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Brandeis University patents (2016 archive)


Recent patent applications related to Brandeis University. Brandeis University is listed as an Agent/Assignee. Note: Brandeis University may have other listings under different names/spellings. We're not affiliated with Brandeis University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "B" | Brandeis University-related inventors


Dna methylation analysis

Disclosed herein are methods for determining whether one or more cpg dinucleotides are methylated using linear after the exponential polymerase chain reaction (“late-pcr”) or linear-expo-linear polymerase chain reaction (“lel-pcr”).. . ... Brandeis University

Tethering cysteine residues using cyclic disulfides

Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including sod1 and dj-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. ... Brandeis University

High temperature selection of nucleotide-supported carbohydrate vaccines and resulting glycosylated oligonucleotides

The invention relates to an oligonucleotide including one or more modified nucleoside bases having the structure -b-l-a wherein for each of the modified nucleosides a is independently a monosaccharide or oligosaccharide, l is a linker molecule, and b is independently a pyrimidine or pyridine base linked to the sugar-phosphate backbone of the oligonucleotide; and wherein the oligonucleotide binds specifically to a carbohydrate-binding monoclonal antibody with an affinity of less than 100 nm. Immunogenic conjugates that include the oligonucleotide, and pharmaceutical compositions that include the oligonucleotide or the immunogenic conjugate are also disclosed. ... Brandeis University

Multivalent glycopeptides that tightly bind to target proteins

The invention relates to a glycopolypeptide that includes one or more modified amino acid residues having a sidechain comprising a monosaccharide or an oligosaccharide, wherein the glycopolypeptide binds specifically to a carbohydrate-binding monoclonal antibody with an affinity of less than 100 nm. Immunogenic conjugates that include the glycopolypeptide, and pharmaceutical compositions that include the glycopolypeptide or the immunogenic conjugate are also disclosed. ... Brandeis University

Mispriming prevention reagents

Provided herein are mispriming prevention reagents, compositions and kits comprising such reagents and methods of use thereof.. . ... Brandeis University

Kits and reaction mixtures for analyzing single-stranded nucleic acid sequences

Provided herein are kits for performing for nucleic acid sequences.. . ... Brandeis University

Modified polymerase compositions, methods and kits

This invention relates to type i dna polymerases, for example, taq dna polymerase, and to methods and reagent kits utilizing such polymerases.. . ... Brandeis University

Polymeric materials having active cross-linkers, methods for making them, and use thereof

The present technology relates to a polymeric material including a plurality of polymer subunits and an active cross-linker, wherein the active cross-linker is covalently linked to the plurality of polymer subunits. The active cross-linker offers a key building block for constructing novel molecular architecture in chemomechanical soft materials and illustrates a new approach to tailor material properties.. ... Brandeis University

Ice-cleaved alpha-synuclein as a biomarker

The present disclosure provides ice-cleaved alpha-synuclein fragments as biomarkers for alpha-synuclein-associated disease or disorder and/or for ice-regulator therapy.. . ... Brandeis University

Drip free glass bottles and methods of making such bottles

A glass bottle is configured to improve the mechanics of liquid flow and prevent drip initiation. Additionally, the glass bottle eliminates dripping during pouring to enable drip free pouring. ... Brandeis University

Inhibitors of deubiquitinating proteases

Disclosed are small molecule inhibitors of deubiquitinating enzymes (dubs), and methods of using them. Certain compounds display a preference for specific ubiquitin specific proteases (usps).. ... Brandeis University

Par-baked and milled coffee beans for use in foods, beverages and dietary supplements

The present invention concerns compositions and methods relating to the addition and use of par-baked and milled coffee beans in food products, beverages, and dietary supplements. Par-baked and milled coffee beans are a novel alternative to more costly chlorogenic acid extracts, and are edible and palatable as a food ingredient. ... Brandeis University

Methods for the development of vaccines based on oligosaccharide-oligonucleotide conjugates

Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying them. The conjugates may be identified using non-human antibodies as binding targets, thereby expanding the power and scope of the invention. ... Brandeis University

Methods and kits for detecting nucleic acid mutants in wild-type populations

This disclosure relates to amplification and detection of a rare variant or variants of a dna sequence in an abundant variant of the sequence, such as detection of a low-level somatic mutations and minority alleles in an excess of normal nucleic acid target sequences.. . ... Brandeis University

01/21/16 / #20160016994

Inhibition of tumor growth with aggregates of small molecules

Disclosed herein are fibrillar molecular aggregates, which are morphologically and phenotypically similar to oligomers of aberrant proteins. The molecular aggregates, formed by self-assembly of small hydrophobic molecules, prevent the growth of microtubules. ... Brandeis University

01/21/16 / #20160015050

Vegetable oil composition containing palm mid-fraction fat and method of reducing plasma cholesterol

A method and composition for reducing the cholesterolemic effect in mammals of ingesting a blended nutritional fat composition containing a palm mid-fraction (pmf) hardstock fat combined with an unsaturated vegetable oil. The composition is solid or semi-solid at 20° c. ... Brandeis University








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