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City Of Hope patents


Recent patent applications related to City Of Hope. City Of Hope is listed as an Agent/Assignee. Note: City Of Hope may have other listings under different names/spellings. We're not affiliated with City Of Hope, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | City Of Hope-related inventors


Meditopes and meditope-binding antibodies and uses thereof

Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.. . ... City Of Hope

Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof

The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (odn) sequence conjugated to a short-activating rna (sarna) or an antisense oligonucleotide sequence (aso), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating immune response), method of immune stimulation, method of activating cebpa, and method of reducing activity of stat transcription factor, by one of the disclosed compounds or compositions.. . ... City Of Hope

Treatment of brca1-defective cancer or resistant cancers

Provided herein are methods of treating cancer in a subject by administering coh29 ((n-(4-(3,4-diydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide)). The methods of treating include treating a brca1-defective subject, a parp1 inhibitor-resistant subject or a dna-damaging anti-cancer agent resistant subject. ... City Of Hope

Coaptive surgical sealing tool

A coaptive surgical sealing tool may be similar to an ordinary hemostat with long (50, 60, 70 or 80 mm) thin jaws for sliding into the liver parenchyma, without tearing the larger blood vessels. The jaws are spring loaded and are designed for uniform compression, and to avoid closing too quickly. ... City Of Hope

5-bromo-indirubins

Disclosed herein are compositions and methods for treating cancer, flt3-aml, and cml.. . ... City Of Hope

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. ... City Of Hope

Covalent disulfide-linked diabodies and uses thereof

The present invention provides recombinant antibody fragments which include a variable domain which has been modified by the addition of a tail sequence to its c-terminal end. The tail sequence comprises a terminal cysteine residue and an amino acid spacer and does not substantially affect the fragment's target-binding affinity. ... City Of Hope

Ribonucleotide reductase inhibitors and methods of use

Provided herein are novel compounds that inhibit ribonucleotide reductase (rr) by binding to rrm2 and interfering with the activity of the rrm1/rrm2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit rr activity and to treat various conditions associated with rrm2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.. ... City Of Hope

Methods of treating pancreatic cancer using gpcr antagonists

Provided herein are, inter alia, compositions and methods for the treatment of cancer and inhibition of metastasis. The compositions include a μ-opioid receptor (mor) polypeptide and a somatostatin receptor 2 (sstr2) polypeptide, wherein the mor polypeptide is bound to a mor antagonist and the sstr2 polypeptide is bound to a sstr2 antagonist. ... City Of Hope

Multivalent meditopes, meditope-binding antibodies and uses thereof

Provided are methods for altering the distribution of a cell surface antigen. Also provided are compositions for use in the methods, including multivalent meditopes, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.. ... City Of Hope

Methods of identifying senp1 inhibitors

Provided herein are methods of detecting binding of an senp1 polypeptide to a compound and methods for screening for inhibitors of senp1. Further provided are aqueous compositions comprising senp1 polypeptides and nmr apparatuses comprising the compositions for nmr analysis.. ... City Of Hope

Methods and compositions for the treatment of cancer or other diseases

The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. ... City Of Hope

Peptide inhibitors of twist

The disclosure provides, inter alia, compositions comprising twist peptide inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.. . ... City Of Hope

Il-6 signaling and breast cancer

The disclosure provides, inter alia, methods of detecting il-6 signaling activity in t cells in breast cancer patients, such as breast cancer patients in remission.. . ... City Of Hope

05/10/18 / #20180125878

Continuously expressed therapeutic rnas for targeted protein binding and methods for their use

An rna composition comprising an rna aptamer and an shrna molecule and/or an mirna molecule are provided. The rna composition may include an aptamer component that binds an enzymatic protein within a target cell and an shrna and/or an mirna component that facilitates trafficking of the aptamer within the target cell, such as, trafficking from the nucleus into the cytoplasm. ... City Of Hope

04/19/18 / #20180105533

Bile acid receptor modulators and methods of use thereof

Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of bile acid receptor activity.. . ... City Of Hope

02/01/18 / #20180030449

Replication capable raav vectors encoding inhibitory sirna and methods of their use

In some embodiments, an antiviral vector is provided. The antiviral vector includes a replication competent adeno-associated virus (aav) and an inhibitory expression cassette that includes a nucleotide sequence that encodes an rnai molecule that inhibits expression of a targeted helper virus (thv) gene. ... City Of Hope

01/18/18 / #20180016533

Substrates for high-density cell growth and metabolite exchange

A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. ... City Of Hope

01/11/18 / #20180008667

Cell penetrating antibodies

Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone through a non-covalent linker including abiotin-binding domain and a biotin domain, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. ... City Of Hope

12/28/17 / #20170368156

Attenuated salmonella bacteria and methods of using

Provided herein are attenuated salmonella bacteria for expressing autoantigen alone or in combination with an immunomodulatory, as well as methods of using these bacteria to treat various autoimmune disorders.. . ... City Of Hope

12/21/17 / #20170360910

Cs1 targeted chimeric antigen receptor-modified t cells

Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing cs1 are described.. . ... City Of Hope

10/05/17 / #20170283802

Design of nucleic acid binding molecules with non-watson crick and non-canonical pairing based on artificial mutation consensus sequences to counter escape mutations

Universal nucleic acid binding molecules (e.g., antisense oligonucleotides or rnai molecules) having an inhibitory or activating nucleic acid sequence which binds a receiving nucleic acid sequence (e.g., rna or dna) are provided. In some embodiments, the universal nucleic acid binding molecules bind the receiving nucleic acid sequence (e.g., rna or dna) via at least one non-watson crick or non-canonical paired base.. ... City Of Hope

09/14/17 / #20170262189

Memory management system and methods

A memory management system and methods of using the same are disclosed herein. The memory management system can include storage devices including a tier 0 memory and a tier 1 memory. ... City Of Hope

09/14/17 / #20170260277

Cd123-specific chimeric antigen receptor redirected t cells and methods of their use

A family of chimeric antigen receptors (cars) containing a cd123 specific scfv was developed to target different epitopes on cd123. In some embodiments, such a cd123 chimeric antigen receptor (cd123car) gene includes an anti-cd123 scfv region fused in frame to a modified igg4 hinge region comprising an s228p substitution, an l235e substitution, and optionally an n297q substitution; a costimulatory signaling domain; and a t cell receptor (tcr) zeta chain signaling domain. ... City Of Hope

08/31/17 / #20170246292

Genetically stable recombinant modified vaccinia ankara (rmva) vaccines and methods of preparation thereof

A vaccine comprising an immunologically effective amount of recombinant modified vaccinia ankara (rmva) virus which is genetically stable after serial passage and produced by a) constructing a transfer plasmid vector comprising a modified h5 (mh5) promoter operably linked to a dna sequence encoding a heterologous foreign protein antigen, wherein the expression of said dna sequence is under the control of the mh5 promoter; b) generating rmva virus by transfecting one or more plasmid vectors obtained from step a) into wild type mva virus; c) identifying rmva virus expressing one or more heterologous foreign protein antigens using one or more selection methods for serial passage; d) conducting serial passage; e) expanding an rmva virus strain identified by step d); and f) purifying the rmva viruses from step e) to form the vaccine. One embodiment is directed to a fusion cytomegalovirus (cmv) protein antigen comprising a nucleotide sequence encoding two or more antigenic portions of immediate-early gene-1 or immediate-early gene-2 (iefusion), wherein the antigenic portions elicit an immune response when expressed by a vaccine.. ... City Of Hope

08/31/17 / #20170246273

Recombinant listeria strain expressing heterologous antigen fusion proteins and methods of use thereof

Disclosed herein are recombinant nucleic acids encoding tumor antigens fused to immunogenic polypeptides and recombinant listeria strains comprising the same, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.. . ... City Of Hope

08/17/17 / #20170233431

Bile acid derivatives and methods for synthesis and use

Provided herein, inter alia, are methods for the preparation of modulators of farnesoid x receptor (fxr), and compositions and uses of the modulators of fxr.. . ... City Of Hope

08/10/17 / #20170226223

Chimeric antigen receptor compositions

Provided herein are compositions which exhibit novel diagnostic capabilities and allow to rapidly add functionality to adoptive immunotherapy. The compositions include isolated nucleic acids encoding proteins including antibody regions capable of binding compounds including a peptidyl moiety (e.g., a meditope). ... City Of Hope

08/10/17 / #20170224733

Administration of engineered t cells for treatment of cancers in the central nervous system

An improved method of treating cancers with engineered t cells is described.. . ... City Of Hope

08/10/17 / #20170224348

Hand-held grasping device

A hand tool has a pivot connection pivotally attaching a first arm to a second arm, with the pivot connection fixed relative to the first arm and movable to first and second positions relative to the second arm. A spring urges the pivot connection into the first position. ... City Of Hope

07/27/17 / #20170211095

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. ... City Of Hope

07/27/17 / #20170211094

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. ... City Of Hope

07/27/17 / #20170211093

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. ... City Of Hope

07/27/17 / #20170211092

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. ... City Of Hope

07/13/17 / #20170198265

Adeno-associated virus vector variants for high efficiency genome editing and methods thereof

Adeno-associated virus (aav) clade f vectors or aav vector variants (relative to aav9) for precise editing of the genome of a cell and methods and kits thereof are provided. Targeted genome editing using the aav clade f vectors or aav vector variants provided herein occurred at frequencies that were shown to be 1,000 to 100,000 fold more efficient than has previously been reported. ... City Of Hope

07/13/17 / #20170196890

Tgr5 agonist complexes for treating diabetes and cancer

Provided herein are complexes of metformin or metformin analogues and a tgr5 ligand that are useful in treating diseases including diabetes, cardiovascular disease, and cancer.. . ... City Of Hope

06/01/17 / #20170153228

Methods for detection of botulinum neurotoxin

Provided herein is a large immuno-sorbent surface area assay (alissa) for the rapid and sensitive detection of botulinum neurotoxins (bonts) and anthrax toxin. This assay is designed to capture a low number of toxin molecules and to measure their intrinsic protease activity via conversion of a fluorogenic or luminescent substrate. ... City Of Hope

06/01/17 / #20170152480

Truncated epiderimal growth factor receptor (egfrt) for transduced t cell selection

A non-immunogenic selection epitope may be generated by removing certain amino acid sequences of the protein. For example, a gene encoding a truncated human epidermal growth factor receptor polypeptide (egfrt) that lacks the membrane distal egf-binding domain and the cytoplasmic signaling tail, but retains an extracellular epitope recognized by an anti-egfr antibody is provided. ... City Of Hope

05/18/17 / #20170137392

Ribonucleotide reductase inhibitors and methods of use

Provided herein are novel compounds that inhibit ribonucleotide reductase (rr) by binding to rrm2 and interfering with the activity of the rrm1/rrm2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit rr activity and to treat various conditions associated with rrm2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.. ... City Of Hope

05/18/17 / #20170135752

Coaptive surgical sealing tool

A coaptive surgical sealing tool may be similar to an ordinary hemostat with long (50, 60, 70 or 80 mm) thin jaws for sliding into the liver parenchyma, without tearing the larger blood vessels. The jaws are spring loaded and are designed for uniform compression, and to avoid closing too quickly. ... City Of Hope

05/04/17 / #20170122938

Nucleic acid-functionalized nanoparticles

Provided herein are functionalized nanoparticle compositions and methods of using the same. The functionalized nanoparticles provided include a nuclease cleavage site and are, inter alia, useful for the formation of nanoparticle aggregates and detection of nuclease activity through nanoparticle aggregate formation.. ... City Of Hope

05/04/17 / #20170119807

Macrocyclic lactones and uses thereof as modulators of purinergic receptors

Described herein, inter alia, are macrocyclic lactones such as ivermectin and methods for their use in treating, for example, hyperproliferative disorders such as cancer.. . ... City Of Hope

04/27/17 / #20170112570

Microwave coaptive surgical sealing tool

A coaptive surgical sealing tool may be similar to an ordinary hemostat with long (50, 60, 70 or 80 mm) thin jaws for sliding into the liver parenchyma, without tearing the larger blood vessels. The jaws are spring loaded and are designed for uniform compression, and to avoid closing too quickly. ... City Of Hope

03/30/17 / #20170086963

Implantable device for retaining live cells and providing nutrients thereto

An implantable medical device, a method of manufacturing, and a method of use are described. The implantable medical device includes an absorption bag connected by a cannula to a discharge bag. ... City Of Hope

03/23/17 / #20170081680

Adeno-associated virus vector variants for high efficiency genome editing and methods thereof

Adeno-associated virus (aav) clade f vectors or aav vector variants (relative to aav9) for precise editing of the genome of a cell and methods and kits thereof are provided. Targeted genome editing using the aav clade f vectors or aav vector variants provided herein occurred at frequencies that were shown to be 1,000 to 100,000 fold more efficient than has previously been reported. ... City Of Hope

03/23/17 / #20170081671

Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy

In one embodiment, a single modality cancer immunotherapy regimen that includes a therapeutic composition is provided. Such a therapeutic composition may include a salmonella strain comprising a plasmid that expresses an shrna molecule that suppresses the expression of an immunosuppressive target and suppresses tumor growth. ... City Of Hope

03/16/17 / #20170073703

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. ... City Of Hope

03/16/17 / #20170073684

Cell-type specific aptamer-sirna delivery system for hiv-1 therapy

The present invention relates to compositions and methods for delivery of sirna to specific cells or tissue. More particularly, the present invention relates to compositions and methods for cell type-specific delivery of anti-hiv sirnas via fusion to an anti-gp120 aptamer.. ... City Of Hope

02/16/17 / #20170043040

Aptamer-mrna conjugates for targeted protein or peptide expression and methods for their use

An aptamer-mrna conjugate is provided. The aptamer-mrna conjugate may include an aptamer component that binds a membrane associated protein on a target cell and an mrna component that is expressed by the target cell.. ... City Of Hope

02/09/17 / #20170038383

Methods, compositions, and kits for detection of aspergillosis

Provided herein are methods for detecting an aspergillus protease in a sample, diagnosing a subject with aspergillosis caused by an aspergillus infection based on the presence of an aspergillus protease in a sample, and methods of aspergillosis treatment that incorporate these diagnostic methods. In certain embodiments, the aspergillus protease is asp f2, and the aspergillus infection is caused a. ... City Of Hope

02/09/17 / #20170035737

Treatment of brca1-defective cancer or resistant cancers

Provided herein are methods of treating cancer in a subject, by administering coh29 ((n-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide)). The methods of treating include treating a brca1-defective subject, a parp1 inhibitor-resistant subject or a dna-damaging anti-cancer agent resistant subject. ... City Of Hope

02/02/17 / #20170029816

Multivalent oligonucleotide assemblies

Provided herein, inter alia, are double stranded oligonucleotide molecules and methods of making the molecules. The double stranded oligonucleotide molecules include a first oligonucleotide strand comprising a first nucleic acid sequence bound to a second nucleic acid sequence through a first spacer, wherein said second nucleic acid sequence is bound to a third nucleic acid sequence through a second spacer and a second oligonucleotide strand comprising a fourth nucleic acid sequence bound to a fifth nucleic acid sequence through a third spacer, wherein said fifth nucleic acid sequence is bound to a sixth nucleic acid sequence through a fourth spacer, wherein the second nucleic acid sequence and the fifth nucleic acid sequence are hybridized to form a double stranded nucleic acid core of said double stranded oligonucleotide.. ... City Of Hope

01/26/17 / #20170022570

Methods, treatment, and compositions for characterizing thyroid nodule

The current disclosure provides, inter alia, method of determining benign nodules from thyroid cancer in a subject that is found to have a thyroid nodule, method of treating thyroid cancer in a subject detected to have thyroid cancer by the method of the current disclosure, compositions for determining benign nodules from thyroid cancer in a subject, and kits including reagents and composition for determining benign nodules from thyroid cancer in a subject.. . ... City Of Hope

01/12/17 / #20170008851

Farnesoid x receptor antagonists

Provided herein are farnesoid x receptor (fxr) antagonists having the structure of formula (i), and pharmaceutical compositions comprising the compound of formula (i) and a pharmaceutically acceptable excipient. Also provided are methods of antagonizing fxr, and methods of treating metabolic disease in a subject in need thereof, comprising administering an effective amount of the fxr antagonists of formula (i) to a subject.. ... City Of Hope

01/05/17 / #20170004254

Multi-targeting short interfering rnas

The present invention relates to novel short interfering rna (sirna) molecules that are multi-targeted. More specifically, the present invention relates to sirna molecules that target two or more sequences. ... City Of Hope








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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