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California Institute Of Technology patents (2016 archive)


Recent patent applications related to California Institute Of Technology. California Institute Of Technology is listed as an Agent/Assignee. Note: California Institute Of Technology may have other listings under different names/spellings. We're not affiliated with California Institute Of Technology, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | California Institute Of Technology-related inventors


Large-scale space-based solar power station: multi-scale modular space power

A space-based solar power station, a power generating satellite module and/or a method for collecting solar radiation and transmitting power generated using electrical current produced therefrom is provided. Each solar power station includes a plurality of satellite modules. ... California Institute Of Technology

Large-scale space-based solar power station: power transmission using steerable beams

A space-based solar power station, a power generating satellite module and/or a method for collecting solar radiation and transmitting power generated using electrical current produced therefrom is provided. Power transmitters can be coordinated as a phased array and the power generated by the phased array is transmitted to one or more power receivers to achieve remote wireless power generation and delivery. ... California Institute Of Technology

Weight benefit evaluator for training data

Technologies are generally described for methods and systems effective to determine a weight benefit associated with application of weights to training data in a machine learning environment. In an example, a device may determine a first function based on the training data, where the training data includes training inputs and training labels. ... California Institute Of Technology

Engineered aggregates for metamaterials

Materials and methods for implementing engineered aggregates in metamaterials are provided. The engineered aggregates may be tuned to oscillate resonantly under the influence of an external force improving the dynamic performance of the metamaterial by impeding dynamic excitation. ... California Institute Of Technology

Large-scale space-based solar power station: packaging, deployment and stabilization of lightweight structures

A space-based solar power station, a power generating satellite module and/or a method for collecting solar radiation and transmitting power generated using electrical current produced therefrom, and/or compactible structures and deployment mechanisms used to form and deploy such satellite modules and power generation tiles associated therewith are provided. Each satellite module and/or power generation tile may be formed of a compactable structure and deployment mechanism capable of reducing the payload area required to deliver the satellite module to an orbital formation within the space-based solar power station and reliably deploy it once in orbit.. ... California Institute Of Technology

Probiotic therapies for autism

Provided is a method and a composition for improving behavioral performance in an individual comprising identifying an individual in need of treatment, and providing such an individual a composition comprising bacteria within the genus bacteroides.. . ... California Institute Of Technology

Systems and methods for generating tunable electromagnetic waves using carbon nanotube-based field emitters

Systems and methods in accordance with embodiments of the invention generate tunable electromagnetic waves using carbon nanotube-based field emitters. In one embodiment, a cnt-based irradiator includes: at least one cnt-based cathode, itself including: a plurality of carbon nanotubes adjoined to a substrate; a plurality of anodic regions; where each anodic region is configured to emit a distinctly different class of photons in a direction away from the at least one cathode in response to a same reception of electrons; where each of the plurality of anodic regions is operable to receive electrons emitted from at least one of said at least one cnt-based cathode; and where each of the at least one cnt-based cathode and the plurality of anodic regions are disposed within a vacuum encasing.. ... California Institute Of Technology

Measurement of fracture toughness of heterogeneous materials

Methods for measuring the effective fracture toughness in a material are described. A rail and roller system are used to apply a gradual force to a specimen. ... California Institute Of Technology

Multiplex labeling of molecules by sequential hybridization barcoding using probes with cleavable linkers

The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. Through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or dna loci. ... California Institute Of Technology

Targeting microbubbles

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.. ... California Institute Of Technology

Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded (trume) light

A method for irradiating scattering medium, including modifying a particle's response to electromagnetic radiation irradiating the particle in a scattering medium, wherein the electromagnetic radiation is scattered by the scattering medium, and modulated by the modifying, into scattered electromagnetic radiation comprising a scattered field; forming a phase conjugate field, wherein the phase conjugate field is a phase conjugate of the scattered field; and irradiating the scattering medium with the phase conjugate field, wherein the phase conjugate field forms a focus at a target defined by the particle.. . ... California Institute Of Technology

Atmospheric condensate collector and electrospray source

An atmospheric condensate collector and electrospray source apparatus. The apparatus has a cooler having a surface with a sharp point. ... California Institute Of Technology

Systems and methods for implementing robust metallic glass-based fiber metal laminates

Systems and methods in accordance with embodiments of the invention implement robust metallic glass-based fiber metal laminates. In one embodiment, a robust metallic glass-based fiber metal laminate includes: a first layer including a fiber-reinforced composite material; and a second layer including a metallic glass-based material; where the metallic glass-based material is based on at least one non-ferromagnetic element.. ... California Institute Of Technology

Sepsis treatment and related compositions methods and systems

Provided herein are methods and systems and related compositions comprising an effective amount of one or more zwitterionic polysaccharide possibly in combination with one or more antibiotics, for treatment and/or prevention of sepsis or a condition associated thereto in an individual.. . ... California Institute Of Technology

12/08/16 / #20160356923

Photonic structures from self assembly of brush block copolymers and polymer blends

The invention provides a class of block copolymers having a plurality of chemically different blocks, at least a portion of which incorporating polymer side chain groups having a helical secondary structure. The invention also provides structures generated by self-assembly of polymer blends including at least one block copolymer component, such as a brush block polymer or wedge-type block polymer. ... California Institute Of Technology

12/08/16 / #20160355852

Methods and systems for sulfimidation or sulfoximidation of organic molecules

The disclosure generally relates to the fields of synthetic organic chemistry. In particular, the present disclosure relates to methods and systems for the imidation of sulfides.. ... California Institute Of Technology

12/08/16 / #20160355799

Polypeptides having cellulase activity

The present disclosure relates to cbh ii chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.. . ... California Institute Of Technology

12/01/16 / #20160352286

Self-contained large scale computing platform

A massively parallel computer system (mpcs) includes a multitude of tiles each adapted to include one or more processing/memory units, power generation unit, and associated circuitry. The tiles are formed in an array of thin, light-weight material that may be foldable and/or collapsible to enable the packaging and folding of the mpcs into a small amount of volume for launch into space. ... California Institute Of Technology

12/01/16 / #20160352022

Parabolic deployable antenna

A deployable antenna is described. The antenna comprises a mesh attached to foldable ribs, a hub and a sub-reflector. ... California Institute Of Technology

12/01/16 / #20160347776

Base-catalyzed silylation of terminal olefinic c-h bonds

The present invention is directed to a mild, efficient, and general direct c(sp2)-h bond silylation of terminal olefins. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal olefinic c—h bond, with a mixture of at least one organosilane, organosilane, or mixture thereof and an alkali metal alkoxide or alkali metal hydroxide, such that the contacting results in the formation of a silylated olefinic product. ... California Institute Of Technology

12/01/16 / #20160346771

Crystalline germanosilicate materials of new cit-13 topology and methods of preparing the same

The present disclosure is directed to novel crystalline germanosilicate compositions and methods of producing the same. In particular, the crystalline germanosilicate compositions are extra-large-pore compositions, designated cit-13 possessing 10- and 14-membered rings. ... California Institute Of Technology

12/01/16 / #20160345556

Population control using engineered translocations

Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.. . ... California Institute Of Technology

11/24/16 / #20160344022

Metal hydride alloys with improved rate performance

Methods of preparing improved metal hydride alloy materials are provided. The alloys include a mixture of at least four of vanadium, titanium, nickel, chromium, and iron. ... California Institute Of Technology

11/24/16 / #20160341945

Laser-based fourier ptychographic imaging systems and methods

Certain embodiments pertain to laser-based fourier ptychographic (lfp) imaging systems, angle direction devices used in the lfp imaging systems, optical switches used in the lfp imaging systems, and lfp imaging methods. The lfp systems include an angle direction device for directing laser light to a sample plane at a plurality of illumination angles at different sample times. ... California Institute Of Technology

11/24/16 / #20160340692

Targeted gene delivery for dendritic cell vaccination

Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (dc). The virus envelope comprises a dc-sign specific targeting molecule. ... California Institute Of Technology

11/24/16 / #20160339423

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of dna, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. ... California Institute Of Technology

11/17/16 / #20160336660

Efficient active multi-drive radiator

An integrated multi-port driven (mpd) antenna that can be driven at many points with different signals. An integrated mpd radiating source utilizing an 8-phase ring oscillator and eight power amplifiers to drive the mpd antenna at 161 ghz with a total radiated power of −2 dbm and a single element eirp of 4.6 dbm has been demonstrated in silicon with single lobe well behaved radiation patterns closely matching simulation.. ... California Institute Of Technology

11/17/16 / #20160336476

P-compensated and p-doped superlattice infrared detectors

Barrier infrared detectors configured to operate in the long-wave (lw) infrared regime are provided. The barrier infrared detector systems may be configured as pin, pbp, barrier and double heterostructrure infrared detectors incorporating optimized p-doped absorbers capable of taking advantage of high mobility (electron) minority carriers. ... California Institute Of Technology

11/17/16 / #20160333866

Metallic wall hall thrusters

A hall thruster apparatus having walls constructed from a conductive material, such as graphite, and having magnetic shielding of the walls from the ionized plasma has been demonstrated to operate with nearly the same efficiency as a conventional nonmagnetically shielded design using insulators as wall components. The new design is believed to provide the potential of higher power and uniform operation over the operating life of a thruster device.. ... California Institute Of Technology

11/17/16 / #20160331868

Light adjustable intraocular lenses using upconverting nanoparticles and near infrared (nir) light

This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable ocular lenses. ... California Institute Of Technology

11/17/16 / #20160331800

Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making

The present application provides stable peptide-based botulinum neurotoxin (bont) serotype a capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing bont serotype a capture agents using iterative on-bead in situ click chemistry.. ... California Institute Of Technology

11/17/16 / #20160331227

Extended duration optical coherence tomography (oct) system

This disclosure relates to the field of optical coherence tomography (oct). This disclosure particularly relates to methods and systems for providing larger field of view oct images. ... California Institute Of Technology

11/03/16 / #20160322514

Solar cells and methods of manufacturing solar cells incorporating effectively transparent 3d contacts

Solar cells in accordance with a number of embodiments of the invention incorporate effectively transparent 3d contacts that redirect light incident on the contacts onto the photoabsorbing surfaces of the solar cells. One embodiment includes a photoabsorbing surface and a plurality of three-dimensional contacts formed on the photoabsorbing surface. ... California Institute Of Technology

11/03/16 / #20160320605

Variable-illumination fourier ptychographic imaging devices, systems, and methods

Certain aspects pertain to fourier ptychographic imaging systems, devices, and methods such as, for example, high na fourier ptychographic imaging systems and reflective-mode na fourier ptychographic imaging systems.. . ... California Institute Of Technology

11/03/16 / #20160320595

Aperture scanning fourier ptychographic imaging

Certain aspects pertain to aperture-scanning fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of an optical arrangement, and a detector that can acquire lower resolution intensity images for different aperture locations, and wherein a higher resolution complex image may be constructed by iteratively updating regions in fourier space with the acquired lower resolution images.. . ... California Institute Of Technology

11/03/16 / #20160320531

Conformal optical metasurfaces

Structures for scattering light at multiple wavelengths are disclosed. Scattering elements are fabricated with different geometric dimensions and arrangements, to scatter or focus light at the the same focal distance for each wavelength, or at different focal distances according to the desired application. ... California Institute Of Technology

11/03/16 / #20160320096

Spectrally selective semiconductor dielectric photonic solar thermal absorber

A solar thermal absorber including a spectrally selective filter comprising a stack of dielectric layers and one or more semiconductor absorber layers. The dielectric layers are transparent to infrared radiation and have a refractive index contrast, and the semiconductor absorber layers have a band gap, such that the semiconductor absorber layers absorb at least a portion of the solar spectrum and the stack reflects infrared radiation.. ... California Institute Of Technology

11/03/16 / #20160319314

Compositions and methods for producing benzylisoquinoline alkaloids

The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise one, two or more heterologous coding sequences wherein each of the heterologous coding sequences encodes an enzyme involved in the metabolic pathway of a benzylisoquinoline, or its precursors or intermediates from a starting compound. ... California Institute Of Technology

11/03/16 / #20160318020

Microfabricated crossflow devices and methods

This invention provides microfabricated devices and methods for detecting, analyzing and sorting biological materials and particles. Droplets containing the particles are provided in an extrusion fluid, passed through a detection region, and then directed into a branch channel according to predetermined characteristics. ... California Institute Of Technology

10/27/16 / #20160316180

Imaging apparatus and image sensor including the same

An imaging apparatus and an image sensor including the same are provided. The imaging apparatus includes first, second, and third optical devices. ... California Institute Of Technology

10/27/16 / #20160315807

Distributed optimal power flow processes for unbalanced radial distribution networks

Node controllers and power distribution networks in accordance with embodiments of the invention enable distributed power control on an unbalanced network. One embodiment includes a node controller including a distributed power control application; a plurality of node operating parameters describing the operating parameter of a node in an unbalanced network; wherein the processor is configured by the distributed power control application to: send node operating parameters to nodes in the set of at least one node; receive operating parameters from the nodes in the set of at least one node; calculate a plurality of updated node operating parameters using an iterative process to determine updated node operating parameters using the node operating parameters that describe the operating parameters of the node, and the operating parameters of the set of at least one node, where each iteration in the iterative process involves evaluation of a subproblem; and adjust node operating parameters.. ... California Institute Of Technology

10/27/16 / #20160313467

Autonomous and controllable systems of sensors and methods of using such systems

An autonomous and controllable system of sensors and methods for using such a system of sensors are described.. . ... California Institute Of Technology

10/27/16 / #20160313304

Reactivation of x chromosome genes

Methods of prohibiting xist-dependent silencing of x chromosome genes include targeting the required xist silencing complex components including sharp, smrt, hdac3, saf-a, lbr, and the respective binding sites of sharp, lbr, and saf-a on xist, thereby prohibiting xist repression, allowing for reactivation of the silenced x chromosome genes.. . ... California Institute Of Technology

10/27/16 / #20160313274

Rotating disk electrode cell

A rotating disk electrode cell has a housing with a reservoir configured to receive a sample for an electrochemical experiment. A shaft is positioned in the housing such that the shaft is free to rotate around the longitudinal axis of the shaft and such that both ends of the shaft are located inside of the housing.. ... California Institute Of Technology

10/27/16 / #20160312215

Methods and compositions for rapid assembly of genetic modules

Provided herein are methods and compositions for rapid assembly of genetic modules, as well as seamless transition from in vitro to in vivo testing of genetic constructs.. . ... California Institute Of Technology

10/20/16 / #20160307359

Particle-based simulation through power diagrams

The use of power diagrams in accordance with embodiments of the invention enable particle based fluid simulation. One embodiment includes a processor, a memory containing a model of a fluid, where the fluid is broken into a set of cells each defining a volume with boundaries that are relative to a distance of a set of points, where the process is configured by the power particle application to: calculate a plurality of forces acting on the set of cells, move the set of cells within the model of the fluid based upon the plurality of forces, and update the model of the fluid with a new set of cells.. ... California Institute Of Technology

10/20/16 / #20160306201

Differential ring modulator

A differential optical modulator includes, in part, a splitter splitting an incoming optical signal into first and second input signals, a first variable coupler generating a first differential output signal in response to the first input signal, and a second variable coupler generating a second differential output signal in response to the second input signal. The first variable coupler includes, in part, first and second couplers and a phase shifter disposed therebetween. ... California Institute Of Technology

10/20/16 / #20160306079

Multi-wavelength optical dielectric metasurfaces

Structures for scattering light at multiple wavelengths are disclosed. Scattering elements are fabricated with different geometric dimensions and arrangements, to scatter or focus light at the same focal distance for each wavelength, or at different focal distances according to the desired application. ... California Institute Of Technology

10/20/16 / #20160304923

Compositions and methods for producing benzylisoquinoline alkaloids

The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise one, two or more heterologous coding sequences wherein each of the heterologous coding sequences encodes an enzyme involved in the metabolic pathway of a benzylisoquinoline, or its precursors or intermediates from a starting compound. ... California Institute Of Technology

10/20/16 / #20160304872

Fractional regulation of transcription

A method of controlling the number of cells in a population of cells having silenced transcription of a target nucleic acid as a function of time includes recruiting a chromatin regulator (cr) to a site proximal to a transcription initiation site of the target nucleic acid to form a fraction of silenced cells in the population of cells. The chromatin regulator may be eed, krab, dnmt3, hdac4, ezh2, rest, or a combination thereof.. ... California Institute Of Technology

10/13/16 / #20160299337

Focusing device, and beam scanner and scope device including the focusing device

Provided is focusing device that includes a substrate and a plurality of scatterers provided at both sides of the substrate. The scatterers on the both sides of the focusing device may correct geometric aberration, and thus, a field of view (fov) of the focusing device may be widened.. ... California Institute Of Technology

10/13/16 / #20160298205

Forming of metallic glass by rapid capacitor discharge

An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (rcdf) tool are provided. The rcdf method utilizes the discharge of electrical energy stored in a capacitor to uniformly and rapidly heat a sample or charge of metallic glass alloy to a predetermined “process temperature” between the glass transition temperature of the amorphous material and the equilibrium melting point of the alloy in a time scale of several milliseconds or less. ... California Institute Of Technology

10/13/16 / #20160298152

Engineered beta-subunit of tryptophan synthase for production of non-canonical amino acids

This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.. ... California Institute Of Technology

10/06/16 / #20160289392

Triblock brush block copolymers

Provided herein is a class of copolymers, including triblock brush copolymers having specific block configurations, for example, abc triblock brush copolymers and aba triblock brush copolymers. In an embodiment, for example, copolymers of the invention incorporate various polymer side chain groups which contribute beneficial physical, chemical, or electronic properties such as increased mechanical or elastic strength, improved ionic or electric conductivity. ... California Institute Of Technology

10/06/16 / #20160287101

Biocompatible packaging for long term implantable sensors and electronics

An implantable medical device is described. In an example, the implantable medical device includes an electromechanical substrate and sensor, such as a pressure sensor, disposed on the substrate. ... California Institute Of Technology

09/29/16 / #20160286505

Sensor web

A sensor web formed of a number of different sensor pods. Each of the sensor pods include a clock which is synchronized with a master clock so that all of the sensor pods in the web have a synchronized clock. ... California Institute Of Technology

09/29/16 / #20160280537

Methods for fabricating high aspect ratio probes and deforming high aspect ratio nanopillars and micropillars

Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.. ... California Institute Of Technology

09/22/16 / #20160275418

Systems and methods for the determining annotator performance in the distributed annotation of source data

Systems and methods for determining annotator performance in the distributed annotation of source data in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a method for clustering annotators includes obtaining a set of source data, determining a training data set representative of the set of source data, obtaining sets of annotations from a set of annotators for a portion of the training data set, for each annotator determining annotator recall metadata based on the set of annotations provided by the annotator for the training data set and determining annotator precision metadata based on the set of annotations provided by the annotator for the training data set, and grouping the annotators into annotator groups based on the annotator recall metadata and the annotator precision metadata.. ... California Institute Of Technology

09/22/16 / #20160275417

Systems and methods for labeling source data using confidence labels

Systems and methods for the annotation of source data using confidence labels in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a method for determining confidence labels for crowdsourced annotations includes obtaining a set of source data, obtaining a set of training data representative of the set of source data, determining the ground truth for each piece of training data, obtaining a set of training data annotations including a confidence label, measuring annotator accuracy data for at least one piece of training data, and automatically generating a set of confidence labels for the set of unlabeled data based on the measured annotator accuracy data and the set of annotator labels used.. ... California Institute Of Technology

09/22/16 / #20160275173

Systems and methods for the distributed categorization of source data

Systems and methods for the crowdsourced clustering of data items in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a method for determining categories for a set of source data includes obtaining a set of source data, determining a plurality of subsets of the source data, where a subset of the source data includes a plurality of pieces of source data in the set of source data, generating a set of pairwise annotations for the pieces of source data in each subset of source data, clustering the set of source data into related subsets of source data based on the sets of pairwise labels for each subset of source data, and identifying a category for each related subset of source data based on the clusterings of source data and the source data metadata for the pieces of source data in the group of source data.. ... California Institute Of Technology

09/22/16 / #20160273958

Sensor integrated metal dielectric filters for solar-blind silicon ultraviolet detectors

A filter for electromagnetic radiation including one or more dielectric spacer regions and one or more reflective regions integrated on a semiconductor substrate, the semiconductor substrate including a semiconductor photodetector, such that the filter transmits ultraviolet radiation to the semiconductor photodetector, the ultraviolet radiation having a range of wavelengths, and the filter suppresses transmission of electromagnetic radiation, having wavelengths outside the range of wavelengths, to the semiconductor photodetector.. . ... California Institute Of Technology

09/22/16 / #20160272503

Molecular sieves and related methods and structure directing agents

Method for preparing molecular sieves and molecular sieves obtained thereby are described. The method includes preparing a reaction mixture, comprising a structure directing agent, at least one source of at least one oxide of a tetravalent element, optionally, one or more sources of one or more oxides selected from the group consisting of oxides of trivalent elements, pentavalent elements, and mixtures thereof, optionally, at least one source of an element selected from groups 1 and 2 of the periodic table; and optionally, hydroxide ions or fluoride ions, and maintaining the reaction mixture under conditions sufficient to form crystals of the molecular sieve. ... California Institute Of Technology

09/22/16 / #20160271694

Multiphoton induced direct aggregate scribing

The present disclosure is directed to processes comprising irradiating an aggregate of chemically bonded or otherwise associated nanoparticles with a light source capable of providing multiphoton excitation, the light source directed to a focal point volume including the aggregate and having sufficient energy to disrupt or fuse the aggregate within the focal point volume to form nanoscale deposits of the nanoparticles.. . ... California Institute Of Technology

09/15/16 / #20160266366

Correcting for aberrations in incoherent imaging systems using fourier ptychographic techniques

. . . . Aberration-corrected incoherent imaging methods and systems that can acquire a sequence of coherent images and an incoherent image of a specimen, implement an embedded pupil function recovery process in junction with fourier ptychographic technique to construct an improved resolution image and pupil function of the imaging system using the sequence of coherent images, determine an optical transfer function based on the estimated pupil function, and remove the aberration from the incoherent image using a deconvolution process to generate an aberration-corrected incoherent image.. . ... California Institute Of Technology

09/15/16 / #20160266319

Method of engineering the dispersion of whispering gallery mode resonators and the resonators with dispersion engineered by the method

A method for fabricating a resonator structure, comprising engineering dispersion of electromagnetic radiation guided along a boundary of an axially symmetric substrate, the engineering comprising micro-structuring a geometry of the boundary, wherein the structure defines a waveguide for electromagnetic radiation.. . ... California Institute Of Technology

09/15/16 / #20160266035

Mid-infrared hyperspectral spectroscopy systems and methods therefor

Mir spectroscopy systems comprising hierarchical spectral dispersion that enables fine spectral resolution and high sensitivity spectroscopy are disclosed. Hierarchical spectral dispersion is derived by employing at least two diffractive lens arrays, located on either side of a test sample, each receiving input radiation having an input spectral range and distributing the input radiation into a plurality of output signals, each having a fraction of the spectral range of the input radiation. ... California Institute Of Technology

09/15/16 / #20160265576

Systems and methods for structurally interrelating components using inserts made from metallic glass-based materials

Systems and methods in accordance with embodiments of the invention operate to structurally interrelate two components using inserts made from metallic glass-based materials. In one embodiment, a method of structurally interrelating two components includes: forming an insert from a metallic glass-based composition; where the formed insert includes a metallic glass-based material; affixing the insert to a first component; and structurally interrelating the second component to the first component using the insert.. ... California Institute Of Technology

09/15/16 / #20160265517

Hall thruster with magnetic discharge chamber and conductive coating

Hall thrusters with conductive coatings are disclosed. A hall thruster comprises magnetic shielding in order to avoid collisions with the inner walls of its discharge chamber. ... California Institute Of Technology

09/15/16 / #20160263937

Systems and methods for implementing flexible members including integrated tools made from metallic glass-based materials

Systems and methods in accordance with embodiments of the invention implement flexible members that include integrated tools made from metallic glass-based materials. In one embodiment, a structure includes: a flexible member characterized by an elongated geometry and an integrated tool disposed at one end of the elongated geometry; where the flexible member includes a metallic glass-based material.. ... California Institute Of Technology

09/08/16 / #20160258942

Optical resonator diagnostic device and methods of use

An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional ic fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.. . ... California Institute Of Technology

09/08/16 / #20160256081

Position sensing and guiding system

A position sensing apparatus includes a position sensor, a voltage/current detector, and an alarm. The position sensor is coupled to the body part and includes a capsule, and first and second electrodes. ... California Institute Of Technology

09/01/16 / #20160254646

Optical frequency divider based on an electro-optical-modulator frequency comb

Microwave-frequency signal generation by generating multiple sideband optical signals separated by phase-modulation frequency fm, generating beat signals between one or two sidebands and one or two optical reference signals, generating a loop-filtered error signal by comparing an electrical reference signal to one of the beat signals or their difference, and controlling with the error signal in a phase-locked loop arrangement a voltage-controlled oscillator (vco) that drives the sideband generation at the frequency fm. A portion of the vco output is the generated microwave-frequency signal.. ... California Institute Of Technology

09/01/16 / #20160254514

Electrochemical systems with electronically conductive layers

Provided are separator systems for electrochemical systems providing electronic, mechanical and chemical properties useful for a variety of applications including electrochemical storage and conversion. Embodiments provide structural, physical and electrostatic attributes useful for managing and controlling dendrite formation and for improving the cycle life and rate capability of electrochemical cells including silicon anode based batteries, air cathode based batteries, redox flow batteries, solid electrolyte based systems, fuel cells, flow batteries and semisolid batteries. ... California Institute Of Technology

09/01/16 / #20160252406

Temperature sensor using piezoelectric resonator and methods of measuring temperature

A method of measuring temperature includes positioning a piezoelectric resonator in an environment exhibiting the temperature to be measured, applying an input signal to the piezoelectric resonator to resonate the piezoelectric resonator, varying a frequency of the input signal over a range of input frequencies, determining the resonance frequency of the piezoelectric resonator, and determining the temperature of the environment by referencing the resonance frequency of the piezoelectric resonator. The resonance frequency of the piezoelectric resonator changes according to a change in the temperature of the environment and the resonance frequency of the piezoelectric resonator corresponds to the temperature of the environment.. ... California Institute Of Technology

09/01/16 / #20160251642

Stable fungal cel6 enzyme variants

The disclosure provides variant ce16a enzymes having increased thermostability, methods of making and using such polypeptides.. . ... California Institute Of Technology

08/25/16 / #20160248136

Metal hydride-air (mh-air) battery for low cost storage applications

Metal hydride-air batteries and methods for their use are provided. An exemplary metal-hydride air battery includes an alkaline exchange membrane provided between the positive electrode and the negative electrode of the battery. ... California Institute Of Technology

08/25/16 / #20160246000

Optomechanical device with mechanical elements and optical filters for actuating and/or detecting the movement of the elements

An optomechanical device with mechanical elements and optical filters for actuating and/or detecting movement of the elements, including a support, and on the support: an array of mechanical elements anchored to the support and configured to move with respect thereto, and an actuating and/or detection device actuating the elements and/or detecting movement of the elements or frequency variations of the movement. The actuating and/or detection device includes an array of optical filters. ... California Institute Of Technology

08/25/16 / #20160245047

Apparatus, system and method for generating power in a wellbore

An apparatus, system and method provides electrical power in a subterranean well. A radioisotope thermoelectric generator may be positioned and installed in a downhole location in a wellbore. ... California Institute Of Technology

08/25/16 / #20160244754

Microrna inhibition for the treatment of inflammation and myeloproliferative disorders

The present disclosure relates to the finding that microrna-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microrna-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of cutl1, arnt1, picalm, jarid2, pu.1, csf1r, hif1α, sla, cepbβ, and bach1, and the like.. ... California Institute Of Technology

08/25/16 / #20160243532

Methods to produce zeolites with the gme topology and compositions derived therefrom

The present disclosure is directed to producing zeolite structures with gme topologies using organic structure directing agents (osdas) comprising a piperidinium cation, and the compositions and structures resulting from these methods. In some embodiments, the crystalline products have a molar ratio of a molar ratio of si:al that is greater than 3.5.. ... California Institute Of Technology

08/25/16 / #20160243531

Processes for preparing zincoaluminosilicates with aei, cha, and gme topologies and compositions derived therefrom

The present disclosure is directed to methods of producing zincoaluminosilicate structures with aei, cha, and gme topologies using organic structure directing agents (osdas), and the compositions and structures resulting from these methods.. . ... California Institute Of Technology

08/18/16 / #20160238753

Flat retroreflectors

A retroreflector device is described, which includes a lens component operable for focusing radiation, which is incident thereto at an angle of incidence. The retroreflector also includes a mirror component operable for reflecting the radiation focused by the lens component back along the angle of incidence. ... California Institute Of Technology

08/18/16 / #20160238594

Methods and compositions for quantifying metabolites and proteins from single cells

Methods and compositions for quantifying the cellular concentration of cyclic adenosine monophosphate (camp), cyclic guanine monophosphate (cgmp), glutathione, glucose, and glutamine in a single cell include the use of conjugates and analogs in immunofluorescent assays for on-chip quantification. These metabolite immunofluorescent assays may be incorporated with proteomic assays for simultaneous single cell analysis of metabolites and proteins.. ... California Institute Of Technology

08/11/16 / #20160233862

Method and apparatus for simultaneous processing of multiple functions

Electronic logic gates that operate using n logic state levels, where n is greater than 2, and methods of operating such gates. The electronic logic gates operate according to truth tables. ... California Institute Of Technology

08/11/16 / #20160228566

Carrier nanoparticles and related compositions, methods and systems

Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.. . ... California Institute Of Technology

08/11/16 / #20160227763

Enhancement of electromagnetic freezing by stabilization and oscillation of biogenic magnetite particles

Novel methods and systems for electromagnetic freezing are disclosed. An oscillating magnetic field can be applied in conjunction with a static magnetic field in order to align magnetic particles inside biological tissues. ... California Institute Of Technology

08/04/16 / #20160226010

Electronic devices employing aligned organic polymers

. . The devices can be fabricated by a method that permits active polymer chains to be polymerized on the surface of an electrode such that the active polymer chains are aligned with one another. The active polymer chains can also be covalently linked to a second electrode so the active polymer chains are located in an active layer of the device. ... California Institute Of Technology

08/04/16 / #20160223723

Optical modulating device having gate structure

An optical modulation device includes a plasmonic nano-antenna layer, a metal layer that faces the plasmonic nano-antenna layer, and a permittivity variation layer and a dielectric material layer between the plasmonic nano-antenna layer and the metal layer. An active area formed in the permittivity variation layer according to an external signal may function as a gate that controls optical modulation performance.. ... California Institute Of Technology

08/04/16 / #20160222423

Enzyme-catalyzed enantioselective aziridination of olefins

The present invention provides methods for catalyzing the conversion of an olefin to a compound containing one or more aziridine functional groups using heme enzymes. In certain aspects, the present invention provides a reaction mixture for producing an aziridination product, the reaction mixture comprising of an olefinic substrate, a nitrene precursor, and a heme enzyme. ... California Institute Of Technology

08/04/16 / #20160222409

Method of targeting gene delivery using viral vectors

Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. ... California Institute Of Technology

07/28/16 / #20160216503

Array level fourier ptychographic imaging

In one aspect an imaging system includes: an illumination system including an array of light sources; an optical system including one or more lens arrays, each of the lens arrays including an array of lenses, each of the lenses in each of the one or more lens arrays in alignment with a corresponding set of light sources of the array of light sources; an imaging system including an array of image sensors, each of the image sensors in alignment with a corresponding lens or set of lenses of the one or more lens arrays, each of the image sensors configured to acquire image data based on the light received from the corresponding lens or set of lenses; a plate receiver system capable of receiving a multi-well plate including an array of wells, the plate receiver system configured to align each of the wells with a corresponding one of the image sensors; and a controller configured to control the illumination of the light sources and the acquisition of image data by the image sensors, the controller further configured to perform: an image acquisition process including a plurality of scans, each scan associated with a unique pattern of illumination, each of the image sensors configured to generate an image for a respective one of the wells during each scan; and an image reconstruction process during which the controller performs a fourier ptychographic operation to generate a reconstructed image for each of the wells based on the image data captured for the respective well during each of the scans.. . ... California Institute Of Technology

07/28/16 / #20160216208

Multi-well fourier ptychographic and fluorescence imaging

Certain aspects pertain to multi-well systems, devices, and methods of fourier ptychographic and fluorescence imaging.. . ... California Institute Of Technology

07/28/16 / #20160215089

Functionalized linear and cyclic polyolefins

This invention relates to methods and compositions for preparing linear and cyclic polyolefins. More particularly, the invention relates to methods and compositions for preparing functionalized linear and cyclic polyolefins via olefin metathesis reactions. ... California Institute Of Technology

07/21/16 / #20160210763

Fourier ptychographic tomography

Certain aspects pertain to fourier ptychographic tomographic systems and methods for acquiring a plurality of uniquely illuminated intensity measurements based on light passing through a thick sample from plane wave illumination at different angles and for constructing three-dimensional tomographic data of the thick sample by iteratively determining three-dimensional tomographic data in the fourier domain that is self-consistent with the uniquely illuminated intensity measurements.. . ... California Institute Of Technology

07/21/16 / #20160208269

Compositions and methods for producing benzylisoquinoline alkaloids

The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise one, two or more heterologous coding sequences wherein each of the heterologous coding sequences encodes an enzyme involved in the metabolic pathway of a benzylisoquinoline, or its precursors or intermediates from a starting compound. ... California Institute Of Technology

07/14/16 / #20160202124

Context imaging raman spectrometer

Methods and systems for raman spectroscopy and context imaging are disclosed. One or two lasers can be used to excite raman scattering in a sample, while a plurality of leds can illuminate the sample at a different wavelength. ... California Institute Of Technology

07/07/16 / #20160197378

Electrolytes for wide operating temperature lithium-ion cells

Provided herein are electrolytes for lithium-ion electrochemical cells, electrochemical cells employing the electrolytes, methods of making the electrochemical cells and methods of using the electrochemical cells over a wide temperature range. Included are electrolyte compositions comprising a lithium salt, a cyclic carbonate, a non-cyclic carbonate, and a linear ester and optionally comprising one or more additives.. ... California Institute Of Technology

06/09/16 / #20160160271

Real time microarrays

This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time.. . ... California Institute Of Technology

06/02/16 / #20160156883

Image sensor including nanostructure color filter

An image sensor includes an optical sensor layer including a plurality of light-sensitive cells configured to sense light to generate electrical signals, and a color filter array layer disposed on the optical sensor layer and including a plurality of color filters respectively facing the plurality of light-sensitive cells. Each of the plurality of color filters includes a nanostructure in which a first material having a first refractive index and a second material having a second refractive index higher than the first refractive index are arranged. ... California Institute Of Technology

06/02/16 / #20160152324

Fluidic fence for performance enhancement

A system, apparatus, device, and method for controlling fluid flow, including one or more devices generating one or more secondary fluid flow structures, wherein the fluid flow structures emanate from the aerodynamic or hydrodynamic surface, have a strength that is controlled independently of the primary flow, and enhance the aerodynamic or hydrodynamic force generated by primary flow predominantly by changing direction of said primary flow whether the flow is attached or separated from the surface, and/or interrupting and re-starting said primary flow forming regions that are not directly affected by the fluid flow structure regardless of whether said primary flow is attached or separated.. . ... California Institute Of Technology

06/02/16 / #20160151782

Fluidic devices and fabrication methods for microfluidics

A fluidic device including a body having a surface and one or more channels located in the body. Recesses are defined on said surface. ... California Institute Of Technology

06/02/16 / #20160151408

Novel therapy for multiple sclerosis using vitamin d and gut bacteria

A method for treating multiple sclerosis in a subject in need of such treatment is provided. The method includes administering a) polysaccharide a and b) vitamin d or a vitamin d metabolite to the subject in an amount effective to treat multiple sclerosis. ... California Institute Of Technology

05/26/16 / #20160149562

High power w-band/f-band schottky diode based frequency multipliers

A solid state device chip including diodes (generating a higher frequency output through frequency multiplication of the input frequency) and a novel on-chip power combining design. Together with the on-chip power combining, the chip has increased efficiency because the diodes' anodes, being micro-fabricated simultaneously on the same patch of a gaas wafer under identical conditions, are very well balanced. ... California Institute Of Technology

05/26/16 / #20160149263

Lithium ion electrolytes with lifsi for improved wide operating temperature range

A lithium ion battery cell includes a housing, a cathode disposed within the housing, wherein the cathode comprises a cathode active material, an anode disposed within the housing, wherein the anode comprises an anode active material, and an electrolyte disposed within the housing and in contact with the cathode and anode. The electrolyte includes a solvent mixture and a lithium salt serving as a primary lithium ion conductor in the electrolyte to allow for lithium ion intercalation and deintercalation processes at the cathode and the anode during charging and discharging of the lithium ion battery cell. ... California Institute Of Technology

05/26/16 / #20160147934

Determination of electronic circuit robustness

Technologies are generally described that relate to analysis of circuits and that facilitate determination of electronic circuit robustness. An example method includes performing, for a cell device by a unit including a processor, statistical analysis to obtain statistical information for the cell device that is indicative of a robustness of the cell device. ... California Institute Of Technology

05/26/16 / #20160146680

Pressure sensor using piezoelectric bending resonators

A pressure sensor including an enclosure and a bending resonator housed in the enclosure. The bending resonator includes a diaphragm connected to the enclosure, a piezoelectric layer on the diaphragm, and an electrode on the piezoelectric layer. ... California Institute Of Technology

05/26/16 / #20160145558

Co-incubating confined microbial communities

This invention provides devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices.. ... California Institute Of Technology

05/26/16 / #20160145397

Associative polymers and related compositions, methods and systems

Described herein are associative polymers capable of controlling a physical and/or chemical property of non-polar compositions and related compositions, methods and systems. Associative polymers herein described have a non-polar backbone and functional groups presented at ends of the non-polar backbone, with a number of the functional groups presented at the ends of the non-polar backbone formed by associative functional groups capable of undergoing an associative interaction with another associative functional group with an association constant (k) such that the strength of each associative interaction is less than the strength of a covalent bond between atoms and in particular less than the strength of a covalent bond between backbone atoms.. ... California Institute Of Technology

05/26/16 / #20160144100

Micro-needle drug delivery systems

Generally, devices, systems and methods of using one or more needle(s) or micro-needle arrays are described in which a shift of fluid volume from a first expansion member position to a second expansion member position drives delivery of the fluid, which can be a drug or drug solution, through the needle(s) or micro-needle arrays.. . ... California Institute Of Technology

05/26/16 / #20160143940

Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems

Psa is delivered to the host by outer membrane vesicles (omvs), secretion structures that target bacterial molecules to host cells. Purified omvs direct the in vitro differentiation of functional tregs with potent suppressive activity in a psa dependent manner. ... California Institute Of Technology

05/19/16 / #20160135697

Portable electronic hemodynamic sensor systems

Systems and methods are provided for extracting hemodynamic information, optionally employing portable electronic devices with optional user interface (ui) features for system implementation. The systems and methods may be employed for acquiring hemodynamic signals and associated electrophysiological data and/or analyzing the former or both in combination to yield useful physiological indicia or results. ... California Institute Of Technology

05/12/16 / #20160133540

Multi-layer packaging scheme for implant electronics

The present invention provides a micropackaged device comprising: a substrate for securing a device with a corrosion barrier affixed to the substrate, wherein the corrosion barrier comprises a first thin-film layer, a metal film coating the thin-film layer and a second thin-film layer to provide a sandwich layer; and optionally at least one feedthrough disposed in the substrate to permit at least one input and or at least one output line into the micropackaged device, wherein the micropackaged device is encapsulated by the corrosion barrier. Methods of producing the micropackaged device are also disclosed.. ... California Institute Of Technology

05/12/16 / #20160131882

Common-mode digital holographic microscope

A digital holographic microscope including a single mode fiber collimated light source which provides illumination for both the ‘science’ and ‘reference’ arms, a pair of microscope objectives located side-by side, and illuminated by the common beam, a relay lens whose center is between the two objectives, and a focal plane element where the interference pattern is measured. A lens-less digital holographic microscope and a reflective digital holographic microscope are also disclosed.. ... California Institute Of Technology

05/12/16 / #20160131640

Microfluidic device

Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. ... California Institute Of Technology

05/12/16 / #20160131560

Methods for phenotyping of intact bones by tissue clearing and staining

In various embodiments, the present application teaches methods and kits for clearing and optionally subsequently visualizing tissue containing bone. In some embodiments, the method includes serially incubating cleared bone in refractive index matching solutions with progressively higher refractive indexes. ... California Institute Of Technology

05/05/16 / #20160128173

Toroidal plasma systems

A toroidal plasma is generated without voltage input. It can be produced using a pressurized water jet directed at a non-conductive, dielectric plate. ... California Institute Of Technology

05/05/16 / #20160126404

Graphene-based multi-junctions flexible solar cell

This disclosure relates to structures for the conversion of light into energy. More specifically, the disclosure describes devices for conversion of light to electricity using photovoltaic cells comprising graphene.. ... California Institute Of Technology

05/05/16 / #20160123958

Apparatus and methods for conducting assays and high throughput screening

The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. ... California Institute Of Technology

05/05/16 / #20160123854

Methods for phenotyping of intact whole tissues

In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and optically-transparent, thereby exposing their cellular structure with intact connectivity. In some embodiments, the present application teaches pact, a protocol for passive tissue clearing and immunostaining of intact organs. ... California Institute Of Technology

05/05/16 / #20160122192

Producing zeolite ssz-39 using isomeric mixtures of organic structure directing agents

The present disclosure is directed to producing zeolite structures, especially zeolite ssz-39, using organic structure directing agents (osdas). In particular, the osdas comprise isomeric mixtures of n,n-dialkyl piperidinium cations.. ... California Institute Of Technology

05/05/16 / #20160120920

Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders

Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (asd), and/or schizophrenia symptoms in a subject in need thereof. The bacterial species can include bacteroides (e.g., b. ... California Institute Of Technology

05/05/16 / #20160120917

Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders

Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (asd), and/or schizophrenia symptoms in a subject in need thereof. The subject in need thereof can have a gut microbiota signature characteristic of an adult. ... California Institute Of Technology

05/05/16 / #20160120916

Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders

Some embodiments include probiotics for use in treatment of one or more autism spectrum disorder (asd) or epilepsy in a subject in need thereof. The probiotics can comprise bacteroides bacteria (e.g., b. ... California Institute Of Technology

04/07/16 / #20160099804

Signal digitizer and cross-correlation application specific integrated circuit

According to one embodiment, a cross-correlator comprises a plurality of analog front ends (afes), a cross-correlation circuit and a data serializer. Each of the afes comprises a variable gain amplifier (vga) and a corresponding analog-to-digital converter (adc) in which the vga receives and modifies a unique analog signal associates with a measured analog radio frequency (rf) signal and the adc produces digital data associated with the modified analog signal. ... California Institute Of Technology

04/07/16 / #20160097715

Integrated wide target range optical coupling-based mach-zehnder sensor

A sensor includes, in part, a multitude of splitters/couplers and optical couplers. One of the splitter/couplers splits an incoming optical signal into first and second optical signals. ... California Institute Of Technology

04/07/16 / #20160097656

Decoupled magnetoquasistatic non-line-of-sight position and orientation sensing for arbitrary distances

Methods and systems for non-line-of-sight positioning are disclosed for arbitrarily short to long ranges, where positioning is achieved using a single anchor not requiring tri-/multi-lateration or tri-/multi-angulation. Magnetoquasistatic fields can be used to determine position and orientation of a device in two or three dimensions. ... California Institute Of Technology

03/24/16 / #20160088205

Multiplexed fourier ptychography imaging systems and methods

Certain embodiments pertain to multiplexed fourier ptychographic imaging systems and methods. In one example, the multiplexed fourier ptychographic imaging system includes an led array configured to illuminate a sequence of led patterns for illuminating a sample being imaged. ... California Institute Of Technology

03/24/16 / #20160084707

Laser spiderweb sensor used with portable handheld devices

A portable spectrometer, including a smart phone case storing a portable spectrometer, wherein the portable spectrometer includes a cavity; a source for emitting electromagnetic radiation that is directed on a sample in the cavity, wherein the electromagnetic radiation is reflected within the cavity to form multiple passes of the electromagnetic radiation through the sample; a detector for detecting the electromagnetic radiation after the electromagnetic radiation has made the multiple passes through the sample in the cavity, the detector outputting a signal in response to the detecting; and a device for communicating the signal to a smart phone, wherein the smart phone executes an application that performs a spectral analysis of the signal.. . ... California Institute Of Technology

03/17/16 / #20160079966

Quadrature-based injection locking of ring oscillators

Technologies are generally described for quadrature-based injection-locking offing oscillators. In some examples, an external signal may be injected into a ring oscillator. ... California Institute Of Technology

03/17/16 / #20160077261

Simultaneous polarization and wavefront control using a planar device

Methods and device for controlling optical scattering are disclosed. An array of 4-fold asymmetric cylinders can act as optical elements scattering electromagnetic waves, where the orientation and dimension of each optical element is determined according to the desired polarization and phase shift response of the device. ... California Institute Of Technology

03/17/16 / #20160076085

Methods for detecting and quantifying viable bacterial endo-spores

Methods and systems for detecting viable bacterial endospores in a sample and related methods to quantify viable bacterial endospores in a sample.. . ... California Institute Of Technology

03/10/16 / #20160071994

Method of making photovoltaic devices with reduced conduction band offset between pnictide absorber films and emitter films

The principles of the present invention are used to reduce the conduction band offset between chalcogenide emitter and pnictide absorber films. Alternatively stated, the present invention provides strategies to more closely match the electron affinity characteristics between the absorber and emitter components. ... California Institute Of Technology

03/10/16 / #20160069810

Surface enhanced raman spectroscopy detection of gases, particles and liquids through nanopillar structures

Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. ... California Institute Of Technology

03/10/16 / #20160069686

Optomechanical disk vibratory gyroscopes

An integrated optomechanical disk vibratory gyroscope device includes a mechanical oscillator having a substantially circular structure. The substantially circular structure is supported by a pillar, and mechanically isolated from a surrounding structure by a gap or slot. ... California Institute Of Technology

03/10/16 / #20160068669

Brush block copolymer infrared 1-d photonic crystals using linear polymer additives

The present invention is directed to brush block copolymer compositions comprising first and second homopolymers or random copolymers whose presence provides access to photonic bandgaps in the infrared frequency range, their use in this capacity, and methods of making the same. The specific parameters associated with these compositions are described within the specification.. ... California Institute Of Technology

03/10/16 / #20160067666

Multiplexed surface enhanced raman sensors for early disease detection and in-situ bacterial monitoring

Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. ... California Institute Of Technology

03/03/16 / #20160060739

Bulk nickel-based chromium and phosphorous bearing metallic glasses

Ni-based cr- and p-bearing alloys that can from centimeter-thick amorphous articles are provided. Within the family of alloys, millimeter-thick bulk-glassy articles can undergo macroscopic plastic bending under load without fracturing catastrophically.. ... California Institute Of Technology

03/03/16 / #20160060358

Induction of antigen-specific tolerance

Described are compositions and methods for the induction of an antigen-specific tolerance in a vertebrate. Also described are compositions and methods for the induction of antigen-specific tolerance using a fusion or a complex of the antigen (e.g., an antibody or an enzyme) against which tolerance is desired with a phosphatidylserine-binding domain derived from a phosphatidylserine-binding protein (including peptides).. ... California Institute Of Technology

03/03/16 / #20160060278

Base-catalyzed silylation of terminal alkyne c-h bonds

The present invention is directed to a mild, efficient, and general direct c(sp)-h bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl c—h bond, with a mixture of at least one organosilane and an alkali metal hydroxide, under conditions sufficient to form a silylated terminal alkynyl moiety. ... California Institute Of Technology

03/03/16 / #20160058808

Microbe-based modulation of serotonin biosynthesis

Methods and compositions that can be used to modulate serotonin level in a subject are disclosed herein. In some embodiments, the methods include adjusting the composition of gut microbiota in the subject. ... California Institute Of Technology

02/25/16 / #20160056474

Design, use and fabrication of microscaffolds and nanoscaffolds

A scaffold includes struts that intersect at nodes. In some instances, a cross section of the cores has at least one dimension less than 100 microns. ... California Institute Of Technology

02/25/16 / #20160056321

Large-scale space-based solar power station: efficient power generation tiles

A space-based solar power station, a power generating satellite module and/or a method for collecting solar radiation and transmitting power generated using electrical current produced therefrom is provided. Each solar power station includes a plurality of satellite modules. ... California Institute Of Technology

02/25/16 / #20160054553

Method and device to achieve spatially confined photointeraction at the focal volume of a microscope

The invention relates to a method and a system to achieve spatially (e.g. Three-dimensionally) confined photomodulation at the focal volume (50) in a ample (55) mounted in a microscope system, comprising two or more laser light sources (41, 42) emitting light (32, 34) of different wavelengths adapted to excite a material in an identical number of independent excitation steps to a higher vibrational state from which the material relaxes, either emitting a conversion light to be detected (“photoexcitation”) or modulating the spectral properties of the material (“photomodulation”).. ... California Institute Of Technology

02/25/16 / #20160051705

Functionalization of and use of functionalized second harmonic generating nanoprobes

Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processes using a variety of imaging techniques are provided. The functionalized second harmonic generating (shg) nanoprobes are comprised of various kinds of nanocrystalline materials that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy, and are provided with functional surface modifications that allow for targeted imaging of a variety of biological and non-biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, dna conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.. ... California Institute Of Technology

02/25/16 / #20160051171

Methods and systems for non-invasive measurement of blood glucose concentration by transmission of millimeter waves through human skin

A device is described for interrogating human skin using tight coupling between the transmitter and receiver of the millimeter waves (mmws). Methods are provided to evaluate changes in the amplitude and/or phase of the transmitted mmws in order to estimate the blood concentration of glucose. ... California Institute Of Technology

02/18/16 / #20160049770

Single-mode, distributed feedback interband cascade lasers

Single-mode, distributed feedback interband cascade lasers (icls) using distributed-feedback gratings (e.g., lateral bragg gratings) and methods of fabricating such icls are provided. The icls incorporate distributed-feedback gratings that are formed above the laser active region and adjacent the ridge waveguide (rwg) of the icl. ... California Institute Of Technology

02/18/16 / #20160048672

Herma - heartbeat microwave authentication

Systems and methods for identifying and/or authenticating individuals utilizing microwave sensing modules are disclosed. A heartbeat microwave authentication (herma) system can enable the active identification and/or authentication of a user by analyzing reflected rf signals that contain a person's unique characteristics related to their heartbeats. ... California Institute Of Technology

02/18/16 / #20160047988

Methods and systems for delaying optical waves

Coupled-resonator optical waveguides (crow) can be used to control a speed of an optical signal. In particular, the coupling distance between the resonators can be adjusted to precisely control a group delay of an optical wave. ... California Institute Of Technology

02/18/16 / #20160047940

Systems and methods for advanced rapid imaging and analysis for earthquakes

Many embodiments provide a hybrid data processing system (hysds) of an end-to-end geodetic imaging data system enabling near-real-time science, assessment, response, and rapid recovery. The hysds may be an operation data processing system that integrates data from many different geodetic data sources and/or sensors, including interferometric synthetic aperture radar (insar), gps, pixel tracking, seismology, and/or modeling, and processes the data to generate actionable high quality science data products. ... California Institute Of Technology

02/18/16 / #20160046934

Signal activated rna interference

The invention provides compositions and methods for signal activated rna interference (sarnai), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mrna, mirna, or other cellular rna products with sequences that characterize diseased states of the cell. ... California Institute Of Technology

02/18/16 / #20160046653

Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts

The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including hydroxide, especially koh, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate; wherein said system is substantially free of a transition-metal compound.. . ... California Institute Of Technology

02/11/16 / #20160040199

Enzymatic methods for nitrogen-atom transfer

The present invention provides methods for catalyzing a nitrene insertion into a c—h bond to produce a product having a new c—n bond, comprising providing a c—h containing substrate, a nitrene precursor and an engineered heme enzyme; and allowing the reaction to proceed for a time sufficient to form a regioselective product having a new c—n bond.. . ... California Institute Of Technology

02/04/16 / #20160036563

Distributed reed-solomon codes for simple multiple access networks

A computer-based distributed error correction scheme with an efficient decoding algorithm is disclosed. The efficiency of the corresponding decoding algorithm, based on standard single source reed-solomon error correcting codes, makes the practical employment of the decc feasible. ... California Institute Of Technology

02/04/16 / #20160036226

Distributed gradient descent for solving optimal power flow in radial networks

Node controllers and power distribution networks in accordance with embodiments of the invention enable distributed power control, one embodiment includes a node controller comprising a memory containing: a plurality of node operating parameters; and a plurality of node operating parameters describing operating parameters for a set of at least one node selected from the group consisting of at least one downstream node and at least one upstream node; wherein the processor is configured by the node controller application to: receive and store in memory a plurality of coordinator parameters describing operating parameters of a node coordinator by the network interface; and calculate updated node operating parameters using an iterative gradient projection process to determine updated node parameters using node operating parameters that describe operating parameters of node and operating parameters of the set of at least one node, where each iteration is determined by the coordinator parameters.. . ... California Institute Of Technology

02/04/16 / #20160036225

Dynamic frequency control in power networks

Node controllers in power distribution networks in accordance with embodiments of the invention enable dynamic frequency control. One embodiment includes a node controller comprising a network interface a processor; and a memory containing a frequency control application; and a plurality of node operating parameters describing the operating parameters of a node, where the node is selected from a group consisting of at least one generator node in a power distribution network wherein the processor is configured by the frequency control application to calculate a plurality of updated node operating parameters using a distributed process to determine the updated node operating parameter using the node operating parameters, where the distributed process controls network frequency in the power distribution network; and adjust the node operating parameters.. ... California Institute Of Technology

02/04/16 / #20160035093

Multi modality brain mapping system (mbms) using artificial intelligence and pattern recognition

A multimodality brain mapping system (mbms), comprising one or more scopes (e.g., microscopes or endoscopes) coupled to one or more processors, wherein the one or more processors obtain training data from one or more first images and/or first data, wherein one or more abnormal regions and one or more normal regions are identified; receive a second image captured by one or more of the scopes at a later time than the one or more first images and/or first data and/or captured using a different imaging technique; and generate, using machine learning trained using the training data, one or more viewable indicators identifying one or abnormalities in the second image, wherein the one or more viewable indicators are generated in real time as the second image is formed. One or more of the scopes display the one or more viewable indicators on the second image.. ... California Institute Of Technology

02/04/16 / #20160033794

Optical phased array using guided resonance with backside reflectors

Methods and systems for controlling the phase of electromagnetic waves are disclosed. A device can consist of a guided resonance grating layer, a spacer, and a reflector. ... California Institute Of Technology

02/04/16 / #20160033766

Directional optical receiver

An optical phased array (opa) receiver selectively detects, measures and differentiates between the amplitudes and directions of signals received from different directions. Because the opa changes the direction that it looks toward electronically and without the use of any mechanical movements, the opa is fast, has an enhanced sensitivity, and can be used in a wide variety applications, such as lens-free imaging systems. ... California Institute Of Technology

02/04/16 / #20160033755

Optical shutter based on sub-wavelength gratings actuated by microelectromechanical systems

Methods and systems for control of electromagnetic waves are disclosed. An optical shutter includes a sub-wavelength grating. ... California Institute Of Technology

02/04/16 / #20160032330

P-450-catalyzed enantioselective cyclopropanation of electron-deficient olefins

The present invention pertains to the use of engineered variants of enzyme cyp102a, also known as p450-bm3, for cyclopropanation of olefins containing electron-withdrawing groups. One exemplary enzyme variant, referred to as bm3-hstar, contains five mutations away from wild-type p450-bm3, and demonstrates high activity towards cyclopropanation of olefinic substrates using ethyldiazoacetate (eda) and other carbene transfer reagents. ... California Institute Of Technology

02/04/16 / #20160030748

High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury

Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease are described.. . ... California Institute Of Technology

01/28/16 / #20160025626

Silicon photonic crystal nanobeam cavity without surface cladding and integrated with micro-heater for sensing applications

A silicon photonic crystal nanobeam cavity device is described, including a heater that can set a desired temperature on the cavity device in order to control its resonant wavelength. The device has no cladding, which is advantageous for sensing. ... California Institute Of Technology

01/28/16 / #20160024482

Alkane oxidation by modified hydroxylases

This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.. ... California Institute Of Technology

01/28/16 / #20160023352

Surrogate: a body-dexterous mobile manipulation robot with a tracked base

Robotics platforms in accordance with various embodiments of the invention can be utilized to implement highly dexterous robots capable of whole body motion. Robotics platforms in accordance with one embodiment of the invention include: a memory containing a whole body motion application; a spine, where the spine has seven degrees of freedom and comprises a spine actuator and three spine elbow joints that each include two spine joint actuators; at least one limb, where the at least one limb comprises a limb actuator and three limb elbow joints that each include two limb joint actuators; a tracked base; a connecting structure that connects the at least one limb to the spine; a second connecting structure that connects the spine to the tracked base; wherein the processor is configured by the whole body motion application to move the at least one limb and the spine to perform whole body motion.. ... California Institute Of Technology

01/21/16 / #20160019334

Multiplex analysis of molecules in single cells by image correlation

Disclosed herein are methods and systems for analyzing visual data from multiple rounds of hybridization interactions where the same molecular target is detected by probes with different detectable labels. In particular, disclosed herein are methods and systems for analyzing sequential hybridization images for molecular profiling, where the images are obtained using multiplex fluorescence in situ hybridization (fish).. ... California Institute Of Technology

01/21/16 / #20160015879

Correction and optimization of wave reflection in blood vessels

The present invention provides methods and modalities that can modify wave reflection in the vascular system in order to create constructive interactions between existing wave dynamics and new reflective waves for the purpose of lowering the workload on the heart and increasing cardiac output, providing a viable option for the prevention and treatment of many heart conditions and diseases.. . ... California Institute Of Technology

01/14/16 / #20160011189

Arrays, substrates, devices, methods and systems for detecting target molecules

Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.. . ... California Institute Of Technology

01/14/16 / #20160009574

Electrolysis electrode

A water purification anode has a first semiconductor contacting a second semiconductor at a heterojunction. The second semiconductor includes tio2 and excludes bismuth and niobium. ... California Institute Of Technology

01/14/16 / #20160008988

Robotics platforms incorporating manipulators having common joint designs

Manipulators in accordance with various embodiments of the invention can be utilized to implement statically stable robots capable of both dexterous manipulation and versatile mobility. Manipulators in accordance with one embodiment of the invention include: an azimuth actuator; three elbow joints that each include two actuators that are offset to allow greater than 360 degree rotation of each joint; a first connecting structure that connects the azimuth actuator and a first of the three elbow joints; a second connecting structure that connects the first elbow joint and a second of the three elbow joints; a third connecting structure that connects the second elbow joint to a third of the three elbow joints; and an end-effector interface connected to the third of the three elbow joints.. ... California Institute Of Technology

01/07/16 / #20160005786

Atomically precise surface engineering for producing imagers

High-quality surface coatings, and techniques combining the atomic precision of molecular beam epitaxy and atomic layer deposition, to fabricate such high-quality surface coatings are provided. The coatings made in accordance with the techniques set forth by the invention are shown to be capable of forming silicon ccd detectors that demonstrate world record detector quantum efficiency (>50%) in the near and far ultraviolet (155 nm-300 nm). ... California Institute Of Technology

01/07/16 / #20160005566

Method and system for electron microscope with multiple cathodes

An electron microscope system includes a laser system operable to generate an optical pulse and a pump pulse and a microscope column. The microscope column includes a multiple cathode structure having a plurality of spatially separated cathode regions. ... California Institute Of Technology

01/07/16 / #20160002682

In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes

The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. ... California Institute Of Technology

01/07/16 / #20160000934

Nanoparticles stabilized with nitrophenylboronic acid compositions

Described herein are polymer conjugates comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic acid.. . ... California Institute Of Technology








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