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Bonac Corporation patents


Recent patent applications related to Bonac Corporation. Bonac Corporation is listed as an Agent/Assignee. Note: Bonac Corporation may have other listings under different names/spellings. We're not affiliated with Bonac Corporation, we're just tracking patents.

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Single-stranded nucleic acid molecule having delivery function and gene expression regulating ability

The present invention provides a single-stranded nucleic acid molecule having a delivery function and capable of inhibiting expression of a target gene. The single-stranded nucleic acid molecule of the present invention is a single-stranded nucleic acid molecule composed of a region (xc), a linker region (lx) and a region (x), wherein said region (xc) is complementary to said region (x), at least one of said region (x) and said region (xc) contains an expression inhibitory sequence that inhibits expression of the target gene, and a bio-related substance having a delivery function is bonded to at least one selected from the group consisting of the 5′-terminus, the 3′-terminus, and said linker region (lx).. ... Bonac Corporation

Method for producing glycoside compounds

. . The invention provides a production method of a glycoside compound or a salt thereof, which includes subjecting a thioether compound and an alcohol compound to a coupling reaction in the presence of a halogenating agent, a desiccant and a lewis acid, and then distillation in the presence of at least one kind of additive selected from a sulfur-containing antioxidant and a maleimide group-containing compound to give a thioether compound and a step of subjecting a glycoside compound and a thioether compound to a coupling reaction in the presence of a halogenating agent, a desiccant and a lewis acid to give a glycoside compound. By this method, a phosphoramidite preferable for the production (synthesis) of a nucleic acid can be produced more efficiently at a high purity.. ... Bonac Corporation

Composition containing nucleic acid molecule stably

The present invention provides a composition containing a nucleic acid molecule and a buffer, and having the features of (a) being in the form of a solution at ambient temperature; and (b) a content of the nucleic acid molecule after storage at 25° c., relative humidity 60% for 4 weeks, of not less than 80% relative to the content at the time of start of the storage.. . ... Bonac Corporation

Single-stranded nucleic acid molecule for inhibiting tgf-beta1 expression

The invention provides a single-stranded nucleic acid molecule of (a) or (b) containing a tgf-β1 gene expression inhibitory sequence. The single-stranded nucleic acid molecule (a) consists of region (xc), linker region (lx) and region (x) from the 5′-side to the 3′-side, wherein linker region (lx) has a non-nucleotide structure containing at least one of a pyrrolidine skeleton and a piperidine skeleton, and at least one of region (x) and region (xc) contains the expression inhibitory sequence. ... Bonac Corporation

Single-stranded nucleic acid molecule for regulating expression of gene having delivering function

The invention provides a single-stranded nucleic acid capable of inhibiting expression of a target gene having a delivery function. The nucleic acid contains, from the 5′-side to the 3′-side, a 5′-side region (xc), a linker region (lx), an inner region (z), a linker region (ly) and a 3′-side region (yc) in this order, wherein the inner region (z) is constituted by linkage of the inner 5′-side region (x) and the inner 3′-side region (y), the 5′-side region (xc) is complementary to the inner 5′-side region (x), the 3′-side region (yc) is complementary to the inner 3′-side region (y), at least one of the inner region (z), the 5′-side region (xc) and the 3′-side region (yc) comprises an expression inhibitory sequence that inhibits expression of a target gene, and at least one of the 5′-terminus, the 3′-terminus, the linker region (lx) and the linker region (ly) is bound to a bio-related substance.. ... Bonac Corporation








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