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Bion Inc patents


Recent patent applications related to Bion Inc. Bion Inc is listed as an Agent/Assignee. Note: Bion Inc may have other listings under different names/spellings. We're not affiliated with Bion Inc, we're just tracking patents.

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Ensuring operator engagement in an exoskeleton bionic device

An operator supervising a wearer of an exoskeleton is verified by performing a verification routine on the operator using the exoskeleton. If the verification routine is unsuccessful, the exoskeleton is caused to follow a pre-established response routine. ... Bion Inc

Design and use of a leg support exoskeleton

A leg support exoskeleton is strapped on as wearable device to support its user during squatting. The exoskeleton includes a knee joint connected to a first line and a second link, which is configured to allow flexion and extension motion between the first link and the second link. ... Bion Inc

Peptide conjugates

Methods and compositions related to the selective, specific disruption of multiple ligand-receptor signaling interactions, such as ligand-receptor interactions implicated in disease, are disclosed. These interactions may involve multiple cytokines in a single receptor family or multiple ligand receptor interactions from at least two distinct ligand-receptor families. ... Bion Inc

Implantable medical devices having resilient mounting tabs and associated methods

A method, for use with an implantable medical device, including the steps of stretching a mounting tab in such a manner that an aperture on the mounting tab increases in size and separating the mounting tab from a bone anchor by moving the stretched mounting tab in such a manner that the bone anchor does not extend through the aperture in the mounting tab.. . ... Bion Inc

Cochlear implants

A cochlear implant including a cochlear lead, an antenna, a processor case, and a printed circuit board assembly located within the processor case. The processor case may include a base with a bottom wall and first and second side walls that together define a one-piece, unitary structure, a first end wall, attached to the bottom wall and to the first and second side walls, including a first plurality of feedthrough pins, a second end wall, attached to the bottom wall and to the first and second side walls, including a second plurality of feedthrough pins, and a cover attached to the first and second side walls and to the first and second end walls.. ... Bion Inc

Membrane filter system

A guide member for directing gas bubble flow along a member surface, the guide member having first and second side edges defining a channel for gas bubbles to flow along, the channel having an open bottom end through which the gas bubbles can enter the channel and an open top end through which the bubbles can exit the channel, and a diverting means adjacent the channel bottom end arranged to direct at least some of the incident gas bubbles in a first direction towards the channel bottom end. A membrane module assembly and a membrane filter system including the guide member.. ... Bion Inc

Methods and apparatus for body weight support system

A body weight support system includes a tether configured to be coupled to an attachment device worn by a user to couple the user to the body weight support system. A method of providing gait training includes defining a reference length of the tether when the attachment device is in an initial position and defining a threshold length of the tether. ... Bion Inc

Systems and methods for determining a stapedius reflex threshold based on electro-acoustic stimulation

A stapedius reflex threshold determination system is communicatively coupled with a loudspeaker and a cochlear implant implanted within a patient. The system identifies a baseline evoked response level associated with a baseline acoustic stimulation level too low to trigger a stapedius reflex within the patient. ... Bion Inc

Characterization of molecules in nanofluidics

Methods are provided for detecting and quantitating molecules using fluidics. In preferred embodiments, the methods comprise analyzing blood to detect the presence of circulating dna or cells from a fetus or tumor.. ... Bion Inc

Antenna apparatus for use with medical implants

An antenna apparatus having a first coil including at least one turn on at least one first-coil substrate and a second coil including at least one turn on at least one second-coil substrate. The first and second coils are electrically connected to one another in parallel.. ... Bion Inc

Stable dry probiotic compositions for special dietary uses

A dry stable probiotic composition is provided. The composition comprises one or more viable probiotic microorganisms, one or more hydrolyzed proteins, one or more disaccharides, one or more oligosaccharides, and one or more polysaccharides, but not trehalose. ... Bion Inc

Funerary construction for containing funerary objects

A funerary construction for containing funerary objects, which comprises a supporting structure with at least one cavity defined for accommodating at least one funerary object; the accommodation cavity has at least one access opening which is closed by at least one closing plate fixed to the supporting structure; at least one covering slab is arranged facing the closing plate and there are elements of mounting the covering slab on the supporting structure; the mounting elements comprise at least one mounting element that is supported by the closing plate and which defines at least one region for resting the covering slab.. . ... Bion Inc

Funerary construction for containing funerary objects

A funerary construction for containing funerary objects, which comprises a supporting structure with at least one cavity defined for accommodating at least one funerary object; the accommodation cavity has at least one access opening which is closed by at least one closing plate fixed to the supporting structure; at least one covering slab is arranged facing the closing plate and there are elements of mounting the covering slab on the supporting structure; the mounting elements comprise at least one mounting element that is supported by the closing plate and which defines at least one region for resting the covering slab.. . ... Bion Inc

Exoskeleton robot

An exoskeleton robot comprises a waist assembly and a leg assembly. The waist assembly includes a first frame, a plate and a second frame. ... Bion Inc

07/19/18 / #20180200134

Shoe assembly for a walking assist device

The present invention discloses a shoe assembly for a walking assist device. The shoe assembly includes a shoe pad, and a shoe cover on the shoe pad. ... Bion Inc

07/19/18 / #20180199891

System for monitoring physiological condition

A system for monitoring a physiological condition of a user includes a first measuring apparatus for personal use, a second measuring apparatus for use by medical professionals, and a server. The first measuring apparatus measures a first physiological parameter of the user. ... Bion Inc

07/19/18 / #20180199867

Method, system, and computer program product for dynamic analysis of a physiological parameter

A method for dynamic analysis of a physiological parameter of a user includes: generating a first event label corresponding to a first measurement value of the physiological parameter measured at a first time point; generating a second event label corresponding to a second measurement value of the physiological parameter measured at a second time point; calculating a time difference between the first and second time points; calculating a measurement value difference between the first and second measurement values when a time difference between the first and second time points is smaller than a time length threshold; and providing an analysis outcome based on the first and second event labels and the measurement value difference.. . ... Bion Inc

07/12/18 / #20180196056

Predictive baseline biomarkers for use of vascular disrupting agents

The present disclosure relates to the biological markers ferritin and il-8 that are predictive for patient response to treatment with a vascular disrupting agent. In particular, the present disclosure relates to biological markers predictive for cancer patient response to treatment with a vascular disrupting agent, as well as methods of treating a cancer patient with a vascular disrupting agent.. ... Bion Inc

07/12/18 / #20180196048

Predictive biomarkers

The present disclosure relates to the biological markers sap, shbg, myoglobin, mmp-9, and scf that are predictive for patient response to treatment with a vascular disrupting agent. In particular, the present disclosure relates to biological markers predictive for cancer patient response to treatment with a vascular disrupting agent, as well as methods of treating a cancer patient with a vascular disrupting agent.. ... Bion Inc

07/12/18 / #20180193642

Systems and methods for facilitating interaural time difference perception by a binaural cochlear implant patient

A binaural cochlear implant system (system) includes first and second microphones associated with first and second ears of a patient, respectively. The microphones detect an audio signal presented to the patient and output first and second signals representative of the audio signal as detected at the first and second ears, respectively. ... Bion Inc

07/05/18 / #20180192209

Binaural hearing systems and methods for preserving an interaural level difference to a distinct degree for each ear of a user

A binaural hearing system (“system”) preserves and/or enhances interaural level differences (“ilds”) between first and second signals. The system includes audio detectors each associated with an ear of a user. ... Bion Inc

07/05/18 / #20180184649

Composition for delivery of active agents to an animal

The present invention provides compositions for delivering an active agent to an animal, comprising an active agent, a first coating, a second coating and a third coating. The active agent is coated with the first coating, the first coating is coated with the second coating, and the second coating is coated with the third coating. ... Bion Inc

06/28/18 / #20180177885

Recombinant vaccines and use thereof

The present invention relates to fusion molecules of antigens, the nucleic acids coding therefor and the use of such fusion molecules and nucleic acids. In particular, said invention relates to fusion molecules, comprising an antigen and the trans-membrane region and cytoplasmic region of a mhc molecule and/or the cytoplasmic region of a mhc or a snare molecule.. ... Bion Inc

06/21/18 / #20180176702

Sound processor module

A behind-the-ear sound processor module includes a bte-housing; an adjustable microphone module attached to the bte-housing for capturing input audio signals from ambient sound; and a sound processor unit for generating, from the input audio signals, a neural hearing stimulation signal to be supplied to an implantable neural stimulation arrangement, wherein the microphone module comprises a plurality of microphones and a support element for carrying the microphones, wherein the support element is movable between a beamformer position enabling the plurality of microphones to act as a directional microphone array in a beamformer audio signal processing mode of the sound processor unit and a t-mic position enabling at least one of the microphones to act as a t-mic in a t-mic audio signal processing mode of the sound processor unit at a position closer to the entrance of the ear canal than in the beamformer position.. . ... Bion Inc

06/21/18 / #20180169236

Identification of surface-associated antigens for tumor diagnosis and therapy

The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. ... Bion Inc

06/14/18 / #20180165501

Extended depth-of-field biometric system

An iris recognition system may include an optical system having an intentional amount of spherical aberration that results in an extended depth of field. A raw image of an iris captured by the optical system may be normalized. ... Bion Inc

06/14/18 / #20180161302

Pharmaceutical combination and uses thereof

The invention relates to pharmaceutical combinations comprising a vascular disrupting agent, in particular the tubulin polymerisation inhibitor bnc105, and an immunotherapeutic agent, in particular an anti-pd-l1, pd-1 or ctla-4 antibody, and use thereof in the treatment of cancer.. . ... Bion Inc

06/07/18 / #20180153713

Biomimetic joint actuators

In a powered actuator for supplying torque, joint equilibrium, and/or impedance to a joint, a motor is directly coupled to a low-reduction ratio transmission, e.g., a transmission having a gear ratio less than about 80 to 1. The motor has a low dissipation constant, e.g., less than about 50 w/(nm)2. ... Bion Inc

05/24/18 / #20180140833

Systems and apparatus for gait modulation and methods of use

An apparatus includes a frame, a sensor, and an electric stimulator. The frame is removably couplable to a portion of a limb. ... Bion Inc

05/24/18 / #20180140694

Dosage regimen for hiv vaccine

The present invention relates to a novel dosage regimen in the treatment of hiv infections and aids. In particular, the present invention relates to a specific novel use of formulations of hiv-specific protein therapeutics, such as anti-hiv-1 specific antibodies and/or hiv-specific vaccine peptides, administered in a dosing regimen together with a latent viral reservoir purging agent. ... Bion Inc

05/17/18 / #20180139388

Image processing method and system for vision system

The present invention provides an image processing method for a vision system. The vision system includes a central processor, at least two camera groups a sensor for obtaining a rotation angle signal of each of the camera groups. ... Bion Inc

05/17/18 / #20180133486

Cochlear implants and magnets for use with same

A cochlear implant including a cochlear lead, a housing, a magnet apparatus located within the flexible housing and including a first partial disk shaped magnet member and a second partial disk shaped magnet member spaced apart from the first partial disk shaped magnet member, an antenna within the housing, and a stimulation processor.. . ... Bion Inc

05/03/18 / #20180117327

Cochlear implant system including an implantable battery

An exemplary cochlear implant system for a patient includes a cochlear implant, a sound processor, and an implantable battery configured to be implanted within the patient. The cochlear implant is configured to 1) determine that a signal is not being provided to the cochlear implant by a device external to the patient, 2) determine, in response to the determination that the signal is not being provided to the cochlear implant, that an amount of power remaining in the implantable battery is above a predetermined threshold amount, and 3) initiate, in response to the determination that the amount of power remaining in the implantable battery is above the predetermined threshold, an idle mode in which the cochlear implant remains powered on while waiting for one or more signals to be provided to the cochlear implant by the device external to the patient.. ... Bion Inc

04/19/18 / #20180104473

Cochlear electrode array with a flexural inflection point

. . . . A cochlear implant device includes a flexible electrode array for insertion into a cochlea. The flexible electrode array includes a number of electrodes; a number of electrical wires coupled to the electrodes; and a flexural inflection point positioned on the flexible electrode array such that, when implanted, is situated at a basal turn of the cochlea.. ... Bion Inc

04/12/18 / #20180098906

Control system for exoskeleton apparatus

A control system for an exoskeleton for a limb of a user wherein the limb has an upper portion connected to the body of a user and a lower limb portion is provided. The control system controls operation of one or more drive motors that rotate one or more joints of the exoskeleton. ... Bion Inc

04/05/18 / #20180094059

Single-chain tnf ligand family molecules and fusion proteins and derivatives thereof

The present invention relates to a polypeptide comprising a component a with at least three tumor necrosis factor (tnf) homology domains of tnf-ligand family members (thd) in which c-terminal and n-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional c-terminal and/or n-terminal amino acids of the thd or variants thereof, and a component b comprising a dimerization domain. Further, the present invention relates to a polypeptide comprising at least three thds in which c-terminal and n-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional c-terminal and/or n-terminal amino acids of the thd or variants thereof. ... Bion Inc

04/05/18 / #20180092536

Methods of exoskeleton communication and control

A first exoskeleton is in communication with a central server or a peripheral device. The first exoskeleton collects first data and transmits the first data to the central server or peripheral device. ... Bion Inc

03/29/18 / #20180087983

Pedal exercise signal detection device

A pedal exercise signal detection device includes a sleeve having an outer circumference having a pressure signal connection device and a pressure detection unit mounted thereon; a first bearing disposed in the sleeve; a stator having a positioning axle having an end formed with a fastening hole; a fastener element fastening the stator and the sleeve together; a pedal having an axle hole into which the sleeve is inserted to be positioned therein and a receiving trough including a through opening corresponding to the pressure signal connection device; and a control circuit board disposed in the receiving trough and including signal reader units that extend through the through opening and corresponding to the pressure signal connection device.. . ... Bion Inc

03/29/18 / #20180086786

Preparation of deoxycholic acid

The present invention relates to new and improved processes for the preparation of deoxycholic acid (dca) and pharmaceutically acceptable salts thereof, as well as to dca and pharmaceutically acceptable salts thereof, the carbon atoms of which are derived solely from plant sources.. . ... Bion Inc

03/29/18 / #20180085582

Systems and methods for creating and using sound processing program templates

An exemplary programming system 1) detects a first input command representative of a request to create a sound processing program, 2) provides, in response to the first input command, a user interface that shows a plurality of default values corresponding to a plurality of parameters associated with the sound processing program, 3) detects a changing, by way of the user interface, of the plurality of default values to a plurality of modified values, 4) detects, subsequent to the changing, a second input command representative of a request to create a sound processing program template configured to serve as a basis for one or more additional sound processing programs, and 5) presents, in response to the second input command, an option that allows the user to select one or more of the modified values to be included in the sound processing program template.. . ... Bion Inc

03/29/18 / #20180085277

Exoskeleton cord loop-type actuator

An exoskeleton includes first and second support structures configured to be coupled to a wearer of the exoskeleton. A joint connects the first and second support structures, the joint enabling relative movement between the first and second structures. ... Bion Inc

03/22/18 / #20180081118

Photonic integration by flip-chip bonding and spot-size conversion

Two or more monolithic or heterogeneously integrated substrates are attached to each other and optically edge-coupled using spot-size converters. Spot-size converters are placed between planar optical waveguides and cleaved or etched facets in each substrate. ... Bion Inc

03/22/18 / #20180078765

Connectorized cochlear implant systems

An exemplary system includes 1) a cochlear implant module configured to be implanted within a patient and including cochlear implant circuitry configured to apply electrical stimulation representative of one or more audio signals to the patient, 2) a first connector assembly coupled to the cochlear implant module and configured to be implanted within the patient, the first connector assembly including a first set of induction coils, 3) an implantable module configured to be implanted within the patient, and 4) a second connector assembly coupled to the implantable module and configured to be implanted within the patient, the second connector assembly including a second set of induction coils. The first and second sets of induction coils are configured to form a multi-channel inductive link between the implantable module and the cochlear implant module. ... Bion Inc

03/22/18 / #20180078764

Information processing and storage in a cochlear stimulation system

Information can be stored in a cochlear stimulation system by determining an item of patient specific information, transferring the item of patient specific information to an implantable portion of the cochlear stimulation system, and permanently storing the item of patient specific information in the implantable portion of the cochlear stimulation system. The item of patient specific information can comprise a parameter for use in generating a stimulation current. ... Bion Inc

03/22/18 / #20180078442

Methods of enhancing the rehabilitation or training of an exoskeleton wearer

Use of an exoskeleton by a wearer of the exoskeleton is improved through several features. In a first feature, the exoskeleton enters a gait therapy preparation mode to prepare the wearer for subsequent gait therapy. ... Bion Inc

03/15/18 / #20180074041

Physiological parameter measurement module

A test strip reader is disclosed. The test strip reader comprises a module main body and a circuit board. ... Bion Inc

03/15/18 / #20180071542

Antennas for use with transcutaneously powered medical implants

An antenna having an inductor assembly including at least two conductors, which each define a conductor diameter dc, and an electrically non-conductive carrier defining at least two lumens in which the at least two conductors are respectively located. The carrier maintains a conductor spacing s between the at least two conductors, and the inductor assembly defines at least one turn. ... Bion Inc

03/15/18 / #20180071221

Immediate release soluble ibuprofen compositions

Described herein are pharmaceutical compositions comprising ibuprofen, ibuprofen salts, or combinations thereof, methods for making the same, and methods for treating subjects in need thereof. In particular, there is described, inter alia, immediate release oral pharmaceutical compositions comprising ionic forms of ibuprofen are described.. ... Bion Inc

03/15/18 / #20180071159

Methods and apparatus for body weight support system

A body weight support system includes a support track, a trolley, and a power rail. The support track has a first portion and a second portion. ... Bion Inc

03/08/18 / #20180064563

Systems and methods for prosthetic wrist rotation

Features for a prosthetic wrist and associated methods of rotation are described. The prosthetic wrist attaches to a prosthetic hand. ... Bion Inc

03/01/18 / #20180055815

Compositions comprising dihydroquercetin for use in methods for treating herpes

Disclosed is the use of a composition including dihydroquercetin and optionally α-tocopherol and/or bisabolol for treating herpes infection. Also disclosed is the use of such a composition for treating inflammation induced by herpes infection in mucosa, as well as a method for treating hsv infection and the associated inflammation.. ... Bion Inc

02/15/18 / #20180042887

Combination treatment protocol

The present disclosure provides a combination and a method for treating chronic lymphocytic leukemia (cll).. . ... Bion Inc

02/15/18 / #20180042803

Exoskeleton and method of transferring a weight of a load from the exoskeleton to a support surface

An exoskeleton comprises at least one load-bearing element including a flexible hose, sleeve or cable having a first end portion and a second end portion opposite the first end portion. The first end portion is engageable with a load and is configured to transfer a weight of the load to the hose, sleeve or cable. ... Bion Inc

02/08/18 / #20180037632

Compositions and methods for diagnosis and treatment of cancer

The present invention relates to the diagnosis and treatment of cancerous diseases, in particular cancerous diseases expressing seprase (fap-alpha; fibroblast activation protein alpha). More particularly, the invention concerns peptides targeting seprase.. ... Bion Inc

02/08/18 / #20180036278

Cpc distribution chromatography of cannabinoids

The invention relates to cannabinoids and their isolation and purification and to obtaining them by means of centrifugal partition chromatography.. . ... Bion Inc

02/08/18 / #20180036196

Methods and apparatus for body weight support system

A body weight support system includes a trolley, a powered conductor operatively coupled to a power supply, and a patient attachment mechanism. The trolley can include a drive system, a control system, and a patient support system. ... Bion Inc

02/01/18 / #20180031832

Head mounted virtual reality object synchronized physical training system

A head mounted virtual reality object synchronized physical training system includes a virtual reality device, a physical training equipment, and a physiological signal sensor. The virtual reality device includes a display operable to display a virtual reality object according to an operation of the user. ... Bion Inc

02/01/18 / #20180031374

Method and system for personal dead-reckoning drift compensation using gait characteristics

Raw dead reckoning data is obtained from an inertial measurement unit (imu) worn by a user. Drift in the raw data is compensated for by detecting a gait of the user and phase of that gait, and constraining the position of the imu to lie within corresponding bounds as the imu moves. ... Bion Inc

02/01/18 / #20180030440

Pharmaceutical composition for treating cancer comprising microrna as active ingredient

The present invention relates to a pharmaceutical composition for treatment of cancer, which comprises, as an active ingredient, one or more mirnas selected from the group consisting of mir-3670, mir-8078, and mir-4477a. The pharmaceutical composition for treatment of cancer according to the present invention exhibits excellent effects of inhibiting cancer cell proliferation and inducing cancer cell apoptosis. ... Bion Inc

02/01/18 / #20180030421

Mixture of purified sods of plant origin

The present invention relates to an original and specific mixture of purified superoxide dismutases (sods) of plant origin, characterised in that said mixture is essentially made up of three superoxide dismutases: a manganese superoxide dismutase, a copper and zinc superoxide dismutase and an iron superoxide dismutase provided in two isoforms, which can be obtained from an extract of the hybrid variety f1 of cucumis melo ma 7950 or the cells thereof cultured in vitro or by transfer and expression of the genes of said sods in prokaryotic or eukaryotic cells. The specific mixture according to the invention imparts to the compositions containing same a greater effectiveness in the treatment or prevention of diseases linked to inflammatory and/or oxidative stress, such as radiation-induced fibroses, cardiovascular diseases, obesity, atherosclerosis, labial herpes and myopathies, as well as in nutritional, pharmaceutical, veterinary or cosmetic uses.. ... Bion Inc

01/25/18 / #20180027342

Audio accessory for auditory prosthesis system that includes body-worn sound processor apparatus

An exemplary auditory prosthesis system includes an audio accessory configured to be external to a patient and that includes 1) a plurality of microphones that receive incoming audio and convert the incoming audio into a plurality of audio signals, 2) a first communication port that connects directly to a communication port of a body-worn sound processor apparatus by way of a first cable, 3) a second communication port that connects directly to a communication port of a headpiece by way of a second cable, and 4) a control module communicatively coupled to the plurality of microphones and the first and second communication ports and that generates a processed audio signal by processing the plurality of audio signals converted by the plurality of microphones from the incoming audio and provides the processed audio signal to the body-worn sound processor apparatus.. . ... Bion Inc

01/25/18 / #20180021943

Exoskeleton and method of increasing the flexibility of an exoskeleton joint

An exoskeleton configured to be coupled to a user includes a plurality of interconnected support elements constituted by rigid compression members interconnected through a tensegrity joint. The joint includes a tensile member having a first end and a second end coupled to first and second ones of the support elements respectively.. ... Bion Inc

01/25/18 / #20180021565

System for transmitting electrical current to a bodily tissue

In some embodiments, an apparatus includes a substantially rigid base and a flexible substrate. The substantially rigid base has a first protrusion and a second protrusion, and is configured to be coupled to an electronic device. ... Bion Inc

01/11/18 / #20180014133

Hearing assistance system

There is provided a hearing assistance system, comprising an audio streaming device, a first hearing device for stimulating a first ear of a user, and a second hearing device for stimulating a second ear of the user, the audio streaming device comprising an audio input interface for receiving an input stereo audio signal, a unit for analyzing the input stereo audio signal in order to determine at least one azimuthal localization cue by comparing the two channels of the stereo signal, a unit for processing the input stereo audio signal in order to produce an output stereo audio signal, and a unit for supplying one channel of the output stereo audio signal to the first hearing device and for supplying the other channel of the output stereo audio signal to the second hearing device.. . ... Bion Inc

01/11/18 / #20180008819

Neural interface insertion and retraction tools

Devices and methods for manipulating devices such as micro-scale devices are provided. The devices can include a tether of various materials surrounded by a stiff body. ... Bion Inc

01/04/18 / #20180000792

Modified release compositions of epalrestat or a derivative thereof and methods for using the same

Modified release pharmaceutical compositions of epalrestat are provided. Methods of manufacturing the tablets and treating various diseases and conditions, including diabetes and diabetic complications, by administering the modified release compositions to patients in need thereof are also provided.. ... Bion Inc

12/14/17 / #20170354737

Stabilizing composition for biological materials

Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20° c. ... Bion Inc

12/14/17 / #20170354702

Drug containing thyme and primrose or thyme and ivy as a pde-4 inhibitor

The invention relates to an extract from thyme (thymus l.) in combination with primrose (primula veris) or ivy (hedera helix) for use as pde-4 inhibitor in the prophylaxis and treatment of selected diseases and to a corresponding pharmaceutical and use thereof.. . ... Bion Inc

12/14/17 / #20170354529

Terrain adaptive powered joint orthosis

A powered device augments a joint function of a human during a gait cycle using a powered actuator that supplies an augmentation torque, an impedance, or both to a joint. A controller estimates terrain slope and modulates the augmentation torque and the impedance according to a phase of the gait cycle and the estimated terrain slope to provide at least a biomimetic response. ... Bion Inc

11/30/17 / #20170340504

Exoskeleton for assisting human movement

The invention relates to an exoskeleton for assisting human movement, which can be fitted to the user in terms of dimensions, tension and ranges of joint motion, either manually or automatically. Said exoskeleton can be fitted to the user in the anteroposterior direction in the sagittal plane, with the user in a horizontal or sitting position, without requiring a functional transfer. ... Bion Inc

11/16/17 / #20170325688

Device for determining surface properties of hollow structures

An elongated device and a system that at the same time allow acquisition of temperature-related data of high spatial and temporal resolution from hollow structures together with other relevant data of physical or chemical variables. In a preferred embodiment infrared or visible light sensors are used to obtain thermal or color images from the inner surface during imposed change of the temperature in the lumen of the hollow structure. ... Bion Inc

11/09/17 / #20170320761

Water treatment reactor

A reactor for treating water, the reactor comprising a buoyant structure for supporting at least one cell for suspension in a body of water in use, wherein each cell is removeably attachable to the buoyant structure and is arranged to house biomedia. A water treatment system comprising the reactor in a body of water. ... Bion Inc

11/09/17 / #20170319421

Ball screw and tensile member exoskeleton joint actuation device

An exoskeleton includes first and second supports coupled to an exoskeleton wearer, a joint connecting the first support to the second support and an actuator. The actuator includes a ball screw, a ball nut assembly coupled to the ball screw and first and second tensile members. ... Bion Inc

11/09/17 / #20170319369

Powered joint orthosis

A powered device augments a joint function of a human during a gait cycle using a powered actuator that supplies an augmentation torque, an impedance, or both to a joint, and a controller that modulates the augmentation torque, the impedance, and a joint equilibrium according to a phase of the gait cycle to provide at least a biomimetic response. Accordingly, the device is capable of normalizing or augmenting human biomechanical function, responsive to a wearer's activity, regardless of speed and terrain.. ... Bion Inc

10/26/17 / #20170308671

Personal health awareness system and methods

Methods and apparatus for providing a health awareness of a medical condition to an individual. An illustrative system includes a healthcare data interface configured to receive clinical data describing healthcare characteristics of the individual, at least one sensor configured to capture over time patient generated data related to the medical condition, and at least one computer processor. ... Bion Inc

10/26/17 / #20170305905

Crystalline form of an anxiolytic compound

The present invention provides a crystalline form b of compound 1, and pharmaceutically compositions thereof. The present invention also provides methods of treating a disease (e.g., a disease of the central nervous system) using the pharmaceutical compositions.. ... Bion Inc

10/26/17 / #20170304619

Targeted channel selection systems and methods

An exemplary targeted channel selection system may determine a target stimulation rate for a user of a cochlear implant system, determine a pulse width value that is representative of one or more pulse widths that are to be used for stimulation pulses applied by the cochlear implant system to the user during a stimulation session, and determine, based on the target stimulation rate and on the pulse width value, a value for n that is specific to the user. In this example, n represents a total number of analysis channels that are to be selected from m available analysis channels for presentation by the cochlear implant system to the user during a stimulation frame of the stimulation session.. ... Bion Inc

10/26/17 / #20170304138

Design and use of a leg support exoskeleton

A leg support exoskeleton is strapped on as wearable device to support its user during squatting. The exoskeleton includes a knee joint connected to a first line and a second link, which is configured to allow flexion and extension motion between the first link and the second link. ... Bion Inc

10/05/17 / #20170282181

Photocleavage method and apparatus to clean fluidic devices

A method and system for improving throughput of a fluidic system such as a biopolymer analysis system by cleaning accumulated or clogging biopolymer from the fluidic system is disclosed. The method and system utilize a light energy source to photocleave the biopolymer molecules that may accumulate or aggregate in the fluidic system or clog a passageway. ... Bion Inc

10/05/17 / #20170281385

Exoskeleton device and method of impeding relative movement in the exoskeleton device

An exoskeleton device includes a first brace coupled to a first portion of a wearer of the exoskeleton device and a second brace coupled to a second portion of the wearer. A first joint connects the first and second braces and allows relative movement between the first and second braces. ... Bion Inc

10/05/17 / #20170281368

Wrist device for a prosthetic limb

A wrist device for a prosthetic limb is provided. The device (1) comprises a base member (3) connectable to the wearer of the device, and a support member (13) connectable to the limb. ... Bion Inc

09/28/17 / #20170273907

Stable formulations of lipids and liposomes

The present invention related to aqueous lipid and/or liposome formulations with an increased chemical stability, to methods of preparing such aqueous formulations as well as to kits comprising them. The present invention further relates to methods of preparing lipid-based pharmaceutical compositions, to pharmaceutical compositions prepared by such methods and to methods of chemically stabilizing aqueous lipid and/or liposome formulations.. ... Bion Inc

09/21/17 / #20170266301

Particles comprising single stranded rna and double stranded rna for immunomodulation

The present invention relates to chimeric particles comprising single stranded rna (ssrna), double stranded rna (dsrna) and at least one cationic agent, a pharmaceutical composition containing said particles and to a method of producing the same. The particles of the present invention are particularly useful as an immunostimulating medicament with a superlative pattern of immunostimulation.. ... Bion Inc

08/31/17 / #20170251312

Speech processor headpiece

A cochlear implant system includes: an electrode array implanted within a cochlea; an internal processor in communication with the electrode array; an implanted antenna which is electrically coupled to the internal processor; and a modular external headpiece which is removably positioned over the implanted antenna, the modular external headpiece including a core containing a sound processor for processing sound and providing a corresponding signal to the implanted antenna; and a modular component configured to releasably engage the core and supply electrical power to the core. A modular speech processor headpiece includes a core comprising a microphone and sound processor for producing a signal representing ambient sound to be transmitted to a cochlear implant, the core further comprising a number of electrical contacts; and a modular component containing a number of electrical contacts corresponding to the electrical contacts of the core; wherein the core is configured to engage with the modular component such that electrical communication is made between the core and the modular component.. ... Bion Inc

08/31/17 / #20170250632

Biomimetic transfemoral prosthesis

In an artificial limb system having an actuator coupled to a joint for applying a torque characteristic thereto, a control bandwidth of a motor controller for a motor included in the actuator can be increased by augmenting a current feedback loop in the motor controller with a feed forward of estimated back electromotive force (emf) voltage associated with, the motor. Alternatively, the current loop is eliminated and replaced with a voltage loop related to joint torque. ... Bion Inc

08/31/17 / #20170246457

Channel selection systems and methods that employ temporal modification

An exemplary sound processor may 1) divide an audio signal into m analysis channels, 2) select only n analysis channels included in the m analysis channels for presentation to a patient during a stimulation frame, wherein n is less than m, 3) increase a probability that a particular analysis channel will be included in the n analysis channels selected for presentation to the patient during the stimulation frame if the particular analysis channel was not selected for presentation to the patient during one or more stimulation frames that temporally precede the stimulation frame, and 4) decrease the probability that the particular analysis channel will be included in the n analysis channels selected for presentation to the patient during the stimulation frame if the particular analysis channel was selected for presentation to the patient during the one or more stimulation frames that temporally precede the stimulation frame.. . ... Bion Inc

08/31/17 / #20170246141

Compositions comprising dihydroquercetin for use in methods for treating the effects associated with skin inflammatory disorders

A method of using a composition including dihydroquercetin, as well as optionally α-tocopherol and/or bisabolol, for treating the effects associated with skin inflammatory disorder, such as those associated with diseases characterized by inappropriate immune response, such as psoriasis, atopic dermatitis and/or urticaria. A process of manufacturing the composition is also described.. ... Bion Inc

08/24/17 / #20170244247

Method and system for bio-mechanical power management

Electrical energy produced by an energy harvester is stored on a temporary basis in an interim energy storage module before transferring it to a load. The current fed to the load is controlled so that a voltage limit of, for example, a capacitor in the interim storage module is not reached. ... Bion Inc

08/24/17 / #20170240607

Modulating gamma-c-cytokine activity

Peptide antagonists of γc-family cytokines, which is associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (gvhd). Thus, inhibitors of γc-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. ... Bion Inc

08/24/17 / #20170239476

Cochlear implants having mri-compatible magnet apparatus and associated methods

A cochlear implant including a cochlear lead, an antenna, a stimulation processor, and a magnet apparatus, associated with the antenna, including a case defining a central axis, a magnet frame within the case and rotatable about the central axis of the case, and a plurality of elongate diametrically magnetized magnets that are located in the magnet frame, the magnets defining a longitudinal axis and a n-s direction and being freely rotatable about the longitudinal axis relative to the magnet frame.. . ... Bion Inc

08/24/17 / #20170239475

Systems and methods for fitting an electro-acoustic stimulation system to a patient

An exemplary fitting system 1) directs, during a fitting session, an eas system to concurrently apply acoustic stimulation to a patient by way of a loudspeaker and electrical stimulation to the patient by way of an electrode located within a cochlea of the patient, 2) determines an interactive effect that the electrical stimulation has on the acoustic stimulation, 3) directs, if the determined interactive effect is suppressive, the eas system to use, during a stimulation session, a first stimulation strategy that steers a current field produced by stimulation of the electrode away from intracochlear acoustic responders within the patient that are associated with the acoustic stimulation, and 4) directs, if the determined interactive effect is enhancing, the eas system to use, during the stimulation session, a second stimulation strategy that steers the current field produced by the stimulation of the electrode towards the intracochlear acoustic responders.. . ... Bion Inc

08/17/17 / #20170232257

Systems and methods for self-fitting an electroacoustic stimulation system to a patient

. . An exemplary system includes an electro-acoustic stimulation (eas) sound processor, a cochlear implant communicatively coupled to the eas sound processor, an electrode array communicatively coupled to the cochlear implant, and a receiver communicatively coupled to the eas sound processor and configured to be in communication with an ear of a patient. The eas sound processor 1) directs, while in a self-fitting mode, the receiver to apply acoustic stimulation to the patient, 2) records, using at least one electrode included in the electrode array, an evoked response that occurs in response to the acoustic stimulation, 3) compares the evoked response to a baseline evoked response recorded by the eas sound processor prior to recording the evoked response, and 4) performs a predetermined action based on the comparison between the evoked response and the baseline evoked response. ... Bion Inc

08/10/17 / #20170226567

Methods and devices for single-molecule whole genome analysis

Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. ... Bion Inc

08/10/17 / #20170224992

Systems and methods for gradually adjusting a control parameter associated with a cochlear implant system

An exemplary sound processor included in a cochlear implant system associated with a patient 1) receives, from a fitting system while the sound processor is communicatively coupled to the fitting system, a command that sets a control parameter associated with the cochlear implant system to an initial value and data representative of a target value associated with the control parameter, 2) detects a decoupling of the sound processor from the fitting system, the decoupling resulting in the sound processor being in a non-fitting state, and 3) gradually adjusts, while the sound processor is in the non-fitting state, the control parameter from the initial value towards the target value in accordance with an adaption time course associated with the control parameter. Corresponding systems and methods are also disclosed.. ... Bion Inc

08/03/17 / #20170223470

Sound processor apparatus with dual-mode earhook interface assembly

An exemplary sound processor apparatus includes 1) an earhook interface assembly that includes a plurality of contacts and that is configured to interchangeably connect to a microphone assembly and an eas receiver assembly by way of the plurality of contacts, and 2) a control module communicatively coupled to the plurality of contacts. In some examples, the control module uses the plurality of contacts as output ports to output one or more eas signals to the eas receiver assembly while the eas receiver assembly is connected to the earhook interface assembly.. ... Bion Inc

08/03/17 / #20170217009

Tool arm mount for aerial work platform

A tool arm mount couples a tool arm to an aerial work platform. The tool arm mount includes a first mounting hook that hangs on a first rail of the aerial work platform and a second mounting hook that hangs on a second rail of the aerial work platform. ... Bion Inc

08/03/17 / #20170216055

Controlling torque in a prosthesis or orthosis based on a deflection of series elastic element

In some embodiments of a prosthetic or orthotic ankle/foot, a prediction is made of what the walking speed will be during an upcoming step. When the predicted walking speed is slow, the characteristics of the apparatus are then modified so that less net-work that is performed during that step (as compared to when the predicted walking speed is fast). ... Bion Inc

07/27/17 / #20170209330

Universal tensegrity joints for human exoskeleton

An exoskeleton includes first and second compression members configured to be coupled to a wearer of the exoskeleton. A tensegrity joint connects the first compression member to the second compression member, the joint including a tensile member having a first end and a second end. ... Bion Inc

07/20/17 / #20170207600

3d photonic integration with light coupling elements

Methods for realizing integrated lasers and photonic integrated circuits on complimentary metal-oxide semiconductor (cmos)-compatible silicon (si) photonic chips, potentially containing integrated electronics, are disclosed. The integration techniques rely on light coupling with integrated light coupling elements such as turning mirrors, lenses, and surface grating couplers. ... Bion Inc

07/20/17 / #20170204153

Method of designing a peptide and/or peptide derivative for modulating gamma-c-cytokine activity

The γc-family cytokines, interleukin-2 (il-2), interleukin-4 (il-4), interleukin-7 (il-7), interleukin-9 (il-9), interleukin-15 (il-15), and interleukin-21 (il-21), are associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (gvhd). Thus, inhibitors of γc-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. ... Bion Inc

07/20/17 / #20170203108

Electrical feedthrough assembly

A device includes a hermetically sealed case with electronic circuitry housed within. One surface of the hermetically sealed case includes a metallic plate and a co-fired ceramic electrical feedthrough with a number of vias. ... Bion Inc

07/20/17 / #20170202725

Systems and methods for transferring exoskeleton trajectory sequences

An exoskeleton trajectory sequence is received with at least one server, and the sequence is transferred to a first device where the sequence is validated. The validation includes a safety check in which a determination is made as to whether the sequence is safe for use with an exoskeleton. ... Bion Inc

07/13/17 / #20170202092

Methods for connecting a wire to a feedthrough pin and apparatus including the same

Methods of connecting wires (126) to feedthrough pins (104) and apparatus including wires connected to feedthrough pins.. . ... Bion Inc

07/13/17 / #20170196752

Methods and apparatus for body weight support system

A body weight support system includes a trolley, a powered conductor operative coupled to a power supply, and a patient attachment mechanism. The trolley can include a drive system, a control system, and a patient support system. ... Bion Inc

07/13/17 / #20170196750

Method and system for intermittently assisting body motion

Motion of a body segment is assisted when the body segment is moving in a positive power mode but not when it is moving in a negative power mode. When the motion of the body segment is cyclical, for example during walking, assistance to the body segment is switched on and off throughout the cycle to correspond to positive and negative power modes respectively. ... Bion Inc

07/06/17 / #20170189785

Personal excercise measuring safety system

A personal exercise measuring safety system is provided, which includes an image acquiring device, an exercise measuring device, a portable digital measuring device. The image acquiring device is configured on one portion of a bicycle by a fixator or configured on a selected portion of an exerciser. ... Bion Inc

07/06/17 / #20170189694

Radio frequency transmitter circuits that provide power to an implant device

Exemplary radio frequency (rf) transmitter circuits that provide power to an implant device are described. An exemplary rf transmitter circuit may be included in an apparatus located external to a patient and may be configured to dynamically adjust an amount of power that is provided to an implant device implanted within the patient.. ... Bion Inc

06/29/17 / #20170183889

Structure for containing cinerary urns and furnerary items in general

. . A structure for containing cinerary urns and funerary items in general, which comprises a plurality of modular elements, such modular elements comprising: a plurality of box-like bodies, each one defining, within it, at least one niche for accommodating at least one cinerary urn and/or at least one funerary item and having a front face which is provided with at least one access opening; a plurality of elements for mutually joining such box-like bodies, which have at least one connecting portion adapted to be fixed to the front face of the box-like bodies arranged mutually adjacent; a plurality of profiled finishing elements designed to cover such joining elements at least partially; a plurality of retention bodies designed to be fixed with respect to such box-like bodies and adapted to peripherally engage closing plates, which are respectively intended for closing the openings of such box-like bodies.. . ... Bion Inc

06/29/17 / #20170183869

Lightweight construction element, manufacturing method therefor, use of same, and lightweight panel and insulating material

A lightweight construction element (1) comprises at least one lightweight panel (2) and a layer of insulating material (4) associated with the lightweight panel (2), wherein the at least one lightweight panel (2) comprises boards (6), which, on at least one of the main surfaces (8) thereof, have a group of grooves (9) running parallel and which boards (6) are arranged in at least one layer (5) and are connected to one another via adhesive bonds. The layer of insulating material (4) comprises wood chips (19), which are removed from starting boards during the manufacture of boards (6) for the lightweight panels (2). ... Bion Inc

06/29/17 / #20170183058

Construction of motorized wheel for vehicle motorization

A motorization apparatus for a motorized wheel comprises an axle secured to a frame of a vehicle. A rotor unit has poles of magnet material. ... Bion Inc

06/22/17 / #20170174643

Novel choline cocrystal of epalrestat

The invention relates to a novel choline cocrystal of 5-[(1z.2e)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel choline cocrystal according to various embodiments of the invention is described. ... Bion Inc

06/22/17 / #20170173783

Exoskeleton and method of providing an assistive torque to an arm of a wearer

An exoskeleton includes a first link that pivots in a transverse plane about a first vertical axis and a second link that pivots in a transverse plane about a second vertical axis. The second link is coupled to the first link. ... Bion Inc

06/22/17 / #20170173207

Absorbent pad that includes a fatty acid composition for odor control

An absorbent pad includes a batt of cellulose fibers, superabsorbent particles intermixed within the batt of cellulose fibers, and an odor control material intermixed within the batt of cellulose fibers, wherein the odor control material is a particulate material including one or more fatty acid. The odor control material preferably further includes selected inorganic compounds, such as sources of nitrogen, phosphorus and iron. ... Bion Inc

06/22/17 / #20170173147

Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish

The invention relates to a composition and a method for manufacturing semi-dry or dry particles containing a mucoadhesive polymer and a bioactive agent such as, but not limited to, an immunogenic substance (e.g., a vaccine), that allows the oral or nasal administration and delivery of the bioactive agent essentially unaltered to mucosal surfaces in the animal, including an aquatic animal.. . ... Bion Inc

06/22/17 / #20170173142

Compositions of multimeric-multiepitope influenza polypeptides and their production

Pharmaceutical suspensions of multimeric-multiepitope influenza polypeptides, processes for their production and their use as immunizing subjects against influenza. In particular, stable aqueous microparticulate suspensions of a multimeric multiepitope polypeptide are disclosed.. ... Bion Inc

06/15/17 / #20170165321

Method for reducing and/or delaying pathological effects of human immunodeficiency virus i (hiv) or for reducing the risk of developing acquired immunodeficiency syndrome (aids)

The present invention relates to novel compositions of active agents and methods for the treatment of hiv infection and aids. In particular, the present invention relates to novel methods for treatment of hiv infection and prevention of aids.. ... Bion Inc

06/08/17 / #20170158430

Automatic warehouse system

The invention is an automatic system for picking and placing boxes on shelves in a warehouse. The system comprises a set of autonomous mobile robots; a network of vertical and horizontal rails that are parallel to the vertical support posts and horizontal shelves of the shelving system in the warehouse; and a real time traffic management (rttm) server, which is a central processing server configured to communicate with the robots and other processors and servers in the warehouse. ... Bion Inc

06/01/17 / #20170152512

Improved nanoparticle type oligonucleotide structure having high efficiency and method for preparing same

The present invention relates to an oligonucleotide structure and a method for preparing the same and, more particularly, to an oligonucleotide structure in which a polymer compound is linked to an oligonucleotide via a covalent bond to improve in vivo stability of the oligonucleotide and cellular delivery efficiency of the oligonucleotide; and to a method for preparing the same. The oligonucleotide structure is improved into a homogenous material, thereby solving the problem in material verification due to polydispersion characteristics occurring when a hydrophilic material linked to the oligonucleotide is a synthetic polymer; the oligonucleotide structure is easy to synthesize compared with the existing process; and the size of a double-stranded oligo rna structure can be accurately adjusted through the control of the repetition number of a hydrophilic material block, and thus, the gene expression regulation function of the oligonucleotide does not deteriorate through the synthesis of the optimized oligonucleotide structure, and the oligonucleotide can be delivered into cells at even a relatively low-concentration dosage. ... Bion Inc

06/01/17 / #20170151349

Particles comprising protamine and rna in combination with endosome destabilizing agents

The present invention relates to particles comprising protamine, rna and at least one endosome destabilizing agent, to methods of their production and to pharmaceutical compositions or kits containing the particles. It further relates to particles comprising protamine and rna for use in methods of treatment or prevention of diseases and to kits comprising such particles together with at least one endosome destabilizing agent.. ... Bion Inc

05/18/17 / #20170140846

Silver-coated copper nanowire and preparation method therefor

The present invention relates to a silver-coated copper nanowire and a preparation method therefor and, more specifically, is characterized by synthesizing a copper nanowire through a chemical method by using piperazine (c4h10n2) and/or hexamethylenediamine (c6h16n2), which are novel copper capping agents, and then coating the same with silver by using a chemical plating method in order to prevent the oxidation of the copper nanowire.. . ... Bion Inc

05/18/17 / #20170136129

Stabilised formulations of rna

The present invention relates to stable low-salt aqueous formulations of particles comprising a polycation, preferably protamine, and rna, which formulations are preferably isotonic, to pharmaceutical compositions or kits comprising such formulations and to their use in medicine. It further relates to methods for preparing the formulations of the invention and to methods for physically stabilizing particles comprising a polycation, preferably protamine, and rna.. ... Bion Inc

05/18/17 / #20170136121

Rna vaccines

A rna vaccine containing a rna molecule encoding an allergen or derivative thereof, in which the allergen is an allergen of alnus glutinosa, alternaria alternata, ambrosia artemisiifolia, apium graveolens, arachis hypogaea, betula verrucosa, carpinus betulus, castanea sativa, cladosporium herbarum, corylus avellana, cryptomeria japonica, cyprinus carpio, daucus carota, dermatophagoides pteronyssinus, fagus sylvatica, felis domesticus, hevea brasiliensis, juniperus ashei, malus domestica, quercus alba or phleum pratense.. . ... Bion Inc

05/18/17 / #20170135980

Predicting response to cancer therapy

The present invention relates to cancer markers that are predictive for cancer patent response to treatment with an m tor inhibitor and a vascular disrupting agent. The present invention further relates to methods of treating a cancer patient subpopulation with a combination of an m tor inhibitor and a vascular disrupting agent.. ... Bion Inc

05/11/17 / #20170128723

System for combined neural and acoustic hearing stimulation

. . There is provided a hearing assistance system comprising an auditory prosthesis device for neural stimulation of a patient's hearing at one of the patient's ears and a hearing aid for acoustic stimulation of the patient's hearing at the same one or the other one of the patient's ears.. . ... Bion Inc

05/11/17 / #20170128717

Electrode assembly for a cochlear lead that inhibits twisting

An electrode assembly for a cochlear lead is configured to stimulate an auditory nerve from within a cochlea. The electrode assembly includes a conductive support structure for supporting an electrode and having two wings that are folded toward each other to form a wire carrier for a bundle of wires of the cochlear lead; and at least one of the wings comprising a tab extending from that wing along a longitudinal axis of the cochlear lead to inhibit twisting of the cochlear lead.. ... Bion Inc

05/11/17 / #20170128313

Apparatus and methods for support track and power rail switching in a body weight support system

A body weight support system includes a support track configured to movably suspend a trolley therefrom. A power rail of the system is coupled to the support track and is in electrical contact with the trolley. ... Bion Inc

05/04/17 / #20170121678

Methods and compositions to stabilize different stem cell states

Provided herein are methods and compositions for maintaining human stem cells in either a nave state or a primed state, inducing, promoting, inhibiting, or controlling the transition from one state to another, and detecting the state of a stem cell. Also disclosed are compositions comprising substantially homogenous populations of primed state or nave state stem cells.. ... Bion Inc

05/04/17 / #20170120051

Connectorized cochlear implant systems and methods

An exemplary method includes cochlear implant circuitry, which is disposed within a cochlear implant module configured to be implanted within a patient, performing the following: 1) detecting that an implantable antenna is connected to a modular connector coupled to the cochlear implant module, 2) operating in accordance with a radio frequency (“rf”) inductive link communication protocol while the implantable antenna is connected to the modular connector, 3) detecting a disconnection of the implantable antenna from the modular connector and a connection of an implantable sound processor to the modular connector, and 4) dynamically switching from operating in accordance with the rf inductive link communication protocol to operating in accordance with a hard wired baseband link communication protocol in response to the connection of the implantable sound processor to the modular connector.. . ... Bion Inc

05/04/17 / #20170119727

A therapeutic protocol for treating ovarian cancer

The present invention is directed to a pharmaceutical combination for treating proliferative disease comprising a compound of formula (i), or a salt, solvate or prodrug thereof, carboplatin or cisplatin, and gemcitabine. The present invention is further directed to a therapeutic protocol to manage ovarian cancer treatment in a female subject involving the administration of the combination to an ovarian cancer subject with recurrent or persistent ovarian cancer following treatment with platinum-based therapy. ... Bion Inc

05/04/17 / #20170119132

Human exoskeleton devices for heavy tool support and use

An exoskeleton includes strapping for coupling the exoskeleton to a wearer. The exoskeleton also includes a hip structure, a thigh link rotatably connected to the hip structure and a shank link rotatably connected to the thigh link. ... Bion Inc

04/27/17 / #20170114145

Humanized antibodies that bind lgr5

. . Disclosed herein are humanized anti-lgr5 antibodies for the treatment of cancer. Antibodies disclosed herein may bind lgr5 without disrupting lgr5-rspo1 binding or signaling, and may disrupt lgr5 signaling through wnt that is independent of rspo1. ... Bion Inc

04/27/17 / #20170113041

Utilization of an extended inter-pulse interval in a modified continuous interleaved stimulation strategy

An exemplary sound processor included in a cochlear implant system comprises a control facility that represents a first frequency domain signal to a patient by 1) directing a cochlear implant included in the cochlear implant system to apply, during a first stimulation frame, a first monophasic stimulation pulse representative of a first temporal portion of the first frequency domain signal that corresponds to the first stimulation frame, the first monophasic stimulation pulse having a first polarity, and 2) directing the cochlear implant to apply, during a second stimulation frame that is temporally subsequent to the first stimulation frame, a second monophasic stimulation pulse representative of a second temporal portion of the first frequency domain signal that corresponds to the second stimulation frame, the second monophasic stimulation pulse configured to at least partially charge balance the first monophasic stimulation pulse and having a second polarity opposite the first polarity.. . ... Bion Inc

04/27/17 / #20170112917

Peptide scaffold design

The present invention relates to novel peptides and methods for treatment, diagnosis and prognosis of virus infections including infections with hcv, hiv, cmv and influenza. The invention further relates to methods for identifying and providing peptides useful for the treatment and diagnosis.. ... Bion Inc

04/27/17 / #20170112862

Method for treating chronic lymphocytic leukemia

The present disclosure provides methods for treating chronic lymphocytic leukemia (cll) with medicaments useful for same. The medicaments can be pharmaceutical compositions or kits comprising compounds of formula (i) or a salt, solvate or prodrug thereof. ... Bion Inc

04/27/17 / #20170112764

Nanoemulsions having reversible continuous and dispersed phases

A nanoemulsion having reversible continuous and dispersed phases. The nanoemulsion includes an aqueous phase and an oil phase, a weight ratio of the aqueous phase to the oil phase being 1:40-100:1. ... Bion Inc

04/20/17 / #20170110937

Steady ratio four-bar linkage for genuflective energy harvesting

A mechanism has four connected links to mimic the motion of a knee joint. A lower link is oriented towards the vertical. ... Bion Inc

04/13/17 / #20170103758

Digital voice signature of transactions

A method that includes receiving, by a server, an access request sent to a network address of a resource server from a user using a user device, the access request comprising a unique record identifier is provided. The method includes placing a call to the user device, receiving from the user a voice response to a prompt associated with an implied security question for the user, comparing the voice response of the user with a selected voice biometrics record, converting the voice response into a speech-to-text phrase, and comparing the speech-to-text phrase against a stored secret text phrase to verify that the speech-to-text phrase matches an answer to the silent security question. ... Bion Inc

04/13/17 / #20170101452

Modulating gamma-c-cytokine activity

Embodiments relate to peptide antagonists of γc-family cytokines, which is associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (gvhd). Thus, inhibitors of γc-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. ... Bion Inc

04/13/17 / #20170100447

Compositions based on plant extracts for inhibition of the 5-alpha reductase

The present invention refers to nutraceutical, cosmetic or pharmaceutical compositions based on a combination of vegetal extracts from flowers or fruits of opuntia ficus and oryza sativa (black rice) for inhibition of the 5-alpha reductase. In particular, the preparations according to the invention are useful in prevention or treatment of benign prostatic hypertrophy or hyperplasia, of androgenic alopecia and acne.. ... Bion Inc

04/06/17 / #20170099551

Speech processor cases

Apparatus and methods for converting one type of speech processor unit into another type of speech processor unit.. . ... Bion Inc

03/30/17 / #20170086991

Hybrid terrain-adaptive lower-extremity systems

Hybrid terrain-adaptive lower-extremity apparatus and methods that perform in a variety of different situations by detecting the terrain that is being traversed, and adapting to the detected terrain. In some embodiments, the ability to control the apparatus for each of these situations builds upon five basic capabilities; (1) determining the activity being performed; (2) dynamically controlling the characteristics of the apparatus based on the activity that is being performed; (3) dynamically driving the apparatus based on the activity that is being performed; (4) determining terrain texture irregularities (e.g., how sticky is the terrain, how slippery is the terrain, is the terrain coarse or smooth, does the terrain have any obstructions, such as rocks) and (5) a mechanical design of the apparatus that can respond to the dynamic control and dynamic drive.. ... Bion Inc

03/23/17 / #20170080227

Programming systems for eliciting evoked responses in a cochlear implant patient and performing predetermined actions in accordance with the evoked responses

An exemplary system includes 1) a programming device configured to be located external to a cochlear implant patient and communicatively coupled to a cochlear implant system associated with the patient, 2) a programming interface device communicatively coupled to the programming device and configured to be located external to the patient, and 3) a receiver communicatively coupled directly to the programming interface device. The programming device directs at least one of the cochlear implant system and the receiver to apply stimulation to the patient, records an evoked response that occurs in response to the stimulation, and performs a predetermined action in accordance with the evoked response. ... Bion Inc

03/23/17 / #20170080226

Screening system and screening method for a cochlea implant device

A system includes a cochlear implant (ci) device and a screening device. The ci device includes an electrode array comprising a plurality of stimulation electrodes to be implanted in a patient's cochlea for electrical stimulation of the cochlea, a stimulation signal unit for generating stimulation signals to be supplied to the stimulation electrodes, and a unit for capturing ecap signals induced at the electrodes in response to stimulation of the cochlea by applying stimulation signals to the electrodes. ... Bion Inc

03/16/17 / #20170073666

Processing of polynucleotides

Methods and compositions for processing polynucleotides are provided according to some embodiments herein. In some embodiments, a sample is immobilized in a porous matrix, and non-polynucleotides are removed from the sample. ... Bion Inc

03/16/17 / #20170072197

Cochlear implant hearing assistance system and method of fitting the same

There is provided a hearing assistance system comprising a cochlear implant device for neural stimulation of the cochlea of one of the patient's ears and a fitting device for adjusting the cochlear implant device.. . ... Bion Inc

03/16/17 / #20170072195

Auditory prosthesis system including sound processor and wireless module for communication with an external computing device

An exemplary auditory prosthesis system includes a sound processor apparatus having 1) an interface assembly that includes at least a first contact that facilitates interchangeable connectivity of a plurality of external components to the sound processor apparatus, the plurality of external components including a programming system, and 2) a control module communicatively coupled to the first contact and that communicates with each of the plurality of external components by way of the first contact. The exemplary auditory prosthesis system may also include a wireless module configured to be interchangeably connected to the interface assembly in place of the programming system, wherein, while the wireless module is interchangeably connected to the interface assembly, the wireless module is communicatively coupled to the control module by way of the first contact. ... Bion Inc

03/16/17 / #20170072035

Tumor vaccination involving a humoral immune response against self-proteins

The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis b virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.. ... Bion Inc

03/16/17 / #20170071812

Devices and methods for improving the utility of an exoskeleton mobility base

A mobility system includes an energy module, an exoskeleton and a mobile base. The exoskeleton has an exoskeleton energy module receptacle that can receive the energy module, and the mobile base has a mobile base energy module receptacle that can also receive the energy module. ... Bion Inc

03/09/17 / #20170065815

Functional electrical stimulation systems

. . A gait modulation system including: (a) a sensor device including a sensor adapted for associating with at least one lower limb of the patient, the sensor for transducing at least one parameter related to a gait of the patient, so as to obtain gait data related to the gait, and (b) a muscle stimulator including: (i) an electrical stimulation circuit, the circuit adapted to supply an electrical stimulation output to an electrode array for performing functional electrical stimulation of at least one muscle of the lower limb, and (ii) a microprocessor, operatively connected to the at least one sensor, the microprocessor adapted for: receiving a stream of gait information based on the gait data; processing the gait information, and controlling the stimulation output based on the processing of the gait information, and wherein the microprocessor is further adapted to identify a failure in the stream of gait information, and to consequently control the electrical stimulation circuit to deliver a fail-safe stimulation output over a portion of a duration of the failure.. . ... Bion Inc

03/02/17 / #20170060256

System and method for controlling an electronic device with a facial gesture controller

A facial gesture controller for controlling an electronic device is provided. The facial gesture controller includes a body, a plurality of sensors, and at least one processor. ... Bion Inc








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