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Caribou Biosciences Inc patents


Recent patent applications related to Caribou Biosciences Inc. Caribou Biosciences Inc is listed as an Agent/Assignee. Note: Caribou Biosciences Inc may have other listings under different names/spellings. We're not affiliated with Caribou Biosciences Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Caribou Biosciences Inc-related inventors


Methods for increasing cas9-mediated engineering efficiency

Methods for use with type ii crispr-cas9 systems for increasing cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid.. ... Caribou Biosciences Inc

Methods of modifying a target nucleic acid with an argonaute

This disclosure provides for compositions and methods for the use of designed nucleic acid-targeting nucleic acids, argonautes, and complexes thereof.. . ... Caribou Biosciences Inc

Engineered nucleic acid-targeting nucleic acids

The present disclosure provides engineered class 2 crispr-cas-associated discontinuous first-stem nucleic-acid targeting nucleic acids, nucleoprotein complexes comprising these nucleic acids, and compositions thereof. Nucleic acid sequences encoding the class 2 crispr-cas-associated discontinuous first-stem nucleic-acid targeting nucleic acids, as well as expression cassettes, vectors and cells comprising such nucleic acid sequences, are described. ... Caribou Biosciences Inc

Engineered nucleic acids-targeting nucleic acids

The present disclosure provides engineered polynucleotide sequences that form scaffolds and nucleoprotein complexes comprising such engineered polynucleotide sequences that form scaffolds and nucleic acid binding proteins. Nucleic acid sequences encoding the engineered polynucleotide sequences that form scaffolds, as well as expression cassettes, vectors and cells comprising such polynucleotide sequences, are described. ... Caribou Biosciences Inc

Modified cascade ribonucleoproteins and uses thereof

A clustered regularly interspaced short palindromic repeat (crispr)-associated complex for adaptive antiviral defence (cascade); the cascade protein complex comprising at least crispr-associated protein subunits cas7, cas5 and cas6 which includes at least one subunit with an additional amino acid sequence possessing nucleic acid or chromatin modifying, visualising, transcription activating or transcription repressing activity. The cascade complex with additional activity is combined with an rna molecule to produce a ribonucleoprotein complex. ... Caribou Biosciences Inc

Cells comprising engineered nucleic-acid targeting nucleic acids

The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the engineered cross-type-nucleic-acid targeting nucleic acids, as well as expression cassettes, vectors and cells comprising such nucleic acid sequences, are described. ... Caribou Biosciences Inc

Compositions and methods of engineered crispr-cas9 systems using split-nexus cas9-associated polynucleotides

The present specification discloses engineered type ii crispr-cas9 systems comprising split-nexus cas9-associated polynucleotides (sn-caspns), including systems comprising three split-nexus cas9-associated polynucleotides (sn1-caspn/sn2-caspn/sn3-caspn) and systems comprising two split-nexus cas9-associated polynucleotides (sn1-caspn/sn2-caspn). Together with a cas9 protein, the sn-caspns facilitate site-specific modifications, including cleavage and mutagenesis, of a target polynucleotide in vitro and in vivo. ... Caribou Biosciences Inc

Compositions and methods of engineered crispr-cas9 systems using split-nexus cas9-associated polynucleotides

The present specification discloses engineered type ii crispr-cas9 systems comprising split-nexus cas9-associated polynucleotides (sn-caspns), including systems comprising three split-nexus cas9-associated polynucleotides (sn1-caspn/sn2-caspn/sn3-caspn) and systems comprising two split-nexus cas9-associated polynucleotides (sn1-caspn/sn2-caspn). Together with a cas9 protein, the sn-caspns facilitate site-specific modifications, including cleavage and mutagenesis, of a target polynucleotide in vitro and in vivo. ... Caribou Biosciences Inc

Compositions and methods of nucleic acid-targeting nucleic acids

This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.. . ... Caribou Biosciences Inc

Engineered nucleic-acid targeting nucleic acids

The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the engineered cross-type-nucleic-acid targeting nucleic acids, as well as expression cassettes, vectors and cells comprising such nucleic acid sequences, are described. ... Caribou Biosciences Inc

Engineered nucleic acid-targeting nucleic acids

The present disclosure provides engineered polynucleotide sequences that form scaffolds and nucleoprotein complexes comprising such engineered polynucleotide sequences that form scaffolds and nucleic acid binding proteins. Nucleic acid sequences encoding the engineered polynucleotide sequences that form scaffolds, as well as expression cassettes, vectors and cells comprising such polynucleotide sequences, are described. ... Caribou Biosciences Inc

Engineered nucleic-acid targeting nucleic acids

The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the engineered cross-type-nucleic-acid targeting nucleic acids, as well as expression cassettes, vectors and cells comprising such nucleic acid sequences, are described. ... Caribou Biosciences Inc

Rna modification to engineer cas9 activity

The disclosure provides for compositions, methods and kits, for reducing off-target effects of genome engineering.. . ... Caribou Biosciences Inc

Directed nucleic acid repair

The present disclosure provides compositions and methods for enhancing directed nucleic acid repair, which are useful in the area of genome engineering.. . ... Caribou Biosciences Inc

02/23/17 / #20170051276

Compositions and methods of nucleic acid-targeting nucleic acids

This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.. . ... Caribou Biosciences Inc

02/16/17 / #20170044508

Compositions and methods of engineered crispr-cas9 systems using split-nexus cas9-associated polynucleotides

The present specification discloses engineered type ii crispr-cas9 systems comprising split-nexus cas9-associated polynucleotides (sn-caspns), including systems comprising three split-nexus cas9-associated polynucleotides (sn1-caspn/sn2-caspn/sn3-caspn) and systems comprising two split-nexus cas9-associated polynucleotides (sn1-caspn/5n2-caspn). Together with a cas9 protein, the sn-caspns facilitate site-specific modifications, including cleavage and mutagenesis, of a target polynucleotide in vitro and in vivo. ... Caribou Biosciences Inc

02/09/17 / #20170037432

Compositions and methods of engineered crispr-cas9 systems using split-nexus cas9-associated polynucleotides

The present specification discloses engineered type ii crispr-cas9 systems comprising split-nexus cas9-associated polynucleotides (sn-caspns), including systems comprising three split-nexus cas9-associated polynucleotides (sn1-caspn/sn2-caspn/sn3-caspn) and systems comprising two split-nexus cas9-associated polynucleotides (sn1-caspn/sn2-caspn). Together with a cas9 protein, the sn-caspns facilitate site-specific modifications, including cleavage and mutagenesis, of a target polynucleotide in vitro and in vivo. ... Caribou Biosciences Inc








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