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Cornell University patents


Recent patent applications related to Cornell University. Cornell University is listed as an Agent/Assignee. Note: Cornell University may have other listings under different names/spellings. We're not affiliated with Cornell University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Cornell University-related inventors


Microfluidic body-on-a-chip device and methods of use thereof

A microfluidic device includes a base comprising a chamber configured to receive a microfluidic component. A sealing member includes a body, an inlet reservoir, and an outlet reservoir, where the inlet reservoir and the outlet reservoir communicate with the chamber through fluid passages when the sealing member and base are removably coupled. ... Cornell University

Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes

The present invention relates to methods and devices for identifying and quantifying, including low abundance, nucleotide base mutations, insertions, deletions, translocations, splice variants, mirna variants, alternative transcripts, alternative start sites, alternative coding sequences, alternative non-coding sequences, alternative splicings, exon insertions, exon deletions, intron insertions, or other rearrangement at the genome level and/or methylated nucleotide bases.. . ... Cornell University

Methods of treating metabolic syndrome related cconditions using retinoic acid receptor agonists

This invention relates to pharmaceutical compositions and methods for treating (including managing) or preventing metabolic syndrome related conditions using one or more rar e.g., rar agonists. Such conditions include, but are not limited to, diseases in pancreas, liver, kidney, testes, muscle, or adipose tissue, as well as other organs that are associated with high fat diet and/or vitamin a deficiency, as well as other conditions associated with abnormal level of triglyceride, cholesterol and/or glucose.. ... Cornell University

Solid-state three-dimensional battery assembly

A solid-state three-dimensional battery assembly includes a solid bicontinuous monolithic carbon anode, a solid electrolyte layer, and a solid cathode. The solid monolithic carbon anode has an ordered three-dimensionally continuous network nanostructure, a length of at least 100 nm, and an average thickness of 3 to 90 nm. ... Cornell University

Cosmetic compositions containing quinones and their topical use on skin and hair

Described are compositions containing quinones that show activity in enhance dna repair and/or prevent damage to dna and/or upregulate genes associated with wound healing. The quinones are thymoquinone, lapachol, myrtucommulone c, or mixtures thereof, and can be formulated into cosmetic compositions for topical administration to a subject in need thereof. ... Cornell University

Yolk-shell nanoparticle, method and applications

A nanoparticle and a method for fabricating the nanoparticle utilize a decomposable material yoke located within permeable organic polymer material shell and separated from the permeable organic polymer material shell by a void space. When the decomposable material yoke comprises a sulfur material and the permeable organic polymer material shell comprises a material permeable to both a sulfur material vapor and a lithium ion within a battery electrolyte the nanoparticle may be used within an electrode for a li/s battery absent the negative effects of battery electrode materials expansion.. ... Cornell University

Vaccine for intrauterine disease

Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and compositions are for subcutaneous administration and are provided as veterinary compositions and as articles of manufacture. ... Cornell University

Methods for prognosing and preventing metastatic liver disease

The present invention is directed to a method for identifying an individual who is at risk for developing metastatic liver disease that involves measuring, in a sample isolated from the individual, exosomal levels of one or more markers of metastatic liver disease. Kits for carrying out this method are also disclosed. ... Cornell University

Methods for diagnosing and treating follicular lymphoma

The invention relates generally to methods for diagnosis and treatment of follicular lymphoma or diffuse large b cell lymphoma. Specifically, the invention relates to detecting a lysine (k)-specific methyltransferase 2d (kmt2d) alteration to diagnose or treat follicular lymphoma or diffuse large b cell lymphoma.. ... Cornell University

Dipeptidomimetics as inhibitors of human immunoproteasomes

The compounds of the present invention are represented by the following compounds having formula i, where the substituents r1, r4, l, m, x, y, and s are as defined herein. The compounds of the present invention are also represented by the following compounds having formula (ia), formula (ib), or formula (ic), where the substituents r1-r4, rx, ry, x, y, and s are as defined herein. ... Cornell University

Charged nanofibers and methods for making

. . Described herein are nanofibers and methods for making nanofibers that include any one or more of (a) a non-homogeneous charge density; (b) a plurality of regions of high charge density; and/or (c) charged nanoparticles or chargeable nanoparticles. In one aspect, the present invention fulfills a need for filtration media that are capable of both high performance (e.g., removal of particle sizes between 0.1 and 0.5 μm) with a low pressure drop, however the invention is not limited in this regard.. ... Cornell University

Androgen suppression, prostate-specific membrane antigen and the concept of conditionally enhanced vulnerability

Disclosed are methods of enhancing prostate cancer vulnerability to an anti-psma targeted therapy by administering an anti-androgen therapy to a subject so that the prostate cancer vulnerability in the subject is enhanced 2-4 weeks after the administration of the anti-androgen therapy and then administering to the subject an antibody or antigen binding fragment thereof that is capable of binding to the extracellular domain of psma after the prostate cancer vulnerability is enhanced. The anti-androgen therapy can be a hormonal therapy or surgical castration. ... Cornell University

Polysaccharide-based hydrogels and hybrid hydrogels and precursors thereof, methods of making same, and uses thereof

Hydrogels and hybrid hydrogels, methods of making the hydrogels/hybrid hydrogels, and methods of using the hydrogels/hybrid hydrogels. The hydrogels have polysaccharide moieties (e.g., chitosan or hyaluronic acid moieties). ... Cornell University

Compounds for inducing anti-tumor immunity and methods thereof

Described herein is a previously unknown function of xbp1 in controlling anti-tumor immunity. It is shown that inhibiting xbp1 in tumor-associated dendritic cells inhibits tumor growth and induces protective anti-tumor immune responses.. ... Cornell University

07/12/18 / #20180196246

Hyperspectral multiphoton microscope for biomedical applications

Optical sensing techniques and devices based on detection of fluorescent emissions at different optical wavelengths by nonlinear optical absorption of different excitation beams at different excitation wavelengths that interact with fluorescently-labeled structures within the sample to cause nonlinear optical absorption of two or more photons at each excitation wavelength. The fluorescent light at different fluorescent emission wavelengths by nonlinear optical absorption of excitation light at a particular excitation wavelength is spectrally separated into different optical channel output beams along different optical channel optical paths at different designated fluorescent imaging wavelength bands and the fluorescent light at different fluorescent imaging wavelengths within each designated fluorescent imaging wavelength is detected. ... Cornell University

07/12/18 / #20180196041

Device and method for point-of-care diagnostics and antibiotic resistance identification, and applications thereof

A device for detecting the presence of a target in a sample including a first port configured to receive a multi-layered substrate having a sample inlet and a reagent inlet. The sample inlet is connected to a first microfluidic channel and the reagent inlet is connected to both the first microfluidic channel and a second microfluidic channel. ... Cornell University

07/12/18 / #20180195077

Methods of enhancing translation ability of rna molecules, treatments, and kits

The present invention relates to methods and a kit for enhancing the translation ability of an rna molecule. The methods involve the use of an rna molecule comprising a methylated adenosine residue in a 5′ untranslated region (utr). ... Cornell University

07/05/18 / #20180188454

Fiber-waveguide evanescent coupler

Methods, systems, and devices are disclosed for implementing a fiber-waveguide evanescent coupling. In one aspect, a device having integrated photonic components includes a substrate, a waveguide formed on the substrate to include a terminal waveguide portion that terminates at one side of the substrate, and a fiber including a fiber core and fiber cladding surrounding the fiber core, in which at least a portion of the fiber cladding is removed at or near a fiber terminal end to enable optical evanescent coupling via a side surface of the fiber core at the or near the fiber terminal end, the fiber core at the or near the fiber terminal end is placed over the one side of the substrate to be above and to overlap with the terminal waveguide portion of the waveguide to enable optical evanescent coupling via side surfaces of the fiber core and the waveguide.. ... Cornell University

06/28/18 / #20180180969

Generation of high energy mid-infrared continuum laser pulses

In one aspect, a method is provided for generating supercontinuum laser pulses within a continuous mid-infrared spectral range in a chalcogenide material. This method includes focusing an input laser beam of femtosecond pulses with a pulse energy higher than 10 microjoule along an optical path of the input laser beam; placing a chalcogenide material at a selected location along the optical path of the laser beam so that the laser intensity at the chalcogenide material is sufficiently high to cause nonlinear optical absorption that causes conversion of input optical energy into supercontinuum laser pulses of a pulse energy at or above a microjoule level at optical wavelengths within a broad continuous mid-infrared spectral range without damaging the chalcogenide material; and simultaneously moving the chalcogenide material laterally relative to the input laser beam to avoid damage to the chalcogenide material.. ... Cornell University

06/28/18 / #20180177840

Methods for prevention and treatment of acute renal injury

The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. ... Cornell University

06/21/18 / #20180169264

Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis

Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. ... Cornell University

06/14/18 / #20180166681

Sulfur containing nanoporous materials, nanoparticles, methods and applications

Sulfur containing nanoparticles that may be used within cathode electrodes within lithium ion batteries include in a first instance porous carbon shape materials (i.e., either nanoparticle shapes or “bulk” shapes that are subsequently ground to nanoparticle shapes) that are infused with a sulfur material. A synthetic route to these carbon and sulfur containing nanoparticles may use a template nanoparticle to form a hollow carbon shape shell, and subsequent dissolution of the template nanoparticle prior to infusion of the hollow carbon shape shell with a sulfur material. ... Cornell University

06/14/18 / #20180164432

Computation devices and artificial neurons based on nanoelectromechanical systems

Techniques, systems, and devices are described for implementing for implementing computation devices and artificial neurons based on nanoelectromechanical (nems) systems. In one aspect, a nanoelectromechanical system (nems) based computing element includes: a substrate; two electrodes configured as a first beam structure and a second beam structure positioned in close proximity with each other without contact, wherein the first beam structure is fixed to the substrate and the second beam structure is attached to the substrate while being free to bend under electrostatic force. ... Cornell University

06/14/18 / #20180162045

3d printing of rolled materials

A shape can be 3d printed by advancing a continuous length of material past a cutting head, cutting the material along one or more paths, providing adhesive on a surface of the material, and spirally winding the material onto a spool, such that the cut paths on each layer of the spiral are in alignment according to the 3d printed shape. A 3d printing system includes a material infeed configured to provide a supply of sheet material, a cutting head for cutting the material, a glue applicator, and a gathering spindle configured to rotate such that the material is spirally wound onto the spindle.. ... Cornell University

06/07/18 / #20180156979

Photonic chips based on multimode fiber-to-waveguide coupling

Optical coupling designs are disclosed to provide a photonic device, for example, that includes a substrate; an optical waveguide formed on the substrate and configured as a multimode waveguide to support light in different optical waveguide modes; and an optical fiber structured as a multimode fiber to support light in different optical fiber modes, the optical fiber located above the optical waveguide and optically coupled to the optical waveguide via evanescent coupling to allow light to be coupled between the optical fiber and the optical waveguide.. . ... Cornell University

06/07/18 / #20180156204

System and methods for fabricating actuators and electrically actuated hydraulic solid materials

With applications such as soft robotics being severely hindered by the lack of strong soft actuators, the invention provides a new soft-actuator material—electrically actuated hydraulic solid (eahs) material—with a stress-density that outperforms any known electrically-actuatable material. One type of actuator is fabricated by making a closed cell that acts as highly paralyzed version of a standard paraffin actuator. ... Cornell University

05/24/18 / #20180140048

Adjustable shoe and method for adjusting a shoe

An adjustable shoe includes an outsole having a middle portion hingedly attached to a forefoot portion and a heel portion. A segmented driveshaft spans from the forefoot portion of the outsole to the heel portion. ... Cornell University

05/17/18 / #20180133346

Ultrasmall nanoparticles and methods of making and using same

An aqueous synthesis methodology for the preparation of silica nanoparticles (snps), core-shell snps having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. At the level of a single atomic layer. ... Cornell University

05/17/18 / #20180133184

Method for treating idiopathic pulmonary fibrosis

Aspects of the disclosure relate to a method for treating idiopathic pulmonary fibrosis (ipf) in a patient with n-acetylcysteine (nac) comprising administering nac to a patient after a sample from the patient has been genotyped and determined to be any one of: a) homozygous or heterozygous for a thymine at the single nucleotide polymorphism rs3750920; b) homozygous or cheterozygous for guanine at the single nucleotide polymorphism rs5743894; or c) homozygous or heterozygous for thymine at the single nucleotide polymorphism rs35705950.. . ... Cornell University

05/10/18 / #20180131504

Method of non-uniform wavelet bandpass sampling

A compressed sensing method based on non-uniform wavelet bandpass sampling. A k-sparse signal of interest is projected onto a sequence of waveforms succeeding one another at the bandpass sampling rate, the waveforms belonging to an overcomplete dictionary, the parameters of the waveforms depending on the characteristics of the bands of the signal. ... Cornell University

05/10/18 / #20180130999

Lithium containing nanofibers

Lithium-containing nanofibers, as well as processes for making the same, are disclosed herein. In some embodiments described herein, using high throughput (e.g., gas assisted and/or water based) electrospinning processes produce nanofibers of high energy capacity materials with continuous lithium-containing matrices or discrete crystal domains.. ... Cornell University

05/03/18 / #20180123114

Lithium metal anode comprising langmuir-blodgett films as an artificial solid electrolyte interface layer, lithium metal battery comprising the same, and preparation method thereof

Provided is a lithium metal anode comprising a langmuir-blodgett films as an artificial solid electrolyte interface layer, a lithium metal battery comprising the same, and a preparation method thereof. Various ultra-thin film layers made of carbon and ceramic are formed on the surface of the lim to serve as a stable artificial sei layer and suppress formation and perforation of lithium dendrite and side reactions.. ... Cornell University

05/03/18 / #20180119334

Modified cellulosic compositions having increased hydrophobicity and processes for their production

The disclosure provides a composition comprising a modified cellulosic surface having aliphatic fatty acid molecules and amine-silica particles that are covalently bonded to cellulose fibers of the cellulosic surface. Also disclosed is a composition comprising a modified cellulosic surface including low surface energy molecules and amine functionalized nanotubes decorated with silica nanoparticles that are covalently bonded to cellulose fibers of the cellulosic surface. ... Cornell University

05/03/18 / #20180119313

Carbonaceous metal/ceramic nanofibers

Provided herein are nanofibers and processes of preparing carbonaceous nanofibers. In some embodiments, the nanofibers are high quality, high performance nanofibers, highly coherent nanofibers, highly continuous nanofibers, or the like. ... Cornell University

05/03/18 / #20180116928

Cosmetic compositions containing quinones and their topical use on skin and hair

Described are compositions containing quinones that show activity in enhance dna repair and/or prevent damage to dna. The quinones are thymoquinone, lapachol, myrtucommulone c, or mixtures thereof, and can be formulated into cosmetic compositions for topical administration to a subject in need thereof. ... Cornell University

04/19/18 / #20180104304

Methods for preventing or treating metabolic syndrome

The invention provides methods of preventing or treating metabolic syndrome in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.. ... Cornell University

04/12/18 / #20180100903

Systems and methods for mr microscopy analysis of resected tissue

The present disclosure discusses systems and methods for imaging tissue. The system can reduce the amount of vibrations that are transmitted from a magnetic resonance imaging device to a tissue sample. ... Cornell University

04/12/18 / #20180100178

Direct assay for allosteric modulators of glutaminase

The present technology relates to gls proteins that have a phenylalanine to tryptophan substitution at the position corresponding to residue 322 of human gac, and methods of using such proteins to screen for compounds that bind to the activation loop of gls and/or modulate glutaminase activity of gls.. . ... Cornell University

04/05/18 / #20180093252

Porous cyclodextrin polymeric materials and methods of making and using same

. . A nucleophilic substitution reaction to crosslink cyclodextrin (cd) polymer with rigid aromatic groups, providing a high surface area, mesoporous cd-containing polymers (p-cdps). The p-cdps can be used for removing organic contaminants from water. ... Cornell University

03/29/18 / #20180089493

Machine vision with dimensional data reduction

A method is described that includes receiving raw image data corresponding to a series of raw images, and processing the raw image data with an encoder of a processing device to generate encoded data. The encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of at least one retinal cell of a vertebrate retina. ... Cornell University

03/29/18 / #20180088120

Elevated psma identifies lethal prostate cancers

Prostate cancer (pc) is an entity that encompasses different types of tumors, including adenocarcinomas and non-adenocarcinomas. Adenocarcinomas and non-adenocarcinomas respond to, and therefore should be treated, with different treatments. ... Cornell University

03/29/18 / #20180087043

Hierarchical magnetic nanoparticle-enzyme mesoporous assemblies embedded in macroporous scaffolds

A hierarchical catalyst composition comprising a continuous or particulate macroporous scaffold in which is incorporated mesoporous aggregates of magnetic nanoparticles, wherein an enzyme is embedded in mesopores of the mesoporous aggregates of magnetic nanoparticles. Methods for synthesizing the hierarchical catalyst composition are also described. ... Cornell University

03/15/18 / #20180072696

Substituted 3-hydroxy-delta-lactones from epoxides

Catalysts and methods for the carbonylation of epoxides to substituted 3-hydroxy-δ-lactones and β-lactones are disclosed.. . ... Cornell University

03/15/18 / #20180071377

Subunit vaccine delivery platform for robust humoral and cellular immune responses

The present invention relates to a probiotic cell transformed with a construct suitable to overexpress and display on the surface of the probiotic cell a fusion protein comprising at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides. Probiotic-derived vesicles displaying this fusion protein as well as methods of inducing an immune response using the probiotic cells or vesicles are also disclosed.. ... Cornell University

03/08/18 / #20180068573

Mindless technologies to subtly influence behavior

Persuasive technologies aim to influence user's behaviors. In order to be effective, many of the persuasive technologies developed so far relies on user's motivation and ability, which is highly variable and often the reason behind the failure of such technology. ... Cornell University

03/08/18 / #20180066037

Transduced t cells expressing human sstr2 and application thereof

The present invention is directed to transduced t cells expressing at least 100,000 molecules of human somatostatin receptor 2 (sstr2), which improves pet/ct imaging sensitivity. The present invention is also directed to transduced t cells expressing sstr2 and chimeric antigen receptor (car). ... Cornell University

03/08/18 / #20180066035

I domain chimeric antigen receptor specific to icam-1

The present invention relates to chimeric antigen receptors (cars) specific to icam-1 comprising i domain of the αl subunit of human lymphocyte function-associated antigen 1 (lfa-1). The invention particularly relates to cars comprising human i domains having different affinities (1 mm to 1 nm kd) to icam-1. ... Cornell University

02/22/18 / #20180051074

Methods to enhance cell-mediated immunity

This disclosure provides a method for enhancing cell-mediated immunity in individuals with disorders such as cancer or infection that involves administering an inhibitor of golph2 to the individuals. For example, inhibition of golph2 increases the endogenous production of il-12.. ... Cornell University

02/08/18 / #20180041166

Device for terahertz signal generation and transmitter

A high-power transmitter with a fully-integrated phase iocking capability is disclosed and characterized. Also provided herein is a thz radiator structure based on a return-path gap coupler, which enables the high-power generation of the disclosed transmitter, and a self-feeding oscillator suitable for ts use with the transmitter.. ... Cornell University

02/01/18 / #20180033954

Nanosecond-timescale low-error switching of 3-terminal magnetic tunnel junction circuits through dynamic in-plane-field assisted spin-hall effect

The disclosed technology provides various implementations of a device based on a spin hall effect (she) and spin transfer torque (stt) effect. In one aspect, a device is provided to include a magnetic structure including a ferromagnetic layer having a magnetization direction that can be changed by spin transfer torque; a she layer that is electrically conducting and exhibits a spin hall effect to, in response to an applied charge current, generate a spin-polarized current that is perpendicular to the applied charge current, the she layer located adjacent to the ferromagnetic layer to inject the spin-polarized current into the ferromagnetic layer; a first electrical contact in contact with the magnetic structure; a second electrical contact in contact with a first location of the she layer; a third electrical contact in contact with a second location of the she layer so that the first and second locations are on two opposite sides of the magnetic structure; a magnetic structure circuit coupled between the first electrical contact and one of the second and third electrical contacts to supply a current or a voltage to the magnetic structure; and a charge current circuit coupled between the second and third electrical contacts to supply the charge current into the she layer, wherein the device is operable at a low write error rate with pulses of a pulse duration of around 2 ns or shorter to switch a direction of the magnetization direction of the ferromagnetic layer in the magnetic structure.. ... Cornell University

02/01/18 / #20180028615

Compositions and methods using il-8 to improve milk production and reproductive health in mammals

The present disclosure provides compositions and methods for improving reproductive health of mammals and increasing milk production from female mammals. The methods involve administering an effective amount of il-8 to a female mammal such that the reproductive health of the mammal is improved, or milk production from the mammal is increased, or the fat content of the milk is increased. ... Cornell University

01/18/18 / #20180016612

Method for rapid in vitro synthesis of bioconjugate vaccines via recombinant production of n-glycosylated proteins in prokaryotic cell lysates

Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. ... Cornell University

01/04/18 / #20180004061

Thin film plasmonic optical modulator

A plasmon-based optical modulator comprises a substrate, a layer of high reflectivity material disposed over the substrate, a relatively thin dielectric layer disposed over a top major surface of the layer of high reflectivity material and a plurality of graphene strips disposed in parallel across a top major surface of the relatively thin dielectric layer, each graphene strip exhibiting a predetermined width w, with adjacent strips separated by a predetermined spacing s. A first electrical contact is coupled to the plurality of graphene strips and a second electrical contact is coupled to the layer of high reflectivity material, where the values of w, s, and voltage applied between the first and second electrical contacts determines a resonant wavelength of the plasmon-based optical modulator, with changes in the applied voltage changing between absorption and non-absorption of an applied optical input signal.. ... Cornell University

01/04/18 / #20180003608

Mems microtensiometer

A device for measuring a chemical potential of a fluid in a plant tissue includes a cavity disposed within a sensor body as a liquid reservoir. The cavity is configured for containing therein a liquid, and the cavity including at least one opening. ... Cornell University

12/07/17 / #20170352027

Authenticated data feed for blockchains

. . . . An apparatus in one embodiment comprises a processing platform having at least one processing device. The processing platform implements a trusted bridge configured for at least temporary coupling between one or more data sources and a smart contract program of a blockchain. ... Cornell University

12/07/17 / #20170350809

Integrated optofluidic system using microspheres

An integrated optofluidic system for trapping and transporting particles for analysis is provided comprising a planar substrate; a microfluidic channel; and a waveguide integrated with the channel. A microsphere particle in the integrated optofluidic system can act as a cavity, allowing light to circulate many thousands of times around the circumference of the microsphere. ... Cornell University

11/30/17 / #20170342447

Methods of and systems for producing caprylic acid and/or caprylate

Methods and systems to produce product compositions comprising caprylate products using chain-elongating bacteria. For example, the caprylate product in the product composition is n-caprylic acid (c8) and the n-caprylic (c8) to n-caproic (c6) acid ratio is higher than 1:1. ... Cornell University

11/30/17 / #20170342097

Methods and compositions to treat type-1 and type-2 diabetes

The present disclosure is directed to novel methods of treating type-1 or type-2 diabetes by inactivating tlr2 and tlr4 genes together in cells capable of producing insulin and/or regenerating β cells, and providing the cells to a subject in need thereof.. . ... Cornell University

11/23/17 / #20170335061

Isotactic polyethers and bimetallic catalysts, methods of making same, and uses thereof

Provided are compositions comprising isotactic polyethers. Methods of making isotactic polyethers, and uses thereof are also disclosed. ... Cornell University

11/16/17 / #20170327649

Films derived from two or more chemically distinct block copolymers, methods of making same, and uses thereof

Methods of making blended, isoporous, asymmetric (graded) films (e.g. Ultrafiltration membranes) comprising two or more chemically distinct block copolymers and blended, isoporous, asymmetric (graded) films (e.g. ... Cornell University

11/16/17 / #20170325520

Thermochromic apparel for detecting physical exhaustion and process for preparation thereof

The present invention relates to a thermochromic garment comprising a thermochromic pigment. The present invention also relates to a process for making a thermochromic garment comprising a thermochromic pigment. ... Cornell University

10/26/17 / #20170304499

Injectable peripheral nerve specific hydrogel

The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following surgical reconstruction.. . ... Cornell University

10/12/17 / #20170290953

Composite tissue-engineered intervertebral disc with self-assembled annular alignment

. . The present invention relates to a tissue-engineered intervertebral disc (ivd) suitable for total disc replacement in a mammal and methods of fabrication. The ivd comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type i collagen. ... Cornell University

09/28/17 / #20170275399

Anion-coordinating polymer electrolytes and related compositions, methods and systems

. . Anion-coordinating polymers comprising one or more anion-coordinating unit of formula (i), optionally in combination with one or more cation-coordinating unit of formula (ii) and/or a linking unit of formula (iii) and related electrolytes, batteries, methods and system.. . ... Cornell University

09/28/17 / #20170275343

Compositions and methods for making water-soluble integral membrane proteins

The present invention relates to a nucleic acid construct having a chimeric nucleic acid molecule comprising a first nucleic acid moiety encoding an amphipathic shield domain protein; a second nucleic acid moiety encoding an integral membrane protein; and a third nucleic acid moiety encoding a water soluble expression decoy protein, as well as a chimeric nucleic acid molecule having a first nucleic acid moiety encoding an amphipathic shield domain protein and a second nucleic acid moiety encoding an integral membrane protein. The present invention further relates to an expression vector, a host cell, and a protein encoded by the nucleic acid construct. ... Cornell University

09/14/17 / #20170262606

Health monitoring using social rhythms stability

Methods, systems, and devices are disclosed for passively monitoring a health condition of a subject using a mobile device. In some aspects, a method includes producing a set of quantitative metrics based on one or more parameters including location, movement, and sound obtained from the mobile device, where the produced set of quantitative metrics includes a location cluster value, a travel distance value, a frequency of conversation value, and an activity value, each of the quantitative metrics over a respective predetermined time period; and processing the set of quantitative metrics to determine a metric indicative of a current clinical state of the subject in connection with one or more measures including daily routines, mood or energy of the subject. ... Cornell University

09/14/17 / #20170258852

Implantable therapeutic delivery system and methods thereof

The present invention relates to an implantable therapeutic delivery system, methods of treatment utilizing the implantable therapeutic delivery system, and methods of fabricating the implantable delivery system. A first aspect of the present invention is directed to an implantable therapeutic delivery system. ... Cornell University

09/07/17 / #20170255837

Retinal encoder for machine vision

A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data.. . ... Cornell University

09/07/17 / #20170253590

Small molecule ire1-alpha inhibitors

Described herein are ire1α inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.. ... Cornell University

09/07/17 / #20170253493

Dimensionally focused nanoparticle synthesis methodology

A methodology for synthesizing a nanoparticle batch, such as but not limited to a metal chalcogenide nanoparticle batch and further such as but not limited to a metal sulfide nanoparticle batch is predicated upon an expectation and observation that at elevated concentrations of at least one reactant material within a heat-up nanoparticle batch synthesis method, the resulting nucleated batch comprises nanoparticles that may be dimensionally focused to provide a substantially monodisperse nanoparticle batch. The embodied methodology is also applicable to a continuous reactor. ... Cornell University

09/07/17 / #20170252350

Small molecule ire1-alpha inhibitors

Described herein are ire1α in inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.. ... Cornell University

08/31/17 / #20170249426

A system and methods for managing healthcare resources

The present invention is directed to a system and a non-transitory computer readable medium for managing use of hospitalization healthcare resources. Specifically, the embodiments of the invention may accept information from one or more sources, select a population unit, define one or more population units according to enhanced comorbidity, assign one or more values to the one or more population units defined according to enhanced comorbidity, and generate a graphical user interface on which one or more values may be depicted. ... Cornell University

08/31/17 / #20170248937

System and methods for three-dimensional printing

A fast and economical system and methods directed to low-fidelity fabrication of three-dimensional (3d) objects using 3d printing. The invention facilitates rapid prototyping by providing a wireframe structure in the form of the underlying design structure of a 3d model, which may be useful for a variety of reasons including to provide a prototype preview that may be used for design validation of a 3d model.. ... Cornell University

08/31/17 / #20170248584

Identifying status of male fertility by determining sperm capacitation

This disclosure provides a method for determining male fertility status. The method comprises determining gm1 distribution patterns following induced sperm capacitation, identifying the frequency of distribution of various patterns, and determining if the frequency distribution of certain gm1 patterns in response to induced capacitation is altered. ... Cornell University

08/31/17 / #20170247145

A device for delivering odors and methods of using the same

Disclosed herein are kits, devices and methods for promoting, supporting and enhancing olfactory function. The kits of the present disclosure relate to devices for stimulating olfactory function that include odorous pods selected from a group of odors or more than one group of odors, whereby each odorous pod is located in a compartment of a receptacle that can be used to promote, support and enhance an individual's olfactory function. ... Cornell University

08/24/17 / #20170242337

Radiation-sensitive composition and pattern-forming method

A radiation-sensitive composition includes particles including a metal oxide as a principal component, and an organic solvent. A metal atom constituting the metal oxide includes a first metal atom that is a zinc atom, a boron atom, an aluminum atom, a gallium atom, a thallium atom, a germanium atom, an antimony atom, a bismuth atom, a tellurium atom, or a combination thereof. ... Cornell University

08/24/17 / #20170241765

Optical sensing based on measurements of displacements induced by optical forces in viscoelastic media using phase-sensitive optical coherence tomography

A system for providing optical actuation and optical sensing can include an optical coherence tomography (oct) device that performs optical imaging of a sample based on optical interferometry from an optical sampling beam interacting with an optical sample and an optical reference beam; an oct light source to provide an oct imaging beam into the oct device which splits the oct imaging beam into the optical sampling beam and the optical reference beam; and a light source that produces an optical actuation beam comprising a plurality of wavelengths that is coupled along with the optical sampling beam to be directed to the sample to actuate particles or structures in the sample so that the optical imaging captures information of the sample under the optical actuation.. . ... Cornell University

08/24/17 / #20170240903

Modulation of breast cancer growth by modulation of xbp1 activity

Described herein is a previously unknown function of xbp1 in triple-negative breast cancer (tnbc). It is shown that xbp1 is preferentially spliced and activated in tnbc, and that deletion of xbp1 significantly blocks triple negative breast tumor growth. ... Cornell University

08/24/17 / #20170239378

Fluorescent silica-based nanoparticles

The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. ... Cornell University

08/10/17 / #20170226283

Polyester stereocomplexes, compositions comprising same, and methods of making and using same

Compositions comprising stereocomplexes of enantiomeric polymer chains having individual repeat units formed from the reaction of an epoxide and cyclic anhydride. The compositions can be made by mixing two types of enantiomeric polymer chains having opposite absolute stereochemistry. ... Cornell University

08/10/17 / #20170224764

Therapeutic targeting of mitochondria to prevent osteoarthritis

The present technology provides methods of preventing or treating osteoarthritis (oa) and/or post-traumatic osteoarthritis (ptoa). In some embodiments, the methods provide administering aromatic-cationic peptides in effective amounts to treat or prevent cartilage degeneration and/or chondrocyte death such as that found in a subject suffering from, or predisposed to oa or ptoa. ... Cornell University

07/27/17 / #20170214514

Methods and systems for synchronization between multiple clock domains

A synchronization solution is described, which, in one aspect, allowed finer grained segmentation of clock domains on a chip. This solution incorporates computation into the synchronization overhead time and is called gradual synchronization. ... Cornell University

07/27/17 / #20170212679

Oblivious parallel random access machine system and methods

A secure parallel processing technique for converting any parallel random access machine (pram) into an oblivious parallel random access machine (opram), whose distribution of memory accesses is statistically independent of the data (with negligible error), while only inducing a polylogarithmic slowdown to both the total and parallel complexities of the program.. . ... Cornell University

07/27/17 / #20170212103

Method for relative quantification of nucleic acid sequence, expression, or copy changes, using combined nuclease, ligation, and polymerase reactions

The present invention is directed to methods for identifying the presence of one or more target nucleotide sequences in a sample that involve a nuclease-ligation reaction. In some embodiments, the ligation products formed in the nuclease-ligation process of the present invention are subsequently amplified using a polymerase chain reaction. ... Cornell University

07/27/17 / #20170210979

Targeting enhanced production through deep carbonate stimulation: stabilized acid emulions containing insoluble solid materials with desired wetting properties

A stabilized emulsified acid composition for deep carbonate formation stimulation is provided. The stabilized acid emulsion composition includes a petroleum operable to provide a barrier between an acid and a reservoir rock, the acid operable to react with the reservoir rock to dissolve the reservoir rock and produce a wormhole, a functional framework operable to stabilize the stabilized acid emulsion, an emulsifier operable to stabilize the stabilized acid emulsion, and a corrosion inhibitor operable to provide protection against corrosion for the metal components of a well. ... Cornell University

07/20/17 / #20170204459

Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions

The present invention relates to a method for the highly specific, targeted capture of regions of human genomes and transcriptomes from the blood, i.e. From cell free circulating dna, exosomes, microrna, circulating tumor cells, or total blood cells, to allow for the highly sensitive detection of mutation, expression, copy number, translocation, alternative splicing, and methylation changes using combined nuclease, ligation, polymerase, and massively parallel sequencing reactions. ... Cornell University

07/20/17 / #20170202894

Omega-3 fatty acid enrichment of poultry products with defatted microalgae animal feed

The present invention relates to omega-3 fatty acid enrichment, and n-6 to n-3 fatty acid ratio improvement, of poultry products using animal feed supplemented with defatted microalgae, and treatment methods involving such poultry products. One aspect of the present invention relates to a method of producing poultry eggs with elevated amounts of n-3 fatty acids. ... Cornell University

07/20/17 / #20170202887

Probiotic compositions and methods

The present invention relates to probiotic compositions and methods of using such compositions. In particular, the present invention provides method of using faecalibacterium spp. ... Cornell University

07/13/17 / #20170200543

Compact undulator system and methods

An undulator with a compact construction is provided that reduces weight, complexity and cost. The compact undulator system and methods provides mechanical integrity without compromising magnetic field quality.. ... Cornell University

07/06/17 / #20170191193

Process for preparing a silicon-carbon nanocomposite nanofiber

Provided herein are nanofibers comprising carbon precursors, nanofibers comprising carbon matrices, and processes for preparing the same. In specific examples, provided herein are high performance lithium ion battery anodic nanofibers comprising non-aggregated silicon domains in a continuous carbon matrix.. ... Cornell University

07/06/17 / #20170191113

Detection of dna methylation using combined nuclease ligation reactions

The present invention is directed to methods for identifying the presence of one or more methylated or unmethylated target nucleotide sequences in a sample that involve coupled methylation sensitive restriction enzyme digestion-ligation and/or extension processes. In some embodiments, the ligation and primary extension products formed in the reaction processes of the present invention are subsequently amplified using a polymerase chain reaction. ... Cornell University

07/06/17 / #20170191077

Compositions and methods for deterring feeding by psyllids

The invention relates to a plant that includes a transgene encoding a heterologous polypeptide conferring on plant expressing said polypeptide resistance to a hemipteroid sap-sucking insect. The transgene is also expressed in a plant component (such as a leaf). ... Cornell University

06/29/17 / #20170187059

Symmetric redox flow battery containing organic redox active molecule

A redox flow battery comprising: a positive compartment containing a positive electrode in contact with a liquid electrolyte comprised of an organic redox active molecule dissolved in a solvent; a negative compartment containing a negative electrode in contact with a liquid electrolyte comprised of said organic redox active molecule dissolved in a solvent; electrical communication means for establishing electrical communication between said positive electrode, said negative electrode and an external load for directing electrical energy into or out of said symmetric redox flow battery; a separator component that separates the electrolyte solutions in the positive and negative compartments while permitting the passage of non-redox-active species between electrolyte solutions in positive and negative compartments; and means capable of establishing flow of the electrolyte solutions past said positive and negative electrodes, respectively. Methods of using the above-described redox flow battery for storing and releasing electrical energy are also described.. ... Cornell University

06/29/17 / #20170183664

Small rnas (srna) that activate transcription

Disclosed herein are compositions for transcriptional regulation of a target gene, and methods of using the compositions. The compositions utilize a novel antisense rna design that activates transcription of a target gene and involve a sense genetic construct that represses transcription of the target gene, and an antisense construct selected from an antisense activating rna, or an antisense genetic construct encoding an antisense activating rna, that binds to the sense genetic construct rna to relieve repression of the target gene, thus activating expression of the gene.. ... Cornell University

06/29/17 / #20170182358

System and method for training tongue as a treatment for obstructive sleep apnea

The present disclosure describes systems and methods for the treatment of obstructive sleep apnea. The system includes a mouthpiece. ... Cornell University

06/22/17 / #20170179558

Solar flow battery

A solar flow battery comprising: a positive compartment containing at least one positive electrode in contact with a positive electrolyte containing a first redox active molecule; a negative compartment containing at least one negative electrode in contact with a negative electrolyte containing a second redox active molecule, wherein said first and second redox active molecules remain dissolved in solution when changed in oxidation state; at least one of said negative or positive electrodes comprises a semiconductor light absorber; electrical communication means between said electrodes and an external load for directing electrical energy into or out of said solar flow battery; a separator component that separates the positive and negative electrolytes while permitting the passage of non-redox-active species; and means for establishing flow of the positive and negative electrolyte solutions past respective electrodes. Methods of using the solar flow battery for storing and releasing electrical energy are also described.. ... Cornell University

06/22/17 / #20170179532

Dendrite inhibiting electrolytes for metal-based batteries

A metal-based battery includes at least one metal electrode immersed within an electrolyte that includes: (1) an aprotic solvent; (2) a simple halogen containing material; and (3) optionally a metal salt that includes a complex halogen containing anion. The simple halogen containing material may include a metal halide salt that includes a metal cation selected from the group including but not limited to lithium and sodium metal cations. ... Cornell University

06/22/17 / #20170178705

Circuits and devices based on enhanced spin hall effect for efficient spin transfer torque

Devices or circuits based on spin torque transfer (stt) and spin hall effect are disclosed by using a spin hall effect (she) metal layer coupled to a magnetic free layer for various applications. The efficiency or strength of the stt effect based on this combination of she and stt can be enhanced by an interface modification between the she metal layer and the magnetic free layer or by modifying or engineering the she metal layer by doping the she metal with certain impurities or other means.. ... Cornell University

06/22/17 / #20170175297

Reinforcing nanofiber additives

Provided herein are high performance reinforcing nanostructure additives, high throughput processes for using such additives, and composites comprising such additives. Such nanostructure additives include nanofibers, including nanofiber fragments, of various matrix materials, including metal(s) (e.g., elemental metal(s), metal alloy(s), etc.), metal oxide(s), ceramic(s), metal carbide(s), carbon (e.g., carbon nanocomposites comprising carbon matrix with metal component embedded therein), and/or combinations thereof.. ... Cornell University

06/22/17 / #20170175101

Mesoporous catalysts of magnetic nanoparticles and free-radicalproducing enzymes, and methods of use

A composition comprising mesoporous aggregates of magnetic nanoparticles and free-radical producing enzyme (i.e., enzyme-bound mesoporous aggregates), wherein the mesoporous aggregates of magnetic nanoparticles have mesopores in which the free-radical-producing enzyme is embedded. Methods for synthesizing the enzyme-bound mesoporous aggregates are also described. ... Cornell University

06/22/17 / #20170173560

Porous cyclodextrin polymeric materials and methods of making and using same

A nucleophilic substitution reaction to crosslink cyclodextrin (cd) polymer with rigid aromatic groups, providing a high surface area, mesoporous cd-containing polymers (p-cdps). The p-cdps can be used for removing organic contaminants from water. ... Cornell University

06/22/17 / #20170172227

Temperature-regulating garment

A fabric for temperature regulation and a wearable device for regulating a temperature of a wearer are disclosed. The wearable device has a fabric and one or more microtubes woven in the fabric. ... Cornell University

06/22/17 / #20170172174

Process and apparatus for rapid freezing of consumable and non-consumable products using the expansion of dense gas

The present disclosure provides, inter alia, processes and apparatuses for rapid freezing of consumable and non-consumable products. In certain embodiments, the processes and apparatuses of the present disclosure yield the rapidly frozen consumable and non-consumable products using the expansion of dense gas. ... Cornell University

06/15/17 / #20170170785

Scalable terahertz phased array and method

A device and method for terahertz signal generation are disclosed. Oscillators are arranged in a two-dimensional array, each oscillator connected to a corresponding antenna. ... Cornell University

06/15/17 / #20170169899

Piezoelectric and logic integrated delay line memory

Delay line memory device, systems and methods are disclosed. In one aspect, a delay line memory device includes a substrate; an electronic unit disposed on the substrate and operable to receive, amplify, and/or synchronize data signals into a bit stream to be transmitted as acoustic pulses carrying data stored in the delay line memory device; a first and a second piezoelectric transducer disposed on the substrate and in communication with the electronic unit, in which the first piezoelectric transducer is operable to transmit the data signals to the acoustic pulses that carry the data through the bulk of the substrate, and the second piezoelectric transducer is operable to transduce the received acoustic pulses to intermediate electrical signals containing the data, which are transferred to the electronic unit via an electrical interconnect to cause refresh of the data in the delay line memory device.. ... Cornell University

06/15/17 / #20170166980

Thyroid tumors identified

The invention relates to methods and kits for detecting thyroid cancer by detecting differences in the expression of genes that are differentially expressed in thyroid cancer cells.. . ... Cornell University

06/15/17 / #20170164935

Urethral catheterless radical prostatectomy

A method and device for facilitating the anastomotic healing of a patient after a radical prostatectomy surgical procedure, without a urethral catheter, comprising the steps of performing a radical prostatectomy, fixedly positioning a splinting element between the urethra and the bladder, across the urethral opening, placing the splinting element during the performing of the radical prostatectomy and prior to surgical closure. The fixed positioning is effected from a position within the bladder with anchoring the splinting element in position relative to the interior of the bladder, setting a separate urine drainage tube, and removing the splinting element, after anastomotic healing, with a retrieval element on the splinting element or with dissolving of the splinting element.. ... Cornell University

06/01/17 / #20170151584

Porous resin structures

A method providing direct access to porous three-dimensionally (3d) continuous polymer network structures and shapes by combining bcp-resol co-assembly with co2 laser-induced transient heating. The co2 laser source transiently heats the bcp-directed resol hybrid films to high temperatures at the beam position, inducing locally controlled resol thermopolymerization and bcp decomposition in ambient conditions. ... Cornell University

05/18/17 / #20170135964

Methods of treating diseases associated with high-fat diet and vitamin a deficiency using retinoic acid receptor agonists

. . This invention relates to pharmaceutical composition and methods of using vitamin a and/or rarβ agonist for the treatment or prevention of diseases or conditions associated with high fat diet and/or vitamin deficiency.. . ... Cornell University

05/11/17 / #20170128565

Methods of treating cmv retinitis by t cell therapy

Disclosed herein are methods of treating cmv (cytomegalovirus) retinitis in a human patient in need thereof, comprising administering to the human patient a population of allogeneic t cells comprising cmv-specific t cells, wherein the human patient is infected with hiv or has been the recipient of a solid organ transplant.. . ... Cornell University

05/04/17 / #20170124535

Systems and methods for securing cryptocurrency purchases

An apparatus in one embodiment comprises a processing platform having at least one processing device. The processing platform implements a database configured to store bindings between user identity information and respective cryptocurrency addresses for users of an address-based cryptocurrency, and an account-identity service system accessible to at least one cryptocurrency vendor. ... Cornell University

05/04/17 / #20170121366

Dipeptides as inhibitors of human immunoproteasomes

The compounds of the present invention are represented by the following compounds having formula (i) where the substituents r1-r10, x, y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.. ... Cornell University

05/04/17 / #20170119018

Compositions comprising defatted microalgae, and treatment methods

The present invention relates to a composition comprising defatted microalgae in a solid, powder, or liquid form formulated for oral administration. The present invention also relates to a composition comprising defatted microalgae formulated as a food additive. ... Cornell University

04/27/17 / #20170112893

Methods for prevention and treatment of acute renal injury

The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. ... Cornell University

04/13/17 / #20170100473

Vaccine for intrauterine disease

Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and compositions are for subcutaneous administration and are provided as veterinary compositions and as articles of manufacture. ... Cornell University

04/06/17 / #20170096658

Mesoporous catalysts of magnetic nanoparticles and free-radicalproducing enzymes, and methods of use

A composition comprising mesoporous aggregates of magnetic nanoparticles and free-radical producing enzyme (i.e., enzyme-bound mesoporous aggregates), wherein the mesoporous aggregates of magnetic nanoparticles have mesopores in which the free-radical-producing enzyme is embedded. Methods for synthesizing the enzyme-bound mesoporous aggregates are also described. ... Cornell University

03/30/17 / #20170089926

Immobilized protein system for rapid and enhanced multiplexed diagnostics

The present invention relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay according to the present invention that produces a measurable signal and detecting the measurable signal. ... Cornell University

03/16/17 / #20170074861

Bio-adhesive gels and methods of use

A gel composition that forms a three dimensional gel microenvironment that is formed of an adhesive protein, a maleimide-functionalized poly alkylene oxide, a linking agent and a nanoparticle, the components forming an interpenetrating network that exhibits improved mechanical and biochemical properties, as well as creates a favorable microenvironment for cellular growth and proliferation. The gel composition also creates a favorable microenvironment for testing various agents on normal or diseased cells, including chemotherapeutic agents on cancer cells or other diseased cells.. ... Cornell University

03/16/17 / #20170073741

Device and methods for epigenetic analysis

Provided herein are methods and devices for single object detection. The methods and devices can be used to identify a plurality epigenetic markers on a genetic material, or a chromatin, encompassing fragments thereof. ... Cornell University

03/16/17 / #20170072010

Combination therapy for head and neck cancer

This invention relates to pharmaceutical composition and methods of using rxr agonist and/or rar agonist for the treatment or prevention of head and neck cancer.. . ... Cornell University

03/09/17 / #20170069365

Electrically gated three-terminal circuits and devices based on spin hall torque effects in magnetic nanostructures apparatus, methods and applications

3-terminal magnetic circuits and devices based on the spin-transfer torque (stt) effect via a combination of injection of spin-polarized electrons or charged particles by using a charge current in a spin hall effect metal layer coupled to a free magnetic layer and application of a gate voltage to the free magnetic layer to manipulate the magnetization of the free magnetic layer for various applications, including non-volatile memory functions, logic functions and others. The charge current is applied to the spin hall effect metal layer via first and second electrical terminals and the gate voltage is applied between a third electrical terminal and either of the first and second electrical terminals. ... Cornell University

03/09/17 / #20170067896

Enhancing serological assays via fusion proteins

A serological assay with an improved linear range of detection is disclosed using a fusion protein system, such as an anti-cytokine/cytokine fusion protein (acyf) system, for evaluating immune responses. Also disclosed are related compositions, fusion proteins, expression vectors, monoclonal antibodies, and kits for practicing the assay method of the present invention.. ... Cornell University

03/09/17 / #20170065049

Green technology for crosslinking protein molecules for various uses

The present disclosure relates to, inter alia, a green technology for crosslinking protein molecules for various uses, where the protein molecules can be contained in protein fibers such as, but not limited to, human hair, animal fibers, and mixtures thereof. In one aspect, the present disclosure relates to a crosslinking agent comprising an oxidized sugar having at least two aldehyde groups. ... Cornell University

03/02/17 / #20170058249

Optofluidic photobioreactor apparatus, method, and applications

An optofluidic photoreactor including an optical waveguide having an input, characterized by an evanescent optical field confined along an outer surface of the optical waveguide produced by radiation propagating in the optical waveguide, means for inputting light to the input of the optical waveguide, and a photoactive material disposed substantially only within the evanescent field. A method for optically activating a photoactive material in an optofluidic photoreactor to convert carbon dioxide and water into other molecules that may be useful as a fuel or a chemical feedstock.. ... Cornell University

03/02/17 / #20170058192

Carbon-based fluorescent tracers as oil reservoir nano-agents

The present invention relates to carbon-based fluorescent nano-agent tracers for analysis of oil reservoirs. The carbon-based fluorescent nano-agents may be used in the analysis of the porosity of a formation. ... Cornell University

03/02/17 / #20170057995

Use of aromatic-cationic peptides to treat cholesterol-induced mitochondrial dysfunction

The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in inhibiting cholesterol-induced cytochrome c peroxidase activity, promoting reduction of cytochrome c, and inhibition of cardiolipin peroxidation to treat, prevent or ameliorate cholesterol-induced mitochondrial dysfunction.. ... Cornell University

02/16/17 / #20170042948

Modulation of fat storage in a subject by altering population levels of christensenellaceae in the gi tract

Disclosed herein are compositions that have substantially purified christensenellaceae bacteria, and uses of these compositions to alter the microbiome of an individual. The addition of christensenellaceae bacteria, such as christensenella, to the microbiome of an individual can treat or prevent weight gain, reduce body weight, inhibit fat accumulation, reduce excess adiposity, and reduce a high body mass index (bmi), and can also treat or prevent conditions correlating with excess weight and fat and a high bmi, such as insulin sensitivity, metabolic syndrome, excess adiposity, and diabetes.. ... Cornell University

02/09/17 / #20170042034

System and methods for additive manufacturing of electromechanical assemblies

A hybrid additive manufacturing approach that incorporates three-dimensional (3d) printing and placement of modules selected from a library of modules to fabricate an electromechanical assembly. By virtue of fabrication of the electromechanical assembly, mechanical properties and electrical properties of the assembly are created. ... Cornell University

02/09/17 / #20170040488

Spatially-annealed nanoparticle films and methods of making and using same

Provided are spatially-annealed nanoparticle films. The films have one or more discrete regions that exhibit size-dependent properties. ... Cornell University

02/09/17 / #20170037408

Neat1 as a prognostic marker and therapeutic target for prostate cancer

This invention relates to diagnosis and prognosis of prostate cancer, as well as therapeutic treatment of prostate cancer. More specifically, the invention provides diagnostic and prognostic methods based on detecting nuclear enriched abundant transcript 1 (neat1) levels in a sample. ... Cornell University

02/02/17 / #20170029592

Soft actuator and methods of fabrication

Soft actuators are fabricated from materials that enable the actuators to be constructed with an open-celled architecture such as an interconnected network of pore elements. The movement of a soft actuator is controlled by manipulating the open-celled architecture, for example inflating/deflating select portions of the open-celled architecture using a substance such as compressed fluid.. ... Cornell University

01/26/17 / #20170025366

Device for prevention of integrated circuit chip counterfeiting

A timer including a sensor and a radiation source is used to prevent counterfeiting of integrated circuits. The timer confirms the date code of the integrated circuit resulting in a more secure supply chain.. ... Cornell University

01/26/17 / #20170025365

Self-destructing chip

Embodiments herein provide for a self-destructing chip including at least a first die and a second die. The first die includes an electronic circuit, and the second die is composed of one or more polymers that disintegrates at a first temperature. ... Cornell University

01/26/17 / #20170025196

Misfit p-type transparent conductive oxide (tco) films, methods and applications

A p-type transparent conductive oxide (tco) mixed metal oxide material layer formed upon a substrate has a formula m1xm2yoz generally, caxcoyoz more specifically, and ca3co4o9 most specifically. Embodiments provide that the p-type tco mixed metal oxide material may be formed absent an epitaxial crystalline relationship with respect to the substrate while using a sol-gel synthesis method that uses a chelating polymer material and not a block copolymer material.. ... Cornell University

01/26/17 / #20170023513

Electropolymerization onto flexible substrates for electronic applications

Electropolymerized polymer or copolymer films on a conducting substrate (e.g., graphene) and methods of making such films. The films may be part of multilayer structures. ... Cornell University

01/26/17 / #20170020961

Methods for treating peripheral nerve damage

Vegf-b, as well as a combination of vegf-b and vegf-a, mediates peripheral nerve repair. Methods to treat damage to the peripheral nervous system are described.. ... Cornell University

01/19/17 / #20170015711

Materials and methods for producing cleaved, hiv-1 envelop glycoprotein trimers

Expression vectors and mammalian cell lines containing them are described that enable the recombinant production of hiv-1 envelope proteins, including sosip modified gp140 trimers capable of inducing broadly neutralizing antibodies.. . ... Cornell University

01/12/17 / #20170009380

Multi-nozzle gas-assisted electrospinning apparatuses

Provided herein are electrospinning systems, apparatuses, components, and processes for the preparation of nanofibers, including high throughput systems, apparatuses, and processes for producing high performance nanofibers.. . ... Cornell University

01/12/17 / #20170007663

Methods and compositions for treating and preventing cognitive dysfunction

The disclosure relates to methods and compositions for preventing or treating cognitive dysfunction. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof. ... Cornell University

01/05/17 / #20170002653

Carbon-based fluorescent tracers as oil reservoir nano-agents

The present invention relates to carbon-based fluorescent nano-agent tracers for analysis of oil reservoirs. The carbon-based fluorescent nano-agents may be used in the analysis of the porosity of a formation. ... Cornell University

01/05/17 / #20170000840

Methods for preventing and treating oral cancers

The disclosure provides methods for preventing or treating oral cancers, and/or reducing the severity of symptoms of oral cancers. In particular, the present technology relates to administering an effective amount of an aromatic-cationic peptide to a subject in need thereof to normalize expression levels of genes involved in oral carcinogenesis.. ... Cornell University








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