglobulin. The kit may further include a label reagent capable of generating a detectable signal.. ... Bi Incorporated

Method and kit for determining the probability that a patient will develop a severe case of dengue

A kit for determining whether a patient will develop severe dengue includes a binding partner for olfactomedin 4 and a binding partner for at least one member selected from the group consisting of dengue virus ns1 protein, platelet factor 4, and α2-macroglobulin. The kit may further include a label reagent capable of generating a detectable signal.. ... Bi Incorporated

Lateral flow assays for non-diagnostic analytes

Methods of determining whether a non-diagnostic analyte is present in a non-diagnostic sample are provided. Aspects of the methods include applying a non-diagnostic sample to a sample receiving region of a lateral flow assay device and reading a detection region to determine whether a non-diagnostic analyte is present in the non-diagnostic sample. ... Bi Incorporated

Apparatus and method for separating and concentrating fluids containing multiple components

An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. ... Bi Incorporated

07/12/18 / #20180195986

Device for electrical measurement of target chemical substance, and method therefor

A device for electrical measurement of a target chemical substance includes: an electrode array element including a base, an electrode array section in which electrodes which are disposed on the base and to each of which a test substance is fixed or can be fixed are arrayed, and a terminal array section in which terminals disposed on the base so as to correspond to the electrodes and electrically connected to the electrodes are arrayed; a processing head having an electrode array element support section supporting the electrode array element detachably to make electrical connection to the terminals possible; a container group including a liquid storing section and a measurement container; a support section moving mechanism; and a measurement section capable of measuring a signal generated by applying a predetermined voltage to a test substance fixed to each of the electrodes in the measurement container.. . ... Bi Incorporated

07/12/18 / #20180195798

Lyophilizer container and method of use thereof

The present embodiments generally relate to containers having utility in the lypohilization of fluids to form powers and to methods of using such containers. One embodiment provides a side-ported syringe. ... Bi Incorporated

07/12/18 / #20180195732

Smokeless fire pit

A combustion device includes a combustion chamber with an outer wall enclosing a combustion space that can contain a fuel source on an adjustable fuel rack, side walls, a lower air jet tube and at least one air upper jet tube, a top opening, a grill top assembly to cover the opening, and a detachable power module. The power module can have batteries and a blower. ... Bi Incorporated

07/12/18 / #20180195573

Bicycle damper

A damper for a bicycle having a primary unit and a remote unit that, in some arrangements, is substantially entirely outside of the primary unit. The primary unit includes a damper tube, a spring chamber, and a piston rod that supports a main piston. ... Bi Incorporated

07/12/18 / #20180195112

Droplet tagging contiguity preserved tagmented dna

Methods and compositions for maintaining dna contiguity for sequencing is provided.. . ... Bi Incorporated

07/12/18 / #20180195102

Cell expression system

An expression system for expressing a protein comprising: a eukaryotic host cell carrying a dihydrofolate reductase (dhfr) deficiency; and an expression vector, the expression vector encoding the human growth hormone gene; a expression vector, the expression vector comprising: a eukaryotic selectable marker including a minimal sv 40 early promoter driving expression of a sequence encoding dihydrofolate reductase for complementing the dhfr deficiency in the host cell; a prokaryotic selectable marker conveying ampicillin resistance to a prokaryotic host cell; a prokaryotic origin of replication; a plurality of multiple cloning sites (mcs); and at least one protein expression module comprising: a simian vacuolating virus 40 (sv40) early promoter, inclusive of its 72 bp enhancer repeats; and a rabbit β-globin intron sequence being separable from a sv40 p a sequence by a first multiple cloning site, for receiving a coding sequence and expressing a desired protein therefrom.. . ... Bi Incorporated

07/12/18 / #20180195093

Metschnikowia species for biosynthesis of compounds

Provided herein are metschnikowia species that produce useful compounds from xylose when cultured, as well as methods to make and use these metschnikowia species.. . ... Bi Incorporated

07/12/18 / #20180195092

Methods and organism with increased xylose uptake

Provided herein are novel xylose transporters and their variants, as well as nucleic acid encoding the novel xylose transporters and their variants. Provided herein are also non-naturally occurring microbial organisms having increased xylose uptake and increased production of bioderived compounds using xylose as a substrate, as well as methods to make and use these microbial organisms.. ... Bi Incorporated

07/12/18 / #20180195084

Method for increasing ability of a plant to resist an invading dna virus

The present invention discloses a method for improving the ability to resist against an intrusive dna virus of a plant. The present invention provides a method for making a plant with improved ability to resist against a dna virus, specifically can comprising the following steps: 1) selecting a sequence comply with 5′-nx-ngg-3′ or 5′-ccn-nx-3′ from the genomic sequence of the dna virus as the target sequence; designing a dna sequence reverse-complementary to said target sequence; 2) constructing said dna sequence to a vector for expressing crispr/cas9 nuclease so as to obtain a recombinant vector capable of transcribing a guide rna and expressing a cas9 protein; the crrna in said guide rna contains a rna fragment transcribed from said dna fragment; 3) introducing said recombinant vector into a recipient plant so as to obtain a plant with improved ability to resist against said dna virus. ... Bi Incorporated

07/12/18 / #20180195061

Methods for labeling a population of rna molecules

A method of labeling, and optionally enriching, for a population of target rna molecules in a mixture of rnas is provided. In some embodiments, the method may comprise (a) adding a label to the 5′ end of 5′-diphosphorylated or 5′-triphosphorylated target rna molecules in a sample by incubating the sample with labeled gtp and a capping enzyme; and (b) optionally enriching for target rna comprising the affinity tag-labeled gmp using an affinity matrix that binds to the affinity tag. ... Bi Incorporated

07/12/18 / #20180195059

Transposase competitor control system

Disclosed is a method of fragmenting dna comprising contacting a sample of target dna with (a) a composition comprising an active transpososome, and (b) a composition comprising an inactive transpososome, under conditions suitable for transpososome activity, wherein a ratio of an amount of the inactive transpososome in the composition of (b) to an amount of the active transpososome in the composition of (a) determines the mean fragment size and a level of insertion bias.. . ... Bi Incorporated

07/12/18 / #20180195051

Methods and organism with increased ethanol production

Provided herein are non-naturally occurring microbial organisms having increased xylose metabolism and increased production of ethanol using xylose as a substrate, as well as methods to make and use these microbial organisms to produce ethanol.. . ... Bi Incorporated

07/12/18 / #20180195040

Engineered endothelial cells expressing an ets transcription factor

In some aspects the present invention relates to engineered endothelial cells, such as e40rf1+ etv2+ engineered endothelial cells. In other aspects the present invention relates to methods of making such engineered endothelial cells, and methods of using such engineered endothelial cells, for example in co-culture applications.. ... Bi Incorporated

07/12/18 / #20180195017

Processed biochar pellets from beneficiated organic-carbon-containing feedstock

A process for making a renewable processed biochar pellet composition made with a pelletizing sub-system followed with a heating sub-system from a processed organic-carbon-containing feedstock made with a beneficiation sub-system is described. Renewable biomass feedstock passed through a beneficiation sub-system to reduce water content to below at least 20 wt % and an intracellular water-soluble salt reduction of at least 60% from that of unprocessed organic-carbon-containing feedstock on a dry basis. ... Bi Incorporated

07/12/18 / #20180194863

Oxygen barriers based on modified cellulose fibers

There is provided a use of a material comprising fibers as an oxygen barrier, wherein the fibers comprise native cellulose and dialcohol cellulose. There is also provided a material comprising fibers and having a density of at least 1200 kg/m3, wherein the fibers comprise native cellulose and dialcohol cellulose and the oxygen permeability of the material according to astm d3985 is below 30 ml·μm/(m2·kpa·24 h) at 23° c. ... Bi Incorporated

07/12/18 / #20180194862

Bispecific binding proteins

The present disclosure provides bispecific proteins that bind to two antigens, as well as their compositions, uses, and methods of making.. . ... Bi Incorporated

07/12/18 / #20180194856

Fusion proteins which bind to human fc receptors

The invention relates to fusion proteins which bind to human fc-receptors. The fusion proteins are initially produced as monomers, and are capable of assembly into multimers at a target site of interest. ... Bi Incorporated

07/12/18 / #20180194855

Anti-ox40 antibodies and their uses

The present disclosure provides novel anti-ox40 antibodies, compositions including the antibodies, nucleic acids encoding the antibodies, and methods of making and using the same.. . ... Bi Incorporated

07/12/18 / #20180194848

Compositions comprising rank/rankl antagonists and related compounds for treating pain

Disclosed herein are methods of treating pain using rank/rankl antagonists.. . ... Bi Incorporated

07/12/18 / #20180194843

Immunoglobulin formulation and method of preparation thereof

A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer which inhibits polysorbate oxidation is described along with methods of making the preparation. Also described are formulations with high antibody concentrations which maintain fixed volumes and which may be used on patients of variable weight.. ... Bi Incorporated

07/12/18 / #20180194832

Tau-binding antibodies

The present invention relates to tau-binding antibodies and binding fragments thereof.. . ... Bi Incorporated

07/12/18 / #20180194805

Use of pentapeptide-3 kttks or hexapeptide-3 kttksf for treating degenerative joint disease

Use of pentapeptide-3 kttks or hexapeptide-3 kttksf for treating degenerative joint disease is disclosed. A pharmaceutical composition comprising an effective amount of pentapeptide-3 kttks or hexapeptide-3 kttksf and a pharmaceutically acceptable carrier is also disclosed.. ... Bi Incorporated

07/12/18 / #20180194801

Method for isolating and purifying recombinant human serum albumin from transgenic rice grain

A method for separating and purifying recombinant human serum albumin (rhsa) from transgenic rice grain, sequentially comprising the steps of: 1) subjecting crude extract of rhsa to cation exchange chromatography to obtain primary product i; 2) subjecting the primary product i to anion exchange chromatography to obtain secondary product ii; 3) subjecting the secondary product ii to hydrophobic chromatography to obtain purified rhsa. The method may further comprise a step of ceramic hydroxyapatite chromatography prior to the hydrophobic chromatography. ... Bi Incorporated

07/12/18 / #20180194795

Guanine-rich oligonucleotides

This invention relates to methods for oligonucleotide synthesis, specifically the synthesis of oligonucleotides that contain a high content of guanine monomers. In more detail, the invention relates to a method for coupling a nucleoside phosphoramidite during the synthesis of an oligonucleotide to a universal support, to a first nucleoside, or to an extending oligonucleotide.. ... Bi Incorporated

07/12/18 / #20180194793

Substituted nucleosides, nucleotides and analogs thereof

Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.. ... Bi Incorporated

07/12/18 / #20180194765

Compositions and methods for inhibiting beta-lactamase

Substituted dihydroisoxazole derivatives useful as inhibitors of β-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.. ... Bi Incorporated

07/12/18 / #20180194717

Amino acid derivatives and absorbable polymers therefrom

The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. ... Bi Incorporated

07/12/18 / #20180194706

Method for manufacturing succinic acid

The invention pertains to a method for preparing succinic acid comprising the steps of —providing an aqueous magnesium succinate solution to an acidification step, wherein the magnesium succinate solution is acidified by the addition of hydrogen chloride, thereby obtaining an aqueous solution comprising succinic acid and magnesium chloride; —subjecting an aqueous solution comprising succinic acid and magnesium chloride derived from the acidification step to a treatment step with active carbon, —precipitating succinic acid from an aqueous mixture comprising succinic acid and magnesium chloride resulting from the active carbon treatment step in a precipitation step to form solid succinic acid and a magnesium chloride solution, —separating the solid succinic acid from the magnesium chloride solution —subjecting the magnesium chloride solution to a thermal decomposition at a temperature of at least 300° c., thereby decomposing the magnesium chloride to magnesium oxide and hydrogen chloride, and —recycling the hydrogen chloride generated in the thermal decomposition step to the acidification step. It has been found the method according to the invention leads to succinic acid crystals with better properties than a comparable method wherein no active carbon treatment is used.. ... Bi Incorporated

07/12/18 / #20180194548

Modular container transport systems

Disclosed are apparatus, systems, and methods, including a cargo transport system comprising a spine assembly, a container assembly, and an outer fairing. The spine assembly comprises a rigid spine and a plurality of mounts arranged on the rigid spine in a plurality of mount rows. ... Bi Incorporated

07/12/18 / #20180194545

Single-dose capsule for the preparation of beverages

A single-dose capsule for the preparation of a beverage comprises a cup (1) with a collar (10) provided with a sealing ring (20) surrounded internally and externally by centring projections (30.i, 40.i), separated circumferentially from gaps (32,42) and arranged aligned in succession along respective circumferential paths (34, 44).. . ... Bi Incorporated

07/12/18 / #20180194470

Modular container transport systems

A cargo transport system comprising a spine assembly and a container assembly. The spine assembly comprises a rigid spine and a plurality of mounts arranged on the rigid spine in a plurality of mount rows. ... Bi Incorporated

07/12/18 / #20180194418

Bicycle seat post with adjustable height

A bicycle seat post assembly includes a lower seat support secured to the frame, an upper seat support secured to the seat and movable relative to the lower seat support, and an adjusting mechanism coupling the lower seat support to the upper seat support. The adjusting mechanism includes a powered actuator engageable with both the lower seat support and the upper seat support and configured to move the upper seat support relative to the lower seat support, and a coupling device selectively connecting the powered actuator to one of the lower seat support or the upper seat support. ... Bi Incorporated

07/12/18 / #20180194267

Modular container transport systems

Disclosed are apparatus, systems, and methods, including a ground transport drive container comprising an outer container having a cuboid shape and comprising a plurality of fittings for securing the outer container to another apparatus; and a drive wheel assembly. The drive wheel assembly comprises one or more wheels and a deployment mechanism secured to the one or more wheels. ... Bi Incorporated

07/12/18 / #20180194148

Recording paper cutting device and printing device

A recording paper cutting device enables cutting of a boundary between a first area of a recording paper and a second area of the recording paper placed at an upstream side of the first area, so that the first area is separately discharged from the second area after the first area is printed. The recording paper cutting device includes first and second cutting parts. ... Bi Incorporated

07/12/18 / #20180194025

Razor blade, razor head, and method of manufacture

An integrally formed rigid razor blade made of martensitic stainless steel includes a cutting edge portion, a base portion, and a bent portion. The cutting edge portion extends along a cutting edge portion axis and has a cutting edge at one end. ... Bi Incorporated

07/12/18 / #20180193846

System and method for multi-axis imaging of specimens

A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.. . ... Bi Incorporated

07/12/18 / #20180193845

System and method for multi-axis imaging of specimens

A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.. . ... Bi Incorporated

07/12/18 / #20180193841

Testing system

The present invention relates to the field of biological sample testing technology, and in particular, to a testing system. The testing system includes a reagent reaction vessel and a test device. ... Bi Incorporated

07/12/18 / #20180193701

Computerized exercise apparatus

A training, rehabilitation, and recovery system comprises an exercise apparatus including a user interface member coupled to a plurality of links and joints, brakes capable of resisting movement of at least a subset of the links or joints, and sensors capable of sensing movement at the joints or the user interface member. The system also includes a processor configured to receive from the sensors positional data of the links or joints over an initial movement of the apparatus by a user, from which positional coordinates of the user interface member are calculated and a reference trajectory is established. ... Bi Incorporated

07/12/18 / #20180193642

Systems and methods for facilitating interaural time difference perception by a binaural cochlear implant patient

A binaural cochlear implant system (system) includes first and second microphones associated with first and second ears of a patient, respectively. The microphones detect an audio signal presented to the patient and output first and second signals representative of the audio signal as detected at the first and second ears, respectively. ... Bi Incorporated

07/12/18 / #20180193638

Wearable injection device integrating iontophoresis and microneedle

A wearable injection device includes: a driven unit; a microneedle injection patch having an injection therein and located on a side surface of the driven unit; and a wearable loop having two ends connected to the two end sides of the driven unit, respectively; wherein the driven unit has a first electrical property and the wearable loop has a second electrical property at a section opposite the driven unit; wherein the microneedle patch includes a microneedle array connected to the injection and attached on a skin of a biological limb, and the wearable loop surrounds the biological limb, and a direct current resulted from the first electrical property of the driven unit and the second electrical property of the wearable loop leads the injection injected into the biological limb via the microneedle array.. . ... Bi Incorporated

07/12/18 / #20180193549

Antithrombogenic hollow fiber membranes and filters

The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.. ... Bi Incorporated

07/12/18 / #20180193536

Bioresorbable drug delivery matrices based on cross-linked polysaccharides, dosage forms designed for delayed/controlled release

Bioactive agents are embedded in a cross-linked dextran and coated with a bioresorbable polymer. When implanted in a mammal, the coated cross-linked dextran composition produces controlled release of the embedded bioactive agent.. ... Bi Incorporated

07/12/18 / #20180193531

Biocompatible and bioabsorbable derivatized chitosan compositions

The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (edc) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of n-deacetylation (dda) of between about 15% and 40%. ... Bi Incorporated

07/12/18 / #20180193526

Malleable demineralized bone composition and method of manufacture

A malleable demineralized bone composition consists of cortical bone made from a first portion and a second portion. The first portion of cortical bone is made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried. ... Bi Incorporated

07/12/18 / #20180193482

Patterned dosing of immunosuppressants coupled to synthetic nanocarriers

Provided herein are methods and related compositions for administering viral vectors and synthetic nanocarriers comprising an immunosuppressant. In some embodiments, the methods and compositions provided herein achieve improved transgene expression and/or immune response reduction, such as downregulated igm and/or igg immune responses.. ... Bi Incorporated

07/12/18 / #20180193463

Etanercept formulations stabilized with combinations of sugars and polyols

The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.. . ... Bi Incorporated

07/12/18 / #20180193461

Pharmaceutical compositions to reduce complications of ocular steroid

The present invention relates to pharmaceutical compositions comprising a combination of a lipid cake mixture comprising one or more phospholipids, with or without cholesterol, and a steroid solution comprising an ocular steroid, derivative thereof, a pharmaceutically acceptable salt thereof or a prodrug thereof, wherein the total amount of the phospholipid in the said composition is about 0.1 umol to less than about 2.5 umol per 50 ul of pharmaceutical composition and the side effects of the ocular steroid are reduced. The pharmaceutical composition is preferably administered by ocular route to treat ophthalmic diseases.. ... Bi Incorporated

07/12/18 / #20180193456

Anti-vascular endothelial growth factor receptor 2 (vegfr2) antibodies

Provided are anti-vascular endothelial growth factor receptor 2 (vegfr2) antibodies, and antigen binding fragments thereof. Also provided are isolated nucleic acid molecules that encode the anti-vegfr2 antibodies or antigen binding fragments thereof, related expression vectors, and host cells. ... Bi Incorporated

07/12/18 / #20180193448

Novel mucosal vaccination approach for herpes simplex virus type-2

Methods and kits for immunizing animals (e.g. Mammals) against viral antigens, including herpes-simplex virus type 2 are provided. ... Bi Incorporated

07/12/18 / #20180193439

Immunotherapy against melanoma and other cancers

A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated t cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated t cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the t cells bind to the peptide in a complex with an mhc class i molecule, and the composition is for treating the patient who has melanoma. ... Bi Incorporated

07/12/18 / #20180193432

Anti-viral therapeutic for infection of the eye

The present disclosure provides novel compositions and methods for treating an infection of the eye resulting from an infection of a member of the picornavirdae virus family. In particular, the present disclosure provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a sialidase domain that can act extracellularly to inhibit infection of a target cell by a pathogen, such as a virus. ... Bi Incorporated

07/12/18 / #20180193423

Peptides comprising non-natural amino acids and methods of making and using the same

This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an α-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. ... Bi Incorporated

07/12/18 / #20180193422

Highly active polypeptides and methods of making and using the same

This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an α-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. ... Bi Incorporated

07/12/18 / #20180193418

Mutated fibroblast growth factor (fgf) 1 and methods of use

The present disclosure provides fgf1 mutant proteins, such as those having an n-terminal deletion, point mutation(s), or combinations thereof, which can reduce blood glucose in a mammal. Such mutant fgf1 proteins can be part of a chimeric protein that includes a β-klotho-binding protein, an fgfr1c-binding protein, a β-klotho-binding protein and a fgfr1c-binding protein, a c-terminal region from fgf19 or fgf21. ... Bi Incorporated

07/12/18 / #20180193414

Compositions and methods for treating neurological disorders

The present invention generally provides vectors, compositions, and methods of using the same for treating neurological disorders, including managing pain. The compositions and methods include the use of g protein-coupled receptors and ligand-gated ion channels to treat neurological indications including pain, epilepsy and satiety disorders. ... Bi Incorporated

07/12/18 / #20180193406

Peptide for skin regeneration or wound treatment and use thereof

The present invention relates to a peptide for skin regeneration or wound healing and a use thereof. The novel peptide according to the present invention not only promotes the wound healing by increasing the production amount of collagen in dermal fibroblasts but also has an excellent whitening effect by inhibiting the production amount of melanin and tyrosinase activity of melanoma cells, and consists of peptides having a very small size to minimize side effects according to administration of external substances of very small peptides. ... Bi Incorporated

07/12/18 / #20180193405

Methods and compositions for the prevention and treatment of disease

The present technology is directed to compositions and methods for preventing, ameliorating, or reducing the severity of one or more signs, or symptoms associated with a reduction of function, decreased expression level of, and/or deficiency in one or more of col4a3, col4a4 and col4a5 genes. Also disclosed herein are methods of preventing or treating alport syndrome in a mammalian subject, reducing risk factors associated with alport syndrome, and/or reducing the likelihood or severity of alport syndrome. ... Bi Incorporated

07/12/18 / #20180193389

Bioeffective krill oil compositions

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. ... Bi Incorporated

07/12/18 / #20180193372

Novel biomarker for diagnosing resistance to anticancer agent for billary tract cancer and use thereof

The present invention provides a novel molecule marker for resistance to an anticancer agent for biliary tract cancer, and diagnostic and therapeutic uses thereof. The marker, according to the present invention, shows significantly increased expression in an anticancer agent-resistant biliary tract cancer cell line compared to a non-anticancer agent-resistant biliary tract cancer cell line. ... Bi Incorporated

07/12/18 / #20180193368

Prevention and treatment of inflammatory conditions

The present embodiments relate to methods for the prevention and treatment of inflammatory conditions such as alcoholic liver disease (ald). More specifically the present embodiments relate to the prevention and treatment of ald through the administration of an retinoic acid receptor (rar) agonist. ... Bi Incorporated

07/12/18 / #20180193359

Chemical entities that kill senescent cells for use in treating age-related disease

Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. ... Bi Incorporated

07/12/18 / #20180193318

Novel methods for treating cancer

The invention provides thiazole-substituted indolin-2-ones as inhibitors of cancer stem cell pathway kinases (cscpk) and related kinases, and methods of using these compounds, to treat subjects in need thereof.. . ... Bi Incorporated

07/12/18 / #20180193303

Novel compounds and compositions for targeting cancer stem cells

The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, methods of producing these naphthofuran compounds, polymorphs, purified compositions and/or particle forms, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof.. . ... Bi Incorporated

07/12/18 / #20180193274

Compositions for ileo-jejunal drug delivery

The current invention affords new formulations which deliver reversible and irreversible covalent kinase inhibitors, in particular btk inhibitors, into the small intestine and specifically into the ileum and jejunum of the small intestine.. . ... Bi Incorporated

07/12/18 / #20180193265

Compositions and methods using same for delivering agents into a target organ protected by a blood barrier

A method of delivering a pharmaceutical agent into a target organ protected by a blood barrier is provided. The method comprising administering to a subject in need thereof an amount of liposomes which comprise the pharmaceutical agent, the amount and the liposomes are selected such that the liposomes accumulate in cells of an immune system of the subject to thereby generate liposome loaded immune cells, the liposome loaded immune cells become activated and cross the blood barrier, and an effective amount of the pharmaceutical agent is released from the liposomes in the target organ of the subject.. ... Bi Incorporated

07/12/18 / #20180193160

Expandable spinal interbody cage

Disclosed herein is a spinal interbody cage, comprising an upper plate, a lower plate, a screw arbor and two slide blocks. The screw arbor includes a first section with an outer thread and a second section with an outer thread. ... Bi Incorporated

07/12/18 / #20180193148

Location, time, and/or pressure determining devices, systems, and methods for deployment of lesion-excluding heart implants for treatment of cardiac heart failure and other disease states

Devices, systems, and methods for treating a heart of a patient may make use of structures which limit a size of a chamber of the heart, such as by deploying one or more tensile member to bring a wall of the heart and a septum of the heart into contact. A plurality of tension members may help exclude scar tissue and provide a more effective remaining ventricle chamber. ... Bi Incorporated

07/12/18 / #20180193136

Intra-annular mounting frame for aortic valve repair

An intra-annular mounting frame for an aortic valve having native aortic cusps is provided which includes a frame body with native leaflet reorienting curvatures and interconnecting points; the curvatures shaped to be received inside the valve below the native aortic cusps and to reorient the native aortic cusps within the aortic valve, where each of the curvatures extends concavely upward from a reference latitudinal plane tangential to each curvature's base.. . ... Bi Incorporated

07/12/18 / #20180193129

Embolic protection during percutaneous heart valve replacement and similar procedures

Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. ... Bi Incorporated

07/12/18 / #20180193115

Placement device for a dental component

The present invention relates to a placement device for a dental component, a method for handling a dental component with a placement device, a dental component for placement with a placement device and a set comprising a placement device and a dental component. The placement device (1) for a dental component (2) is preferably an implant and comprises a proximal end (11), a distal end (12) and a coupling mechanism (20) for coupling the distal end (12) to the dental component. ... Bi Incorporated

07/12/18 / #20180193089

Catheter with supporting structure having variable dimensions

This disclosure is directed to a catheter having a multi-electrode assembly with a high electrode density. The multi-electrode assembly may be a basket-shaped electrode assembly or a brush-shaped electrode assembly each having a plurality of spines. ... Bi Incorporated

07/12/18 / #20180193073

Adjustable rib and sternal implant

An implant assembly for a human sternum and ribs can include a sternal implant and a rib link. The sternal implant can be couplable to a sternum. ... Bi Incorporated

07/12/18 / #20180193068

Variable angle locking insert for intramedullary nail

A system including an intramedullary nail and an insert dimensioned to be positioned within the intramedullary nail. The insert can include a rotating component configured to rotate about a rotational axis transverse to a longitudinal axis of the intramedullary nail. ... Bi Incorporated

07/12/18 / #20180193067

Intramedullary device with compound fastener trajectories

An intramedullary device, having a first longitudinal axis extending between a proximal end and a distal end thereof, is provided. The intramedullary device may include a first bore and a second bore. ... Bi Incorporated

07/12/18 / #20180193065

Spinous process implants and associated methods

The present invention provides spinous process implant and associated methods. In one aspect of the invention the implant limits the maximum spacing between the spinous processes. ... Bi Incorporated

07/12/18 / #20180193052

Combined debrider and coagulator

A medical apparatus, including an insertion tube that includes an outer tube having a proximal end and a distal end configured for insertion into a body cavity, with a radial cutting window opening through a wall of the outer tube in proximity to the distal end. The insertion tube also includes an inner tube, contained in and configured to rotate within the outer tube and including a cutting blade that traverses the radial cutting window opening as the inner tube rotates. ... Bi Incorporated

07/12/18 / #20180193015

Method and apparatus for forming a self-locking adjustable loop

An apparatus can include a first flexible member having first and second ends and a first body extending therebetween, where the first body defines a first passage portion. A second flexible member can have first and second ends and a second body extending therebetween, where the second body defines second and third passage portions. ... Bi Incorporated

07/12/18 / #20180193013

Suture assembly with suture load distribution

A method for securing a flexible member may include forming a bore in a bone; inserting an anchor into the bore, the anchor including a passage and being coupled to a flexible member; slideably positioning a first load distributing member along the flexible member; inserting the first load distributing member into the bore such that the flexible member engages the first load distributing member; and applying tension to a portion of the flexible member to secure the anchor and load distributing member within the bone.. . ... Bi Incorporated

07/12/18 / #20180193011

Adaptive devices and methods for endoscopic wound closures

This invention is directed to devices and methods for improving wound closures produced during endoscopic surgery. These methods are directed to delivering and applying a quantity of hemostatic agents in either powder, solid, liquid, or gel form onto an open wound produced e.g., by polyp removal, followed by the application of pressure. ... Bi Incorporated

07/12/18 / #20180192989

Methods and systems for ultrasonic imaging

A method for ultrasonic imaging comprises: emitting doppler pulses to a target to be detected; performing a doppler scan with doppler pulses; receiving echo signals from the target, wherein the echo signals include doppler pulse echo signals; processing the echo signals, wherein processing comprises an imaging step, the imaging step comprising parallel processing steps including a 2d image processing step, a flow image processing step, and a spectrum image processing step, wherein the 2d image processing step is configured for processing the echo signals to obtain 2d image signals, the flow image processing step is configured for processing the echo signals to obtain flow image signals, and the spectrum image processing step is configured for processing the echo signals to obtain spectrum image signals; and displaying the processed echo signals.. . ... Bi Incorporated

07/12/18 / #20180192988

Ultrasound gray-scale imaging system and method

An ultrasound grayscale imaging system includes a probe; a transmitting circuit which excites the probe to transmit multiple groups of non-focused ultrasound beams to a flow; a receiving circuit which receives echoes to obtain multiple groups of non-focused ultrasound echo signals; a signal processing unit which obtains flow data according to the multiple groups of non-focused ultrasound echo signals; an image processing unit which obtains b mode ultrasound image sequence according to the flow data; and a display device which displays the b mode ultrasound image sequence.. . ... Bi Incorporated

07/12/18 / #20180192958

Multi-electrode assembly with controlled folding mechanism

This disclosure is directed to a catheter having a multi-electrode assembly with a high electrode density. The multi-electrode assembly may be a basket-shaped electrode assembly or a brush-shaped electrode assembly each having a plurality of spines. ... Bi Incorporated

07/12/18 / #20180192933

Container device for collecting, storing and processing blood or a blood compound

Container device (1) for collecting, storing and processing blood or a blood compound, which comprises a tube (10) with a connector (23) on its distal end (13), a piston set (30, 50) that can move through an interior space (14) of the tube (10), and a valve set (70, 90) preventing the flow of fluid through the distal opening (16) of the tube (10). The valve set (70, 90) is operable to allow the flow of the fluid through the distal opening (16). ... Bi Incorporated

07/12/18 / #20180192904

Catheter spine assembly with closely-spaced bipole microelectrodes

An electrophysiologic catheter with a distal electrode assembly carrying very closely-spaced bipole microelectrodes on a plurality of divergent spines that can flexibly spread over tissue surface area minimized detection of undesirable noise, including far-field signals. Each spine has a flexible microelectrode panel having a substrate, at least one pair of microelectrodes, a trace for each microelectrode, and a soldering pad. ... Bi Incorporated

07/12/18 / #20180192822

Combustion device utilizing thermoelectrical generation

This invention provides a portable combustion device that provides a cleaner combustion, provides a more efficient overall combustion through the use of a fan that directs a predetermined volume of airflow over the combustible fuel—typically wood or similar cellulose-based biological solids and provides a cooking surface that is a grill top. The combustion device has a combustion chamber into which the fuel source is placed for combustion. ... Bi Incorporated

07/12/18 / #20180192676

Development of an asparagine-reducing yeast by adaptive evolution and uses thereof to reduce acrylamide formation

The present disclosure relates to a method of isolating a yeast strain that is able to degrade l-asparagine under non-inducing conditions comprising repeated cycles of adaptive evolution and mutagenesis followed by strain selection. Also included are yeast strains obtained by the method, and methods and uses thereof for reducing asparagine, and thus acrylamide, during food preparation and processing.. ... Bi Incorporated

07/05/18 / #20180192209

Binaural hearing systems and methods for preserving an interaural level difference to a distinct degree for each ear of a user

. . . . . . A binaural hearing system (“system”) preserves and/or enhances interaural level differences (“ilds”) between first and second signals. The system includes audio detectors each associated with an ear of a user. ... Bi Incorporated

07/05/18 / #20180191938

Method and system for capturing images of a liquid sample

A method and system for capturing images of a liquid sample during flow is disclosed. One approach to obtaining images of the sample which are in focus is to carry out a focusing algorithm in order to focus an imaging device on the sample once the sample has started flowing. ... Bi Incorporated

07/05/18 / #20180190454

Non-contact switch devices for use on material handling equipment

The disclosure provides a non-contact switch device for use on material handling equipment, including a reed switch and a magnet, wherein the non-contact switch device has on and off positions achieved by the presence or absence of magnetic induction between the magnet and the reed switch. The non-contact switch devices are disclosed in the form of a main power switch, an interlock switch, a limit switch.. ... Bi Incorporated

07/05/18 / #20180190428

Magnet production

A process is provided for the production of rare earth magnets comprising the steps of exposing a rare earth alloy to hydrogen gas at an elevated temperature so as to effect hydrogenation and disproportionation of the alloy, mechanically processing the disproportionated alloy, and degassing the processed alloy so as to effect hydrogen desorption and recombination of the alloy. The process of the invention finds use in the production and shaping of rare earth magnets, and may be particularly applicable to the production of thin magnetic sheets.. ... Bi Incorporated

07/05/18 / #20180190009

Selecting points on an electroanatomical map

Described embodiments include a system that includes a display and a processor. The processor is configured to position an indicator, in response to a positioning input from a user, over a particular point on a three-dimensional electroanatomical map that is displayed on the display, and over which are displayed a plurality of markers that mark respective data points. ... Bi Incorporated

07/05/18 / #20180189990

Methods, apparatus and systems for data visualization and related applications

In a data visualization system, a method of creating a visual representation of data, the method including the steps of providing instructions to an end user to assist the end user in: constructing multiple graphical representations of data, where each graphical representation is one of a predefined type and includes multiple layers of elements that contribute to the end user's understanding of the data; arranging multiple graphical representations of different types within the visual representation in a manner that enables the end user to understand and focus on the data being represented; and displaying the visual representation.. . ... Bi Incorporated

07/05/18 / #20180189989

Systems and methods for real-time data quantification, acquisition, analysis and feedback

This disclosure relates to systems, media, and methods for quantifying and monitoring exercise parameters and/or motion parameters, including performing data acquisition, analysis, and providing scientifically valid, clinically relevant, and/or actionable diagnostic feedback. Disclosed embodiments may receive real-time sensor data from a motion sensor or sensors mounted on a user and/or equipment while a user performs a test motion. ... Bi Incorporated

07/05/18 / #20180189969

Visualization of distances on an electroanatomical map

Described embodiments include an apparatus that includes a display and processor. The processor is configured to receive, from a user, an input that indicates one or more points of interest on an electroanatomical map, of an anatomical surface, that is displayed on the display, and to superimpose on the map, in response to the input, a plurality of contours, each one of the contours being at a different respective geodesic distance, with respect to the surface, from the points of interest. ... Bi Incorporated

07/05/18 / #20180189539

Touch screen and electronic device having the same

A touch screen includes a touch panel and an ultrasonic probe. A touch panel includes a cover plate, a first sensing structure including a plurality of receiving electrode lines, a glass sheet, and a second sensing structure including a plurality of transmitting electrode lines. ... Bi Incorporated

07/05/18 / #20180189359

Systems and methods for harvesting data associated with fraudulent content in a networked environment

Exemplary embodiments of the present disclosure relate to systems, methods, and non-transitory computer-readable media for harvesting, parsing, and analyzing item identifiers in networked content to identify fraudulent content.. . ... Bi Incorporated

07/05/18 / #20180189212

Multi-sensing using multiple serial protocols over a common interconnection scheme

A multi-sensing system (20) includes multiple sensor units (28) that include respective sensors (44), (ii) are connected to one another in a cascade using serial data lines (32), and (iii) are connected to a common clock line (36) and to a common alignment line (40). The sensor units are configured to selectably communicate in accordance with first and second different serial communication protocols using the same serial data lines, clock line and alignment line. ... Bi Incorporated

07/05/18 / #20180188848

Touch screen and electronic device having the same

A touch screen includes a touch panel and an ultrasonic probe. A touch panel includes a cover plate, a first sensing structure including a plurality of receiving electrode lines, and a second sensing structure including a plurality of transmitting electrode lines. ... Bi Incorporated

07/05/18 / #20180188641

Microarray led flash

A microarray led flash, applied to a mobile phone for lighting an adjustable flashlight or projecting an image, comprises a μled array module, a mixing optical module and an optical module. The μled array module is configured in a shell of the mobile phone for generating a patterning light source. ... Bi Incorporated

07/05/18 / #20180188609

Photoluminescent polarizers and electronic devices including the same

A photoluminescent polarizer including: a base having a first surface, a second surface opposite to the first surface, and a plurality of grid elements disposed on the first surface; wherein a grid element includes a first lateral face, a second lateral face, and at least one photoluminescent unit stack disposed on at least one of the first lateral face and the second lateral face, wherein the first lateral face is angled away from a line perpendicular to the first surface of the base and the second lateral face angled toward the first lateral face and away from the line, wherein the photoluminescent unit stack is disposed on at least one of the first lateral face and/or to the second lateral face, wherein the photoluminescent unit stack comprises a light emitting film and a metal film, the metal film disposed on a surface of the light emitting film.. . ... Bi Incorporated

07/05/18 / #20180188517

Low resolution slide imaging and slide label imaging and high resolution slide imaging using dual optical paths and a single imaging sensor

A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. ... Bi Incorporated

07/05/18 / #20180188284

Systems and methods for real-time data quantification, acquisition, analysis and feedback

This disclosure relates to systems, media, and methods for quantifying and monitoring exercise parameters and/or motion parameters, including performing data acquisition, analysis, and providing scientifically valid, clinically relevant, and/or actionable diagnostic feedback. Disclosed embodiments may receive real-time sensor data from a motion sensor or sensors mounted on a user and/or equipment while a user performs a test motion. ... Bi Incorporated

07/05/18 / #20180188276

Multi-stage sample recovery system

Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high-throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. ... Bi Incorporated

07/05/18 / #20180188274

Method for measuring a plurality of status parameters of a fluid contained in a container

A method is provided for measuring status parameters of a fluid contained in a container (10). The container (10) is configured for single use and has a wall on which a sensor-carrier plate is fixed in a fluid-tight manner. ... Bi Incorporated

07/05/18 / #20180188263

Method for analyzing posttranslational modifications using gel ief and mass spectrometry

The present invention relates to the field of proteomics and more specifically to a method for analyzing a sample possible containing peptides or modified peptides; in particular useful for biomarker discovery or validation of biomarkers. The method uses isoelectric focusing and mass spectrometry (ms) and enables identification of modified peptides with high resolution and predictability.. ... Bi Incorporated

07/05/18 / #20180188216

Improvements in and relating to fluid path networks

Disclosed is a fluid path network (100) comprising plural fluid paths (110) interconnected by plural nodal chambers (120), three or more of said plural paths opening into each of said chambers, and said chambers being adapted the accept a removable fluid path modifying insert (130/140/150 figs. 3a-3c). ... Bi Incorporated

07/05/18 / #20180188195

Systems and methods for multiplexed hemostasis test panels

The invention features a diagnostic platform utilizing t2 magnetic resonance to directly measure integrated reactions in whole blood samples such as clotting, fibrinogen, clot contraction, and fibrinolysis to provide a comprehensive assessment of hemostatic parameters on a single instrument in minutes. The methods of the invention can be performed with less than 1 ml of blood and minimal sample handling.. ... Bi Incorporated

07/05/18 / #20180188178

Fluorescent microscopic imaging method and apparatus

A fluorescence microscopic imaging method includes: after a to-be-detected sample plate is placed, lightening, according to experimental requirements, at least one monochromatic fluorescence excitation light source with a same color among multiple monochromatic fluorescence excitation light sources as a target light source, where monochromatic fluorescence excitation light emitted by each monochromatic fluorescence excitation light source obliquely enters a preset detection region of the to-be-detected sample plate; collecting, at a side of the to-be-detected sample plate facing away from the target light source, fluorescence of particles within the preset detection region excited by irradiation of monochromatic fluorescence excitation light emitted by the target light source, and magnifying the preset detection region a preset number of times; filtering the excited fluorescence of the particles within the preset detection region; and acquiring a fluorescence image of the preset detection region.. . ... Bi Incorporated

07/05/18 / #20180188142

Sample prep method

Disclosed is a method of supported liquid extraction (sle), wherein adsorption of at least one analyte to a solid phase is performed in the presence of salt. The method may include contacting a sample with salt, adsorption phase such as diatomaceous earth and optionally a subsequent step of phospholipid depletion. ... Bi Incorporated

07/05/18 / #20180188130

Method and apparatus for an integrity test of a test container

A method, a device and a use of the device are provided for carrying out an integrity test on a test container (1) that has at least one flexible casing material. The method includes the steps of: filling a test fluid into the test container (1); and detecting the presence of test fluid directly outside the test container (1). ... Bi Incorporated

07/05/18 / #20180187811

Connection system

The invention relates to a connection system for releasably coupling a first body (5) with a flange (25) to a fluid-conducting system in a force-fitting manner, and the invention also relates to a connection system for releasably coupling the interior of a first fluid-conducting body (5) to the interior of a second fluid-conducting body (3) in a force-fitting manner. The second body (3) has a second end with a circumferential wall (22), a membrane contact portion (9) which can be found on the wall, and an opening (43). ... Bi Incorporated

07/05/18 / #20180187240

Double-functional oligonucleotide comprising complementary nucleotide sequence, mis-matched nucleotide sequence, reporter, and quencher, and a methods for nucleic acid amplification and measurement using the same

The present disclosure relates to a complementary double-stranded oligo, in which, for the amplification of a particular gene sequence, an inosine linker is linked to the 5′-terminus of a primer for the corresponding sequence, a sequence complementary to the primer is linked to the inosine linker, and at least one mis-matched nucleotide is included in the complementary sequence to form a bubble structure; in which, depending on the treatment temperature, at a predetermined temperature or lower, a single stranded oligo is turned into a double-stranded form to exist in an inactivation form, and at a predetermined temperature or higher, the oligo is activated into a single-stranded oligo; and in which, a fluorescent substance and a quenching material are attached to the oligo, so that the oligo can be applied as a primer or a probe, and thus only two oligos can realize the gene amplification and fluorescent signal real-time measurement with high specificity.. . ... Bi Incorporated

07/05/18 / #20180187224

Processes for the formation of furandicarboxylic acid (fdca) via a multistep biocatalytic oxidation reaction of 5-hydroxymethylfurfural (hmf)

The present invention relates to processes for the formation of furandicarboxylic acid (fdca), in particular 2,5-furandicarboxylic acid (2,5-fdca), and mono- and diester derivatives thereof, via a multistep biocatalytic oxidation reaction of 5-hydroxymethylfurfural (hmf) using, for example, an enzyme selected from the group consisting of xanthine oxidoreductase (xor), galactose oxidase variant m3-5, aldehyde dehydrogenase, and/or ketoreductase. The invention also relates to copolymers that comprise the furandicarboxylic acid monomers and derivatives thereof, processes for the formation of the copolymers and uses for the copolymers.. ... Bi Incorporated

07/05/18 / #20180187214

Subgroup b recombinant human adenovirus vector, and methods for constructing and for using the same

A subgroup b recombinant human adenovirus vector ad11-5ep (seq id no: 1), which is constructed by a method including: substituting a 365 bp fragment containing an enhancer and a promoter of an upstream coding sequence of ad5 e1a (seq id no: 2) for a corresponding region of a serotype ad11 (seq id no: 3) of a subgroup b human adenovirus vector by homologous recombination to construct the subgroup b recombinant human adenovirus vector ad11-5ep (seq id no: 1).. . ... Bi Incorporated

07/05/18 / #20180187184

Novel constructs and screening methods

The invention relates to the field of functional genomics. The invention provides novel polynucleotides and vectors as well as libraries and kits comprising the same. ... Bi Incorporated

07/05/18 / #20180187181

Combined lysis protocol for comprehensive cell lysis

Disclosed are methods for lysis of cells, such as bacteria present in microbiomes, that combine three lysis steps—(1) heat, (2) detergent and (3) base—into a single step and that can be completed in a short period of time, e.g., a few minutes. The methods combine a normally incompatible detergent and base lysis, allows for simplified removal of detergent after lysis, and importantly, yields improved quantities of genomic dna (gdna) from difficult to lyse bacteria.. ... Bi Incorporated

07/05/18 / #20180187167

Cellulolytic compositions comprising monooxygenase polysaccharide enzymes with improved activity

The invention refers to methods and compositions for stabilizing and increasing the activity of enzymatic mixtures comprising gh61 (pmo or polysaccharide monooxigenase) polypeptides used for the degradation of cellulosic material during the saccharification step of biofuel production processes. This improvement is achieved by the addition of a nickel cation to said enzymatic mixtures before and/or during the saccharification step. ... Bi Incorporated

07/05/18 / #20180187145

Optimally activated dendritic cells that induce an improved or increased anti-tumor immune response

The present disclosure provides populations of cells comprising partially mature and optimally activated dendritic cells that can be used for administration to individuals having a cancer and/or tumor. Partially matured dendritic cells, those contacted with a dendritic cell maturation agent for about 10 to about 19 hours, upon administration efficiently take up and process tumor antigens in the area of the tumor site, complete maturation, and can subsequently migrate to the lymph nodes of a treated individual. ... Bi Incorporated

07/05/18 / #20180187140

Bioreactor system and method

A bioreactor (1; 2; 3) includes a receiving container (10) for receiving a disposable bag (44). A bottom surface (11) of the receiving container (10) is designed to support the disposable bag (44) in the receiving container (10). ... Bi Incorporated

07/05/18 / #20180187013

A biofiller for rubber reinforcement

A biofiller for rubber reinforcement; said biofiller is surface treated upto 10% by weight of microcrystalline lignocellulose with aldehyde and/or ketone. The said bio-filler has economic significance as well as reduces pollution as it replaces 2% carbon black from the rubber composition which is substantial amount after reviewing overall use of carbon black in rubber industries such as tyre industry, worldwide. ... Bi Incorporated

07/05/18 / #20180186897

Novel vaccines in prevention and treatment of malaria

The present invention provides a pharmaceutical composition, for example a vaccine, which comprises a rifin, which is able to bind to a mutated lair-1 fragment, which broadly binds to erythrocytes infected with plasmodium falciparum. Such a rifin may be useful in the prevention and/or treatment of malaria.. ... Bi Incorporated

07/05/18 / #20180186895

Antibodies targeting b-cell receptor complex membrane bound igm and uses thereof

The present invention relates to antibodies targeting the membrane bound igm (migm) of the b-cell receptor complex found in b-cell lymphomas and leukemias and uses thereof. Another aspect of the present invention is the use of anti-b-cell migm antibodies in the treatment of be-cell malignancies, including b-cell lymphomas and leukemias.. ... Bi Incorporated

07/05/18 / #20180186890

Anti-cd276 antibodies (b7h3)

Polypeptides and proteins that specifically bind to and immunologically recognize cd276 are disclosed. Chimeric n antigen receptors (cars), anti-cd276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. ... Bi Incorporated

07/05/18 / #20180186889

Anti-cd40 antibodies and their uses

The present disclosure provides novel anti-cd40 antibodies, compositions including the new antibodies, nucleic acids encoding the antibodies, and methods of making and using the same.. . ... Bi Incorporated

07/05/18 / #20180186884

Anti-vegfr antibody and uses thereof

The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (vegfr-2). The present invention also relates to a method for inhibiting vegfr-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to vegfr-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.. ... Bi Incorporated

07/05/18 / #20180186881

Anti-human tim-3 antibodies and methods of use thereof

An anti-human t-cell immunoglobulin domain and mucin domain 3 (tim-3) antibody, can bind the peptides, comprising the amino-acid sequence rkgdvsl (seq id no: 9) and/or ekfnlkl (seq id no: 10) of human tim-3 protein. The antibody can regulate immune cell activity. ... Bi Incorporated

07/05/18 / #20180186880

Native human antibodies for immune checkpoint modulation targets tim-3 and b7-h3

Novel monoclonal antibodies directed against immune checkpoint modulator (icm) proteins tim-3 and b7-h3 are useful in treating cancer and immune system disorders.. . ... Bi Incorporated

07/05/18 / #20180186868

Antibody against human nrg1 protein

An object is to provide an antibody capable of specifically recognizing a human nrg1 protein isoform, and suppressing signal transduction in which the isoform is involved. An antibody capable of binding to a region at positions 221 to 234 of a human nrg1-α protein or an antibody capable of binding to a region at positions 213 to 239 of a human nrg1-β1 protein was successfully obtained. ... Bi Incorporated

07/05/18 / #20180186863

Modified antibody regions and uses thereof

The present invention relates to modified fc regions of antibodies, and uses thereof, such as in antibodies that contain an fc region of the present invention.. . ... Bi Incorporated

07/05/18 / #20180186852

Long-acting polypeptides and methods of producing same

A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (ctp) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (ctp) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.. ... Bi Incorporated

07/05/18 / #20180186848

Thermostable human epidermal growth factor-spider venom fusion protein with increased skin cell proliferation effect and cosmetic composition for improving skin wrinkle and maintaining elasticity of skin comprising the same as effective component

A thermostable human epidermal growth factor-spider venom fusion protein with increased skin cell proliferation effect has the amino acid sequence of seq id no: 2, a gene of e. Coli codon-optimized nucleotide sequence of seq id no: 1 for encoding the human epidermal growth factor-spider venom fusion protein, a recombinant vector including the gene, a host cell transformed with the recombinant vector, and a method for producing in a host cell a human epidermal growth factor-spider venom fusion protein by transforming a host cell with the recombinant vector, and a cosmetic composition for improving skin wrinkle and maintaining skin elasticity including a human epidermal growth factor-spider venom fusion protein, and as the cosmetic composition has excellent thermostability and has an effect of enhancing the activity of improving skin wrinkle and maintaining skin elasticity, it can be advantageously used in future in the field of cosmetics or cosmetic plastic surgery.. ... Bi Incorporated

07/05/18 / #20180186834

Novel peptide and use thereof

This invention relates to a peptide consisting of an amino acid sequence of seq id no:1 or a pharmaceutically acceptable salt thereof, and to the use thereof. According to this invention, cancer can be effectively prevented or treated.. ... Bi Incorporated

07/05/18 / #20180186831

Enhanced purification of antibodies and antibody fragments by apatite chromatography

Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed.. ... Bi Incorporated

07/05/18 / #20180186829

Novel process for the preparation of pasireotide

The present invention relates to a novel process for the preparation of pasireotide of formula 11 [cyclo [phe-{4-(oco—nh—ch2—ch2—nh2)) pro}-phg-dtrp-lys-tyr(bzl)]]. The invention also relates to a novel intermediate compound of formula 8 and process thereof which is used for preparation of compound of formula 11.. ... Bi Incorporated

07/05/18 / #20180186827

Ectonucleotidase inhibitors and methods of use thereof

The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cancer using the novel heterocyclic compounds of the invention.. ... Bi Incorporated








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