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Bioatla Llc patents


Recent patent applications related to Bioatla Llc. Bioatla Llc is listed as an Agent/Assignee. Note: Bioatla Llc may have other listings under different names/spellings. We're not affiliated with Bioatla Llc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "B" | Bioatla Llc-related inventors


Modified antibody regions and uses thereof

The present invention relates to modified fc regions of antibodies, and uses thereof, such as in antibodies that contain an fc region of the present invention.. . ... Bioatla Llc

Novel composition to improve gut health and animal performance and methods of making the same

The present invention relates to compositions comprising at least about 8% β-glucans and/or at least about 8% α-fucans, which has a prebiotic effect and act as a replacement for in-feed antibiotics. The present invention also relates to extraction methods to obtain such extracts and various uses for the compositions comprising β-glucans and/or α-fucans.. ... Bioatla Llc

Anti-cd22 antibodies

Anti-cd22 antibodies, including isolated nucleic acids that encode at least one such anti-cd22 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.. . ... Bioatla Llc

Mirac proteins

This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.. ... Bioatla Llc

Conditionally active chimeric antigen receptors for modified t-cells

This disclosure relates to a chimeric antigen receptor for binding with a target antigen. The chimeric antigen receptor comprises at least one antigen specific targeting region evolved from a wild-type protein or a domain thereof and having at least one of: (a) a decrease in activity in the assay at the normal physiological condition compared to the antigen specific targeting region of the wild-type protein or a domain thereof, and (b) an increase in activity in the assay under the aberrant condition compared to the antigen specific targeting region of the wild-type protein or a domain thereof. ... Bioatla Llc

Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts

A method of preparing a conditionally active biologic protein by selecting a wild-type biologic protein, evolving the dna which encodes the wild-type biologic protein using one or more evolutionary techniques to create mutant dnas, expressing the mutant dnas in a eukaryotic cell production host to obtain a mutant protein, subjecting the mutant protein and the wild-type protein to an assay under a normal physiological condition and to an assay under an aberrant condition, selecting a conditionally active mutant protein which exhibits at least one of: (a) a decrease in activity in the assay at the normal physiological condition compared to the wild-type protein, and (b) an increase in activity in the assay under the aberrant condition compared to the wild-type protein; and producing the conditionally active biologic protein in the same eukaryotic cell production host used in the expression step.. . ... Bioatla Llc

Express humanization of antibodies

The disclosure provides a method for generation of humanized full length antibodies in mammalian cells. A library of humanized variants is provided with high, validated human framework diversity without requiring back-mutations to retain original affinity. ... Bioatla Llc

Diagnostics using conditionally active antibodies

A method of detecting tumor cells in a sample containing cells. In the method, a sample is encapsulated to produce a capsule with the sample encapsulated therein. ... Bioatla Llc

Conditionally active biological proteins

This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at some physiological conditions. For example, conditionally active biologic proteins are active in tumors, but virtually inactive at other body parts, or conditionally active antibodies cap able of crossing blood-brain-barrier.. ... Bioatla Llc

Mirac proteins

This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.. ... Bioatla Llc








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