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Bion Inc patents (2018 archive)


Recent patent applications related to Bion Inc. Bion Inc is listed as an Agent/Assignee. Note: Bion Inc may have other listings under different names/spellings. We're not affiliated with Bion Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "B" | Bion Inc-related inventors


Design and use of a leg support exoskeleton

A leg support exoskeleton is strapped on as wearable device to support its user during squatting. The exoskeleton includes a knee joint connected to a first line and a second link, which is configured to allow flexion and extension motion between the first link and the second link. ... Bion Inc

Peptide conjugates

Methods and compositions related to the selective, specific disruption of multiple ligand-receptor signaling interactions, such as ligand-receptor interactions implicated in disease, are disclosed. These interactions may involve multiple cytokines in a single receptor family or multiple ligand receptor interactions from at least two distinct ligand-receptor families. ... Bion Inc

Implantable medical devices having resilient mounting tabs and associated methods

A method, for use with an implantable medical device, including the steps of stretching a mounting tab in such a manner that an aperture on the mounting tab increases in size and separating the mounting tab from a bone anchor by moving the stretched mounting tab in such a manner that the bone anchor does not extend through the aperture in the mounting tab.. . ... Bion Inc

Cochlear implants

A cochlear implant including a cochlear lead, an antenna, a processor case, and a printed circuit board assembly located within the processor case. The processor case may include a base with a bottom wall and first and second side walls that together define a one-piece, unitary structure, a first end wall, attached to the bottom wall and to the first and second side walls, including a first plurality of feedthrough pins, a second end wall, attached to the bottom wall and to the first and second side walls, including a second plurality of feedthrough pins, and a cover attached to the first and second side walls and to the first and second end walls.. ... Bion Inc

Membrane filter system

A guide member for directing gas bubble flow along a member surface, the guide member having first and second side edges defining a channel for gas bubbles to flow along, the channel having an open bottom end through which the gas bubbles can enter the channel and an open top end through which the bubbles can exit the channel, and a diverting means adjacent the channel bottom end arranged to direct at least some of the incident gas bubbles in a first direction towards the channel bottom end. A membrane module assembly and a membrane filter system including the guide member.. ... Bion Inc

Methods and apparatus for body weight support system

A body weight support system includes a tether configured to be coupled to an attachment device worn by a user to couple the user to the body weight support system. A method of providing gait training includes defining a reference length of the tether when the attachment device is in an initial position and defining a threshold length of the tether. ... Bion Inc

Systems and methods for determining a stapedius reflex threshold based on electro-acoustic stimulation

A stapedius reflex threshold determination system is communicatively coupled with a loudspeaker and a cochlear implant implanted within a patient. The system identifies a baseline evoked response level associated with a baseline acoustic stimulation level too low to trigger a stapedius reflex within the patient. ... Bion Inc

Characterization of molecules in nanofluidics

Methods are provided for detecting and quantitating molecules using fluidics. In preferred embodiments, the methods comprise analyzing blood to detect the presence of circulating dna or cells from a fetus or tumor.. ... Bion Inc

Antenna apparatus for use with medical implants

An antenna apparatus having a first coil including at least one turn on at least one first-coil substrate and a second coil including at least one turn on at least one second-coil substrate. The first and second coils are electrically connected to one another in parallel.. ... Bion Inc

Stable dry probiotic compositions for special dietary uses

A dry stable probiotic composition is provided. The composition comprises one or more viable probiotic microorganisms, one or more hydrolyzed proteins, one or more disaccharides, one or more oligosaccharides, and one or more polysaccharides, but not trehalose. ... Bion Inc

Funerary construction for containing funerary objects

A funerary construction for containing funerary objects, which comprises a supporting structure with at least one cavity defined for accommodating at least one funerary object; the accommodation cavity has at least one access opening which is closed by at least one closing plate fixed to the supporting structure; at least one covering slab is arranged facing the closing plate and there are elements of mounting the covering slab on the supporting structure; the mounting elements comprise at least one mounting element that is supported by the closing plate and which defines at least one region for resting the covering slab.. . ... Bion Inc

Funerary construction for containing funerary objects

A funerary construction for containing funerary objects, which comprises a supporting structure with at least one cavity defined for accommodating at least one funerary object; the accommodation cavity has at least one access opening which is closed by at least one closing plate fixed to the supporting structure; at least one covering slab is arranged facing the closing plate and there are elements of mounting the covering slab on the supporting structure; the mounting elements comprise at least one mounting element that is supported by the closing plate and which defines at least one region for resting the covering slab.. . ... Bion Inc

Exoskeleton robot

An exoskeleton robot comprises a waist assembly and a leg assembly. The waist assembly includes a first frame, a plate and a second frame. ... Bion Inc

Shoe assembly for a walking assist device

The present invention discloses a shoe assembly for a walking assist device. The shoe assembly includes a shoe pad, and a shoe cover on the shoe pad. ... Bion Inc

07/19/18 / #20180199891

System for monitoring physiological condition

A system for monitoring a physiological condition of a user includes a first measuring apparatus for personal use, a second measuring apparatus for use by medical professionals, and a server. The first measuring apparatus measures a first physiological parameter of the user. ... Bion Inc

07/19/18 / #20180199867

Method, system, and computer program product for dynamic analysis of a physiological parameter

A method for dynamic analysis of a physiological parameter of a user includes: generating a first event label corresponding to a first measurement value of the physiological parameter measured at a first time point; generating a second event label corresponding to a second measurement value of the physiological parameter measured at a second time point; calculating a time difference between the first and second time points; calculating a measurement value difference between the first and second measurement values when a time difference between the first and second time points is smaller than a time length threshold; and providing an analysis outcome based on the first and second event labels and the measurement value difference.. . ... Bion Inc

07/12/18 / #20180196056

Predictive baseline biomarkers for use of vascular disrupting agents

The present disclosure relates to the biological markers ferritin and il-8 that are predictive for patient response to treatment with a vascular disrupting agent. In particular, the present disclosure relates to biological markers predictive for cancer patient response to treatment with a vascular disrupting agent, as well as methods of treating a cancer patient with a vascular disrupting agent.. ... Bion Inc

07/12/18 / #20180196048

Predictive biomarkers

The present disclosure relates to the biological markers sap, shbg, myoglobin, mmp-9, and scf that are predictive for patient response to treatment with a vascular disrupting agent. In particular, the present disclosure relates to biological markers predictive for cancer patient response to treatment with a vascular disrupting agent, as well as methods of treating a cancer patient with a vascular disrupting agent.. ... Bion Inc

07/12/18 / #20180193642

Systems and methods for facilitating interaural time difference perception by a binaural cochlear implant patient

A binaural cochlear implant system (system) includes first and second microphones associated with first and second ears of a patient, respectively. The microphones detect an audio signal presented to the patient and output first and second signals representative of the audio signal as detected at the first and second ears, respectively. ... Bion Inc

07/05/18 / #20180192209

Binaural hearing systems and methods for preserving an interaural level difference to a distinct degree for each ear of a user

A binaural hearing system (“system”) preserves and/or enhances interaural level differences (“ilds”) between first and second signals. The system includes audio detectors each associated with an ear of a user. ... Bion Inc

07/05/18 / #20180184649

Composition for delivery of active agents to an animal

The present invention provides compositions for delivering an active agent to an animal, comprising an active agent, a first coating, a second coating and a third coating. The active agent is coated with the first coating, the first coating is coated with the second coating, and the second coating is coated with the third coating. ... Bion Inc

06/28/18 / #20180177885

Recombinant vaccines and use thereof

The present invention relates to fusion molecules of antigens, the nucleic acids coding therefor and the use of such fusion molecules and nucleic acids. In particular, said invention relates to fusion molecules, comprising an antigen and the trans-membrane region and cytoplasmic region of a mhc molecule and/or the cytoplasmic region of a mhc or a snare molecule.. ... Bion Inc

06/21/18 / #20180176702

Sound processor module

A behind-the-ear sound processor module includes a bte-housing; an adjustable microphone module attached to the bte-housing for capturing input audio signals from ambient sound; and a sound processor unit for generating, from the input audio signals, a neural hearing stimulation signal to be supplied to an implantable neural stimulation arrangement, wherein the microphone module comprises a plurality of microphones and a support element for carrying the microphones, wherein the support element is movable between a beamformer position enabling the plurality of microphones to act as a directional microphone array in a beamformer audio signal processing mode of the sound processor unit and a t-mic position enabling at least one of the microphones to act as a t-mic in a t-mic audio signal processing mode of the sound processor unit at a position closer to the entrance of the ear canal than in the beamformer position.. . ... Bion Inc

06/21/18 / #20180169236

Identification of surface-associated antigens for tumor diagnosis and therapy

The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. ... Bion Inc

06/14/18 / #20180165501

Extended depth-of-field biometric system

An iris recognition system may include an optical system having an intentional amount of spherical aberration that results in an extended depth of field. A raw image of an iris captured by the optical system may be normalized. ... Bion Inc

06/14/18 / #20180161302

Pharmaceutical combination and uses thereof

The invention relates to pharmaceutical combinations comprising a vascular disrupting agent, in particular the tubulin polymerisation inhibitor bnc105, and an immunotherapeutic agent, in particular an anti-pd-l1, pd-1 or ctla-4 antibody, and use thereof in the treatment of cancer.. . ... Bion Inc

06/07/18 / #20180153713

Biomimetic joint actuators

In a powered actuator for supplying torque, joint equilibrium, and/or impedance to a joint, a motor is directly coupled to a low-reduction ratio transmission, e.g., a transmission having a gear ratio less than about 80 to 1. The motor has a low dissipation constant, e.g., less than about 50 w/(nm)2. ... Bion Inc

05/24/18 / #20180140833

Systems and apparatus for gait modulation and methods of use

An apparatus includes a frame, a sensor, and an electric stimulator. The frame is removably couplable to a portion of a limb. ... Bion Inc

05/24/18 / #20180140694

Dosage regimen for hiv vaccine

The present invention relates to a novel dosage regimen in the treatment of hiv infections and aids. In particular, the present invention relates to a specific novel use of formulations of hiv-specific protein therapeutics, such as anti-hiv-1 specific antibodies and/or hiv-specific vaccine peptides, administered in a dosing regimen together with a latent viral reservoir purging agent. ... Bion Inc

05/17/18 / #20180139388

Image processing method and system for vision system

The present invention provides an image processing method for a vision system. The vision system includes a central processor, at least two camera groups a sensor for obtaining a rotation angle signal of each of the camera groups. ... Bion Inc

05/17/18 / #20180133486

Cochlear implants and magnets for use with same

A cochlear implant including a cochlear lead, a housing, a magnet apparatus located within the flexible housing and including a first partial disk shaped magnet member and a second partial disk shaped magnet member spaced apart from the first partial disk shaped magnet member, an antenna within the housing, and a stimulation processor.. . ... Bion Inc

05/03/18 / #20180117327

Cochlear implant system including an implantable battery

An exemplary cochlear implant system for a patient includes a cochlear implant, a sound processor, and an implantable battery configured to be implanted within the patient. The cochlear implant is configured to 1) determine that a signal is not being provided to the cochlear implant by a device external to the patient, 2) determine, in response to the determination that the signal is not being provided to the cochlear implant, that an amount of power remaining in the implantable battery is above a predetermined threshold amount, and 3) initiate, in response to the determination that the amount of power remaining in the implantable battery is above the predetermined threshold, an idle mode in which the cochlear implant remains powered on while waiting for one or more signals to be provided to the cochlear implant by the device external to the patient.. ... Bion Inc

04/19/18 / #20180104473

Cochlear electrode array with a flexural inflection point

. . . . A cochlear implant device includes a flexible electrode array for insertion into a cochlea. The flexible electrode array includes a number of electrodes; a number of electrical wires coupled to the electrodes; and a flexural inflection point positioned on the flexible electrode array such that, when implanted, is situated at a basal turn of the cochlea.. ... Bion Inc

04/12/18 / #20180098906

Control system for exoskeleton apparatus

A control system for an exoskeleton for a limb of a user wherein the limb has an upper portion connected to the body of a user and a lower limb portion is provided. The control system controls operation of one or more drive motors that rotate one or more joints of the exoskeleton. ... Bion Inc

04/05/18 / #20180094059

Single-chain tnf ligand family molecules and fusion proteins and derivatives thereof

The present invention relates to a polypeptide comprising a component a with at least three tumor necrosis factor (tnf) homology domains of tnf-ligand family members (thd) in which c-terminal and n-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional c-terminal and/or n-terminal amino acids of the thd or variants thereof, and a component b comprising a dimerization domain. Further, the present invention relates to a polypeptide comprising at least three thds in which c-terminal and n-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional c-terminal and/or n-terminal amino acids of the thd or variants thereof. ... Bion Inc

04/05/18 / #20180092536

Methods of exoskeleton communication and control

A first exoskeleton is in communication with a central server or a peripheral device. The first exoskeleton collects first data and transmits the first data to the central server or peripheral device. ... Bion Inc

03/29/18 / #20180087983

Pedal exercise signal detection device

A pedal exercise signal detection device includes a sleeve having an outer circumference having a pressure signal connection device and a pressure detection unit mounted thereon; a first bearing disposed in the sleeve; a stator having a positioning axle having an end formed with a fastening hole; a fastener element fastening the stator and the sleeve together; a pedal having an axle hole into which the sleeve is inserted to be positioned therein and a receiving trough including a through opening corresponding to the pressure signal connection device; and a control circuit board disposed in the receiving trough and including signal reader units that extend through the through opening and corresponding to the pressure signal connection device.. . ... Bion Inc

03/29/18 / #20180086786

Preparation of deoxycholic acid

The present invention relates to new and improved processes for the preparation of deoxycholic acid (dca) and pharmaceutically acceptable salts thereof, as well as to dca and pharmaceutically acceptable salts thereof, the carbon atoms of which are derived solely from plant sources.. . ... Bion Inc

03/29/18 / #20180085582

Systems and methods for creating and using sound processing program templates

An exemplary programming system 1) detects a first input command representative of a request to create a sound processing program, 2) provides, in response to the first input command, a user interface that shows a plurality of default values corresponding to a plurality of parameters associated with the sound processing program, 3) detects a changing, by way of the user interface, of the plurality of default values to a plurality of modified values, 4) detects, subsequent to the changing, a second input command representative of a request to create a sound processing program template configured to serve as a basis for one or more additional sound processing programs, and 5) presents, in response to the second input command, an option that allows the user to select one or more of the modified values to be included in the sound processing program template.. . ... Bion Inc

03/29/18 / #20180085277

Exoskeleton cord loop-type actuator

An exoskeleton includes first and second support structures configured to be coupled to a wearer of the exoskeleton. A joint connects the first and second support structures, the joint enabling relative movement between the first and second structures. ... Bion Inc

03/22/18 / #20180081118

Photonic integration by flip-chip bonding and spot-size conversion

Two or more monolithic or heterogeneously integrated substrates are attached to each other and optically edge-coupled using spot-size converters. Spot-size converters are placed between planar optical waveguides and cleaved or etched facets in each substrate. ... Bion Inc

03/22/18 / #20180078765

Connectorized cochlear implant systems

An exemplary system includes 1) a cochlear implant module configured to be implanted within a patient and including cochlear implant circuitry configured to apply electrical stimulation representative of one or more audio signals to the patient, 2) a first connector assembly coupled to the cochlear implant module and configured to be implanted within the patient, the first connector assembly including a first set of induction coils, 3) an implantable module configured to be implanted within the patient, and 4) a second connector assembly coupled to the implantable module and configured to be implanted within the patient, the second connector assembly including a second set of induction coils. The first and second sets of induction coils are configured to form a multi-channel inductive link between the implantable module and the cochlear implant module. ... Bion Inc

03/22/18 / #20180078764

Information processing and storage in a cochlear stimulation system

Information can be stored in a cochlear stimulation system by determining an item of patient specific information, transferring the item of patient specific information to an implantable portion of the cochlear stimulation system, and permanently storing the item of patient specific information in the implantable portion of the cochlear stimulation system. The item of patient specific information can comprise a parameter for use in generating a stimulation current. ... Bion Inc

03/22/18 / #20180078442

Methods of enhancing the rehabilitation or training of an exoskeleton wearer

Use of an exoskeleton by a wearer of the exoskeleton is improved through several features. In a first feature, the exoskeleton enters a gait therapy preparation mode to prepare the wearer for subsequent gait therapy. ... Bion Inc

03/15/18 / #20180074041

Physiological parameter measurement module

A test strip reader is disclosed. The test strip reader comprises a module main body and a circuit board. ... Bion Inc

03/15/18 / #20180071542

Antennas for use with transcutaneously powered medical implants

An antenna having an inductor assembly including at least two conductors, which each define a conductor diameter dc, and an electrically non-conductive carrier defining at least two lumens in which the at least two conductors are respectively located. The carrier maintains a conductor spacing s between the at least two conductors, and the inductor assembly defines at least one turn. ... Bion Inc

03/15/18 / #20180071221

Immediate release soluble ibuprofen compositions

Described herein are pharmaceutical compositions comprising ibuprofen, ibuprofen salts, or combinations thereof, methods for making the same, and methods for treating subjects in need thereof. In particular, there is described, inter alia, immediate release oral pharmaceutical compositions comprising ionic forms of ibuprofen are described.. ... Bion Inc

03/15/18 / #20180071159

Methods and apparatus for body weight support system

A body weight support system includes a support track, a trolley, and a power rail. The support track has a first portion and a second portion. ... Bion Inc

03/08/18 / #20180064563

Systems and methods for prosthetic wrist rotation

Features for a prosthetic wrist and associated methods of rotation are described. The prosthetic wrist attaches to a prosthetic hand. ... Bion Inc

03/01/18 / #20180055815

Compositions comprising dihydroquercetin for use in methods for treating herpes

Disclosed is the use of a composition including dihydroquercetin and optionally α-tocopherol and/or bisabolol for treating herpes infection. Also disclosed is the use of such a composition for treating inflammation induced by herpes infection in mucosa, as well as a method for treating hsv infection and the associated inflammation.. ... Bion Inc

02/15/18 / #20180042887

Combination treatment protocol

The present disclosure provides a combination and a method for treating chronic lymphocytic leukemia (cll).. . ... Bion Inc

02/15/18 / #20180042803

Exoskeleton and method of transferring a weight of a load from the exoskeleton to a support surface

An exoskeleton comprises at least one load-bearing element including a flexible hose, sleeve or cable having a first end portion and a second end portion opposite the first end portion. The first end portion is engageable with a load and is configured to transfer a weight of the load to the hose, sleeve or cable. ... Bion Inc

02/08/18 / #20180037632

Compositions and methods for diagnosis and treatment of cancer

The present invention relates to the diagnosis and treatment of cancerous diseases, in particular cancerous diseases expressing seprase (fap-alpha; fibroblast activation protein alpha). More particularly, the invention concerns peptides targeting seprase.. ... Bion Inc

02/08/18 / #20180036278

Cpc distribution chromatography of cannabinoids

The invention relates to cannabinoids and their isolation and purification and to obtaining them by means of centrifugal partition chromatography.. . ... Bion Inc

02/08/18 / #20180036196

Methods and apparatus for body weight support system

A body weight support system includes a trolley, a powered conductor operatively coupled to a power supply, and a patient attachment mechanism. The trolley can include a drive system, a control system, and a patient support system. ... Bion Inc

02/01/18 / #20180031832

Head mounted virtual reality object synchronized physical training system

A head mounted virtual reality object synchronized physical training system includes a virtual reality device, a physical training equipment, and a physiological signal sensor. The virtual reality device includes a display operable to display a virtual reality object according to an operation of the user. ... Bion Inc

02/01/18 / #20180031374

Method and system for personal dead-reckoning drift compensation using gait characteristics

Raw dead reckoning data is obtained from an inertial measurement unit (imu) worn by a user. Drift in the raw data is compensated for by detecting a gait of the user and phase of that gait, and constraining the position of the imu to lie within corresponding bounds as the imu moves. ... Bion Inc

02/01/18 / #20180030440

Pharmaceutical composition for treating cancer comprising microrna as active ingredient

The present invention relates to a pharmaceutical composition for treatment of cancer, which comprises, as an active ingredient, one or more mirnas selected from the group consisting of mir-3670, mir-8078, and mir-4477a. The pharmaceutical composition for treatment of cancer according to the present invention exhibits excellent effects of inhibiting cancer cell proliferation and inducing cancer cell apoptosis. ... Bion Inc

02/01/18 / #20180030421

Mixture of purified sods of plant origin

The present invention relates to an original and specific mixture of purified superoxide dismutases (sods) of plant origin, characterised in that said mixture is essentially made up of three superoxide dismutases: a manganese superoxide dismutase, a copper and zinc superoxide dismutase and an iron superoxide dismutase provided in two isoforms, which can be obtained from an extract of the hybrid variety f1 of cucumis melo ma 7950 or the cells thereof cultured in vitro or by transfer and expression of the genes of said sods in prokaryotic or eukaryotic cells. The specific mixture according to the invention imparts to the compositions containing same a greater effectiveness in the treatment or prevention of diseases linked to inflammatory and/or oxidative stress, such as radiation-induced fibroses, cardiovascular diseases, obesity, atherosclerosis, labial herpes and myopathies, as well as in nutritional, pharmaceutical, veterinary or cosmetic uses.. ... Bion Inc

01/25/18 / #20180027342

Audio accessory for auditory prosthesis system that includes body-worn sound processor apparatus

An exemplary auditory prosthesis system includes an audio accessory configured to be external to a patient and that includes 1) a plurality of microphones that receive incoming audio and convert the incoming audio into a plurality of audio signals, 2) a first communication port that connects directly to a communication port of a body-worn sound processor apparatus by way of a first cable, 3) a second communication port that connects directly to a communication port of a headpiece by way of a second cable, and 4) a control module communicatively coupled to the plurality of microphones and the first and second communication ports and that generates a processed audio signal by processing the plurality of audio signals converted by the plurality of microphones from the incoming audio and provides the processed audio signal to the body-worn sound processor apparatus.. . ... Bion Inc

01/25/18 / #20180021943

Exoskeleton and method of increasing the flexibility of an exoskeleton joint

An exoskeleton configured to be coupled to a user includes a plurality of interconnected support elements constituted by rigid compression members interconnected through a tensegrity joint. The joint includes a tensile member having a first end and a second end coupled to first and second ones of the support elements respectively.. ... Bion Inc

01/25/18 / #20180021565

System for transmitting electrical current to a bodily tissue

In some embodiments, an apparatus includes a substantially rigid base and a flexible substrate. The substantially rigid base has a first protrusion and a second protrusion, and is configured to be coupled to an electronic device. ... Bion Inc

01/11/18 / #20180014133

Hearing assistance system

There is provided a hearing assistance system, comprising an audio streaming device, a first hearing device for stimulating a first ear of a user, and a second hearing device for stimulating a second ear of the user, the audio streaming device comprising an audio input interface for receiving an input stereo audio signal, a unit for analyzing the input stereo audio signal in order to determine at least one azimuthal localization cue by comparing the two channels of the stereo signal, a unit for processing the input stereo audio signal in order to produce an output stereo audio signal, and a unit for supplying one channel of the output stereo audio signal to the first hearing device and for supplying the other channel of the output stereo audio signal to the second hearing device.. . ... Bion Inc

01/11/18 / #20180008819

Neural interface insertion and retraction tools

Devices and methods for manipulating devices such as micro-scale devices are provided. The devices can include a tether of various materials surrounded by a stiff body. ... Bion Inc

01/04/18 / #20180000792

Modified release compositions of epalrestat or a derivative thereof and methods for using the same

Modified release pharmaceutical compositions of epalrestat are provided. Methods of manufacturing the tablets and treating various diseases and conditions, including diabetes and diabetic complications, by administering the modified release compositions to patients in need thereof are also provided.. ... Bion Inc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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