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Deciphera Pharmaceuticals Llc patents (2017 archive)

Recent patent applications related to Deciphera Pharmaceuticals Llc. Deciphera Pharmaceuticals Llc is listed as an Agent/Assignee. Note: Deciphera Pharmaceuticals Llc may have other listings under different names/spellings. We're not affiliated with Deciphera Pharmaceuticals Llc, we're just tracking patents.

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Methods for inhibiting tie-2 kinase useful in the treatment of cancer

The present invention relates to methods of inhibiting tie2 kinase useful in the treatment of tumor growth, invasiveness, intravasation, dissemination, metastasis, and immunosuppression. Specifically, the invention relates to methods of using 1-(3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea and salts thereof of formula i.. ... Deciphera Pharmaceuticals Llc

Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression

It has been shown that compound 1 unexpectedly and potently inhibits tie2 kinase, and that compound 1 inhibits drug resistance mechanisms in both the tumor and in the surrounding microenvironment through balanced inhibition of tie2, met, and vegfr2 kinases. Thus, compound 1 provides a single therapeutic agent able to address multiple hallmarks of cancer by inhibiting tie2, met, and vegfr2 kinases in the tumor microenvironment [hanahan 2011]. ... Deciphera Pharmaceuticals Llc

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