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California Institute Of Technology patents (2018 archive)


Recent patent applications related to California Institute Of Technology. California Institute Of Technology is listed as an Agent/Assignee. Note: California Institute Of Technology may have other listings under different names/spellings. We're not affiliated with California Institute Of Technology, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | California Institute Of Technology-related inventors


Highly efficient multi-port radiataor

A radiator is formed by forming a multitude of slot antennas adjacent one another such that the spacing between each pair of adjacent slot antennas is smaller than the wavelength of the signal being transmitted or received by the radiator. The radiator achieves high efficiency by reducing the excitation of substrate modes, and further achieves high output power radiation by combining power of multiple cmos power amplifiers integrated in the radiator structure. ... California Institute Of Technology

Nanoscale field-emission device and method of fabrication

Nanoscale field-emission devices are presented, wherein the devices include at least a pair of electrodes separated by a gap through which field emission of electrons from one electrode to the other occurs. The gap is dimensioned such that only a low voltage is required to induce field emission. ... California Institute Of Technology

Conformal optical metasurfaces

Structures for scattering light at multiple wavelengths are disclosed. Scattering elements are fabricated with different geometric dimensions and arrangements, to scatter or focus light at the same focal distance for each wavelength, or at different focal distances according to the desired application. ... California Institute Of Technology

Alkane oxidation by modified hydroxylases

This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.. ... California Institute Of Technology

Heme protein catalysts for carbon-boron bond formation in vitro and in vivo

Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the presence of a heme protein, e.g., a cytochrome c, a cytochrome p450, a globin, a protoglobin, a nitric oxide dioxygenase, a peroxidase, or a catalase, or a variant thereof, under conditions sufficient to form the organoboron product. ... California Institute Of Technology

Solar fuels generator

The solar fuels generator includes an ionically conductive separator between a gaseous first phase and a second phase. A photoanode uses one or more components of the first phase to generate cations during operation of the solar fuels generator. ... California Institute Of Technology

Optical system

An optical system and an image sensor including the same are provided. The optical system includes first, second, and third optical devices. ... California Institute Of Technology

Smart bandage

A sensing chip attached to a bandage monitors the healing process of a wound by detecting growth factors, thrombin and fibrinogen. The complementary metal-oxide semiconductor includes a functionalized working electrode, functionalized counter electrode and functionalized reference electrode. ... California Institute Of Technology

Z-selective olefin metathesis of peptides

The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.. ... California Institute Of Technology

Deployable reflectarray antenna

A deployable reflectarray antenna stowable in a 6u cubesat volume is deployed through tape deployers and quartz cables. The telescoping waveguide is attached to the horn with a threaded insert. ... California Institute Of Technology

High performance inorganic complexes for next-generation redox flow batteries

In an aspect, a redox flow battery comprises a catholyte and an anolyte; wherein at least one of said catholyte and said anolyte is a metal-coordination complex, said metal-coordination complex comprising: (i) a metal; (ii) one or more first ligands coordinated with said metal atom, wherein each of said first ligands is independently a lewis basic ligand; and one or more second ligands associated with said one or more first ligands, wherein each of said second ligands is independently a lewis acid ligand; and a nonaqueous solvent, wherein said catholyte, said anolyte or both are dissolved in said nonaqueous solvent. One or more first ligands may be provided in a primary coordination sphere of said metal-coordination complex and one or more second ligands may be provided in a secondary coordination sphere of said metal-coordination complex. ... California Institute Of Technology

Method and apparatus for the spectroscopic detection of low concentrations of hydrogen sulfide gas

Spectroscopic apparatus and methods incorporating a gas sensor configured to detect low concentration gases, including gases that are hazardous volatiles are provided. Low concentration gases can comprise gases where detection of concentrations on the order of parts-per-million (ppm), and in many embodiments part-per-billion (ppb) is required. ... California Institute Of Technology

Solar fuels generator with ph separation

A solar fuels generator includes an anolyte and a catholyte in contact with a separator. The separator is configured such that the ph of the anolyte and the ph of the catholyte are each held at a steady state ph level during operation of the solar fuels generator. ... California Institute Of Technology

Multiplex q-pcr arrays

This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (pcr) in the presence of an array of nucleic acid probes. ... California Institute Of Technology

09/06/18 / #20180251828

Multiplex q-pcr arrays

This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (pcr) in the presence of an array of nucleic acid probes. ... California Institute Of Technology

08/23/18 / #20180239168

Micro fenestrated contact lens

A sclera or contact lens with an image of an eye that is fenestrated, or uniformly speckled with many sub-millimeter sized transparent regions or holes, is disclosed. The micro fenestrated contact lens can be worn on a strabismic, or misaligned, eye so that its image is aligned with the wearer's dominant eye. ... California Institute Of Technology

08/16/18 / #20180233964

Smart rf lensing: efficient, dynamic and mobile wireless power transfer

An rf lens includes a multitude of radiators adapted to transmit radio frequency electromagnetic em waves whose phases are modulated so as to concentrate the radiated power in a small volume of space in order to power an electronic device positioned in that space. Accordingly, the waves emitted by the radiators are caused to interfere constructively at that space. ... California Institute Of Technology

08/16/18 / #20180233963

Smart rf lensing: efficient, dynamic and mobile wireless power transfer

An rf lens includes a multitude of radiators adapted to transmit radio frequency electromagnetic em waves whose phases are modulated so as to concentrate the radiated power in a small volume of space in order to power an electronic device positioned in that space. Accordingly, the waves emitted by the radiators are caused to interfere constructively at that space. ... California Institute Of Technology

08/16/18 / #20180233650

High temperature superconducting materials

A superconducting composition of matter including overlapping first and second regions. The regions comprise unit cells of a solid, the first region comprises an electrical insulator or semiconductor, and the second region comprises a metallic electrical conductor. ... California Institute Of Technology

08/16/18 / #20180230524

Integrated electrochemical nucleic acid based sensors and related platforms

A sensor incorporates one or more working electrodes, a counter electrode and a reference electrode. The sensor is inserted in a needle and connected to control electronics to detect the concentration of target molecules. ... California Institute Of Technology

08/16/18 / #20180230491

Method for expression of small rna molecules within a cell

The invention provides methods and compositions for the expression of small rna molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded rna complexes. ... California Institute Of Technology

08/16/18 / #20180230186

Selective recovery

Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.. ... California Institute Of Technology

08/16/18 / #20180229808

Systems, methods, and apparatuses for reducing hydrodynamic frictional drag

Systems, methods and apparatuses are provided for the reduction of hydrodynamic frictional drag. These systems, methods and apparatuses can include a vessel surface having an external layer and a plurality of dimples, wherein the external layer comprises a hydrophilic material, and wherein each of the dimples includes an inner surface having a superhydrophobic coating. ... California Institute Of Technology

08/09/18 / #20180226841

Smart rf lensing: efficient, dynamic and mobile wireless power transfer

An rf lens includes a multitude of radiators adapted to transmit radio frequency electromagnetic em waves whose phases are modulated so as to concentrate the radiated power in a small volume of space in order to power an electronic device positioned in that space. Accordingly, the waves emitted by the radiators are caused to interfere constructively at that space. ... California Institute Of Technology

08/09/18 / #20180225411

Methods for prediction of binding site structure in proteins and/or identification of ligand poses

A method for modification and/or evaluation of ligand-protein and protein-protein systems is provided. Specifically, the method involves generating a final set of ligand or protein poses based on an initial set of ligand or protein poses. ... California Institute Of Technology

08/09/18 / #20180224587

Image sensor including nanostructure color filter

An image sensor includes an optical sensor layer including a plurality of light-sensitive cells configured to sense light to generate electrical signals, and a color filter array layer disposed on the optical sensor layer and including a plurality of color filters respectively facing the plurality of light-sensitive cells. Each of the plurality of color filters includes a nanostructure in which a first material having a first refractive index and a second material having a second refractive index higher than the first refractive index are arranged. ... California Institute Of Technology

08/09/18 / #20180222781

Water purification using porous carbon electrode

A water purification electrode composed of a porous carbon material is disclosed. The electrode may be used as a flow-through cathode in an electro-peroxone process providing high h2o2 production activity for electrochemical wastewater treatment. ... California Institute Of Technology

08/02/18 / #20180219115

Semiconductor structures for fuel generation

This disclosure relates to photovoltaic and photo-electrosynthetic cells, devices, methods of making and using the same.. . ... California Institute Of Technology

07/26/18 / #20180207625

Enantiomerically enriched, polycrystalline molecular sieves

This disclosure describes enantiomerically enriched chiral molecular sieves and methods of making and using the same. In some embodiments, the molecular sieves are silicates or germanosilicates of stw topology.. ... California Institute Of Technology

07/26/18 / #20180206747

Portable electronic hemodynamic sensor systems

Systems and methods are provided for extracting hemodynamic information, optionally employing portable electronic devices with optional user interface (ui) features for system implementation. The systems and methods may be employed for acquiring hemodynamic signals and associated electrophysiological data and/or analyzing the former or both in combination to yield useful physiological indicia or results. ... California Institute Of Technology

07/19/18 / #20180203960

Systems and methods for level set discrete element method particle simulation

Systems and methods for level set discrete element method particle simulation in accordance with embodiments of the invention are disclosed. In one embodiment, a particle simulation device includes a processor and a memory storing a particle analysis application, wherein the processor, on reading the particle analysis application obtains image data describing a plurality of particles, models a plurality of grains based on the image data, where each modeled grains includes a level set function corresponding to one of the plurality of particles, calculates the motion of each of the plurality of grains based on a force applied to the plurality of grains, and generates a transformed particle model based on the plurality of grains and the calculated motion.. ... California Institute Of Technology

07/19/18 / #20180202904

Methods and devices for soft and osseous tissue clearing and fluorescent imaging

Described herein is a bone tissue clearing method with enhanced optical access. Compositions and techniques for bone tissue clearing include continuous convective flow during the clearing process, amino alcohol to minimize tissue autofluorescence, and an imaging procedure that minimizes refractive index variations in light-sheet microscopy. ... California Institute Of Technology

07/19/18 / #20180201395

Micro-emitters for electrospray systems

Micro-emitter arrays and methods of microfabricating such emitter arrays are provided. The microfabricated emitter arrays incorporate a plurality of emitters with heights greater than 280 microns with uniformity of +/−10 microns arranged on a supporting silicon substrate, each emitter comprising an elongated body extending from the top surface of the substrate and incorporating at least one emitter tip on the distal end of the elongated body thereof. ... California Institute Of Technology

07/12/18 / #20180197617

Error characterization and mitigation for 16nm mlc nand flash memory under total ionizing dose effect

A data device includes a memory having a plurality of memory cells configured to store data values in accordance with a predetermined rank modulation scheme that is optional and a memory controller that receives a current error count from an error decoder of the data device for one or more data operations of the flash memory device and selects an operating mode for data scrubbing in accordance with the received error count and a program cycles count.. . ... California Institute Of Technology

07/12/18 / #20180196138

Optical modulating device and system including the same

Provided are an optical modulating device and a system including the optical modulating device. The optical modulating device includes a substrate, and a phase modulator formed on the substrate and including a fabry-perot cavity. ... California Institute Of Technology

07/12/18 / #20180196137

Optical modulating device and system employing same

Provided are an optical modulating device and a system employing the same. The optical modulating device includes a phase modulator including a meta surface including a nanoantenna configured to couple light incident on the phase modulator, and including a quantum well layer having a multi-quantum well and configured to modulate a phase of light by modulating a refractive index according to an electrical control, and a reflective layer provided at on the phase modulator opposite to a side of the meta surface of the phase modulator and configured to resonate light coupled through the nanoantenna.. ... California Institute Of Technology

07/12/18 / #20180196044

Use of gut microbiota in the diagnosis and therapeutics of parkinson's disease

Disclosed herein are methods and compositions that can be used to treat and diagnose parkinsonism, for example parkinson's disease, and uses for the same.. . ... California Institute Of Technology

07/05/18 / #20180187193

Microrna inhibition for the treatment of inflammation and myeloproliferative disorders

The present disclosure relates to the finding that microrna-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microrna-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of cutl1, arntl, picalm, jarid2, pu.1, csf1r, hif1α, sla, cepbβ, and bach1, and the like.. ... California Institute Of Technology

06/28/18 / #20180179555

Targeted gene delivery for dendritic cell vaccination

Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (dc). The virus envelope comprises a dc-sign specific targeting molecule. ... California Institute Of Technology

06/28/18 / #20180177922

Light adjustable intraocular lenses using upconverting nanoparticles and near infrared (nir) light

This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable ocular lenses. ... California Institute Of Technology

06/28/18 / #20180177619

Mixed variable decoding for neural prosthetics

In an embodiment, the invention relates to neural prosthetic devices in which control signals are based on the cognitive activity of the prosthetic user. The control signals may be used to control an array of external devices, such as prosthetics, computer systems, and speech synthesizers. ... California Institute Of Technology

06/21/18 / #20180175382

Composite electrode materials for fluoride-ion electrochemical cells

The present disclosure relates to a method of making core-shell and yolk-shell nanoparticles, and to electrodes comprising the same. The core-shell and yolk-shell nanoparticles and electrodes comprising them are suitable for use in electrochemical cells, such as fluoride shuttle batteries. ... California Institute Of Technology

06/21/18 / #20180172704

Compositions and methods for programmable sensing and control through combinatorial molecular interactions

Methods and compositions are provided for the selective activation of a bmp-dependent response in certain cell types. Methods include identifying a ligand or ligand combinations as well as cell receptor profiles that result in selectively activating a ligand-dependent response through interactions with ligand receptors on a first cell type that do not activate the ligand-dependent response in a second cell type.. ... California Institute Of Technology

06/21/18 / #20180171001

Broadly neutralizing anti-hiv antibodies and epitope therefor

The present invention relates to broadly neutralizing anti-hiv-1 antibodies and isolated antigens. Also disclosed are related methods and compositions.. ... California Institute Of Technology

06/21/18 / #20180169265

Carrier nanoparticles and related compositions, methods and systems

Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.. . ... California Institute Of Technology

06/14/18 / #20180164276

Sensing and actuation of biological function using addressable transmitters operated as magnetic spins

Methods and apparatuses for sensing biological functions are disclosed. Sensors can be implanted in an organ, such as the brain, and a magnetic field gradient applied to the biological tissue. ... California Institute Of Technology

06/07/18 / #20180159139

Nanofibers decorated with nanoparticles and methods of their manufacture

Nanostructured materials, and methods and apparatus for their production are provided. Nanostructured materials comprise nanofibers having nanoparticles deposited along the outer surface thereof. ... California Institute Of Technology

06/07/18 / #20180155819

Layered structures for the protection of molecules

A multilayer structure can selectively bind certain molecules, due to reentrant spaces having an appropriate size. The multilayers can be fabricated by alternating layers of two different materials having different etching rate. ... California Institute Of Technology

06/07/18 / #20180155271

Silylations of aromatic substrates with base-activated organosilanes

The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.. . ... California Institute Of Technology

06/07/18 / #20180154342

Processes for preparing zincoaluminosilicates with aei, cha, and gme topologies and compositions derived therefrom

The present disclosure is directed to methods of producing zincoaluminosilicate structures with aei, cha, and gme topologies using organic structure directing agents (osdas), and the compositions and structures resulting from these methods.. . ... California Institute Of Technology

05/31/18 / #20180152204

Balanced reed-solomon codes

Balanced reed-solomon codes in accordance with embodiments of the invention enable balanced load in distributed storage systems. One embodiment includes a storage controller, wherein the storage processor is configured by the controller reed-solomon application to: receive a data segment; partition the data segment into a first block of data and a second block of data; transmit the first block of data to a first node controller in the plurality of node controllers; transmit the second block of data to a second node controller in the plurality of node controllers; wherein the node processor in the first node controller is configured by the node reed-solomon application to: receive the first block of data; encode the first block of data using a balanced and sparsest error-correcting code; and store the encoded first block of data in the node memory of the first node controller.. ... California Institute Of Technology

05/24/18 / #20180142307

Recording and mapping lineage information and molecular events in individual cells

Methods and systems for recording and mapping lineage information and molecular events in individual cells are provided. Molecular changes, which may result from random or specific molecular events, are introduced to defined regions in cells over multiple cell cycle generations. ... California Institute Of Technology

05/17/18 / #20180137991

Electrochemical energy storage systems and methods

A three-dimensional electrode array for use in electrochemical cells, fuel cells, capacitors, supercapacitors, flow batteries, metal-air batteries and semi-solid batteries.. . ... California Institute Of Technology

05/17/18 / #20180134664

Dna2 inhibitors for cancer treatment

Disclosed herein, inter alia, are compositions and methods for inhibiting dna2.. . ... California Institute Of Technology

05/10/18 / #20180128683

Monolithic assembly of reflective spatial heterodyne spectrometer

Novel monolithic cyclical reflective spatial heterodyne spectrometers (crshs) are presented. Monolithic crshs in accordance with the invention have a single frame wherein a flat mirror, roof mirror, and symmetric grating are affixed. ... California Institute Of Technology

05/10/18 / #20180127539

Functionalized linear and cyclic polyolefins

This invention relates to methods and compositions for preparing linear and cyclic polyolefins. More particularly, the invention relates to methods and compositions for preparing functionalized linear and cyclic polyolefins via olefin metathesis reactions. ... California Institute Of Technology

05/10/18 / #20180126364

Methods to produce zeolites with the gme topology and compositions derived therefrom

The present disclosure is directed to producing zeolite structures with gme topologies using organic structure directing agents (osdas) comprising a piperidinium cation, and the compositions and structures resulting from these methods. In some embodiments, the crystalline products have a molar ratio of a molar ratio of si:al that is greater than 3.5.. ... California Institute Of Technology

05/03/18 / #20180123699

Optical sparse phased array receiver

A sparse optical phased array transmitter/receiver includes, in part, a multitude of transmitting/receiving elements that are sparsely positioned. Accordingly, the transmitting/receiving elements are not uniformly distributed at equal distance intervals along a one-dimensional, two-dimensional, or a three-dimensional array. ... California Institute Of Technology

05/03/18 / #20180121832

Weight generation in machine learning

Technologies are generally described for systems, devices and methods relating to a machine learning environment. In some examples, a processor may identify a training distribution of a training data. ... California Institute Of Technology

05/03/18 / #20180119259

Systems and methods for shaping sheet materials that include metallic glass-based materials

Systems and methods in accordance with embodiments of the invention advantageously shape sheet materials that include metallic glass-based materials. In one embodiment, a method of shaping a sheet of material including a metallic glass-based material includes: heating a metallic glass-based material within a first region within a sheet of material to a temperature greater than the glass transition temperature of the metallic glass-based material; where the sheet of material has a thickness of between 0.1 mm and 10 mm; where at least some portion of the sheet of material does not include metallic glass-based material that is heated above its respective glass transition temperature when the metallic glass-based material within the first region is heated above its respective glass transition temperature; and deforming the metallic glass-based material within the first region while the temperature of the metallic glass-based material within the first region is greater than its respective glass transition temperature.. ... California Institute Of Technology

05/03/18 / #20180118706

Synthetic route to anhydroryanodol, ryanodol and structural analogues

This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogues thereof and novel compounds prepared thereby.. . ... California Institute Of Technology

04/19/18 / #20180106673

Geostationary earth orbit (geo) earth multispectral mapper (gemm)

A multi-spectral imager useful for weather mapping, comprising an array of filters on at least one focal plane array (fpa) including pixels. Each of the filters are associated with a different set of the pixels, and each of the filters transmit a portion of electromagnetic radiation, comprising a different band of wavelengths, to the set of the pixels associated with the filter. ... California Institute Of Technology

04/19/18 / #20180105859

Digital quantification of dna replication and/or chromosome segregation based determination of antimicrobial susceptibility

Disclosed herein are methods and devices for using digital isothermal amplification to detect subtle responses to environmental stimuli, such as detecting antibiotic susceptibility using digital quantification of dna replication and/or chromosome segregation.. . ... California Institute Of Technology

04/12/18 / #20180101083

Integrated optical phased arrays with optically enhanced elements

An optical phase array, includes, in part, n optical signal emitting elements, and n lenses each associated with a different one of the n optical signal emitting elements and positioned to form an image of its associated signal emitting element, where n is an integer greater than 1. The optical signal emitting elements may be a grating coupler, an edge coupler, and the like. ... California Institute Of Technology

04/12/18 / #20180101032

Thermally enhanced fast optical phase shifter

An optical phase shifter includes, in part, a waveguide, a heating element adapted to heat the waveguide, and a cooling element adapted to cool the waveguide. The heating element may be integrated within a substrate in which the waveguide is formed. ... California Institute Of Technology

04/12/18 / #20180100863

Functional characterization of immune repertoires

Provided herein are method and kits for elucidation of immunological repertoires (comprising functional pairs of immune cell receptors and antigens). In some embodiments, an immune cell receptor and an antigen that it binds to are isolated, and sequence information is obtained about the immune cell receptor and antigen. ... California Institute Of Technology

04/05/18 / #20180094294

Microfabricated crossflow devices and methods

This invention provides microfabricated devices and methods for detecting, analyzing and sorting biological materials and particles. Droplets containing the particles are provided in an extrusion fluid, passed through a detection region, and then directed into a branch channel according to predetermined characteristics. ... California Institute Of Technology

04/05/18 / #20180092738

Radioluminescent phototherapy eye device

Embodiments of the present disclosure are directed to a phototherapy eye device. In an example, the phototherapy eye device includes a number of radioluminescent light sources and an anchor. ... California Institute Of Technology

03/29/18 / #20180088462

Additive manufacturing of architectured materials

This disclosure provides a scalable and reproducible process to create complex 3d metal materials with sub-micron features by applying lithographic methods to transparent metal- or inorganic-rich polymer resins.. . ... California Institute Of Technology

03/29/18 / #20180088309

Embedded pupil function recovery for fourier ptychographic imaging devices

Certain aspects pertain to fourier ptychographic imaging systems, devices, and methods that implement an embedded pupil function recovery. . ... California Institute Of Technology

03/29/18 / #20180087164

Tuning electrode surface electronics with thin layers

The disclosure provides for thin films that can be used to tune the catalytic characteristics of heterogeneous electrocatalysts.. . ... California Institute Of Technology

03/29/18 / #20180086652

Electrolysis electrode featuring nanotube array and methods of manufacture and using same for water treatment

An electrolysis electrode having an array of nanotubes is disclosed. The electrode may provide high chlorine evolution and hydroxyl radical production activity for electrochemical wastewater treatment. ... California Institute Of Technology

03/22/18 / #20180080830

Gel based thermal sensors

A temperature sensor is described, which includes a sensor gel having a polymer, water and ions, and a first and a second electrode separated from each other by the sensor gel. The present disclosure further relates to a system which has a temperature sensor, a voltage source or electric current source, and a measurement device for detecting voltage or electric current. ... California Institute Of Technology

03/22/18 / #20180079800

Human immunodeficiency virus neutralizing antibodies and methods of use thereof

The invention provides broadly neutralizing antibodies directed to epitopes of human immunodeficiency virus, or hiv. The invention further provides compositions containing hiv antibodies used for prophylaxis, and methods for diagnosis and treatment of hiv infection.. ... California Institute Of Technology

03/22/18 / #20180079651

Novel methods for producing crystalline microporous solids with the rth topology and compositions derived from the same

This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having rth topologies having a range of si:al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation structuring agents.. . ... California Institute Of Technology

03/22/18 / #20180078902

Systems, methods and devices for electro-osmotic propulsion in a microfluidic environment

Systems, methods and devices are provided for electro-osmotic propulsion in a microfluidic environment. These systems, methods and devices can include a body having a channel comprising a pair of open ends, and a plurality of electrodes coupled to the body, wherein the electrodes are configured to generate a voltage and cause an electro-osmotic flow of a fluid through the channel. ... California Institute Of Technology

03/15/18 / #20180076820

Accurate, finely tunable electronic delay generation with high process variation tolerance

A delay generation circuit includes a modulator and a delay-locked loop. The delay-locked loop includes a delay line configured to be responsive to a phase difference between a first clock signal and one of a multitude of output signals of the delay line. ... California Institute Of Technology

03/15/18 / #20180072772

Mutant akt-specific capture agents, compositions, and methods of using and making

The present application provides stable peptide-based akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing akt capture agents using iterative on-bead in situ click chemistry.. ... California Institute Of Technology

03/15/18 / #20180071693

Filtration membranes, and related nano and/or micro fibers, composites, methods and systems

Filtration membrane comprising polymeric nanofibers and/or microfibers attaching dendrimer component presenting reactive sites selective for chemicals to be filtered, and related nanofibers and microfibers, composite materials, compositions, methods and system.. . ... California Institute Of Technology

03/08/18 / #20180066303

Immunohistochemistry via hybridization chain reaction

The present disclosure relates to methods involving hcr reactions that involve using trigger oligos to activate probes that initiate hcr.. . ... California Institute Of Technology

03/08/18 / #20180064747

Dna-functionalized scaffolds for drug capture applications

This disclosure is directed to structured compositions, including dna-functionalized scaffolds, for drug capture, and methods and devices for sequestering chemotherapeutics from physiological fluids using the functionalized scaffolds.. . ... California Institute Of Technology

03/08/18 / #20180064688

Compositions and methods for treatment of prostate cancer

The present invention relates to compositions and methods for the treatment of prostate cancer. The present invention relates to polyamides and prostate agents, for example, to inhibit an androgen receptor signaling axis, and the use of these compositions in the treatment of prostate cancer.. ... California Institute Of Technology

03/01/18 / #20180057952

Electrolysis electrode and methods of manufacture and using same in water purification system

A heterojunction anode for electrolysis is disclosed. The anode has a first conductive metal oxide (fcmo) layer, a second semiconductor layer contacting the fcmo layer, and one or more islands of a third semiconductor contacting the second semiconductor layer. ... California Institute Of Technology

03/01/18 / #20180057806

Engineered synthase for production of tryptophan derivatives and intransigent substrates

This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.. ... California Institute Of Technology

03/01/18 / #20180057514

Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts

The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including hydroxide, especially koh, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.. . ... California Institute Of Technology

03/01/18 / #20180055919

Antigen specific tregs and related compositions, methods and systems

Antigen specific regulatory t cells are described and related compositions, methods and systems. Methods to generate an antigen specific anti-inflammatory regulatory t cell is provided, the method comprising contacting either a t cell or an antigen presenting cell with a zwitterionic polysaccharide conjugated to the antigen for a time and under condition to generate an antigen specific regulatory t cell that is capable of inhibiting a pro-inflammatory response against the antigen.. ... California Institute Of Technology

02/22/18 / #20180052110

Multiplexing and quantification in pcr with reduced hardware and requirements

Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and verifying the amplicons in a reaction are presented. ... California Institute Of Technology

02/22/18 / #20180049716

Enhanced stethoscope devices and methods

An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. ... California Institute Of Technology

02/15/18 / #20180044804

Hydrocarbon oxidation by water oxidation electrocatalysts in non-aqueous solvents

Provided herein are processes and systems for oxidation of a hydrocarbon reactant to generate an oxidized hydrocarbon product; said process comprising: contacting a water oxidation electrocatalyst with said hydrocarbon reactant and water in the presence of a non-aqueous solvent; wherein an anodic bias is applied to said water oxidation electrocatalyst, thereby generating said oxidized hydrocarbon product; and wherein said water oxidation electrocatalyst comprises one or more transition metals other than ru. Optionally, said water is provided in said non-aqueous solvent at a concentration less than or equal to 0.5 vol. ... California Institute Of Technology

02/08/18 / #20180038922

Gas-filled structures and related compositions, methods and systems for magnetic resonance imaging

Gas vesicle protein structures and related compositions, methods, and systems for singleplexed and/or multiplexed magnetic resonance imaging of a target site alone or in combination with ultrasound are described, in which the gas vesicle protein structures provide contrast for the imaging.. . ... California Institute Of Technology

02/01/18 / #20180031330

Multi-phase thermal control apparatus, evaporators and methods of manufacture thereof

. . Multi-phase thermal control systems, evaporators, variable porous wick elements, heat transfer structures, and methods for their production are provided. Two-phase evaporators for use in such multi-phase thermal control systems are also provided. ... California Institute Of Technology

02/01/18 / #20180030551

Chromophore-based characterization and detection methods

This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. ... California Institute Of Technology

02/01/18 / #20180030501

Genetically engineered gas vesicle gene clusters, genetic circuits, vectors, prokaryotic cells, compositions, methods and systems for contrast-enhanced imaging

Hybrid gas vesicle gene cluster (gvgc) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (gva) genes native to a gva prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (gvs) genes native to one or more gvs prokaryotic species, at least one of the one or more gvs prokaryotic species different from the gva prokaryotic species, and related gas vesicle reporting (gvr) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce gvs, hybrid gvgc and/or image a target site.. . ... California Institute Of Technology

02/01/18 / #20180030207

Linear cyclodextrin copolymers

Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. ... California Institute Of Technology

02/01/18 / #20180028693

Gas-filled structures and related compositions, methods and systems to image a target site

Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.. . ... California Institute Of Technology

01/25/18 / #20180020955

Intrinsic frequency analysis for left ventricle ejection fraction or stroke volume determination

Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the dicrotic notch. ... California Institute Of Technology

01/18/18 / #20180018713

Delay-tolerant information-centric networking (dticn)

A method and system provide the ability to distribute content on a network. A network system of nodes is established. ... California Institute Of Technology

01/18/18 / #20180015224

Dampers and methods for performing measurements in an autoinjector

Systems and methods for measuring and damping forces within autoinjectors in accordance with embodiments of the invention are disclosed. In one embodiment of the invention, an injection system comprises a syringe disposed within a housing, the syringe having a first end and a second end; a needle disposed at the second end of the syringe; a plunger disposed at the first end of the syringe and configured to move toward the second end of the syringe; a stopper disposed between the plunger and the second end of the syringe; a first damper disposed between the plunger and the stopper, such that the first damper is capable of damping a first event occurring between the plunger and the stopper; and a second damper disposed at the second end of the syringe, such that the second damper is capable of damping a second event occurring at the second end of the syringe.. ... California Institute Of Technology

01/11/18 / #20180010166

Fractional initiator hybridization chain reaction

The present disclosure relates to methods and compositions involving hcr reactions that involve initiators that are split into two or more parts. Effective hcr is dependent upon two or more of these split initiators being brought into proximity (e.g., via binding events mediated by a target) such that a full initiator is formed that is capable of triggering hcr signal amplification.. ... California Institute Of Technology

01/04/18 / #20180006424

High-q optical resonator with monolithically integrated waveguide

A ring optical resonator is formed on a substrate. An outer circumferential surface of the resonator substantially confines one or more circumferential resonant optical modes. ... California Institute Of Technology








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