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Cold Spring Harbor Laboratory patents


Recent patent applications related to Cold Spring Harbor Laboratory. Cold Spring Harbor Laboratory is listed as an Agent/Assignee. Note: Cold Spring Harbor Laboratory may have other listings under different names/spellings. We're not affiliated with Cold Spring Harbor Laboratory, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Cold Spring Harbor Laboratory-related inventors


Compositions and methods for treating leukemia

The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.. . ... Cold Spring Harbor Laboratory

System and method for light sheet microscope and clearing for tracing

An exemplary system and method for imaging tissue includes using an illumination objective, directing one or multi photon excitation lights onto a portion of a tissue from a position on top and at an oblique angle relative to the tissue while the tissue is mounted on a stage. The method further includes generating a tissue-penetrating light-sheet from the one or multi photon excitation lights. ... Cold Spring Harbor Laboratory

Methods of identifying essential protein domains

Provided herein, in some aspects, are methods of determining whether a candidate protein, more specifically a functional domain of a candidate protein, is essential for viability of cells of interest using clustered regularly interspaced short palindromic repeat (cpjspr)-cas9 technology which holds great promise for genetic screening and for the discovery of therapeutic targets.. . ... Cold Spring Harbor Laboratory

Novel structurally designed shrnas

Provided is an improved design of shrna based on structural mimics of mir-451 precursors. These mir-451 shrna mimics are channeled through a novel small rna biogenesis pathway, require ago2 catalysis and are processed by drosha but are independent of dicer processing. ... Cold Spring Harbor Laboratory

Nucleotide sequences encoding fasciated ear3 (fea3) and methods of use thereof

. . Methods and compositions for modulating shoot apical meristem size are provided. Methods are provided for modulating the expression of fea3 sequence in a host plant or plant cell to modulate agronomic characteristics such as altered size and number of organs, including plant seeds.. ... Cold Spring Harbor Laboratory

Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides

The present invention, smash (short multiply aggregated sequence homologies), is a technique designed to pack multiple independent mappings into every read. Specifically, the invention relates to a composition comprising a first mixture of different chimeric genomic nucleic acid fragments, wherein each different fragment in the mixture comprises randomly ligated dna segments, wherein each dna segment in the fragment is a nucleic acid molecule at least 27 base pairs in length resulting from random fragmentation of a single genome. ... Cold Spring Harbor Laboratory

Transposable elements, tdp-43, and neurodegenerative disorders

A method that includes measuring the expression level of at least one transposon in a biological sample from a subject; and determining whether the measured transposon expression exceeds a predetermined level, and if so, administering to the subject a transposon inhibitor in an amount effective to reduce the expression level of a transposon.. . ... Cold Spring Harbor Laboratory

Compositions and methods for modulation of smn2 splicing

Disclosed herein are compounds, compositions and methods for modulating splicing of smn2 mrna in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.. ... Cold Spring Harbor Laboratory

Extracellular vesicle methods and compositions

Disclosed herein are methods and compositions for treating cancers.. . ... Cold Spring Harbor Laboratory

Transposon activation during aging and neuronal decline

The present invention relates to transposon activation and mobilization, particularly in the brain, during normal aging; reporter systems to detect such mobilization, along with cells and transgenic animals containing such systems; methods of monitoring neuronal function during normal aging; methods of determining the risk of age-related neuronal decline and age-related mortality; and the use of transposon inhibitors and apoptosis inhibitors to delay age-related neuronal decline and age-related mortality.. . ... Cold Spring Harbor Laboratory

Compositions and methods for modulation of smn2 splicing in a subject

Disclosed herein are compounds, compositions and methods for modulating splicing of smn2 mrna in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.. ... Cold Spring Harbor Laboratory








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