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Department Of Veterans Affairs patents


Recent patent applications related to Department Of Veterans Affairs. Department Of Veterans Affairs is listed as an Agent/Assignee. Note: Department Of Veterans Affairs may have other listings under different names/spellings. We're not affiliated with Department Of Veterans Affairs, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Department Of Veterans Affairs-related inventors


Small molecules that bind mr1

Disclosed are small molecules and pharmaceutical compositions comprising them that can be used in treating diseases associated with the major histocompatibility complex (mhc) molecule mr1.. . ... Department Of Veterans Affairs

Preparation and use of a composition for prevention and mitigation of the effects of radiation

Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise γ-tocotrienol (gt3) and δ-tocotrienol (dt3) in ratios wherein the dt3 is predominate. ... Department Of Veterans Affairs

Myricanol derivatives and uses thereof for treatment of neurodegenerative diseases

The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative dieses associated with abnormal accumulation of protein tau.. . ... Department Of Veterans Affairs

Ghrh agonists for the treatment of ischemic disorders

Disclosed herein are compositions of ghrh agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion injury in a subject in need may involve administering a therapeutically effective amount of at least one ghrh agonist peptide to the subject. ... Department Of Veterans Affairs

Method for assessing fall risk based on tracking data of a moving target

Techniques are provided for assessing a risk of fall based on tracking data of a subject tracking a moving target. Tracking data of a first subject to the moving target is determined based on sensing a body of the first subject that measure a position of one or more body segments at time increments over a time period. ... Department Of Veterans Affairs

Cellular seeding and co-culture of a three dimensional fibroblast construct

The present invention provides methods for cellular seeding onto three-dimensional fibroblast constructs, three-dimensional fibroblast constructs seeded with muscle cells, and uses therefore.. . ... Department Of Veterans Affairs

Mu opioid receptor agonist analogs of the endomorphins

The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain. Embodiments of the invention are directed to cyclic pentapeptide and hexapeptide analogs of endomorphin that have (i) a carboxy-terminal extension with an amidated hydrophilic amino acid and (ii) a substitution in amino acid position 2. ... Department Of Veterans Affairs

Compounds and compositions for ossification and methods related thereto

The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. ... Department Of Veterans Affairs

Method and apparatus for providing economical, portable deficit-adjusted adaptive assistance during movement phases of an impaired ankle

A method is described for providing deficit-adjusted adaptive assistance during movement phases of an impaired ankle. The method includes determining, on the processor, a value for a deficit parameter for each movement phase of a compound ankle function based on a difference between a parameter trace for a normal subject and the parameter trace for an impaired subject. ... Department Of Veterans Affairs

Methods of reducing or preventing intimal damage caused by mechanical stimulation of endothelial cells

Embodiments of the disclosure encompass methods and/or compositions for ameliorating or preventing intimal damage caused by mechanical stimulation of endothelial cells. The damage may be caused by use of a device within an artery, vein, or capillary of an individual, such as to remove a thrombus, an embolus or an atherosclerotic plaque in the vessel. ... Department Of Veterans Affairs

Casket transport and lowering device system

A casket transport and lowering device system is presented. The system includes a transportable frame with extendable rails configured to rotate and extend out over a gravesite. ... Department Of Veterans Affairs

Injectable composition for in-situ repair and regeneration of an injured ligament or tendon and methods of use

. . The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is also useful for the delivery of growth factors, therapeutic agents and cells into the area of tendon or ligament injury.. ... Department Of Veterans Affairs

Maintenance and propagation of mesenchymal stem cells

Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.. . ... Department Of Veterans Affairs

Development and vascular applications of shape memory external stents

The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. ... Department Of Veterans Affairs

05/03/18 / #20180118657

Methods for inhibiting muscle atrophy

In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... Department Of Veterans Affairs

04/19/18 / #20180108139

System and method for n-dimensional image segmentation using convolutional neural networks

Disclosed are systems and methods for image segmentation using convolutional networks. Image data comprising an image hypervolume can be received. ... Department Of Veterans Affairs

04/12/18 / #20180099027

Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists

The present invention provides methods for preventing, attenuating neuronal damage or stimulating neuronal repair prior or following central nervous system injury.. . ... Department Of Veterans Affairs

03/15/18 / #20180074059

Biomarkers for diagnosis and prognosis of lung cancer

. . . . . . Provided herein are methods for non-invasively diagnosing and/or prognosing a lung cancer and for determining the efficacy of a therapeutic treatment regimen for the lung cancer. Expression levels of at least two small non-coding rnas, for example, micrornas and small nucleolar rnas, are measured and used to calculate an area under the curve (auc) that provides a probability of lung cancer in the subject. ... Department Of Veterans Affairs

03/15/18 / #20180071079

Methods of treating a musculoskeletal tissue interface injury using decellularized composite tissue bioscaffolds

Provided are methods for treating a musculoskeletal tissue interface injury using decellularized, allogeneic or xenogeneic composite tissue bioscaffolds.. . ... Department Of Veterans Affairs

03/01/18 / #20180057790

Functional myelination of neurons

Hair follicle bulge region/llp region cd34(+) mescs can be isolated from mammalian skin bearing hair follicles. These cells are multipotent and retain the ability to differentiate into cells of neural crest lineage, including glia-like cells that express the glial marker gfap, and are able to express myelin basic protein, and to remyelinate naked (unmyelinated or demyelinated) neuronal processes with a functional, dense myelin sheath. ... Department Of Veterans Affairs

02/15/18 / #20180044409

Antibody-mediated transduction of heat shock proteins into living cells

The invention provides for a fusion protein comprising a 3e10 fv joined to a hsp-70, hsp-27, hsp-90 or grp-78 or portion thereof, and optionally, the 3e10 fv comprising an amino acid sequence agih at its amino terminus.. . ... Department Of Veterans Affairs

02/15/18 / #20180042793

Collapsible manual wheelchair system for improved propulsion and transfers

A manual wheelchair including a collapsible frame having a first lateral member that is connected to first and second braces at their respective first ends. A drive wheel axel extends along a first axis of rotation and engages a drive wheel, the first brace, and a portion of a transmission. ... Department Of Veterans Affairs

02/08/18 / #20180037529

Myricanol derivatives and uses thereof for treatment of neurodegenerative diseases

The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.. . ... Department Of Veterans Affairs

02/08/18 / #20180036311

Treatment for hereditary neuropathy with liability to pressure palsies (hnpp)

A method of treating demyelinating diseases involves administering a pak1 inhibitor that is pf-3758309 to a subject in need of such treatment.. . ... Department Of Veterans Affairs

01/25/18 / #20180022698

Novel methods, compounds, and compositions for anesthesia

Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need of anesthesia a compound disclosed herein. ... Department Of Veterans Affairs

01/25/18 / #20180021319

Compositions and methods for treating gastrointestinal infections

The invention described herein provides compositions and methods for treating or preventing helicobacter pylori infection.. . ... Department Of Veterans Affairs

01/11/18 / #20180011815

Active stability devices and systems for mobile devices

A system for use with a mobile device includes at least one sensor to sense a variable related to tilting of the mobile device and at least one activatable system in operative connection with the sensor. The at least one activatable system increases stability of the mobile device upon actuation/change in state thereof on the basis of data measured by the at least one sensor. ... Department Of Veterans Affairs

01/11/18 / #20180009760

Compounds, compositions and associated methods comprising 3-aryl quinolines

Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.. ... Department Of Veterans Affairs

01/04/18 / #20180002741

Method of diagnosis and treating gastrointestinal and neurological diseases associated with species of genus clostridium

The invention includes a method of diagnosis and treating autism associated with an overgrowth of beta2-toxin-gene-positive clostridium perfringens in the gut of an autistic subject. In one embodiment, the method comprises administering to the subject (e.g. ... Department Of Veterans Affairs

01/04/18 / #20180001012

Portable lung assist device

The present invention relates to a portable lung assist device. In one embodiment, the portable lung assist device comprises an integrated oxygenator, blood pump, and cannula. ... Department Of Veterans Affairs

12/28/17 / #20170371248

Optical illumination system

Systems and methods are provided that combine an amplitude modulation slm with a phase modulating slm in the same optical illumination system. The combination of the amplitude modulation slm and the phase modulation slm allows the optical illumination to compensate for the limitations of amplitude modulation slm by using phase modulating slm and conversely to compensate for the limitations of phase modulation slm by using amplitude modulating slm.. ... Department Of Veterans Affairs

12/28/17 / #20170369577

Recombinant cd74 polypeptides

Disclosed are recombinant cd74 polypeptides mutated relative to the naturally occurring cd74 polypeptides with improved properties such as binding of cd74 ligands such as mif and rtl1000 as well as polynucleotides that encode the polypeptides, expression vectors comprising the polynucleotides, bacteria that include the expression vectors, and methods of making the recombinant polypeptides.. . ... Department Of Veterans Affairs

12/28/17 / #20170369531

Mu opioid receptor agonist analogs of the endomorphins

The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain. Embodiments of the invention are directed to cyclic pentapeptide and hexapeptide analogs of endomorphin that have (i) a carboxy-terminal extension with an amidated hydrophilic amino acid and (ii) a substitution in amino acid position 2, and in some embodiments, a 2′,6′-dimethyltyrosine (dmt) residue in place of the n-terminal tyrosine residue a position 1. ... Department Of Veterans Affairs

12/28/17 / #20170367629

Method and pulse oximeter apparatus using chemical heating

Method and apparatus for providing reliable blood oxygen (sao2) and heart rate measurements includes a chemical energy heating source in conjunction with a harness that is adapted to secure the chemical energy heating source and a pulse oximeter probe proximate to a region of the body which is to be warmed prior to measurement. Preferably, the chemical energy heating source is in the form a mixture including a metal powder, which releases heat at a predetermined rate via oxidation of the metal powder when exposed to the atmosphere. ... Department Of Veterans Affairs

12/21/17 / #20170362276

Mu opioid receptor agonist analogs of the endomorphins

The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain. Embodiments of the invention are directed to cyclic analogs of endomorphin. ... Department Of Veterans Affairs

12/07/17 / #20170348521

Extracranial implantable devices, systems and methods for the treatment of medical disorders

The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.. ... Department Of Veterans Affairs

11/23/17 / #20170334981

Cell-penetrating anti-dna antibodies and uses thereof inhibit dna repair

Antibodies that penetrate cell nuclei and inhibit dna repair or interfere with dna metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to dna-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-dna antibodies or derivatives thereof, alone or in combination with treatment that induces dna damage such as dna-damaging chemotherapy or radiation. ... Department Of Veterans Affairs

11/23/17 / #20170333454

Inhibitors of ncca-atp channels for therapy

Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (phn), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular ncca-atp channel and include, for example, inhibitors of sur1 and/or inhibitors of trpm4. ... Department Of Veterans Affairs

11/09/17 / #20170319655

Muc1 decoy peptides for treatment and prevention of bacterial infections

Pseudomonas aeruginosa flagellin protein recruits the mammalian host sialidase enzyme neuraminidase-1 (neu1) to remove sialic acid residues from the extracellular domain of the mammalian cell-surface protein muc1 (muc1-ed), thereby exposing a cryptic binding site on the muc1-ed protein backbone for flagellin binding. Neu1-driven muc1-ed desialylation rapidly increases p. ... Department Of Veterans Affairs

10/26/17 / #20170307593

Methods for treating neural cell swelling

A composition comprising a novel ca2+-activated, [atp]i-sensitive nonspecific cation (ncca-atp) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [ca]i. ... Department Of Veterans Affairs

10/26/17 / #20170304479

Holder for disinfection of tonometer tips or the like and method of use

A holder device for holding a plurality of tonometer tips or the like during a disinfection procedure has a top wall, spaced rims extending downward from the top wall to engage a support surface and hold the top wall above the support surface, and handle portions extending upwards from the top wall. The top wall has a plurality of spaced holes of predetermined diameter each configured to hold a tip extending partially through the hole with a lower end of the tip spaced above a support surface. ... Department Of Veterans Affairs

10/12/17 / #20170291961

Multivalent fragments of antibody 3e10 and methods of use thereof

Antigen binding molecules that bind to the epitope of 3e10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain variable fragments (scfv) of monoclonal antibody 3e10, wherein the variant scfv has one or more insertions, deletions, or substitutions relative to a corresponding 3e10 scfv, and wherein the molecule can bind, preferably specifically bind, to the epitope of 3e10. ... Department Of Veterans Affairs

09/07/17 / #20170253879

Aptamer-rnai therapeutic compositions

A recombinant nucleic acid comprising an aptamer that binds cd4 and an rnai sequence that silences the expression of rorγ2 is described herein. Pharmaceutical compositions comprising the recombinant nucleic acid, particularly topical compositions are also described. ... Department Of Veterans Affairs

07/27/17 / #20170209700

Parasympathetic activation by vagus nerve stimulation

The vagus nerve and branches of the vagus nerve are stimulated below the laryngeal nerve branch bifurcation in order to induce desired parasympathetic responses, such as decreased heart rate, without also triggering any adverse sympathetic responses. Stimulating surfaces of an open field bipolar electrode are positioned on or inserted through the pleural membrane overlying the vagus nerve at a location having substantially no cardiac sympathetic fibers adjacent to the vagus nerve. ... Department Of Veterans Affairs

07/20/17 / #20170206323

Systems and methods for automated order and notification for patient interventions based on health records

Systems and methods for automatic order generation and notification for patient interventions. In an embodiment, a data repository comprising a plurality of patient health records is analyzed to identify a subset of the patient health records matching one or more criteria. ... Department Of Veterans Affairs

06/29/17 / #20170182089

Administration of a thiol-based chemoprotectant compound

A method of administration of a thiol-based chemoprotectant agent including nac (n-acetylcysteine) and sts (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. ... Department Of Veterans Affairs

06/22/17 / #20170173345

Multi-tiered wireless powering system for long-term implantable medical devices

A wireless powering system for an implantable medical device includes a first unit having a power source and an inductive coil. A second unit has an energy storage component and in alternate embodiments one or two inductive coils. ... Department Of Veterans Affairs

06/22/17 / #20170173307

Novel non-invasive method for direct delivery of therapeutics to the spinal cord in the treatment of spinal cord pathology

Most spinal cord therapies are administered systemically, with only a small portion of the therapeutic reaching the spinal cord. A novel method for delivering therapeutics directly to the spinal cord is provided. ... Department Of Veterans Affairs

06/22/17 / #20170173039

Compositions and methods to treat addiction

The present invention provides compositions and methods comprising talampanel and/or perampanel for treating or preventing an addictive disease or disorder, such as alcoholism, in a subject in need thereof. Ampa receptor (ampa-rs) antagonists (i.e., blockers), such as perampanel and talampanel, reduce drug and alcohol seeking behaviors in mammals since activation of glutamatergic ampa receptors promotes addictive behaviors in mammals.. ... Department Of Veterans Affairs

06/22/17 / #20170172998

Desethylhydroxychloroquine for the treatment of diseases associated with inflammation

Compositions and methods are provided for inhibiting or treating the early and established stages of inflammatory diseases by administration of an effective dose of the desethylhydroxychloroquine (dhcq). A benefit of the methods is the ability to deliver a dose of agent that is effective in treating inflammation while sparing the individual from retinal toxicity.. ... Department Of Veterans Affairs

06/08/17 / #20170157127

Methods of facilitating cell survival using neurotrophin mimetics

Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75ntr receptor molecule. ... Department Of Veterans Affairs

04/27/17 / #20170114117

Compounds that bind macrophage migration inhibitory factor

Recombinant polypeptides, pharmaceutical compositions comprising recombinant polypeptides, and methods of treating autoimmune and/or inflammatory diseases using the pharmaceutical compositions are disclosed. The polypeptides are based upon the trimerization and/or mif binding domains of cd74.. ... Department Of Veterans Affairs

04/27/17 / #20170112860

Novel non-selective cation channel in neuronal cells and methods for treating brain swelling

The present invention is directed to therapeutic compounds, treatment methods, and kits affecting the ncca-atp channel of neural tissue, including neurons, glia and blood vessels within the nervous system, and methods of using same. The ncca-atp channel is newly expressed in neural tissue following injury such as ischemia, and is regulated by the sulfonylurea receptor sur1, being inhibited by sulfonylurea compounds, e.g., glibenclamide and tolbutamide, and opened by diazoxide. ... Department Of Veterans Affairs

04/20/17 / #20170105952

Histone acetyl transferase activators and histone deacetylase inhibitors in the treatment of alcoholism

The present invention relates to the reduction of a symptom of an alcohol withdrawal state comprising administering a modulator of histone acetylation.. . ... Department Of Veterans Affairs

03/16/17 / #20170076052

Methods and systems for dynamic management of a health condition

Methods and systems relate to dynamic management of a health condition based on the changing needs and status of individual patient(s) and/or provider(s). The method may include processing information to determine one or more health management factors for a patient; generating a health management plan for managing a health condition of the patient based on the one or more management factors, the management plan including one or more goals, treatment regimen information, one or more prompt conditions, one or more attributes of one or more treatment events, or a combination thereof; and generating one or more prompt(s) based on the management plan.. ... Department Of Veterans Affairs

03/16/17 / #20170073429

Cell penetrating anti-guanosine antibody based therapy for cancers with ras mutations

It has been established that cancer cells with oncogenic mutants in the small gtpase k-ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells can be challenging. A subset of lupus autoantibodies is associated with anti-guanosine activity, and is capable of cellular penetration. ... Department Of Veterans Affairs

03/16/17 / #20170071192

Methods and compositions for vein harvest and autografting

The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ecm) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low ph, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. ... Department Of Veterans Affairs

02/09/17 / #20170037196

Novel hydrogel tissue expanders

The present invention provides tissue expanders comprising biodegradable, chemically cross-linked hydrogels which are elastic in the dry state. These biocompatible tissue expanders are self-inflating and membrane-free. ... Department Of Veterans Affairs

02/09/17 / #20170035771

Compounds and compositions for ossification and methods related thereto

The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. ... Department Of Veterans Affairs

02/02/17 / #20170028048

Methods for producing an immune response to tuberculosis

Methods for producing an immune response to mycobacterium tuberculosis (mtb) are disclosed herein. In several examples, the immune response is a protective immune response. ... Department Of Veterans Affairs

01/26/17 / #20170022164

Quinolone-3-diarylethers

Disclosed are derivative compounds of elq-300 that include an ester at position 4. These compounds have enhanced properties relative to elq-300. ... Department Of Veterans Affairs

01/26/17 / #20170020891

Use of dopamine and serotonin receptor antagonists for treatment in a subject with retinal degeneration

Disclosed herein are methods of treating disorders of the retina (e.g., macular degeneration, retinitis pigmentosa, etc.) comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound (for example, an antipsychotic drug) that blocks or diminishes agonist-mediated responses upon binding to either dopamine d2-like receptors or serotonin 5-ht2 receptors.. . ... Department Of Veterans Affairs

01/12/17 / #20170007681

Methods and compositions used in treating inflammatory and autoimmune diseases

Methods of treating neuroinflammation by administration of a selective protein c activator, such as recombinant human we thrombin and optionally one or more of its cofactors are disclosed. Also disclosed are pharmaceutical compositions for use in the treatment of mammals that exhibit symptoms of neurological inflammation. ... Department Of Veterans Affairs

01/12/17 / #20170007477

Collapsible manual wheelchair system for improved propulsion and transfers

A manual wheelchair including a collapsible frame having a first lateral member that is connected to first and second braces at their respective first ends. A drive wheel axel extends along a first axis of rotation and engages a drive wheel, the first brace, and a portion of a transmission. ... Department Of Veterans Affairs

01/12/17 / #20170007476

Manual wheelchair system for improved propulsion and transfers

A manual wheelchair including a collapsible frame having a first lateral member that is connected to first and second braces at their respective first ends. A drive wheel axel extends along a first axis of rotation and engages a drive wheel, the first brace, and a portion of a transmission. ... Department Of Veterans Affairs

01/05/17 / #20170000801

Triarylmethane analogs and their use in treating cancers

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. ... Department Of Veterans Affairs








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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