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Constellation Pharmaceuticals Inc patents


Recent patent applications related to Constellation Pharmaceuticals Inc. Constellation Pharmaceuticals Inc is listed as an Agent/Assignee. Note: Constellation Pharmaceuticals Inc may have other listings under different names/spellings. We're not affiliated with Constellation Pharmaceuticals Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Constellation Pharmaceuticals Inc-related inventors


 new patent  Ezh2 inhibitors and modulation of regulatory t-cell function

Provided herein are methods of treating cancers characterized by a high frequency of one or more suppressive immune cells, comprising administering a therapeutically effective amount of an enhancer of zeste homolog 2 (ezh2) inhibitor. Also provided are combination therapies using an ezh2 inhibitor and a second agent that is an immunomodulator.. ... Constellation Pharmaceuticals Inc

Combination therapies for modulation of histone methyl modifying enzymes

Provided herein are pharmaceutical compositions comprising an ezh2 inhibitor and a type i interferon, processes for preparing such pharmaceutical compositions, and uses thereof in modulating the activity of histone methyl modifying enzymes.. . ... Constellation Pharmaceuticals Inc

Modulators of methyl modifying enzymes, compositions and uses thereof

. . . . Provided are novel compounds of formula (i): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of formula (i), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.. ... Constellation Pharmaceuticals Inc

Therapeutic compounds and uses thereof

The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as kdm2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.. ... Constellation Pharmaceuticals Inc

Therapeutic compounds and uses thereof

The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as kdm2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.. ... Constellation Pharmaceuticals Inc

Use of cbp/ep300 and bet inhibitors for treatment of cancer

. . . . . . . . . . . . The present invention relates to the use of cbp/ep300 inhibitors and bet inhibitors for the treatment of cancer. In some embodiments, the use is to treat cancer that is resistant to bet inhibitors.. ... Constellation Pharmaceuticals Inc

Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide

The present disclosure relates to a crystalline form of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide, which is useful as an inhibitor of bromodomain-containing proteins. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline form and methods of using said compositions in the treatment of various disorders.. ... Constellation Pharmaceuticals Inc

Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof

The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.. ... Constellation Pharmaceuticals Inc

Modulators of methyl modifying enzymes, compositions and uses thereof

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.. . ... Constellation Pharmaceuticals Inc

Expression levels of bcl-xl, bcl2, bcl-w, and bad and cancer therapies

Described herein are novel methods for treating subjects with a cancer which is not overexpressing at least one of bcl-xl, bcl-w, and bad, and optionally further overexpressing bcl-2. Also provided herein are tools for determining and/or assessing, and for the administration of, cancer treatments involving bet bromodomain inhibitors, bcl-xl inhibitors, or combinations thereof.. ... Constellation Pharmaceuticals Inc








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