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Codexis Inc patents


Recent patent applications related to Codexis Inc. Codexis Inc is listed as an Agent/Assignee. Note: Codexis Inc may have other listings under different names/spellings. We're not affiliated with Codexis Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Codexis Inc-related inventors


Engineered transaminase polypeptides for industrial biocatalysis

The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.. ... Codexis Inc

Engineered glycosyltransferases and steviol glycoside glucosylation methods

The present invention provides engineered glycosyltransferase (gt) enzymes, polypeptides having gt activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (sus) enzymes, polypeptides having sus activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. ... Codexis Inc

Transaminase biocatalysts

The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.. . ... Codexis Inc

Penicillin-g acylases

The present disclosure relates to engineered penicillin g acylase (pga) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.. . ... Codexis Inc

Transaminase polypeptides

The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.. ... Codexis Inc

Ketoreductase polypeptides for the reduction of acetophenones

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.. ... Codexis Inc

Biocatalysts and methods for the synthesis of armodafinil

The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(r)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (r)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.. ... Codexis Inc

Variant lovd polypeptides and their uses

The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.. . ... Codexis Inc

Ketoreductase polypeptides for the production of (r)-3-hydroxythiolane

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.. ... Codexis Inc

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.. . ... Codexis Inc

Penicillin-g acylases

The present invention provides engineered penicillin g acylase (pga) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered pga enzymes.. . ... Codexis Inc

Lov-d acyltransferase mediated acylation

Methods for the improved acylation of chemical substrates using lovd acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.. ... Codexis Inc

Engineered biocatalysts and methods for synthesizing chiral amines

The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.. . ... Codexis Inc

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.. . ... Codexis Inc

03/08/18 / #20180066239

Ketoreductase polypeptides for the preparation of phenylephrine

The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.. . ... Codexis Inc

02/08/18 / #20180037880

Engineered phenylalanine ammonia lyase polypeptides

The present invention provides engineered phenylalanine ammonia-lyase (pal) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (pal) polypeptides.. . ... Codexis Inc

02/08/18 / #20180037872

Biocatalysts and methods for the synthesis of armodafinil

The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(r)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (r)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.. ... Codexis Inc

02/01/18 / #20180030419

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.. . ... Codexis Inc

01/25/18 / #20180023059

Ketoreductase polypeptides

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4s)-2-oxo-4-phenyl (1,3-oxazolidin-3-yl))-1-(4-fluorophenyl) pentane-1,5-dione to (4s)-3-[(5s)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4s)-3-[(5s)-5 -(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making ezetimibe.. ... Codexis Inc

01/18/18 / #20180016568

Engineered phenylalanine ammonia lyase polypeptides

The present invention provides engineered phenylalanine ammonia-lyase (pal) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (pal) polypeptides.. . ... Codexis Inc

01/11/18 / #20180010100

Biocatalysts for the preparation of hydroxy substituted carbamates

The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.. . ... Codexis Inc

01/04/18 / #20180002676

Ketoreductase polypeptides for the synthesis of chiral compounds

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.. ... Codexis Inc

12/21/17 / #20170360900

Human alpha-galactosidase variants

The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (ph <4.5) and basic (ph >7) conditions. ... Codexis Inc

12/14/17 / #20170355968

Biocatalysts and methods for hydroxylation of chemical compounds

The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.. . ... Codexis Inc

12/14/17 / #20170355966

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.. . ... Codexis Inc

11/23/17 / #20170334886

N-substituted 4-aminoquinazoline derivatives and methods of use

The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides lapatinib analogs that provide therapeutic benefits.. ... Codexis Inc

11/09/17 / #20170321202

Penicillin-g acylases

The present invention provides engineered penicillin g acylase (pga) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.. . ... Codexis Inc

10/12/17 / #20170292141

Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system

The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare l-tert-leucine using a leucine dehydrogenase.. ... Codexis Inc

10/05/17 / #20170283781

Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs

The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.. . ... Codexis Inc

09/28/17 / #20170275598

Novel p450-bm3 variants with improved activity

The present invention provides improved p450-bm3 variants with improved activity. In some embodiments, the p450-bm3 variants exhibit improved activity over a wide range of substrates.. ... Codexis Inc

09/28/17 / #20170273978

Imidazoyl anilide derivatives and methods of use

The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides nilotinib analogs that provide therapeutic benefits.. ... Codexis Inc

09/21/17 / #20170268028

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.. . ... Codexis Inc

08/31/17 / #20170247667

Novel p450-bm3 variants with improved activity

The present invention provides improved p450-bm3 variants with improved activity. In some embodiments, the p450-bm3 variants exhibit improved activity over a wide range of substrates.. ... Codexis Inc

08/10/17 / #20170226546

Engineered ketoreductase polypeptides

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. ... Codexis Inc

07/27/17 / #20170211206

Methods, systems, and software for identifying bio-molecules with interacting components

The present invention provides methods for rapidly and efficiently searching biologically-related data space. More specifically, the present invention provides methods for identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. ... Codexis Inc

07/20/17 / #20170204405

Methods, systems, and software for identifying bio-molecules using models of multiplicative form

The present invention provides methods for identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. More specifically, some embodiments of the present invention provide methods for building sequence-activity models comprising multiplicative terms and using the models to guide directed evolution. ... Codexis Inc

07/20/17 / #20170204378

Biocatalysts for ezetimibe synthesis

The present disclosure relates to non-naturally occurring polypeptides useful for preparing ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.. . ... Codexis Inc

07/06/17 / #20170191050

Engineered phenylalanine ammonia lyase polypeptides

The present invention provides engineered phenylalanine ammonia-lyase (pal) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (pal) polypeptides.. . ... Codexis Inc

07/06/17 / #20170191043

Biocatalysts and methods for the synthesis of substituted lactams

The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.. . ... Codexis Inc

06/22/17 / #20170175090

Engineered transaminase polypeptides for industrial biocatalysis

The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.. ... Codexis Inc

06/22/17 / #20170175087

Enone reductases

The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.. ... Codexis Inc

06/08/17 / #20170159038

Engineered tyrosine ammonia lyase

The present invention provides engineered tyrosine ammonia-lyase (tal) polypeptides and compositions thereof. In some embodiments, the engineered tal polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic ph levels. ... Codexis Inc

06/08/17 / #20170159035

Gh61 glycoside hydrolase protein variants and cofactors that enhance gh61 activity

The present invention provides various gh61 protein variants comprising various amino acid substitutions. The gh61 protein variants have an improved ability to synergize with cellulase enzymes, thereby increasing the yield of fermentable sugars obtained by saccharification of biomass. ... Codexis Inc

06/08/17 / #20170159028

Biocatalytic process for preparing eslicarbazepine and analogs thereof

The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.. . ... Codexis Inc

05/11/17 / #20170134338

Dns application server

A method for providing access to an internet resource includes receiving a dns query including a hostname to be resolved, receiving status data, invoking a code by a name indicated by the hostname, conveying the status data to the code, receiving from the code a selection of an infrastructure, and generating a dns response directing a resolution to the infrastructure.. . ... Codexis Inc

05/04/17 / #20170121744

Biocatalysts and methods for hydroxylation of chemical compounds

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.. . ... Codexis Inc

05/04/17 / #20170121689

Ketoreductase polypeptides for the production of azetidinone

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.. ... Codexis Inc

04/13/17 / #20170101643

Fungal proteases

The present invention provides fungal proteases and improved fungal strains that are deficient in protease production.. . ... Codexis Inc

03/30/17 / #20170088868

Transaminase biocatalysts

The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.. . ... Codexis Inc

03/23/17 / #20170081685

Variant lovd polypeptides and their uses

The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.. . ... Codexis Inc

03/16/17 / #20170073654

Engineered biocatalysts useful for carbapenem synthesis

The present disclosure provides engineered pnb esterase polypeptides useful for the synthesis of the carbapenem antibiotic, imipenem. The disclosure also provides polynucleotides encoding the engineered pnb esterases, host cells capable of expressing the engineered pnb esterases, and methods of using the engineered pnb esterases in the production of imipenem.. ... Codexis Inc

03/16/17 / #20170073651

Transaminase polypeptides

The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.. ... Codexis Inc

03/09/17 / #20170067036

Biocatalysts and methods for the synthesis of armodafinil

The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(r)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (r)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.. ... Codexis Inc

03/09/17 / #20170067033

Fungal strains

The present invention provides improved fungal strains. In some embodiments, the improved fungal strains find use in hydrolyzing cellulosic material to glucose.. ... Codexis Inc

03/09/17 / #20170067032

Ketoreductase polypeptides for the reduction of acetophenones

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.. ... Codexis Inc

02/02/17 / #20170034119

Internet infrastructure survey

A system for surveying internet access quality includes a nameserver, registered to be authoritative for a domain name and configured to receive a dns query to resolve a pseudo-hostname and to extract from the pseudo-hostname an access quality indicator, and a web portal configured to transmit a data survey code to a web browser, the data survey code being configured to access a resource, to determine the access quality indicator responsively to the resource access, to generate the pseudo-hostname including the access quality indicator and the domain name, and to initiate the dns query.. . ... Codexis Inc

01/26/17 / #20170022527

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.. . ... Codexis Inc

01/26/17 / #20170022484

Engineered biocatalysts and methods for synthesizing chiral amines

The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.. . ... Codexis Inc

01/12/17 / #20170009213

Novel p450-bm3 variants with improved activity

The present invention provides improved p450-bm3 variants with improved activity. In some embodiments, the p450-bm3 variants exhibit improved activity over a wide range of substrates.. ... Codexis Inc

01/05/17 / #20170002333

Ketoreductase polypeptides for the production of azetidinone

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.. ... Codexis Inc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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