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Corel Corporation patents


Recent patent applications related to Corel Corporation. Corel Corporation is listed as an Agent/Assignee. Note: Corel Corporation may have other listings under different names/spellings. We're not affiliated with Corel Corporation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Corel Corporation-related inventors


Particulate constructs for release of active agents

A positioning device for a mobile x-ray detector, an x-ray device containing such a mobile positioning device, and a method mutually align a mobile x-ray detector and an x-ray emitter in relation to one another. In order to enable exact mutual alignment or positioning of the mobile x-ray detector in relation to the x-ray emitter, a positioning device is used for a mobile x-ray detector. . . . . . . . . . . . . . . . . . . Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.. . ... Corel Corporation

Compositions and methods for immunomodulation

The present invention relates to modulation of the tumor microenvironment to increase cancer specific immune responses. Conjugates, nanoparticles and formulations of the present invention relieve the inhibitory effect induced by tumor cells, and enhance antitumor immunity. ... Corel Corporation

Compositions and methods for immuno-oncology therapies

The present invention relates to cancer immunotherapy. Conjugates and nanoparticles comprising active agents that can elicit a cancer specific immune response are provided. ... Corel Corporation

Sustained release nanocomposite, a process for producing the same and use thereof

The present invention relates to nanocomposites for the controlled delivery of active ingredients into the central nervous system. The nanocomposite according to the present invention comprises a biocompatible core part comprising biodegradable material, and polyelectrolytes able to form a electrostatic van der waals interactions with the material of the core part. ... Corel Corporation

Growth hormones with prolonged in-vivo efficacy

The present invention relates to polypeptide compound optimized for subcutaneous administration, exemplified by growth hormone conjugates having a linker providing non-covalent binding to albumin.. . ... Corel Corporation

Potentiation of anticancer agents

The present invention relates to carriers, conjugate and pharmaceutical compositions and their use to increase the potency of drugs and to modify the pharmacokinetics of compounds. More particularly, the present invention relates to conjugates comprising the carrier described herein and their use in the treatment and diagnostic of cancer.. ... Corel Corporation

Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components

The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.. . ... Corel Corporation

Silylated biomolecule-based hydrogel for culturing cardiomyocytes and stem cells, and use of the hydrogel thereof for treating heart failure

The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.. . ... Corel Corporation

Composition for use in treating and preventing inflammation related disorder

The present invention is related to a use for treating and preventing inflammation related disorder of a composition containing a drug and hyaluronic acid (ha) or ha mixture, whereas the ha or the ha mixture as a delivery vehicle can be a formulation including at least two has having different average molecular weights. The composition has been demonstrated to be capable of reducing the therapeutic dose of a drug on the treatment and prevention of inflammation related disorders is acute inflammatory disease, chronic obstructed pulmonary disease, coeliac disease, conjunctivitis, otitis, allergic rhinitis, gingivitis, aphthous ulcer, bronchitis, gastroesophageal reflux disease (gerd), esophagitis, gastritis, enteritis, peptic ulcer, inflammatory bowel disease (ibd), crohn's disease, irritable bowel syndrome (ibs), intestinal inflammation or allergy, urethritis, cystitis, vaginitis, proctitis, eosinophilic gastroenteritis, or rheumatoid arthritis.. ... Corel Corporation

Polymersomes, liposomes, and other species associated with fluidic droplets

The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be at least partially biocompatible and/or biodegradable. ... Corel Corporation

Sustained release of bioactive factors from zwitterionic hydrogels

Methods of producing microporous zwitterionic cryogels are described, wherein the cryogels are useful for sustaining release of therapeutic agents. The disclosed cryogels overcome several limitations associated with existing compositions, for example the disclosed cryogels have high loading efficiencies and a sustained release profile with minimal burst of up to 4 months or more. ... Corel Corporation

Film-forming compositions based on starchy material and articles obtained thereof

The instant invention relates to new film-forming compositions based on starchy material, comprising isosorbide. The instant invention also relates to products made from the film-forming compositions of the invention, in particular hard and soft capsules shells, and to methods for the manufacture of such products.. ... Corel Corporation

Method and apparatus for creating structured water by exposing water transversal and longitudinal to ultra- low frequency electromagmetic fields

An apparatus and method is provided for healing and regeneration of live human and animal bodies and influencing interaction and intercommunication at the cellular level. The apparatus can include one or more environmental and/or body sensors. ... Corel Corporation

Timed release of substances to treat ocular disorders

A system is disclosed for simple, non-invasive, sustained delivery of ophthalmic substances to the interior of the eye, for the prevention and treatment of eye diseases and conditions. Liposomes and inverted micelles are disclosed as suitable vehicles, and timed release of the substances is affected. ... Corel Corporation

08/09/18 / #20180221480

Anti-vla-4 antibodies

This invention relates to alpha-4 binding antibodies, and fragments thereof.. . ... Corel Corporation

08/09/18 / #20180221479

Agents for use in the treatment of glioma

The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma who if and 111°, as well as iv0 (glioblastoma), in a subject.. . ... Corel Corporation

08/09/18 / #20180221478

Treatment of patients diagnosed with pancreatic ductal adenocarcinoma using using monoclonal antibodies against the epidermal growth factor receptor (egfr)

The present disclosure relates to the field of immunotherapy of cancer, in particular pancreatic ductal adenocarcinoma (pdac). Means and methods for treatment of a population of pdac patients suffering from pdac tumours which express wildtype kras, hras or nras are disclosed. ... Corel Corporation

08/09/18 / #20180221471

Monovalent anti-cd3 adjuvants

This document provides methods and materials related to using monovalent anti-cd3 antibodies (e.g., monovalent anti-cd3 fab fragments) as adjuvants to increase the immune response produced against an antigen (e.g., a tumor associated antigen). For example, vaccine compositions containing monovalent anti-cd3γε fab fragments in combination with tumor associated antigens (e.g., tumor associated antigens having little or no immunogenicity in the absence of monovalent anti-cd3γε fab fragments) alone or in combination with adjuvants for signals two and/or three required for full activation of t cell immune function, as well as methods and materials for using monovalent anti-cd3γε fab fragments to increase the immune response produced against an antigen (e.g., a tumor associated antigen) within a mammal (e.g., a human) are provided.. ... Corel Corporation

08/09/18 / #20180221469

Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (mv-deltac virus) in cancer therapy

The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory c protein has been knocked out (mv-deltac). It concerns in particular the use of said genetically modified infectious mv-deltac in the treatment of malignant tumour or cancer conditions, and for the preparation of agents or compositions for such treatment.. ... Corel Corporation

08/09/18 / #20180221462

Use of elafin for disorders associated with elastase independent increase in troponin

The present invention relates to the use of elafin for the treatment and/or prevention of diseases or disorders associated with an increase in troponin levels, which are non elastase dependent. The present invention in a preferred embodiment relates to a method and composition, using elafin, for protecting the heart muscle or other muscles from damage induced by abnormal blood flow and/or inflammation, which may result from, for example, a heart infarction. ... Corel Corporation

08/09/18 / #20180221461

Carbapenemases for use with antibiotics for the protection of the intestinal microbiome

This invention relates, in part, to various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.. . ... Corel Corporation

08/09/18 / #20180221459

Enzyme replacement therapy for mucopolysaccharidosis iiid

The present disclosure relates to compositions and methods for treating sanfilippo syndrome (also known as sanfilippo disease type d, sanfilippo d, mucopolysaccharidosis type iiid, mps iiid). The method can entail injecting to the spinal fluid of a mps iiid patient an effective amount of a composition comprising a recombinant human acetylglucosamine-6-sulfatase (gns) protein comprising the amino acid sequence of seq id no: 1 or an amino acid sequence having at least 90% sequence identity to seq id no: 1 and having the enzymatic activity of the human gns protein. ... Corel Corporation

08/09/18 / #20180221457

Glycerol-3-phosphate phosphatase activators

The present disclosure relates to the identification and the use of activators of a mammalian glycerol-3-phosphate phosphatase (hg3pp) for increasing gro3p conversion to glycerol and glycerol release from a mammalian cell. The activators of hg3pp can be used in the prevention, treatment and/or alleviation of symptoms associated with obesity, type 2 diabetes and/or metabolic syndrome x. ... Corel Corporation

08/09/18 / #20180221456

Bacteriophage lysin and antibiotic combinations against gram positive bacteria

The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly staphylococcal bacteria, with combinations of lysin, particularly streptococcal lysin, particularly the lysin plyss2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).. . ... Corel Corporation

08/09/18 / #20180221454

Thioredoxin, thioredoxin peptides or derivatives for treatment of age-related hypertension

The incidence of high blood pressure is strikingly high with advancing age, and is an independent prognostic factor for the onset or progression of a variety of cardiovascular disorders (cvd). There is a critical need for a curative therapy against age-related hypertension. ... Corel Corporation

08/09/18 / #20180221452

Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiment of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gi tract. Many embodiments provide a swallowable device for delivering the agents. ... Corel Corporation

08/09/18 / #20180221451

Long acting liraglutide compositions

The present invention relates to a composition comprising particles, wherein said particles comprise poly(lactide-co-glycolide) polymer, therapeutically effective amount of liraglutide or a pharmaceutically acceptable salt thereof and a hydrophilic particle size modulating agent, wherein, the composition is free of added divalent metal ions. The composition provides effective blood glucose control for about 7 days when administered as once a week formulation to a period of about 30 days after single administration of a monthly dose to a patient in need thereof.. ... Corel Corporation

08/09/18 / #20180221450

Formulation comprising a stabilized complex of corticotropin releasing hormone and alpha-2 macroglobulin

The present invention relates to a crh formulation having improved stability/efficacy. The improved crh formulation is particularly suitable for treatment of various disorders. ... Corel Corporation

08/09/18 / #20180221449

Compositions for changing body composition, methods of use, and methods of treatment

The present disclosure provides compositions including an amylin receptor agonist and a beta-2-adreno-receptor agonist (e.g., an anti-hyperglycemia agent), compositions including at least two different anti-catabolic agents, compositions including at least two different anti-adiposity agents, methods of treating a condition (e.g., muscle wasting, muscle wasting-related condition, excess adiposity, an excess adiposity-related condition, and the like), methods of increasing muscle mass, formation of thermogenic brown adipose tissue (bat), and/or decreasing white adipose tissue (wat) content, methods of treating muscle wasting, methods of treating excess adiposity, and the like.. . ... Corel Corporation

08/09/18 / #20180221448

Novel polypeptide having chemokine activity

The present invention relates to a novel polypeptide having chemokine activity and, more specifically, to a polypeptide composed of the amino acid sequence represented by seq id no: 1 and a use thereof. The polypeptide of the present invention is composed of seq id no: 1 and exhibits chemokine activity through the binding with ccr3, and thus, the polypeptide has a high utilization effect for various purposes, such as immunoregulation, and diagnosis, treatment, and medicine development for ccr3-mediated diseases or disease symptoms.. ... Corel Corporation

08/09/18 / #20180221447

Compositions and methods for treating pulmonary hypertension

In some aspects, the disclosure relates to gdf/bmp antagonists and methods of using gdf/bmp antagonists to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (ph), particularly treating, preventing or reducing the progression rate and/or severity of one or more ph-associated complications. The disclosure also provides methods of using a gdf/bmp antagonist to treat, prevent, or reduce the progression rate and/or severity of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, and right ventricular hypertrophy. ... Corel Corporation

08/09/18 / #20180221444

Applications of mussel adhesive protein product in treatment and prevention of diseases related to melanin

Disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of diseases related to melanin. Specifically disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of pigmentations such as chloasma, freckles, melanosis, applications in skin cancers represented by melanoma, and applications in treatment of pigmentation possibly caused by skin diseases or drugs.. ... Corel Corporation

08/09/18 / #20180221443

Use of human small leucine zipper protein in osteogenesis procedure

The present invention relates to a use of a human small leucine zipper protein in the osteogenesis procedure. More specifically, slzip increases the transcriptional activity of runx2 and inhibits the transcriptional activity of pparγ2, thereby increasing the osteoblast differentiation, so that slzip performs an important role in the osteogenesis procedure, and thus can be used as a marker for treating bone disease and developing new medicines.. ... Corel Corporation

08/09/18 / #20180221441

Method for identifying, expanding, and removing adult stem cells and cancer stem cells

The invention further relates to means suitable for cancer treatment and even more specific for the treatment of cancer by eradicating cancer stem cells.. . ... Corel Corporation

08/09/18 / #20180221440

Method of treating respiratory disorders

The invention relates to the use of agents that bind the complement protein c5 in the treatment of diseases associated with inappropriate complement activation, and in particular in the treatment of respiratory disorders.. . ... Corel Corporation

08/09/18 / #20180221437

Pharmaceutical composition for preventing or treating mycobacterium species infection and method using the same

Provided are a pharmaceutical composition for preventing or treating mycobacterium sp. Infection or a related symptom thereof, wherein the pharmaceutical composition includes a compound including a peptide represented by formula 1, or an isomer, a derivative, a solvate, or a pharmaceutically acceptable salt thereof; and a method using the same. ... Corel Corporation

08/09/18 / #20180221436

Treatments of oxidative stress conditions

The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. ... Corel Corporation

08/09/18 / #20180221435

Itch treatment using a combination of neurokinin-1, gastrin releasing peptide, and glutamate receptor antagonists

Methods, and compositions are provided for inhibition of histamine and non-histamine dependent itch signal transmission or scratch behavior. In one aspect, the present invention further comprises administering to the subject an inhibitor of histamine-dependent itch signal transmission. ... Corel Corporation

08/09/18 / #20180221434

Multi-peptide composition

The invention relates to a specific peptide combination. The peptide combination may be present in a pharmaceutically acceptable composition. ... Corel Corporation

08/09/18 / #20180221432

A drug for the effective control of acute and or chronic pain and a method for its administration

The proposed drug relates to medicine and veterinary applications, in particular, as a means for effective control of acute and/or chronic pain, and may be used in emergency medicine for the treatment of acute and/or chronic pain, including the late stages of cancer. The stated means is based on a compound for preventing and/or treating acute or chronic pain in a subject, including an analgesic peptide having an amino acid sequence h-tyr-d-arg-phe-gly-nh2 or an amino acid sequence h-tyr-d-arg-phe-sar-oh. ... Corel Corporation

08/09/18 / #20180221430

Formulation containing an extract of alpinia galanga, a process for the preparation thereof, and uses thereof

Various embodiments relate to formulations containing an extract of alpinia galanga; a method of improving cognitive performance by administering an extract of alpinia galanga; and a process for preparing an extract of alpinia galanga.. . ... Corel Corporation

08/09/18 / #20180221428

Quit your itching cream

The present invention relates to compositions and methods for the treatment of topical skin conditions, comprising of peppermint oil, lavender oil, tea tree oil and a suitable amount of a pharmaceutically acceptable carriers, shea butter and coconut oil.. . ... Corel Corporation

08/09/18 / #20180221424

Composition for prevention or treatment of arthritis, containing sargassum serratifolium extract as active ingredient

The present invention relates to a composition for the prevention or treatment of arthritis, the composition containing a sargassum serratifolium extract as an active ingredient. The extract of sargassum serratifolium according to the present invention has an excellent activity to reduce or inhibit the activity of il-1β, il-6, or tnf-α, which is an inflammatory cytokine, and has an excellent effect alleviating arthritis in an arthritis animal model so that it can be usefully used as a composition for treating arthritis. ... Corel Corporation

08/09/18 / #20180221422

Stable dry probiotic compositions for special dietary uses

A dry stable probiotic composition is provided. The composition comprises one or more viable probiotic microorganisms, one or more hydrolyzed proteins, one or more disaccharides, one or more oligosaccharides, and one or more polysaccharides, but not trehalose. ... Corel Corporation

08/09/18 / #20180221420

Method to suppress the systemic toxicity of chemotherapeutic drugs

This invention relates to the combination of manuka honey with other chemotherapeutic agents to treat cancer and reduce the toxicity of the treatment. The invention relates also to an intravenous pharmaceutical composition comprising a diluent; at least 50% w/v of manuka honey diluted by the diluent; and at least one chemotherapeutic agent selected from the group consisting of paclitaxel 5 mg/kg of a patient to be treated; paclitaxel 8 mg/kg of a patient to be treated; oxaliplatin 6 mg/kg of a patient to be treated; and any pharmaceutically acceptable salts thereof. ... Corel Corporation

08/09/18 / #20180221417

Treatment of dry eye using amnion released factors

Disclosed are means, methods and compositions of matter for treatment of dry eye disease using factors released from placental amniotic tissue when cultured in a liquid media. In one embodiment of the invention amnion is extracted from a hemochorial placenta and cultured in a means to maintain viability of said amnion. ... Corel Corporation

08/09/18 / #20180221412

Methods and compositions relating to mesenchymal stem cell exosomes

The invention provides compositions comprising mesenchymal stem cell (msc) derived exosomes, and methods of their use in subjects having certain lung diseases including inflammatory lung disease.. . ... Corel Corporation

08/09/18 / #20180221411

Improved cell therapies

The present invention relates to methods for the improved treatment of an inflammatory disorder, where the treatment comprises administration of sex-matched stem or progenitor cells, such as mesenchymal stem cells (mscs), or sex-matched cell secretions, or a combination thereof to a subject. The invention also relates to kits and compositions which may be used in such methods.. ... Corel Corporation

08/09/18 / #20180221408

Novel chewable eye health formulation

Risk of visual impairment including age-related macular degeneration (amd) and cataracts increase with age. This increased risk can be caused by changes in the structure and function of the eye or changes in structures of the central nervous system that support visual perception. ... Corel Corporation

08/09/18 / #20180221405

Silicate containing compositions and methods of treatment

The present invention relates to compositions comprising a silicate and methods of use thereof. In particular, the compositions of the present invention are suitable for treating inflammatory conditions, cancer, bacterial and viral infections, and infected and uninfected wounds. ... Corel Corporation

08/09/18 / #20180221403

New use of dextran sulfate

The present embodiments relate to the use of dextran sulfate formulated for systemic administration for treatment, inhibition or prevention of cardiac fibrosis in a subject.. . ... Corel Corporation

08/09/18 / #20180221402

Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells

Disclosed are methods for delivering a therapeutic or diagnostic agent to the cytosol of a cell in a subject. The disclosed methods generally include administering to the subject an effective amount of a lipid nanoparticle comprising the therapeutic or diagnostic agent and an effective amount of a membrane-destabilizing polymer. ... Corel Corporation

08/09/18 / #20180221401

Sterile formulation comprising a stable phosphorothioate oligonucleotide

The present invention relates to a composition comprising a phosphorothioate oligonucleotide and at least one fatty acid and/or at least one emulsifying agent, wherein said composition is sterile and wherein said composition comprises at least one agent comprising a thiol group and at least one phosphate compound, preferably said composition is an ophthalmic composition. The present invention also relates to a method for obtaining the same and to the therapeutic use thereof.. ... Corel Corporation

08/09/18 / #20180221400

Compositions and methods relating to galectin detection

Compositions and methods for detection and assessment of galectins are provided by the present invention, including a labeled compositions, pharmaceutical composition including a labeled composition for galectin detection and a pharmaceutically acceptable carrier, method of aiding in diagnosis and/or treatment of a condition characterized by upregulation of one or more galectins in a subject in need thereof and precursor compositions for synthesis of chemical compositions, including but not limited to labeled compositions for detection and assessment of galectins.. . ... Corel Corporation

08/09/18 / #20180221395

Methods for cancer and immunotherapy using prodrugs of glutamine analogs

And the pharmaceutically acceptable salts thereof, wherein r1, r2, r2′, and x are as defined as set forth in the specification. Compounds having formula (i) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-l-norleucine (don).. ... Corel Corporation

08/09/18 / #20180221394

Veterinary composition comprising torasemide for the treatment of pulmonary edema associated with heart failure in domestic animals

The invention relates to novel veterinary compositions comprising torasemide or a pharmaceutically acceptable salt thereof and administered in domestic animals according to a predetermined dosage for symptomatic treatment of pulmonary edema associated with heart failure.. . ... Corel Corporation

08/09/18 / #20180221392

Pain-killing composition comprising a salicylic acid derivative

The subject-matter of the present invention is the use of a therapeutic composition comprising, in an applying carrier, at least one essential oil for relieving muscle and/or joint pain in an animal subject, wherein said composition topically treats an area of the skin of said subject, characterized in that said composition comprises methyl salicylate, which constitutes, with at least one essential oil of the composition containing same in only a small amount or not at all, an active agent within which the rate of transport of the methyl salicylate through the skin is increased by virtue of the oil, which is an essential oil.. . ... Corel Corporation

08/09/18 / #20180221391

Synthetic bile acid compositions and methods

Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.. ... Corel Corporation

08/09/18 / #20180221388

Non-irritating testosterone emulsions

Disclosed herein are emulsions comprising testosterone or related androgens, castor oil, cyclodextrin, pemulen tr-2, polyoxyl 40, and other ingredients. The compositions are useful for treating keratoconjunctivitis sicca and meibomian gland disease.. ... Corel Corporation

08/09/18 / #20180221385

A pharmaceutical preparation for improving absorption and postprandial hypoglycemic action of insulin

The present disclosure relates to compositions and combinations comprising one or more insulin(s) and one or more vasoactive agent(s), and use thereof for increasing subcutaneous insulin absorption and/or treating diabetes and/or treating or preventing hyperglycemia or complications in a patient in need thereof.. . ... Corel Corporation

08/09/18 / #20180221384

Compositions of midazolam for buccal administration in the treatment of seizures to obtain rapid onset of action

The present invention relates to a unit dosage composition in the form of a film or a water containing from 0.25 mg to 2 mg of midazolam or a pharmaceutically acceptable salt thereof, and a film-forming substance.. . ... Corel Corporation

08/09/18 / #20180221382

Inhibition of mk2 in the treatment of cancer

The present invention relates to the discovery that mk2 is highly expressed in cancer tissue and the inhibition of mk2 using an mk2 inhibitor represents a viable approach to the treatment of cancer, including drug resistant cancers, metastatic cancers and recurrent cancers. Mk2 inhibitors as described herein may be used alone or in combination with an at least one additional anti-cancer agent for the treatment of cancer.. ... Corel Corporation

08/09/18 / #20180221376

Methods for treating cancer using hsp90 inhibitors

The disclosure also provides compositions and methods related to combination therapy with hsp90 inhibitors and bcl-2 pathway inhibitors for treating cancer. The disclosure also provides compositions and methods related to the use of low dose' hsp90 inhibitors in the treatment of cancer, alone and in combination with other therapeutic agents.. ... Corel Corporation

08/09/18 / #20180221367

Compounds and their use as bace inhibitors

The present invention relates to compounds of formula (i) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of aβ-related pathologies such as down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to mci (“mild cognitive impairment”), alzheimer's disease, memory loss, attention deficit symptoms associated with alzheimer's disease, neurodegeneration associated with diseases such as alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.. ... Corel Corporation

08/09/18 / #20180221366

Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives

The present invention relates to compositions and methods for cancer treatment comprising compounds of formulae i, ii, and iii. In some aspects, the invention relates to the treatment of b-cell lymphoma or other hematopoietic cancers. ... Corel Corporation

08/09/18 / #20180221360

Dose-dumping resistant controlled release dosage form

The present invention provides a simple and improved dosage form that provides a controlled release of methylphenidate contained in the core thereof. The invention also provides methods of administering the dosage form and of treating conditions that are therapeutically responsive to methylphenidate. ... Corel Corporation

08/09/18 / #20180221359

Administration of ethyl 3-[(2-{[4-(hexyloxycarbonyl-aminoiminomethyl)phenyl-amino]methyl}-1-methyl-1h-benzimidazol-5-carbonyl)pyridin-2-ylamino]propionate

The invention relates to a new administration form for the oral application of the active substance ethyl 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1h-benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionate and the pharmacologically acceptable salts thereof.. . ... Corel Corporation

08/09/18 / #20180221358

Pharmaceutical compositions comprising a local anaesthetic such as bupivacaine for local administration to the mouth or throat

The present invention relates to compositions comprising a lipophilic local anaesthetic, preferably bupivacaine or a pharmaceutically active salt thereof, which are formulated for local administration to the mouth or throat of a subject. The compositions are useful in the treatment or alleviation of pain, burning or xerostomia of the oral cavity, pharynx, oral mucosa and pharyngeal mucosa or for use in providing local anesthesia of the oral cavity, pharynx, oral mucosa and pharyngeal mucosa. ... Corel Corporation

08/09/18 / #20180221356

Method of wound healing

The present invention relates to a method of treating a wound, comprising administering to a subject in need thereof a therapeutically effective amount of an aza adamantane compound according to formula (i), or a pharmaceutically acceptable salt, thereof. . ... Corel Corporation

08/09/18 / #20180221354

3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof

4-azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of a 4-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components. ... Corel Corporation

08/09/18 / #20180221353

3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof

4-azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of a 4-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components. ... Corel Corporation

08/09/18 / #20180221352

3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof

7-azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 7-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components. ... Corel Corporation

08/09/18 / #20180221351

3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof

6-azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components. ... Corel Corporation

08/09/18 / #20180221350

3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components. ... Corel Corporation

08/09/18 / #20180221347

Cftr corrector for the treatment of genetic disorders affecting striated muscle

The present invention relates to the use of cftr correctors in the treatment of genetic disorders affecting striated muscle selected from sarcoglycanopathies, brody's disease (bd) and the recessive forms of cathecolaminergic polymorphic ventricular tachycardia (cpvt).. . ... Corel Corporation

08/09/18 / #20180221346

Human protein tyrosine phosphatase inhibitors and methods of use

The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (hptp-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising said human protein tyrosine phosphatase beta (hptp-β) inhibitors, and to methods for regulating angiogenesis.. ... Corel Corporation

08/09/18 / #20180221341

3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof

7-azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 7-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components. ... Corel Corporation

08/09/18 / #20180221337

Methods and compositions for treating metabolic reprogramming disorders

And the pharmaceutically acceptable salts thereof, wherein r1, r2, r2′, and x are as defined as set forth in the specification. Compounds having formula (i) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-l-norleucine (don).. ... Corel Corporation

08/09/18 / #20180221334

Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis

Wherein r1 is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.. ... Corel Corporation

08/09/18 / #20180221332

Flash-melt cannabinoid formulations

The present invention relates to dosage forms for the production of flash-melt cannabis resin and extract oral dosage forms. . ... Corel Corporation

08/09/18 / #20180221328

Treatment of obesity using non-daily administration of 6-o-(4-dimethylaminoethoxy) cinnamoyl fumagillol

The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions using non-daily administration of, e.g., a metap-2 inhibitor.. . ... Corel Corporation

08/09/18 / #20180221321

Methods and products related to glutaminase inhibitors

The invention relates to methods and related compositions for enhancing cancer therapy and in particular glutaminase inhibitor therapy. The methods involve methods for identifying patients susceptible to glutaminase inhibitor therapy as well as sensitizing patients to glutaminase inhibitor therapy.. ... Corel Corporation

08/09/18 / #20180221317

Composition for the treatment of superficial lesions

The invention relates to a composition for the treatment of superficial lesions, in particular skin lesions, mucous membrane lesions and/or nail lesions, an applicator comprising such a composition and the use of such a composition. The composition comprises an effective amount of trichloroacetic acid, at least one thickener, and at a physiologically acceptable solvent. ... Corel Corporation

08/09/18 / #20180221314

Oral liquid compositions of guanfacine

The present invention relates to oral liquid compositions of guanfacine. The liquid compositions can be immediate release or extended release compositions. ... Corel Corporation

08/09/18 / #20180221313

Use of hydroxycarbamide for preventing retinal nonperfusion

The present invention relates to the use of hydroxycarbamide (hc) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (crvo). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (crvo) has been recently diagnosed and is consequently in a rapidly progressive phase. ... Corel Corporation

08/09/18 / #20180221310

Method of treating cancer with a combination of benzylideneguanidine derivatives and chemotherapeutic agent

The present invention relates to a composition for use in treating a glioma or ameliorating the effects of a glioma, particularly glioblastoma, wherein said composition comprises a first active agent selected from the group consisting of a compound of formula (i), or a pharmaceutically acceptable salt thereof, (i) and a second active agent, which is temozolomide, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.. . ... Corel Corporation

08/09/18 / #20180221309

Treatment and prevention of fungal infections

Various embodiments disclosed relate to treatment of fungal infections. The present invention provides a method of treating a fungal infection including contacting a fungus including a β-glucan that is at least partially masked from immune system detection with a therapeutically effective amount of a compound that at least partially unmasks the β-glucan to increase immunogenicity of the fungus.. ... Corel Corporation

08/09/18 / #20180221308

Prolonged release pharmaceutical composition containing 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol

A pharmaceutical formulation for prolonged release of the active ingredient 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol or a pharmaceutically acceptable salt thereof in a matrix containing between 1 and 80 wt % of at least one pharmaceutically acceptable hydrophilic or hydrophobic polymer as a matrix forming agent and exhibiting in vivo the following release rate: 3 to 35% by weight (based on 100% by weight active ingredient) 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 0.5 hours; 5 to 50% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 1 hour; 10 to 75% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 2 hours; 15 to 82% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 3 hours; 30 to 97% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 6 hours; more than 50% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 12 hours; more than 70% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 18 hours, and more than 80% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 24 hours.. . ... Corel Corporation

08/09/18 / #20180221307

Tamper resistant dosage form with bimodal release profile manufactured by co-extrusion

The invention relates to a monolithic pharmaceutical dosage form comprising a hot melt-extruded first segment (s1) and a second segment (s2); wherein the first segment (s1) contains at least a first pharmacologically active ingredient (a1) and/or the second segment (s2) contains at least a second pharmacologically active ingredient (a2); and the segment (s1) and/or the segment (s2) is tamper-resistant and/or exhibits a breaking strength of at least 300 n.. . ... Corel Corporation

08/09/18 / #20180221304

Cannabinoid-containing complex mixtures for the treatment of mast cell-associated or basophil-mediated inflammatory disorders

Provided herein are cannabinoid-containing complex mixtures suitable for use as active pharmaceutical ingredients. The complex mixtures are comprised of the major cannabinoid, cannabidiol, a first minor cannabinoid, which is cannabigerol, at least a first selected terpene, and optionally a second minor cannabinoid. ... Corel Corporation

08/09/18 / #20180221301

Transdermal systems containing multilayer adhesive matrices to modify drug delivery

The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.. ... Corel Corporation

08/09/18 / #20180221293

Mucus penetrating particles with high molecular weight and dense coatings

Mucus penetrating particles (mpps) include one or more core polymers, one or more therapeutic, prophylactic and/or diagnostic agents; and one or more surface modifying agents. The surface modifying agents coat the surface of the particle in a sufficient density to enhance the diffusion of the modified nanoparticles throughout the mucosa, relative to equivalent nanoparticles that are not surface modified. ... Corel Corporation

08/09/18 / #20180221290

Extended release suspension compositions

The present invention relates to a method for preparing a stable extended release suspension composition comprising multiple coated cores of an active ingredient by using a suspension base, wherein the suspension base ensures substantially similar in-vitro dissolution release profile of the active ingredient upon storage of the suspension compositions for at least seven days.. . ... Corel Corporation

08/09/18 / #20180221289

Phospholipid-cholesteryl ester nanoformulations and related methods

In one aspect, the invention provides therapeutic agent nanoparticles coated with cholesteryl esters, formulations of the nanoparticles suitable for injection, methods for administering therapeutic agents and for treating diseases and conditions treatable by the therapeutic agents using the formulations. In a related aspect, the invention provides synthetic high density lipoprotein nanoparticles useful for therapeutic agent delivery, and methods for their preparation and use.. ... Corel Corporation

08/09/18 / #20180221287

Methods for delivering insulin preparations into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gi tract. Many embodiments provide a swallowable device for delivering the agents. ... Corel Corporation

08/09/18 / #20180221285

Oral formulations of deferasirox

Orally administerable deferasirox formulations are disclosed having reduced release under gastric conditions and fast release at near neutral ph or at neutral ph.. . ... Corel Corporation

08/09/18 / #20180221284

Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix

A pharmaceutical formulation comprising an erosion matrix comprising one or more fumaric acid esters as well as one or more rate-controlling agents, wherein erosion of said erosion matrix permits controlled release of said fumaric acid ester(s).. . ... Corel Corporation

08/09/18 / #20180221283

Nanosuspension containing particles and extract of natural materials

The present application relates to a method for the preparation of a nanosuspension comprising nanoparticles of at least one natural material and an extract of at least one natural material, wherein the method comprises the steps of providing particles of at least one natural material having a particle size (d100) of less than 320 μm; providing an extract of at least one natural material; dispersing said particles of at least one natural material and said extract of at least one natural material in a solvent; and milling the dispersion to a particle size (d90) of below 1000 nm (d90<1000 nm). Furthermore, the present application also relates to a nanosuspension prepared according to said method, and the use of such nanosuspension for the preparation of a medicament and/or nutritional supplement.. ... Corel Corporation

08/09/18 / #20180221282

Methods for making pharmaceutical solid dosage forms of spray-dried dispersions

A process for drying a spray dried dispersion, comprising: a) providing a spray-dried dispersion comprising particles wherein the particles comprise an active agent and a polymer and optionally one or more surfactants, the dispersion having an average particle diameter of less than about 100 m; b) blending an amount of silicon dioxide with the dispersion to form a dispersion-silicon dioxide blend, wherein the amount of silicon dioxide relative to the amount of dispersion is between about 0.5 and 2.0% by weight; c) drying the blend with a secondary dryer.. . ... Corel Corporation

08/09/18 / #20180221281

Sol-gel phase-reversible hydrogel templates and uses thereof

Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. ... Corel Corporation

08/09/18 / #20180221280

Heat-stable dry powder pharmaceutical compositions and methods

Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. ... Corel Corporation

08/09/18 / #20180221279

Modified drugs for use in liposomal nanoparticles

Drag derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drag derivatized with a weak-base moiety that facilitates active loading of the drag through a ln transmembrane ph or ion gradient into the aqueous interior of the ln. ... Corel Corporation

08/09/18 / #20180221278

Prsustained release opthalmic formuation and methods for using the same

The present invention provides a sustained release formulation of an active pharmaceutical ingredient (“api”). In particular, the sustained release formulation is adapted for topical administration or administration via injection and comprises a nanoemulsion of oil-in-water. ... Corel Corporation

08/09/18 / #20180221277

Transdermal drug delivery using amphiphilic dendron-coil micelles

The invention generally relates to the field of drug delivery. In particular, the invention relates to amphiphilic dendron-coils, micelles thereof and their use for the transdermal delivery of drugs.. ... Corel Corporation

08/09/18 / #20180221275

Oral product

An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-stable polymer matrix, cellulosic fibers embedded in the mouth-stable polymer matrix, and an additive dispersed in the mouth-stable polymer matrix. ... Corel Corporation

08/09/18 / #20180221272

Antipsychotic injectable depot composition

The present invention is directed to a composition that can be used to deliver an antipsychotic drug such as risperidone as an injectable in-situ forming biodegradable implant for extended release providing therapeutic plasma levels from the first day. The composition is in the form of drug suspension on a biodegradable and biocompatible copolymer or copolymers solution using water miscible solvents that is administered in liquid form. ... Corel Corporation

08/09/18 / #20180221269

Lightening method using special siloxane compounds

The present disclosure relates a method for the lightening of keratinous fibers, particularly human hair, wherein a lightening agent (am) containing at least one special dimethylcyclosiloxane and at least one special polydimethylsiloxane is used. Use of the special siloxanes results in improved care of the keratinous fibers with simultaneous improvement of the lightening effect. ... Corel Corporation

08/09/18 / #20180221267

Personal care compositions comprising polymers derived from vinyl alcohol ethers and applications thereof

Wherein q, r1, a, b, and c are described herein. The invention further provides hair care compositions comprising the polymers. ... Corel Corporation

08/09/18 / #20180221266

Low viscosity hair care composition

This invention relates to a foamable concentrated hair care composition comprising an anionic surfactant and a co-surfactant. The hair care composition may further comprise a silicone, wherein the silicone particle size is less than about 10 microns. ... Corel Corporation

08/09/18 / #20180221264

Hair growth composition and method

The present invention relates to compositions for and methods of retarding hair loss or facilitating hair growth comprising a hair growth active and a c8-c24 alcohol ester of a carboxylic acid.. . ... Corel Corporation

08/09/18 / #20180221260

Tablet including abrasive for dental cleaning

Consumable abrasive-containing oral hygiene tablets are described. The tablets include glycine as an abrasive. ... Corel Corporation

08/09/18 / #20180221252

Sun protection towelettes

This invention relates to a package containing one or more sun protection towelettes moistened or pre-saturated with sunscreen with different values of spf for application on skin of users. The one or more sun protection towelettes are pre-saturated with stabled uv sunscreen having long shelf life. ... Corel Corporation

08/09/18 / #20180221249

Dental adhesive

The present invention relates to an aqueous dental composition having a ph of less than 7 as well as to the use of a stabilizer for the preparation of an aqueous dental composition having a ph of less than 7. In particular, the present invention relates to an aqueous dental composition having a ph of less than 7 comprising (i) one or more polymerizable compounds having at least one polymerizable double bond; (ii) a polymerization initiator system containing a) an 1,2-diketone photoinitiator compound having a light absorption maximum in the range from 300 to 500 nm; and b) a coinitiator compound; (iii) a stabilizer of the following formula (i) and/or (ii), wherein the rs, which may be the same or different, independently represent a branched c3-8 alkyl or alkenyl group, or a c3-8 cycloalkyl or cycloalkenyl group, r′ represents a hydrogen atom, a c1-6 alkyl or c2-6 alkenyl group, or a c1-6 fluoroalkyl or c2-6 fluoroalkenyl group, x represents a group selected from a c1-8 alkyl group or a c3-8 cycloalkyl group, and n is 0, 1 or 2; and a solvent mixture comprising an organic solvent and at least 1 percent by weight of water based on the total weight of the aqueous dental composition.. ... Corel Corporation

08/09/18 / #20180221245

Tablet press

The invention concerns a tablet press (10) which is typically portable and comprises a base (12) and a press member (24) held relative to the base by a spacer (20). The base (12) comprises a die (38b) for receiving a powder in use, wherein the spacer (20) depends from the base and is moveable relative thereto under the control of an actuator (28) such that the press member (24) is reversibly actuable between an at-rest condition in which the press member is spaced from the die and an actuated condition in which the press member is located in the die so as to apply a load to a powder therein so as to compact the powder into a tablet. ... Corel Corporation

08/09/18 / #20180221236

Path calculator for users with mobility limitations

Method, system, and computer program product for providing turn-by-turn directions to mobility impaired individuals. Movement of users associated with certain mobility classes are tracked to determine when the users deviate from certain geographical features, such as sections of sidewalk. ... Corel Corporation

08/09/18 / #20180221231

Device for detecting the position of movable operating table components

A device for detecting the position of movable operating table components that has a multilayer sensor film that is attached to a first operating table component; a slider that is mounted on a second operating table component which is movable relative to the first operating table component, the slider being equipped with a pressure piece that elastically compresses the multilayer sensor film; and -n electrical circuit, which generates a signal in accordance with the position of the pressure piece on the sensor film. . ... Corel Corporation

08/09/18 / #20180221224

Dual deployment ramp

The present disclosure provides dual deployment ramps (and related ramp systems) for a vehicle, the ramps comprising a ramp assembly, the ramp assembly comprising a mid-panel and a first and second end-panel, the end-panels pivotably attached to opposite ends of the mid-panel; a slide cable comprising a first and second end, the first end engaging the first end-panel and the second end engaging the second end-panel; opposing roller plate assemblies comprising one or more pulleys for engagement of the slide cable, the roller plate assemblies positioned below the ramp assembly and at each end thereof below the respective first and second end-panel; and a cable drum assembly positioned below the ramp assembly and between the opposing roller plate assemblies, the cable drum assembly comprising a cable drum engaging the slide cable to provide reversible movement to the slide cable for pulling one of the first and second end-panels to move the ramp assembly in one of opposing directions for providing dual deployment. The present disclosure also provides vehicles comprising the ramps and ramp systems described herein.. ... Corel Corporation

08/09/18 / #20180221223

Urinary incontinence device for animals

A urinary incontinence device for animals comprising a main panel with a first wing, center section, second wing, and crotch section that are laterally allied to form a single rectangular shape. The wings, center section and crotch section are comprised of three layers of fabric cut from the same pattern, including an outer waterproof cover, an intermediate absorbent layer, and an inner wicking layer. ... Corel Corporation

08/09/18 / #20180221214

Bonding apparatus and method

The present disclosure relates to methods and apparatuses for mechanically bonding substrates together. The apparatuses may include a pattern roll including a pattern element protruding radially outward. ... Corel Corporation

08/09/18 / #20180221207

Devices for filtering sound and related methods

A sound-filtering device can include an entry port that receives sound from an environment when the device is coupled to an ear of a user. The device can further include an exit port that delivers sound that has passed through the device to the ear of the user. ... Corel Corporation

08/09/18 / #20180221188

Orthotic appliance with continuously adjustable positioning of corrective elements

A wearable orthotic appliance to which at least one corrective element for correcting neuromuscular imbalances may be removably attached is made of fabric assembly held in compressive tension when worn by a user, the fabric assembly including a cavity or chamber into which the corrective element may be placed and secured at any of a plurality of continuously-adjustable positions. Maintenance of the corrective element position during use of the appliance may be assisted by establishing a compression gradient over selected areas of the appliance during assembly. ... Corel Corporation

08/09/18 / #20180221186

Gastric obstruction device deployment assembly and methods of delivering and deploying a gastric obstruction device

The present invention relates to gastric obstruction device deployment systems and a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal occluding member connected to a distal occluding member by a tether. The proximal occluding member is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. ... Corel Corporation

08/09/18 / #20180221181

Stent

The invention relates to a stent for transluminal implantation in hollow organs, in particular in blood vessels, ureters, esophagi, colons, duodena, or bile ducts, comprising a substantially tubular body, which can be transferred from a compressed state having a first cross-sectional diameter into an expanded state having an enlarged second cross-sectional diameter, wherein the stent comprises a plurality of cells, which are defined by bordering elements formed by the tubular body. The stent is distinguished in that some of the cells are extended in the longitudinal direction of the stent in comparison with the remaining cells in order to form a slanted end face of the stent.. ... Corel Corporation

08/09/18 / #20180221179

Adjustable socket system

An adjustable socket system includes a plurality of shell components and longitudinal supports connected to a base and is movable between an open configuration to loosen the fit of the adjustable socket system, and a closed configuration to secure the fit of the adjustable socket system on residual limb received therein. A tightening system includes a tensioning unit having a handle defining a moment arm rotatable about a rotation axis, and a tensioning element operatively coupled to the handle via a movable connection point and to the shell components via a control point. ... Corel Corporation

08/09/18 / #20180221176

Prosthetic device, system and method for increasing vacuum attachment

A prosthetic system includes a prosthetic valve having a valve body with a shaft defining a flow channel fluidly connectable to an interior of a socket. One or more ports in the valve body are in fluid communication with the flow channel and a membrane is positioned in the valve body. ... Corel Corporation

08/09/18 / #20180221154

Method and device for reducing implant contamination from handling

An orthopedic implant has a removable handling cover coupled thereto which includes a thin-walled layer extending over a grasping portion of the outer surface. An outer container can sealingly house the orthopedic implant within a sterile environment and support the orthopedic implant in an orientation that presents the handling cover for grasping. ... Corel Corporation

08/09/18 / #20180221153

Bendable graft containment cage

A bone graft containment device includes a plurality of cage segments connected to one another along a longitudinal axis, each of the cage segments connected to an adjacent one of the cage segments via a connection which permits movement of the cage segments relative to one another so that the bone graft containment device is deformable to a desired configuration for placement within a target space of a bone, each cage segment extending along from a first end to a second end and including a channel extending therethrough so that channels of the plurality of cage segments, in an initial configuration, are aligned along the longitudinal axis, the channels configured to be packed with a bone graft material.. . ... Corel Corporation

08/09/18 / #20180221152

Bendable graft containment cage

A bone graft containment device includes a plurality of cage segments connected to one another along a longitudinal axis, each of the cage segments connected to an adjacent one of the cage segments via a connection which permits movement of the cage segments relative to one another so that the bone graft containment device is deformable to a desired configuration for placement within a target space of a bone, each cage segment extending along from a first end to a second end and including a channel extending therethrough so that channels of the plurality of cage segments, in an initial configuration, are aligned along the longitudinal axis, the channels configured to be packed with a bone graft material.. . ... Corel Corporation

08/09/18 / #20180221138

Accommodating intraocular lens (aiol) assemblies, and discrete components therefor

Accommodating intraocular (aiol) assemblies for enabling post implantation in situ manual selective displacement of an aiol along a human eye's visual axis relative to stationary anchor points. Axial displacement may be over a continuous range or alternatively at discrete axial stopping positions typically from about 100 μm to about 300 μm apart. ... Corel Corporation

08/09/18 / #20180221136

Cover device and method of applying cover device for constructing and protecting a nipple/areola complex

A cover device may include a body with an inner surface and an outer surface, each of the inner surface and the outer surface extending from a first end face of the body to a second end face of the body. The inner surface may define a channel extending through the body from the first end face to the second end face. ... Corel Corporation

08/09/18 / #20180221132

Artificial blood vessel, method for producing artificial blood vessel, and method for producing porous tissue regeneration substrate

The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel. ... Corel Corporation

08/09/18 / #20180221125

Device to be fitted in the mouth in order to isolate a dental area, facilitating correct dental treatment

The invention relates to a device which is inserted into the mouth so as to isolate the dental part or area of the mouth to be treated, allowing improved vision, preventing the cheek and the tongue from impinging on the working area, and protecting the tissues of the patient from the dental instruments. Furthermore, the sucking capacity of the device prevents the saliva or any other fluid generated during the treatment from affecting both vision and the performance of a correct technique for carrying out the dental treatment.. ... Corel Corporation

08/09/18 / #20180221124

Dental treatment appliance

A dental treatment appliance includes a handle, a nozzle for engaging the teeth of the user and for delivering a burst of working fluid to the teeth of a user, and a datum component also for engaging the teeth of the user. Each of the nozzle and the datum component is moveable relative to the handle. ... Corel Corporation

08/09/18 / #20180221120

Colored translucent zirconia sintered body and powder, and use thereof

A zirconia sintered body is provided having a color tone equivalent to the color tone guides of various natural teeth and having the same aesthetics as a natural front tooth. The present invention provides a colored translucent zirconia sintered body comprising zirconia containing greater than 4.0 mol % and not greater than 6.5 mol % of yttria, less than 0.25 mol % of erbia, less than 2,000 ppm of iron oxide in terms of fe2o3, less than 0.01 wt. ... Corel Corporation

08/09/18 / #20180221118

Multi sectional dental zirconia milling block, process of production and use thereof

The invention relates to a porous dental milling block comprising at least two geometrically defined material sections a and b, material section a comprising a tetragonal zirconia crystal phase in an amount a-t in % and a cubic zirconia crystal phase in an amount a-c in %, material section b comprising cubic zirconia crystal phase in an amount b-t in % and cubic zirconia crystal phase in an amount b-c in %, wherein (amount of tetragonal phase a-t in %)/(amount of cubic phase content a-c in %)>1 and (amount of tetragonal phase content b-t in %)/(amount of cubic phase content b-c in %)<1. The invention also relates to a process of production of the porous dental milling block and its use for producing a dental article.. ... Corel Corporation

08/09/18 / #20180221114

Orthodontic bracket assemblies with torque-adjusting drums

Orthodontic bracket assemblies with torque-adjusting drums. The drum defines at least a majority of the archwire slot of the corresponding bracket assembly, and the drum may be selectively rotated about its longitudinal axis to adjust the prescriptive force that is applied to a patient's tooth during orthodontic use of the bracket assembly. ... Corel Corporation

08/09/18 / #20180221113

Hybrid orthodontic archwires

Hybrid orthodontic archwire designs are disclosed. Hybrid archwires may have bracket-archwire sections and interproximal archwire sections in which each section can vary in cross-section shape, size, and/or material properties. ... Corel Corporation

08/09/18 / #20180221109

Multi-drilling guide device for implantation

The present disclosure relates to a multi drilling guide device for operating an implant. By way of example, the multi drilling guide device includes: a rod extending in a longitudinal direction; a fixing portion combined with one end of the rod and having a drill hole penetrating therethrough; and a guide portion coupled to the rod so as to be movable and rotatable along the rod and having a guide hole.. ... Corel Corporation

08/09/18 / #20180221108

Surgical marker element, surgical referencing unit, and surgical navigation system

The invention relates to a marker element, in particular a medical or surgical marker element, for a referencing unit of a navigation system, which marker element is configured to be reflective to electromagnetic radiation, further comprising a layer comprising a multitude of retroreflective elements. An improved referencing unit and an improved navigation system are also provided.. ... Corel Corporation

08/09/18 / #20180221101

Curved cannula surgical system control

A robotic system includes a master device and a slave manipulator configured to support an instrument. The instrument includes an instrument shaft having a proximal end and a distal end, and an end effector coupled to the distal end. ... Corel Corporation

08/09/18 / #20180221098

Surgical robotic systems with target trajectory deviation monitoring and related methods

A method may be provided to operate a surgical robotic system including a robotic arm configured to position a surgical end-effector with respect to an anatomical location of a patient. Position information may be received where the position information is generated using a sensor system remote from the robotic arm and remote from the patient. ... Corel Corporation

08/09/18 / #20180221097

Methods of using a robotic spine system

A method of using a robotic guidance system for performing surgery on a spine is provided. The method includes utilizing a computerized tomographic scan image of a location on a spinal column of a patient, such that the computerized tomographic scan image is connected to a computer and visible on a monitor connected to the computer. ... Corel Corporation

08/09/18 / #20180221096

Methods, systems, and devices for causing end effector motion with a robotic surgical system

Various exemplary methods, systems, and devices for causing end effector motion with a robotic surgical system are provided. In general, a surgical tool can be configured to releasably and removably couple to a robotic surgical system. ... Corel Corporation

08/09/18 / #20180221093

Systems and methods for soft tissue navigation

There are provided systems and methods for soft tissue navigation. A sensor unit provides tracking information to determine positional data for a patient's structural anatomy and gravity direction measurements to determine a direction of gravity relative to the anatomy. ... Corel Corporation

08/09/18 / #20180221084

Device for laparoscopic surgery

A surgical device which combines cautery and tissue debris conveyance via a combination of suction and an archimedes screw, the cautery electrode encased within the archimedes screw, the device comprising a device body housing a motor for rotating the screw, a cannula having an aperture for exposing an instrument, extending from the body portion, and a connector system operatively associated with the body portion, the connector system organized to provide pre-determined relative locations of connection for operably connecting the cannula, a cautery electrode and an archimedes screw to the device body such the cautery electrode tip is positionable outside the aperture of the cannula and the archimedes screw is disposed within the cannula in a position for conveying tissue entering the cannula via suction.. . ... Corel Corporation

08/09/18 / #20180221082

Rf fractional device for treatment inside of natural openings

The invention relates to a device for medical treatment to restore shape and enhance functionality of body related to the natural opening structure.. . ... Corel Corporation

08/09/18 / #20180221081

Surgical instrument with interchangeable micro-tips

A surgical instrument includes a housing, a shaft extending from the housing, and an end effector assembly that is disposed at a distal end of the shaft. The end effector assembly includes a tubular portion, a connection arm, and a toolbox. ... Corel Corporation

08/09/18 / #20180221076

Surgical forceps and methods of manufacturing the same

A forceps includes a shaft defining first opposed distal recesses, a drive bar slidably disposed within the shaft and defining second opposed distal recesses, and an end effector assembly including first and second jaw members. Each jaw member defines a proximal flange and a distal jaw body. ... Corel Corporation

08/09/18 / #20180221067

Divergent, biplanar and segmental plate for bone fixation

Provided is a bone fixation plate, which is based on a divergent, biplanar and segmental concept which consists in the use of self-stable screws with a divergent biplanar arrangement by segments, wherein each segment is composed by self-stable screws which diverge certain degrees to each other, ending thereby located on different fixation planes. Thus, the divergent biplanar fixation favors the stability in relation to torsional loads in locked systems, since unlike the fixation with cortical screws where the bone helps to support the loads by having an implant-bone contact, when self-stable screws are used the loads are transmitted in the interface between them and the implant, being very prone to “cutting out” and the fracture of the screws when these are located in only one fixation plane.. ... Corel Corporation

08/09/18 / #20180221066

Active fracture compression implants

An assembly and method are disclosed. The assembly includes an orthopaedic implant and an active compression member. ... Corel Corporation








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