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California Institute Of Technology patents (2015 archive)


Recent patent applications related to California Institute Of Technology. California Institute Of Technology is listed as an Agent/Assignee. Note: California Institute Of Technology may have other listings under different names/spellings. We're not affiliated with California Institute Of Technology, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | California Institute Of Technology-related inventors


12/31/15 / #20150380989

Methods for optically powering transducers and related transducers

The present disclosure describes a method for optically powering transducers and related transducers with a photovoltaic collector. An optical fiber power delivery method and a free space power delivery method are also provided. ... California Institute Of Technology

12/31/15 / #20150380767

Crosslinked polymer electrolyte

A composite electrolyte can include a crosslinked polymer formed from telechelic precursor polymers having at least two photoactivatable end functional groups and a molecular weight before crosslinking of between about 1,000 and 1,000,000 daltons (da); and a lithium (li) salt. Electrochemical cells and batteries including such electrolytes are also disclosed, along with various methods of manufacture.. ... California Institute Of Technology

12/31/15 / #20150375227

Microfabricated crossflow devices and methods

This invention provides microfabricated devices and methods for detecting, analyzing and sorting biological materials and particles. Droplets containing the particles are provided in an extrusion fluid, passed through a detection region, and then directed into a branch channel according to predetermined characteristics. ... California Institute Of Technology

12/24/15 / #20150371929

Implant device and method of making the same

The invention provides chip packaging and processes for the assembly of retinal prosthesis devices. Advantageously, photo-patternable adhesive or epoxy such as photoresist is used as glue to attach a chip to the targeted thin-film (e.g., parylene) substrate so that the chip is used as an attachment to prevent delamination.. ... California Institute Of Technology

12/24/15 / #20150369809

Targeting phosphofructokinase and its glycosylation form for cancer

The present invention relates to methods of treating cancer, suppressing or inhibiting tumorigenesis, tumor growth or cancer progression, and suppressing or inhibiting cancer cells from altering cellular metabolism in favor of cancerous growth. Also provided are compositions comprising an agent that decreases glycosylation of phosphofructokinase 1 or increases phosphofructokinase 1 expression or activity.. ... California Institute Of Technology

12/24/15 / #20150369220

Manipulation of flexible materials through self-propelled bodies

A system is described comprising self-propelled bodies such as bacteria or nanoparticles, which can be activated with an external field to move in a desired direction. The self-propelled bodies, or swimmers, are contained in a flexible membrane which is mechanically manipulated through the movement of the swimmers. ... California Institute Of Technology

12/24/15 / #20150368811

Highly active mixed-metal catalysts made by pulsed-laser ablation in liquids

The invention is directed to mixed-metal nanocatalysts, particularly nano-dimensioned layered double-hydroxide nanostacks, methods of making nanocatalysts using laser ablation techniques, and the electrochemical devices comprising and using these nanocatalysts, for example in the electrochemical oxidation of water oxidation.. . ... California Institute Of Technology

12/24/15 / #20150368111

Method and system for graphene formation

A system for graphene production includes a plurality of gas sources, a plurality of mass flow controllers, and a processing chamber. The system also includes a plasma source operable, a vacuum pump, a processor, and a non-transitory computer-readable storage medium including a plurality of computer-readable instructions. ... California Institute Of Technology

12/17/15 / #20150359668

Light delivery device and related compositions, methods and systems

Devices and systems for delivering light to a target are described. Methods of using such light delivery device and system are also described. ... California Institute Of Technology

12/10/15 / #20150357541

Compliant interfacial layers in thermoelectric devices

A thermoelectric power generation device is disclosed using one or more mechanically compliant and thermally and electrically conductive layers at the thermoelectric material interfaces to accommodate high temperature differentials and stresses induced thereby. The compliant material may be metal foam or metal graphite composite (e.g. ... California Institute Of Technology

12/10/15 / #20150357075

Methods and devices for in situ synthesis of metal oxides in carbon nanotube arrays

A method for controlling microstructural and nanostructural arrangement of nominally-aligned arrays of carbon nanotubes (cnts) is disclosed. The method comprises synthesizing metal oxide particles in situ in nominally-aligned arrays of carbon nanotubes (cnts) after synthesis of cnts. ... California Institute Of Technology

12/10/15 / #20150355098

Rotating scattering plane based nonlinear optical spectrometer to study the crystallographic and electronic symmetries of crystals

A method for measuring nonlinear electromagnetic (em) radiation emitted by a material, comprising rotating a beam of em radiation to form a rotating beam; irradiating a surface of a material with the rotating beam at an oblique angle with respect to the surface, wherein the rotating irradiates a plurality of scattering planes in the material; and detecting nonlinear radiation emitted by the material in response to the rotating beam, such that the nonlinear radiation generated by each of the scattering planes is detected by the detector. This method opens the possibility of applying nonlinear optics as a probe of lattice and electronic symmetries on small bulk single crystals in ultra low temperature, high magnetic field or high pressure environments, which can greatly complement diffraction based techniques.. ... California Institute Of Technology

12/10/15 / #20150353619

Non-canonical insulins and their uses

In some aspects, the invention relates to an insulin derivative, comprising a cyclic amino acid at position b28 or b29, wherein the cyclic amino acid is not l-proline. In some aspects, the invention relates to a method of making said insulin derivative. ... California Institute Of Technology

12/03/15 / #20150346753

Systems and methods for convex relaxations and linear approximations for optimal power flow in multiphase radial networks

Centralized node controllers in accordance with embodiments of the invention enable linear approximation of optimal power flow. One embodiment includes a centralized node controller including: a network interface, a processor, and a memory containing: a centralized power control application a network topology, where the network is multiphase unbalanced and comprises a plurality of connected nodes; wherein the processor is configured by the centralized controller application to: request node operating parameters from the plurality of connected nodes; calculate network operating parameters using a linear approximation of optimal power flow and the node operating parameters from the plurality of connected nodes; send network operating parameters to the plurality of connected nodes.. ... California Institute Of Technology

12/03/15 / #20150346726

Controllable buoys and networked buoy systems

Buoyant sensor networks are described, comprising floating buoys with sensors and energy harvesting capabilities. The buoys can control their buoyancy and motion, and can organize communication in a distributed fashion. ... California Institute Of Technology

12/03/15 / #20150344932

Method and compositions for the detection of protein glycosylation

The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with posttranslational glycosylations. The methods can be used to detect o-glcnac posttranslational modifications on proteins on which such modifications were undetectable using other techniques. ... California Institute Of Technology

12/03/15 / #20150344523

Mutant akt-specific capture agents, compositions, and methods of using and making

The present application provides stable peptide-based akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing akt capture agents using iterative on-bead in situ click chemistry.. ... California Institute Of Technology

12/03/15 / #20150344109

Controllable buoys and networked buoy systems

Buoyant sensor networks are described, comprising floating buoys with sensors and energy harvesting capabilities. The buoys can control their buoyancy and motion, and can organize communication in a distributed fashion. ... California Institute Of Technology

11/26/15 / #20150340863

Systems and methods for optimal power flow on a radial network

Node controllers and power distribution networks in accordance with embodiments of the invention enable distributed power control. One embodiment includes a node controller including a distributed power control application; a plurality of node operating parameters describing the operating parameter of a node and a set of at least one node selected from the group consisting of an ancestor node and at least one child node; wherein send node operating parameters to nodes in the set of at least one node; receive operating parameters from the nodes in the set of at least one node; calculate a plurality of updated node operating parameters using an iterative process to determine the updated node operating parameters using the node operating parameters that describe the operating parameters of the node and the set of at least one node, where the iterative process involves evaluation of a closed form solution; and adjust node operating parameters.. ... California Institute Of Technology

11/19/15 / #20150333482

Index-coupled distributed-feedback semiconductor quantum cascade lasers fabricated without epitaxial regrowth

Quantum cascade (qc) lasers and methods of fabricating such qc lasers are provided. The qc lasers incorporate a dfb grating without requiring the use of relying on epitaxial regrowth processes. ... California Institute Of Technology

11/19/15 / #20150333480

High-coherence semiconductor light sources

A laser resonator includes an active material, which amplifies light associated with an optical gain of the resonator, and passive materials disposed in proximity with the active material. The resonator oscillates over one or more optical modes, each of which corresponds to a particular spatial energy distribution and resonant frequency. ... California Institute Of Technology

11/19/15 / #20150332125

Automated feature analysis, comparison, and anomaly detection

Novel methods and systems for automated data analysis are disclosed. Data can be automatically analyzed to determine features in different applications, such as visual field analysis and comparisons. ... California Institute Of Technology

11/19/15 / #20150331228

Ptychography imaging systems and methods with convex relaxation

Certain aspects pertain to ptychographic imaging systems and methods with convex relaxation. In some aspects, a ptychographic imaging system with convex relaxation comprises one or more electromagnetic radiation sources, a digital radiation intensity detector, and a processor in communication with the digital radiation detector. ... California Institute Of Technology

11/19/15 / #20150331193

Self-equalizing photo detector

A self-equalizing photo-detector (sepd) includes, in part, a multitude of optical splitters and photo detectors, and at least one optical delay element. The first optical splitter splits an optical signal into second and third optical signals. ... California Institute Of Technology

11/19/15 / #20150329961

Carbon nanotube foams with controllable mechanical properties

Syntheses of carbon nanotubes (cnt) are disclosed. The syntheses can take place on a thermally oxidized silicon surface placed inside a furnace prior to a reaction. ... California Institute Of Technology

11/19/15 / #20150329769

Ultra-light ultra-strong proppants

The present invention provides a method of preparing a proppant material by heating a reaction mixture comprising a plurality of oxides in a reactive atmosphere to a temperature above the melting point of the reaction mixture to form a melt, and then allowing the melt to solidify in a mold in the form of spherical particles. The present invention also provides a method of preparing a proppant material by heating a reaction mixture comprising a plurality of oxides and one or more additives in a reactive atmosphere to a temperature below the melting point of the reaction mixture to form a powder including one or more reaction products, and then processing the powder to form spherical particles. ... California Institute Of Technology

11/19/15 / #20150329603

Compositions and methods related to parasites

In some aspects, the invention relates to compositions and methods for preventing or treating a hookworm infection. In some aspects, the invention relates to nucleic acids, peptides, proteins, antigens, and cells that encode, comprise, and/or express one or more hookworm amino acid sequences, e.g., for use in manufacturing a vaccine.. ... California Institute Of Technology

11/19/15 / #20150329362

Simple method for producing superhydrophobic carbon nanotube array

Efficient methods for producing a superhydrophobic carbon nanotube (cnt) array are set forth. The methods comprise providing a vertically aligned cnt array and performing vacuum pyrolysis on the cnt array to produce a superhydrophobic cnt array. ... California Institute Of Technology

11/19/15 / #20150328616

Surface mediated synthesis of polynucleotides, polypeptides and polysaccharides and related materials, methods and systems

Surface mediated polymer synthesizing methods and related systems and materials are described where monomers are attached to monomer binding regions on a surface and subsequently form chemical bonds with adjacent monomers on the surface to form linear polymers selected from polynucleotide, polypeptides and polysaccharides.. . ... California Institute Of Technology

11/19/15 / #20150328313

Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and methods of using same

Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. ... California Institute Of Technology

11/12/15 / #20150323322

Automated vessel navigation using sea state prediction

Systems and methods for sea state prediction and autonomous navigation in accordance with embodiments of the invention are disclosed. One embodiment of the invention includes a method of predicting a future sea state including generating a sequence of at least two 3d images of a sea surface using at least two image sensors, detecting peaks and troughs in the 3d images using a processor, identifying at least one wavefront in each 3d image based upon the detected peaks and troughs using the processor, characterizing at least one propagating wave based upon the propagation of wavefronts detected in the sequence of 3d images using the processor, and predicting a future sea state using at least one propagating wave characterizing the propagation of wavefronts in the sequence of 3d images using the processor. ... California Institute Of Technology

11/12/15 / #20150322207

Carrier nanoparticles and related compositions, methods and systems

Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.. . ... California Institute Of Technology

11/12/15 / #20150321195

Temperature control devices and methods

Temperature control devices and methods are described. The described temperature control devices and methods comprise optical emission and detection assemblies and can be used in pcr and qpcr applications.. ... California Institute Of Technology

11/05/15 / #20150316763

Optimized actuators for ultra-thin mirrors

A method and apparatus for correcting error modes of a deformable mirror, including selecting or targeting one or more target error modes of a deformable mirror; and designing a pattern and/or shape of one or more electrodes, wherein the pattern and/or shape of the electrodes are designed to optimally correct the target error modes when the electrodes are disposed on the deformable mirror via an active material. Also disclosed is a deformable structure, including a composite shell including a plurality of plies each including carbon fibers embedded in a resin; a nanolaminate comprising individual nanolayers attached to a first side of the composite shell; an actuation structure attached to a second side of the composite shell; and a flexible electrode routing layer attached to the actuation structure.. ... California Institute Of Technology

11/05/15 / #20150316530

Using a field effect device for identifying translocating charge-tagged molecules in a nanopore sequencing device

A detector apparatus includes a field-effect transistor configured to undergo a change in amplitude of a source-to-drain current when at least a portion of a charge-tagged molecule translocates through the nanopore. In some implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is located in a membrane. ... California Institute Of Technology

10/29/15 / #20150312555

Single-lens, single-sensor 3-d imaging device with a central aperture for obtaining camera position

A device and method for three-dimensional (3-d) imaging using a defocusing technique is disclosed. The device comprises a lens, a central aperture located along an optical axis for projecting an entire image of a target object, at least one defocusing aperture located off of the optical axis, a sensor operable for capturing electromagnetic radiation transmitted from an object through the lens and the central aperture and the at least one defocusing aperture, and a processor communicatively connected with the sensor for processing the sensor information and producing a 3-d image of the object. ... California Institute Of Technology

10/29/15 / #20150311662

Stable microwave-frequency source based on cascaded brillouin lasers

A microwave-frequency source, generating an output electrical signal at an output frequency fm, comprises a pump laser source, an optical resonator, and a photodetector. Free spectral range vfsr of the optical resonator equals an integer submultiple of a brillouin shift frequency vb of the optical resonator (i.e., vb=mvfsr). ... California Institute Of Technology

10/29/15 / #20150309011

Microfluidic device

Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. ... California Institute Of Technology

10/29/15 / #20150305774

In vitro platform and methods for culturing embryos for implantation

A mammalian in vitro system for culturing an embryo includes a collagen or fibrin matrix and endometrial and/or stromal cells. The in vitro platforms and methods according to embodiments of the invention allow for in vitro embryonic development (including implantation) prior to transfer of the embryo complex in vivo for further development.. ... California Institute Of Technology

10/22/15 / #20150304653

Mapping electrical crosstalk in pixelated sensor arrays

The effects of inter pixel capacitance in a pixilated array may be measured by first resetting all pixels in the array to a first voltage, where a first image is read out, followed by resetting only a subset of pixels in the array to a second voltage, where a second image is read out, where the difference in the first and second images provide information about the inter pixel capacitance. Other embodiments are described and claimed.. ... California Institute Of Technology

10/22/15 / #20150304094

Dynamic polarization modulation and control

A method for sending a data from an electromagnetic radiator by polarization modulation of an electromagnetic wave includes radiating from the radiator first and second electromagnetic waves including first and second polarizations respectively, the first polarization being different than the second polarization. The first and second electromagnetic waves form a third electromagnetic wave having a third polarization different from the first or second polarization. ... California Institute Of Technology

10/22/15 / #20150301034

Label-free detection of nanoparticles and biological molecules using microtoroid optical resonators

Systems and methods are provided for detecting one or more particles such as individual unlabeled molecules or single nanoparticles. In examples described herein, optical energy is introduced into a microtoroid or other microcavity to generate an evanescent field. ... California Institute Of Technology

10/22/15 / #20150300884

340 ghz multipixel transceiver

A multi-pixel terahertz transceiver is constructed using a stack of semiconductor layers that communicate using vias defined within the semiconductor layers. By using a stack of semiconductor layers, the various electrical functions of each layer can be tested easily without having to assemble the entire transceiver. ... California Institute Of Technology

10/22/15 / #20150299757

Sensor probe for bio-sensing and chemical-sensing applications

The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. ... California Institute Of Technology

10/22/15 / #20150299236

Z-selective metathesis catalysts

A novel chelated ruthenium-based metathesis catalyst bearing an n-2,6-diisopropylphenyl group is reported and displays near-perfect selectivity for the z-olefin (>95%), as well as unparalleled tons of up to 7,400, in a variety of homodimerization and industrially relevant metathesis reactions. This derivative and other new catalytically-active species were synthesized using an improved method employing sodium carboxylates to induce the salt metathesis and c—h activation of these chelated complexes. ... California Institute Of Technology

10/22/15 / #20150299073

Catalytic anti-markovnikov oxidation and hydration of olefins

The disclosure provides a dual-catalysis system for direct conversion of olefins to alcohols. The cooperative catalytic system contains one oxidizing catalyst and one transfer-hydrogenation catalyst. ... California Institute Of Technology

10/22/15 / #20150298171

Monolithic flexure pre-stressed ultrasonic horns

A monolithic ultrasonic horn where the horn, backing, and pre-stress structures are combined in a single monolithic piece is disclosed. Pre-stress is applied by external flexure structures. ... California Institute Of Technology

10/22/15 / #20150297105

Portable electronic hemodynamic sensor systems

Systems and methods are provided for extracting hemodynamic information, optionally employing portable electronic devices with optional user interface (ui) features for system implementation. The systems and methods may be employed for acquiring hemodynamic signals and associated electrophysiological data and/or analyzing the former or both in combination to yield useful physiological indicia or results. ... California Institute Of Technology

10/01/15 / #20150280321

Low power multi-gigabit per second millimeter-wave data-link employing modulated reflections

A system for wirelessly communicating between a base station and a mobile device, including a reflector integrated with a mobile device, wherein the reflector reflects carrier radiation transmitted from a base station, to form a reflection of the carrier radiation, and input data from the mobile device modulates a reflection coefficient of the reflector, thereby modulating the reflection such that the reflection of the carrier radiation carries the input data to the base station.. . ... California Institute Of Technology

10/01/15 / #20150276947

Subnanosecond scintillation detector

A scintillation detector, including a scintillator that emits scintillation; a semiconductor photodetector having a surface area for receiving the scintillation, wherein the surface area has a passivation layer configured to provide a peak quantum efficiency greater than 40% for a first component of the scintillation, and the semiconductor photodetector has built in gain through avalanche multiplication; a coating on the surface area, wherein the coating acts as a bandpass filter that transmits light within a range of wavelengths corresponding to the first component of the scintillation and suppresses transmission of light with wavelengths outside said range of wavelengths; and wherein the surface area, the passivation layer, and the coating are controlled to increase the temporal resolution of the semiconductor photodetector.. . ... California Institute Of Technology

10/01/15 / #20150276089

Microfabricated elastomeric valve and pump systems

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.. . ... California Institute Of Technology

10/01/15 / #20150274813

Broadly-neutralizing anti-hiv antibodies

The present invention relates to anti-hiv antibodies. Also disclosed are related methods and compositions. ... California Institute Of Technology

09/24/15 / #20150268191

Chemical sensing and/or measuring devices and methods

Methods for fabricating silicon nanowire chemical sensing devices, devices thus obtained, and methods for utilizing devices for sensing and measuring chemical concentration of selected species in a fluid are described. Devices may comprise a metal-oxide-semiconductor field-effect transistor (mosfet) structure.. ... California Institute Of Technology

09/24/15 / #20150267251

Multiplex labeling of molecules by sequential hybridization barcoding

The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or dna loci.. ... California Institute Of Technology

09/24/15 / #20150267233

Compositions and methods for producing benzylisoquinoline alkaloids

The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise one, two or more heterologous coding sequences wherein each of the heterologous coding sequences encodes an enzyme involved in the metabolic pathway of a benzylisoquinoline, or its precursors or intermediates from a starting compound. ... California Institute Of Technology

09/24/15 / #20150267232

In vivo and in vitro carbene insertion and nitrene transfer reactions catalyzed by heme enzymes

This invention relates to the use of heme-containing enzymes to catalyze carbene and nitrene insertion and transfer reactions with greater selectivity, mild reaction conditions, and convenient production.. . ... California Institute Of Technology

09/17/15 / #20150264250

Free orientation fourier camera

Certain aspects pertain to fourier camera systems and methods. In one aspect, a fourier camera comprises a first optical system, a second optical system, a variable aperture filter, and a light detector. ... California Institute Of Technology

09/17/15 / #20150262035

Automated feature analysis, comparison, and anomaly detection

Novel methods and systems for automated data analysis are disclosed. Data can be automatically analyzed to determine features in different applications, such as visual field analysis and comparisons. ... California Institute Of Technology

09/17/15 / #20150259657

Stable fungal cel6 enzyme variants

The disclosure provides variant cel6a enzymes having increased thermostability, methods of making and using such polypeptides.. . ... California Institute Of Technology

09/17/15 / #20150258240

Light-triggered shape-changeable hydrogels and their use in optical devices

The present invention is directed to optical hydrogels, whose shape and/or refractive indices can be catalyzed by the application of light, methods of preparing the same, and optical devices and lenses derived therefrom.. . ... California Institute Of Technology

09/10/15 / #20150255637

Photovoltaic devices incorporating thin chalcogenide film electrically interposed between pnictide-containing absorber layer and emitter layer

The present invention provides strategies for improving the quality of the insulating layer in mis and sis devices in which the insulator layer interfaces with at least one pnictide-containing film the principles of the present invention are based at least in part on the discovery that very thin (20 nm or less) insulating films comprising a chalcogenide such as i-zns are surprisingly superior tunnel barriers in mis and sis devices incorporating pnictide semiconductors. In one aspect, the present invention relates to a photovoltaic device, comprising: a semiconductor region comprising at least one pnictide semiconductor; an insulating region electrically coupled to the semiconductor region, wherein the insulating region comprises at least one chalcogenide and has a thickness in the range from 0.5 nm to 20 nm; and a rectifying region electrically coupled to the semiconductor region in a manner such that the insulating region is electrically interposed between the collector region and the semiconductor region.. ... California Institute Of Technology

09/10/15 / #20150254573

Alternative training distribution data in machine learning

Technologies are generally described for methods and systems in a machine learning environment. In some examples, a method may include retrieving training data from a memory. ... California Institute Of Technology

09/10/15 / #20150253196

Uncooled ir detector arrays based on nanoelectromechanical systems

We describe the use of a high-quality-factor torsional resonator of microscale dimensions. The resonator has a paddle that is supported by two nanoscale torsion rods made of a very low thermal conductivity material, such as amorphous (“a-”) silicon. ... California Institute Of Technology

09/03/15 / #20150249456

Mercury trapped ion frequency standard for ultra-stable reference applications

An atomic clock including an ion trap assembly, a c-field coil positioned for generating a first magnetic field in the interrogation region of the ion trap assembly, a compensation coil positioned for generating a second magnetic field in the interrogation region, wherein the combination of the first and second magnetic fields produces an ion number-dependent second order zeeman shift (zeeman shift) in the resonance frequency that is opposite in sign to an ion number-dependent second order doppler shift (doppler shift) in the resonance frequency, the c-field coil has a radius selected using data indicating how changes in the radius affect an ion-number-dependent shift in the resonance frequency, such that a difference in magnitude between the doppler shift and the zeeman shift is controlled or reduced, and the resonance frequency, including the adjustment by the zeeman shift, is used to obtain the frequency standard.. . ... California Institute Of Technology

09/03/15 / #20150247190

Methods and systems for microfluidics imaging and analysis

Disclosed herein are methods and devices for assessing sample for the presence of a disease or organism using images from devices such as a consumer cell phones.. . ... California Institute Of Technology

09/03/15 / #20150246140

Compositions and methods for modulating sleep and wakefulness

In some aspects, the invention relates to methods of treating conditions associated with sleep disorders, comprising administering an agent that modulates the activity of a neuropeptide receptor or a neuropeptide receptor ligand. In some aspects, the invention relates to methods of screening agents that modulate the activity of a neuropeptide receptor in an organism, optionally using cells or organisms comprising a genetic modification that affects a neuropeptide signaling pathway. ... California Institute Of Technology

08/27/15 / #20150241342

Digital phase conjugation using moving target as guide star

A method for irradiating a scattering medium, including irradiating a scattering medium with radiation from a laser, to form scattered radiation having a scattered field; measuring a difference in the scattered field caused by motion of a moving target in or behind the scattering medium; forming a phase conjugate of the difference to form a phase conjugate field; and irradiating the scattering medium with the phase conjugate field formed using one or more radiation modulating elements. Thus we present that movement of objects can be used as a novel guide star in digital optical phase conjugation (dopc). ... California Institute Of Technology

08/27/15 / #20150238960

Microfluidic nucleic acid analysis

Nucleic acid from cells and viruses sampled from a variety of environments may purified and expressed utilizing microfluidic techniques. In accordance with one embodiment of the present invention, individual or small groups of cells or viruses may be isolated in microfluidic chambers by dilution, sorting, and/or segmentation. ... California Institute Of Technology

08/27/15 / #20150238742

Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface

The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. ... California Institute Of Technology

08/27/15 / #20150237838

Regulation of insect populations

The present technology generally relates to compositions, methods, and populations that allow for the regulation of insect population.. . ... California Institute Of Technology

08/20/15 / #20150236396

Dielectric waveguides splitter and hybrid/isolator for bidirectional link

. . A system, method, device, and apparatus provide a dielectric waveguide splitter/bi-directional link. A dielectric substrate fabricated into a first y-junction waveguide with a first port splitting into a first branch leading to a second port and a second branch leading to a third port. ... California Institute Of Technology

08/20/15 / #20150234052

Real-time and post-processed orbit determination and positioning

Novel methods and systems for the accurate and efficient processing of real-time and latent global navigation satellite systems (gnss) data are described. Such methods and systems can perform orbit determination of gnss satellites, orbit determination of satellites carrying gnss receivers, positioning of gnss receivers, and environmental monitoring with gnss data.. ... California Institute Of Technology

08/20/15 / #20150232814

Methods and systems for sulfimidation or sulfoximidation of organic molecules

The disclosure generally relates to the fields of synthetic organic chemistry. In particular, the present disclosure relates to methods and systems for the imidation of sulfides.. ... California Institute Of Technology

08/20/15 / #20150231675

Sheet forming of metallic glass by rapid capacitor discharge

An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (rcdf) tool are provided. The rcdf method utilizes the discharge of electrical energy stored in a capacitor to uniformly and rapidly heat a sample or charge of metallic glass alloy to a predetermined “process temperature” between the glass transition temperature of the amorphous material and the equilibrium melting point of the alloy in a time scale of several milliseconds or less. ... California Institute Of Technology

08/13/15 / #20150225801

Recording and mapping lineage information and molecular events in individual cells

Methods and systems for recording and mapping lineage information and molecular events in individual cells are provided. Molecular changes, which may result from random or specific molecular events, are introduced to defined regions in cells over multiple cell cycle generations. ... California Institute Of Technology

08/13/15 / #20150223738

Plasmonics nanostructures for multiplexing implantable sensors

Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. ... California Institute Of Technology

08/13/15 / #20150223701

Breathing and heartbeat feature extraction and victim detection

Systems and methods for detecting biometrics using a life detecting radar are disclosed. Life detecting radars can include transmit antennas configured to transmit continuous microwave (“cw”) radio signals that reflect back upon making contact with various objects. ... California Institute Of Technology

08/06/15 / #20150222092

Iii-v photonic crystal microlaser bonded on silicon-on-insulator

Novel methods and systems for miniaturized lasers are described. A photonic crystal is bonded to a silicon-on-insulator wafer. ... California Institute Of Technology

08/06/15 / #20150222073

Methods of modulating microlasers at ultralow power levels, and systems thereof

A microlaser system includes an optical source, a microlaser, an actuator switch, and a photovoltaic power source. The microlaser, which includes a control element, is optically pumped by at least a portion of light emitted by the optical source. ... California Institute Of Technology

08/06/15 / #20150221977

Electrolytes for low impedance, wide operating temperature range lithium-ion battery module

A lithium ion battery cell includes a housing, a cathode disposed within the housing, wherein the cathode comprises a cathode active material, an anode disposed within the housing, wherein the anode comprises an anode active material, and an electrolyte disposed within the housing and in contact with the cathode and anode. The electrolyte consists essentially of a solvent mixture, a lithium salt in a concentration ranging from approximately 1.0 molar (m) to approximately 1.6 m, and an additive mixture. ... California Institute Of Technology

08/06/15 / #20150221800

Spectral light splitting module and photovoltaic system including concentrator optics

A light splitting optical module that converts incident light into electrical energy, the module including a solid optical element comprising an input end for receiving light, a first side, and a second side spaced from the first side, a first solar cell adjacent to the first side of the solid optical element, and a second solar cell adjacent to the second side of the solid optical element. The first solar cell is positioned to absorb a first subset of incident light and reflect a first remainder of the incident light to the second solar cell through the solid optical element.. ... California Institute Of Technology

08/06/15 / #20150221445

Photoassisted high efficiency conversion of carbon-containing fuels to electricity

Electricity is generated by oxidizing a carbon-containing fuel in a photoelectrochemical fuel cell via a cyclic oxidation pathway to yield carbon dioxide and water, and collecting the electrons released via the cyclic oxidation pathway to yield a flow of electrons. The cyclic oxidation pathway includes a series of reactions of which is a photooxidation reaction. ... California Institute Of Technology

08/06/15 / #20150219806

Controllable planar optical focusing system

An optical device has a first metasurface disposed over a substrate. A high-contrast pattern of the first metasurface is operable for modifying, over a first phase profile, a phase front of an incident light beam. ... California Institute Of Technology

08/06/15 / #20150219657

Phosphorylated akt-specific capture agents, compositions, and methods of using and making

The present application provides stable peptide-based akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing akt capture agents using iterative on-bead in situ click chemistry.. ... California Institute Of Technology

08/06/15 / #20150216431

Intrinsic frequency hemodynamic waveform analysis

Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the dicrotic notch. ... California Institute Of Technology

07/30/15 / #20150213789

Systems and methods for musical sonification and visualization of data

The current disclosure is directed to systems and methods for automatically converting multi-dimensional, complex data sets to musical symbols while representing the converted data in an animated graph. The system groups the data into a number of subsets of data according to a set of user-configured rules and maps the grouped data points to musical notes according to configurable mapping parameters.. ... California Institute Of Technology

07/30/15 / #20150209690

Microfluidic separation device and method of making same

A device and method for making a microfluidic separation device. A microfluidic separation device could include a microfluidic column having an inlet, the microfluidic column being configured to hold a first fluid and the microfluidic column including a porous portion, and an outlet attached to the microfluidic column, the outlet being configured to output a second fluid. ... California Institute Of Technology

07/30/15 / #20150208945

Microwave radar sensor modules

Systems and methods for detecting biometrics using microwave radar sensor modules are disclosed. Integrated microwave sensor modules can include a transmitter unit configured to generate at least one continuous wave transmit signal based upon at least one frequency control signal, a receiver unit configured to utilize a cancellation path to cancel contributions to a return signal based upon at least one cancellation path control signal, and a microcontroller unit that includes a processor, a memory containing a microcontroller application, where the microcontroller application configures the processor to generate at least one frequency control signal to generate least one cw transmit signal having a plurality of frequencies, generate at least one cancellation path control signal to automatically adjust the cancellation path in real time, receive at least one demodulated signal, digitize the at least one demodulated signal, and update the at least one frequency control and cancellation path control signals.. ... California Institute Of Technology

07/23/15 / #20150207009

Photovoltaic system with stacked spectrum splitting optics and photovoltaic array tuned to the resulting spectral slices produced by the spectrum splitting optics

The present invention provides photovoltaic devices that comprise multiple bandgap cell arrays in combination with spectrum splitting optics. The spectrum splitting optics include one or more optical spectrum splitting modules that include two or more optical splitting, diffractive elements that are optically in series to successively and diffractively split incident light into segments or slices that are independently directed onto different photovoltaic cell(s) of the array having appropriate bandgap characteristics.. ... California Institute Of Technology

07/23/15 / #20150206067

Weight generation in machine learning

Technologies are generally described for systems, devices and methods relating to a machine learning environment. In some examples, a processor may identify a training distribution of a training data. ... California Institute Of Technology

07/23/15 / #20150206066

Generation of weights in machine learning

Technologies are generally described for systems, devices and methods relating to determining weights in a machine learning environment. In some examples, a training distribution of training data may be identified, information about a test distribution of test data, and a coordinate of the training data and the test data may be identified. ... California Institute Of Technology

07/23/15 / #20150206065

Weight benefit evaluator for training data

Technologies are generally described for methods and systems effective to determine a weight benefit associated with application of weights to training data in a machine learning environment. In an example, a device may determine a first function based on the training data, where the training data includes training inputs and training labels. ... California Institute Of Technology

07/23/15 / #20150204793

Method and system for raman spectroscopy using plasmon heating

A method of identifying a sample includes placing the sample in proximity to a plurality of nanoparticles and irradiating the plurality of nanoparticles with laser radiation. A plasmon resonance process results in heating of the plurality of nanoparticles due to the laser irradiation. ... California Institute Of Technology

07/23/15 / #20150203977

Confinement of reaction components at electrode surface

A co2 reduction electrode includes an active layer on an electrode base. The active layer includes a polymer that includes one or more reaction components selected from a group consisting of a co2 reduction catalyst and an activator that bonds co2 so as to form a co2 reduction intermediate.. ... California Institute Of Technology

07/23/15 / #20150203974

Catalytic platform for co2 reduction

Carbon dioxide reduction includes bonding co2 with an activator so as to form an activated intermediate. An electrical potential is applied to the intermediate so as to cause reduction of the co2 in the intermediate. ... California Institute Of Technology

07/23/15 / #20150203973

Thin film electrocatalysis

Carbon dioxide reduction includes bonding co2 with an activator so as to form an activated intermediate. An electrical potential is applied to the intermediate so as to cause reduction of the co2 in the intermediate. ... California Institute Of Technology

07/23/15 / #20150203634

Linear cyclodextrin copolymers

Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. ... California Institute Of Technology

07/23/15 / #20150203358

Novel methods for producing crystalline microporous solids with iwv topology and compositions derived from the same

This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having iwv topologies having a range of si:al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation templates.. . ... California Institute Of Technology

07/23/15 / #20150203357

Novel methods for producing crystalline microporous solids with a new cit-7 topology and compositions derived from the same

This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having cit-7 topologies having a range of si:al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation structuring agents.. . ... California Institute Of Technology

07/23/15 / #20150202612

Novel methods for producing crystalline microporous solids with the rth topology and compositions derived from the same

This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having rth topologies having a range of si:al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation structuring agents.. . ... California Institute Of Technology

07/23/15 / #20150202603

Novel methods for producing crystalline microporous solids with the heu topology and compositions derived from the same

This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having heu topologies having a range of si:al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation structuring agents.. . ... California Institute Of Technology

07/23/15 / #20150201883

Intrinsic frequency based determination of insulin resistance

Systems, devices, and methods are described in which intrinsic frequency calculation (direct and/or by approximation) of a pulse pressure waveform is used make a determination of metabolic syndrome and/or insulin resistance or sensitivity. The pulse pressure waveform may be obtained non-invasively using a smartphone platform or be otherwise obtained.. ... California Institute Of Technology

07/16/15 / #20150197771

Domain-swap t cell receptors

Disclosed herein are genetically engineered t cell receptors, and methods, vectors, and genetically engineered t cells related to genetically engineered t cell receptors.. . ... California Institute Of Technology

07/02/15 / #20150187718

Three-dimensional high surface area electrodes

Three dimensional high surface electrodes are described. The electrodes are fabricated by methods including the steps: designing the pillars; selecting a material for the formation of the pillars; patterning the material; transferring the pattern to form the pillars; insulating the pillars and providing a metal layer for increased conductivity. ... California Institute Of Technology

07/02/15 / #20150183633

Microfabricated elastomeric valve and pump systems

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.. . ... California Institute Of Technology

06/25/15 / #20150180000

Separator enclosures for electrodes and electrochemical cells

The disclosure provides electrochemical cells including a separator enclosure which encloses at least a portion of a positive or negative electrode. In an embodiment, the separator generates a contact force or pressure on at least a portion of the electrode which can improve the performance of the cell. ... California Institute Of Technology

06/25/15 / #20150175667

Targeted gene delivery for dendritic cell vaccination

Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (dc). The virus envelope comprises a dc-sign specific targeting molecule. ... California Institute Of Technology

06/18/15 / #20150171398

Electrochemical separators with inserted conductive layers

Disclosed are electrochemical cells including a composite separator capable of changing the performance of the cell by a) changing the internal electric field of the cell, b) activating lost active material, c) providing an auxiliary current collector for an electrode and/or d) limiting or preventing hot spots and/or thermal runaway upon formation of an electronic short in the system. An exemplary composite separator includes at least one electronically conducting layer and at least one electronically insulating layer. ... California Institute Of Technology

06/18/15 / #20150171326

Systems and methods for integrating a single dna molecule into a molecular electronic device

The disclosed subject matter provides a techniques for precisely and/or functionally cutting carbon nanotubes, e.g., single walled carbon nanotubes (“swnts”) and integrating a single nucleic acid molecule (e.g., a dna molecule) into a gap formed into the carbon nanotubes. In one aspect, a method of fabricating a molecular electronic device includes disposing a swnt on a base layer, forming a gap in the swnt using a lithographic process, and disposing a single dna strand across the gap so that each end of the nucleic acid contacts a gap termini. ... California Institute Of Technology

06/18/15 / #20150167092

Fret-based analytes detection and related methods and systems

Fret-based analytes detection and related methods and systems are described where a pair of fret labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the förster distance of the fret chromophores presented on the fret labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of fret labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring fret signals from at least one fret chromophore.. . ... California Institute Of Technology

06/18/15 / #20150166579

Transition-metal-free silylation of aromatic compounds

The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate; wherein said system is substantially free of a transition-metal compound.. . ... California Institute Of Technology

06/11/15 / #20150160450

Embedded pupil function recovery for fourier ptychographic imaging devices

Certain aspects pertain to fourier ptychographic imaging systems, devices, and methods that implement an embedded pupil function recovery. . ... California Institute Of Technology

06/11/15 / #20150160384

Flat retroreflectors

A retroreflector device is described, which includes a lens component operable for focusing radiation, which is incident thereto at an angle of incidence. The retroreflector also includes a mirror component operable for reflecting the radiation focused by the lens component back along the angle of incidence. ... California Institute Of Technology

06/11/15 / #20150159187

Stable, functional chimeric cellobiohydrolase class i enzymes

The present disclosure relates to cbh i chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.. . ... California Institute Of Technology

06/04/15 / #20150155108

Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles

A method of increasing the area of carbon nanotubes used in fabricating capacitors is described. The method involves reacting carbon nanotubes with electrically conductive ions, molecules or nanoparticles that increase the surface area of the nanotubes. ... California Institute Of Technology

06/04/15 / #20150154347

System and method for constrained multistate reaction pathway design

Methods and systems for designing the sequences of multiple nucleic acid strands intended to hybridize in solution via a prescribed reaction pathway are described. Sequence design is formulated as a multistate optimization problem using a set of target test tubes containing different subsets of the strands to represent reactant, intermediate, and product states of the system. ... California Institute Of Technology

06/04/15 / #20150153319

Sensing and actuation of biological function using addressable transmitters operated as magnetic spins

Methods and apparatuses for sensing biological functions are disclosed. Sensors can be implanted in an organ, such as the brain, and a magnetic field gradient applied to the biological tissue. ... California Institute Of Technology

06/04/15 / #20150152435

Method for expression of small rna molecules within a cell

The invention provides methods and compositions for the expression of small rna molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded rna complexes. ... California Institute Of Technology

05/28/15 / #20150145350

Active cmos recovery units for wireless power transmission

A rectifying circuit includes, in part, first and second nmos transistors, an impedance matching network, and an rf block circuit. The source and gate terminals of the first nmos transistor respectively receive the ground potential and a biasing voltage. ... California Institute Of Technology

05/28/15 / #20150145091

Single-band and dual-band infrared detectors

Bias-switchable dual-band infrared detectors and methods of manufacturing such detectors are provided. The infrared detectors are based on a back-to-back heterojunction diode design, where the detector structure consists of, sequentially, a top contact layer, a unipolar hole barrier layer, an absorber layer, a unipolar electron barrier, a second absorber, a second unipolar hole barrier, and a bottom contact layer. ... California Institute Of Technology

05/21/15 / #20150141670

Diels-alder reactions catalyzed by lewis acid containing solids: renewable production of bio-plastics

The present disclosure is related to silica-based lewis acid catalysts, being essentially devoid of strong brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.. ... California Institute Of Technology

05/21/15 / #20150141603

Latent, high-activity olefin metathesis catalysts containing an n-heterocyclic carbene ligand

The invention provides novel organometallic complexes useful as olefin metathesis catalysts. The complexes have an n-heterocyclic carbene ligand and a chelating carbene ligand associated with a group 8 transition metal center. ... California Institute Of Technology

05/21/15 / #20150137895

Quadrature-based injection locking of ring oscillators

Technologies are generally described for quadrature-based injection-locking of ring oscillators. In some examples, an external signal may be injected into a ring oscillator. ... California Institute Of Technology

05/07/15 / #20150125383

Catalysts for thermochemical fuel production and method of producing fuel using thermochemical fuel production

To provide a catalyst, which is formed from a perovskite oxide, for thermochemical fuel production, and a method of producing fuel using thermochemical fuel production that is capable of allowing a fuel to be produced in a thermochemical manner. Provided is a catalyst for thermochemical fuel production, which is used for producing the fuel from thermal energy by using a two-step thermochemical cycle of a first temperature and a second temperature that is equal to or lower than the first temperature, wherein the catalyst is formed from a perovskite oxide having a compositional formula of axo3±δ (provided that, 0≦δ≦1). ... California Institute Of Technology

05/07/15 / #20150125157

High bandwidth optical links for micro-satellite support

A method, systems, apparatus and device enable high bandwidth satellite communications. An onboard tracking detector, installed in a low-earth orbit satellite, detects a position of an incoming optical beam received/transmitted from a first ground station of one or more ground stations. ... California Institute Of Technology

04/30/15 / #20150118188

Direct photopatterning of robust and diverse materials

The present invention relates to methods of metathesizing olefins using catalysts previously considered to be practically inactive. The present invention further relates to novel photosensitive compositions, their use as photoresists, and methods related to patterning polymer layers on substrates. ... California Institute Of Technology

04/23/15 / #20150112219

Intrinsic frequency analysis for left ventricle ejection fraction or stroke volume determination

Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the dicrotic notch. ... California Institute Of Technology

04/23/15 / #20150111950

Inhibition of dna2 in fanconi anemia

Inhibition of dna2 in fanconi anemia (fa) cells remedies the over-resection of dna, thereby stabilizing the fa cells. Inhibition of dna2 in fa cells allows for safe treatment of cancers in fa patients, a decrease in the lethality of fa cells, a decrease in bone marrow failure of fa patients, and a means for decreasing the incidence of cancer for fa patients.. ... California Institute Of Technology

04/23/15 / #20150111023

In-situ heated deposition of parylene to enhance pore penetration into silicone

Coating porous material, such as pdms, with parylene n, c, d, and af-4 by vapor deposition polymerization is described in which a temperature of the porous material's surface being coated is heated to between 60° c. And 120° c., or 80° c. ... California Institute Of Technology

04/23/15 / #20150110712

Crystalline molecular sieves and related structure-directing agents, methods and systems

A composition and method for preparing molecular sieves having a stw framework structure are described wherein a structure directing agent comprising quaternary cation 1,2,3,4,5-pentamethyl-1h-imidazol-3-ium is contacted with a source of an oxide of a first tetravalent element with or without a source of an oxide of another tetravalent elements and/or a source of a trivalent element in a molar ratio of tetravalent element: trivalent element 100:1 and greater.. . ... California Institute Of Technology

04/16/15 / #20150106071

Methods and systems for comparing vertical axis turbine arrays and providing configurations thereof

A method for providing potential flow elements including a vortex to capture rotation of a turbine, a dipole to capture a blockage effect of the turbine, a sink to capture extracted energy from wind by the turbine, and a source to capture recovery of flow due to inflow from around the turbine is described. Methods for providing configurations of a vawt array based on a desired attribute of the array, using a low-order model when the array is subject to physical constraints are also described.. ... California Institute Of Technology

04/16/15 / #20150104293

V-shaped arrangements of turbines

A v-shaped arrangement of turbines adapted to orient in such a manner that crosswind enters the arrangement in a direction that is substantially parallel to the axis bisecting the arrangement is described. The v-shaped arrangement includes clockwise rotating turbines and counterclockwise rotating turbines.. ... California Institute Of Technology

04/16/15 / #20150104191

Amplification-free electro-optical oscillator

An electro-optical oscillator includes, in part, a modulator, a signal splitter, n photodiodes with n being an integer greater than one, a signal combiner, and a filter. The modulator modulates an optical signal in accordance with a feedback signal. ... California Institute Of Technology

04/16/15 / #20150101933

Translocation and nucleotide reading mechanisms for sequencing nanodevices

By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are strategically placed around or above a nanopore. ... California Institute Of Technology

04/16/15 / #20150101664

Protecting the surface of a light absorber in a photoanode

A photoanode includes a passivation layer on a light absorber. The passivation layer is more resistant to corrosion than the light absorber. ... California Institute Of Technology

04/09/15 / #20150099658

Anti-gp41 antibody-specific capture agents, compositions, and methods of using and making

The present application provides stable peptide-based anti-gp41 antibody capture agents and methods of use as detection and diagnosis agents. The application further provides methods of manufacturing anti-gp41 antibody capture agents using iterative on-bead in situ click chemistry.. ... California Institute Of Technology

04/02/15 / #20150094697

Medicament delivery systems

Described herein are systems, devices, and methods for the delivery of substances to, or the sampling of substances from, a patient using a portable and preferably implantable device. The substances introduced to and/or taken from the patient are preferably fluidic and are driven by a miniature pump, such as a microimpedance pump. ... California Institute Of Technology

04/02/15 / #20150093758

Psa capture agents, compositions, methods and preparation thereof

Disclosed herein are novel synthetic prostate specific antigen (psa)-targeted capture agents that specifically bind psa. In certain embodiments, these psa capture agents are biligand or triligand capture agents containing two or three target-binding moieties, respectively.. ... California Institute Of Technology

03/26/15 / #20150087001

Methods for phenotyping of intact whole tissues

In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and optically-transparent, thereby exposing their cellular structure with intact connectivity. In some embodiments, the present application teaches pact, a protocol for passive tissue clearing and immunostaining of intact organs. ... California Institute Of Technology

03/19/15 / #20150079342

Method and system for graphene formation

. . A method of forming graphene includes placing a substrate in a processing chamber and introducing a cleaning gas including hydrogen and nitrogen into the processing chamber. The method also includes introducing a carbon source into the processing chamber and initiating a microwave plasma in the processing chamber. ... California Institute Of Technology

03/19/15 / #20150079038

Selective recovery

Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.. ... California Institute Of Technology

03/19/15 / #20150078754

Optically balanced opto-electrical oscillator

An opto-electrical oscillator includes, in part, first and second optical phase modulators, a coupler, an optical-to-electrical signal conversion circuit, and a control circuit. The first optical phase modulator modulates the phase of a first optical signal in response to a first feedback signal to generate a first phase modulated signal. ... California Institute Of Technology

03/19/15 / #20150075744

Systems and methods for fabricating structures including metallic glass-based materials using low pressure casting

Systems and methods in accordance with embodiments of the invention fabricate objects including metallic glass-based materials using low-pressure casting techniques. In one embodiment, a method of fabricating an object that includes a metallic glass-based material includes: introducing molten alloy into a mold cavity defined by a mold using a low enough pressure such that the molten alloy does not conform to features of the mold cavity that are smaller than 100 μm; and cooling the molten alloy such that it solidifies, the solid including a metallic glass-based material.. ... California Institute Of Technology

03/12/15 / #20150073385

Remote reservoir microneedle drug delivery systems

Transdermal drug delivery patch devices are described in which microneedle array insertion or application forces are decoupled or separated from drug delivery actuation or application forces. Dual-reservoir devices are described in detail for such purposes as are associated methods of use in various examples.. ... California Institute Of Technology

03/05/15 / #20150064396

Method for selectively anchoring and exposing large numbers of nanoscale structures

Methods for fastening nanoscale structures within an anchoring structure to form a nanostructure composite and nanostructure composites formed therefrom. A primary fluid layer is formed on an anchoring substrate. ... California Institute Of Technology

02/26/15 / #20150057516

Fully wireless continuously wearable sensor for measurement of eye fluid

Novel methods and systems for monitoring the health of an eye are disclosed. For example, a resonant circuit may be fabricated on a contact lens and this circuit may be coupled to a second circuit having the same resonant current frequency. ... California Institute Of Technology

02/26/15 / #20150057178

Signal encoding and decoding in multiplexed biochemical assays

This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. ... California Institute Of Technology

02/26/15 / #20150056129

New methods and materials for the thermochemical production of hydrogen from water

The present disclosure is directed to methods of catalytically reducing carbon dioxide, each method comprising: contacting a composition comprising a spinel-type transition iron oxide with an alkali metal carbonate, bicarbonate, or mixture thereof at a first temperature to form co, and an alkali metal ion-transition metal oxide; hydrolytically extracting at least a portion of alkali metal ions from the alkali metal ion-transition metal oxide by the reaction with co2 and liquid h2o at a second temperature; and thermochemically reducing the transition metal composition of the second step at a third temperature, with the associated formation of o2.. . ... California Institute Of Technology

02/26/15 / #20150056109

Solar fuel generator

The disclosure provides conductive membranes for water splitting and solar fuel generation. The membranes comprise an embedded semiconductive/photoactive material and an oxygen or hydrogen evolution catalyst. ... California Institute Of Technology

02/26/15 / #20150054979

Variable-illumination fourier ptychographic imaging devices, systems, and methods

Certain aspects pertain to fourier ptychographic imaging systems, devices, and methods such as, for example, high na fourier ptychographic imaging systems and reflective-mode na fourier ptychographic imaging systems.. . ... California Institute Of Technology

02/19/15 / #20150051411

Synthetic transtaganolide and basiliolide products, derivatives thereof, and synthesis methods thereof

Compounds represented by formula i are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.. ... California Institute Of Technology

02/19/15 / #20150050746

Methods for fabricating high aspect ratio probes and deforming high aspect ratio nanopillars and micropillars

Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.. ... California Institute Of Technology

02/19/15 / #20150050701

Cellulase compositions having improved thermostability and synergy

A variant cel5a endoglucanase has increased thermostability, increased enzymatic activity and/or increased expression in a host, relative to wild type cel5a. The improved variant cel5a endoglucanase may be used to hydrolyze more cellulose at a higher temperature for a more efficient and cost-effective production of biofuels as compared to wild type cel5a. ... California Institute Of Technology

02/19/15 / #20150050233

Compositions containing inclusion complexes

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. ... California Institute Of Technology

02/19/15 / #20150047688

Methods and systems for self-cleaning of photovoltaic panels

Systems, devices, and methods are provided for self-cleaning photovoltaic panels that utilize piezo devices capable of causing vibrational movement in the panels.. . ... California Institute Of Technology

02/19/15 / #20150047683

In2te3 precipitates in bulk bi2te3 for thermoelectric applications

The present invention teaches a successful synthesis regime to grow highly oriented plate-like in2te3 nanostructures inside bulk thermoelectric bi2te3 using a thermodynamically driven nucleation and growth technique. As described herein, the inventive materials can further be doped with +2 and +4 rare earth elements, and others, in order to achieve the desired performance characteristics.. ... California Institute Of Technology

02/19/15 / #20150047463

Systems and methods for implementing bulk metallic glass-based macroscale gears

Systems and methods in accordance with embodiments of the invention implement bulk metallic glass-based macroscale gears. In one embodiment, a method of fabricating a bulk metallic glass-based macroscale gear, where at least either the thickness of the gear is greater than 3 mm or the diameter of the gear is greater than 9 mm, includes: obtaining design parameters of the gear to be formed; selecting a bulk metallic glass from which the gear will be formed based on the obtained design parameters, where the selected bulk metallic glass is characterized by a resistance to standard modes of wear and a resistance to brittle fracture such that a gear can be formed from the selected bulk metallic glass that accords with the obtained design parameters; and fabricating the gear from the selected bulk metallic glass that accords with the obtained design parameters.. ... California Institute Of Technology

02/12/15 / #20150044084

Methods for fabricating gradient alloy articles with multi-functional properties

Systems and methods for fabricating multi-functional articles comprised of additively formed gradient materials are provided. The fabrication of multi-functional articles using the additive deposition of gradient alloys represents a paradigm shift from the traditional way that metal alloys and metal/metal alloy parts are fabricated. ... California Institute Of Technology

02/05/15 / #20150038455

Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity

. . The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive methods.. ... California Institute Of Technology

02/05/15 / #20150038436

Tailored glycopolymers as anticoagulant heparin mimetics

The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive methods.. ... California Institute Of Technology

02/05/15 / #20150037782

Enhancement of electromagnetic freezing by stabilization and oscillation of biogenic magnetite particles

Novel methods and systems for electromagnetic freezing are disclosed. An oscillating magnetic field can be applied in conjunction with a static magnetic field in order to align magnetic particles inside biological tissues. ... California Institute Of Technology

02/05/15 / #20150036302

Long-term packaging for the protection of implant electronics

The present invention provides a micropackaged device comprising: a substrate for securing a device; a corrosion barrier affixed to said substrate; optionally at least one feedthrough disposed in said substrate to permit at least one input and or at least one output line into said micropackaged device; and an encapsulation material layer configured to encapsulate the micropackaged device.. . ... California Institute Of Technology

02/05/15 / #20150036038

Aperture scanning fourier ptychographic imaging

Certain aspects pertain to aperture-scanning fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of an optical arrangement, and a detector that can acquire lower resolution intensity images for different aperture locations, and wherein a higher resolution complex image may be constructed by iteratively updating regions in fourier space with the acquired lower resolution images.. . ... California Institute Of Technology

01/29/15 / #20150031832

Carrier nanoparticles and related compositions, methods and systems

Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.. . ... California Institute Of Technology

01/29/15 / #20150031753

Complexing agents for compositions containing inclusion complexes

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. ... California Institute Of Technology

01/29/15 / #20150031460

Games having biotechnological content

Systems and methods for use in playing biotic games having a biologically active material as a component. Various games that provide for one or more human players to interact with biologically active materials are disclosed. ... California Institute Of Technology

01/29/15 / #20150031116

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of dna, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. ... California Institute Of Technology

01/29/15 / #20150030529

Isothermal synthesis of fuels with reactive oxides

A method for converting thermal energy to chemical energy by reducing a reactive oxide substrate at a constant temperature under a first atmosphere with a lower oxygen partial pressure, and then contacting the reduced oxide at the same temperature with a second atmosphere with a higher oxygen partial pressure, during which oxygen is driven into the reduced oxide by the oxygen chemical potential difference between the two atmospheres, thereby leaving fuel behind, i.e. Producing fuel. ... California Institute Of Technology

01/29/15 / #20150029579

Chip-based frequency comb generator with microwave repetition rate

A frequency comb generator fabricated on a chip with elimination of a disadvantageous reflow process, includes an ultra-high q disk resonator having a waveguide that is a part of a wedge structure fabricated from a silicon dioxide layer of the chip. The disk resonator allows generation of a frequency comb with a mode spacing as low as 2.6 ghz and up to 220 ghz. ... California Institute Of Technology

01/22/15 / #20150025126

Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network

A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the invention is described. ... California Institute Of Technology

01/22/15 / #20150024954

Aptamer regulated nucleic acids and uses thereof

The invention relates to aptamer-regulated, ligand-responsive nucleic acids, or “ampliswitches,” and uses thereof. Particular embodiments include a ligand-responsive nucleic acid that comprises a primer sequence domain and an aptamer domain that is responsive to a ligand.. ... California Institute Of Technology

01/22/15 / #20150024481

Sample preparation devices and systems

Devices and system for preparing samples are described. Such devices can comprise fluidic chambers, reservoirs, and movable structures for controlling the movement of samples. ... California Institute Of Technology

01/22/15 / #20150020575

System for analyzing a gas mixture including at least one chromatography column

A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas mixture, the detection mechanism including at least one detector of nanosensor type of an outlet of the column and a detector of nanosensor type in the column, capable of detecting passage of the compounds. It is then possible to determine the velocity of each of the compounds within the system.. ... California Institute Of Technology

01/15/15 / #20150019179

Methods for designing quadruple-ridged flared horn antennas

Novel methods and systems for antenna design are disclosed. A quadruple-ridged flared horn antenna can be designed based on geometry and frequency requirements. ... California Institute Of Technology

01/15/15 / #20150018291

The utility of nematode small molecules

The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.. ... California Institute Of Technology

01/15/15 / #20150017038

Helically actuated positive-displacement pump and method

First and second structures are connected by helical fibers. The orientation between the first and second structures are changed, and by doing so, the positions of the helical fibers are correspondingly changed. ... California Institute Of Technology

01/15/15 / #20150014885

Systems and methods for additive manufacturing processes that strategically buildup objects

Systems and methods in accordance with embodiments of the invention implement additive manufacturing techniques that employ different sets of deposition characteristics and/or material formation characteristics during the additive manufacture of an object so as to strategically build up the object. In many embodiments, material used to build up an object is deposited at different deposition rates during the additive manufacture of the object, and the object is thereby strategically built up. ... California Institute Of Technology

01/08/15 / #20150011042

Method of making photovoltaic devices incorporating improved pnictide semiconductor films

The present invention uses a treatment that involves an etching treatment that forms a pnictogen-rich region on the surface of a pnictide semiconductor film the region is very thin in many modes of practice, often being on the order of only 2 to 3 nm thick in many embodiments. Previous investigators have left the region in place without appreciating the fact of its presence and/or that its presence, if known, can compromise electronic performance of resultant devices. ... California Institute Of Technology

01/08/15 / #20150010976

Regio- and enantioselective alkane hydroxylation with modified cytochrome p450

Cytochrome p450 bm-3 from bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively using atmospheric dioxygen as an oxidant. Mutant 9-10a-a328v hydroxylates octane primarily at the 2-position to form s-2-octanol (40% ee). ... California Institute Of Technology

01/08/15 / #20150010788

Carbon nanotubes - graphene hybrid structures for separator free silicon - sulfur batteries

Provided herein are electrochemical systems and related methods of making and using electrochemical systems. Electrochemical systems of the invention implement novel cell geometries and composite carbon nanomaterials based design strategies useful for achieving enhanced electrical power source performance, particularly high specific energies, useful discharge rate capabilities and good cycle life. ... California Institute Of Technology

01/08/15 / #20150010578

Delivery of proteins using adeno-associated virus (aav) vectors

Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (aav) vectors.. . ... California Institute Of Technology

01/08/15 / #20150009149

Imaging surround system for touch-free display control

The subject system hardware and methodology combine disparate cameras into a cohesive gesture recognition environment. To render an intended computer, gaming, display, etc. ... California Institute Of Technology

01/01/15 / #20150005568

Remote activation of the midbrain by transcranial direct current stimulation of prefrontal cortex

A method and system of remotely stimulating the midbrain area is disclosed. Transcranial direct current stimulation is applied via a cathode attached to the right dorsolateral prefrontal cortex and an anode attached to the ventromedial prefrontal cortex. ... California Institute Of Technology

01/01/15 / #20150004683

Methods and apparatus for assays of bacterial spores

Described herein are methods and apparatus for assays of bacterial spores. In particular, methods and apparatus for lateral flow immunoassay for bacterial spore detection and quantification, live/dead assay for bacterial spores, lifetime-gated measurements of bacterial spores and imaging bacterial spores using an active pixel sensor, and unattended monitoring of bacterial spores in the air are described.. ... California Institute Of Technology

01/01/15 / #20150004668

Alkane oxidation by modified hydroxylases

This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.. ... California Institute Of Technology

01/01/15 / #20150004615

Small conditional rnas

The present subject matter relates to the use conditional hairpins, such as, but not limited to shrnas. The conditional formation of these structures can allow for further events, such as gene silencing (in some embodiments).. ... California Institute Of Technology

01/01/15 / #20150004094

Molecular sieves with a linde type a topology and related methods and systems

A method for preparing molecular sieves with a linde type a (lta) topology structure, and molecular sieves obtained thereby are described wherein a structure directing agent comprising a triquaternary cation is contacted with a source of a first oxide of a first tetravalent element or a source of a first oxide of a trivalent element; and a source of an oxide of a pentavalent elements.. . ... California Institute Of Technology

01/01/15 / #20150002921

Point-wise phase matching for nonlinear frequency generation in dielectric resonators

An optical resonator fabricated from a uniaxial birefringent crystal, such as beta barium borate. The crystal is cut with the optical axis not perpendicular to a face of the cut crystal. ... California Institute Of Technology








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