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Cellular Research Inc patents


Recent patent applications related to Cellular Research Inc. Cellular Research Inc is listed as an Agent/Assignee. Note: Cellular Research Inc may have other listings under different names/spellings. We're not affiliated with Cellular Research Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Cellular Research Inc-related inventors


Methods for expression profile classification

Disclosed herein are methods and systems for identifying targets for distinguishing cell types. In some embodiments, the method comprises: hierarchically clustering expression profiles of cells to generate a dendrogram with each leaf representing the expression profile of a different individual cell. ... Cellular Research Inc

Methods for cell label classification

Disclosed herein are methods and systems for classifying cell labels, for example identifying a signal cell label. In some embodiments, the method comprises: obtaining sequencing data of barcoded targets created using targets in cells barcoded using barcodes, wherein a barcode comprises a cell label and a molecular label. ... Cellular Research Inc

Methods and compositions for labeling targets and haplotype phasing

Disclosed herein are methods for estimating the copy number of a target chromosome in a sample. In some embodiments, the methods include: partitioning a sample comprising one or more copies of the first target chromosome, into a plurality of partitioned samples; stochastically barcoding the one or more copies of the first target chromosome in the plurality of partitioned samples using a first plurality of stochastic barcodes, wherein each of the first plurality of stochastic barcodes comprises a first chromosome label and a first molecular label; and estimating the copy number of the first target chromosome in the sample using the first chromosome label and the second molecular label. ... Cellular Research Inc

Enzyme-independent molecular indexing

The present disclosure relates to compositions, methods and kits for quantitative analysis of a plurality of nucleic acid target molecules in a sample. In some embodiments, the methods comprise associating molecular label sequences with target nucleic acid molecules without an enzymatic reaction.. ... Cellular Research Inc

Massively parallel single cell analysis

The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. ... Cellular Research Inc

Molecular label counting adjustment methods

Disclosed herein are methods and systems for determining the numbers of targets. In some embodiments, the method comprise: stochastically barcoding targets using stochastic barcodes; obtaining sequencing data; for one or more of the targets: counting the number of molecular labels with distinct sequences associated with the target in the sequencing data; identifying clusters of molecular labels of the target using directional adjacency; collapsing the sequencing data using the clusters of molecular labels of the target identified; and estimating the number of the target.. ... Cellular Research Inc

Normalization of nucleic acid libraries

This disclosure provides methods and compositions for removing one or more high abundance species from a plurality of nucleic acid molecules. In some embodiments, the methods and compositions can be used for normalizing nucleic acid libraries. ... Cellular Research Inc

Error correction in amplification of samples

Disclosed herein are methods and systems for correcting errors in sample amplification, including the errors occurred in determining the number of targets in samples. In some embodiments, the method comprises: stochastically barcoding a plurality of targets in the samples using oligonucleotides comprising stochastic barcodes to generate stochastically barcoded targets; contacting one or more defined barcoded primers with each of the one or more samples; and determining an amplification noise.. ... Cellular Research Inc

Molecular indexing of internal sequences

The present disclosure relates to compositions, methods and kits for labeling an internal sequence of a target nucleic acid molecule with molecular barcodes. In some embodiments, the methods comprise intramolecular circulation of a labeled target nucleic acid molecule. ... Cellular Research Inc

Spatially addressable molecular barcoding

The disclosure provides for methods, compositions, systems, devices, and kits for determining the number of distinct targets in distinct spatial locations within a sample. In some examples, the methods include: stochastically barcoding the plurality of targets in the sample using a plurality of stochastic barcodes, wherein each of the plurality of stochastic barcodes comprises a spatial label and a molecular label; estimating the number of each of the plurality of targets using the molecular label; and identifying the spatial location of each of the plurality of targets using the spatial label. ... Cellular Research Inc

Methods and systems for digitally counting features on arrays

Methods, systems and platforms for digital imaging of multiple regions of an array, and detection and counting of the labeled features thereon, are described.. . ... Cellular Research Inc

Methods and compositions for library normalization

The disclosure provides for methods, compositions, and kits for normalizing nucleic acid libraries, for example sequencing libraries.. . ... Cellular Research Inc








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