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Deutsches Krebsforschungszentrum patents


Recent patent applications related to Deutsches Krebsforschungszentrum. Deutsches Krebsforschungszentrum is listed as an Agent/Assignee. Note: Deutsches Krebsforschungszentrum may have other listings under different names/spellings. We're not affiliated with Deutsches Krebsforschungszentrum, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Deutsches Krebsforschungszentrum-related inventors


Modulators of the function of the core domain of annexins, and uses thereof in autoimmune and/or cancer therapy

The present invention relates to a method for identifying a compound that modulates the interaction of an annexin core domain with a receptor selected from the group of c-type lectin receptors and lrp-1 in a cell, and uses thereof in autoimmune and/or cancer therapy.. . ... Deutsches Krebsforschungszentrum

Method and apparatus for imaging a sample

A method and apparatus for imaging an area of interest (22) of a sample (20) is disclosed. The sample (20) comprises a plurality of fluorophores (25). ... Deutsches Krebsforschungszentrum

Chromatic phase plate

A segmented chromatic phase plate comprises at least three stacks. The three stacks are arranged around and stacked along a main axis, and have same overall heights. ... Deutsches Krebsforschungszentrum

Agents for use in the treatment of glioma

The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma who if and 111°, as well as iv0 (glioblastoma), in a subject.. . ... Deutsches Krebsforschungszentrum

Contour collimator for radiotherapy

The invention relates to a contour collimator for radiotherapy, comprising a plurality of plate-shaped diaphragm elements provided in a guiding block and movably arranged with respect to one another to form a contour diaphragm for a radiation beam emitted by a radiation source towards the collimator, and at least one drive for moving the diaphragm elements, wherein a drive of its own is associated with each diaphragm element, the drives of a group of diaphragm elements are arranged substantially adjacent to one another, and the drive is a linear motor, wherein each linear motor comprises a linearly movable rod directly fixed to the associated diaphragm element. The invention facilitates a design of a contour collimator with a shape being as compact as possible, and wherein both precise and stable adjustability of the diaphragm elements is achieved without a backlash. ... Deutsches Krebsforschungszentrum

Novel promiscuous hpv16-derived t helper epitopes for immunotherapy

The present invention relates to novel amino acid sequences of peptides derived from hpv 16 that are able to bind to mhc complexes of class ii, and elicit an immune response. The present invention further relates to pharmaceutical products, such as vaccines and t-cells, based on said epitopes.. ... Deutsches Krebsforschungszentrum

Fluorescence microscope instrument comprising an actively switched beam path separator

A fluorescence microscope instrument includes a light source; an objective focusing light from the light source into a sample and collecting fluorescence light emitted out of the sample; a detector detecting the fluorescence light; and a beam path separator arranged in a first beam path between the light source and the objective and in a second beam path between the objective and the detector. Wavelengths of the light to be directed to the sample and of the fluorescence light to be detected by the detector fall into an extended range of wavelengths. ... Deutsches Krebsforschungszentrum

Method for large scale production and purification of parvovirus

Described is a reproducible, effective and scalable process for parvovirus production including characterization strategies, preferably production of h-1pv.. . ... Deutsches Krebsforschungszentrum

Combination therapy with a flavagline and 2-deoxyglucose

The present invention relates to a combined preparation comprising 2-deoxyglucose and a flavagline and to the use of said combined preparation as a medicament or in the treatment of cancer. Moreover, the present invention relates to a flavagline for use in a combination therapy against cancer comprising administration of 2-deoxyglucose; and to 2-deoxyglucose for use in a combination therapy against cancer comprising administration of a flavagline. ... Deutsches Krebsforschungszentrum

Histone anti-cancer vaccines

The present invention pertains to novel immunogenic peptide sequences that can be used as vaccines in the treatment of cancer diseases such as brain cancers and specifically glioma. The cancer vaccines of the invention are designed based on the k27m mutated variant of the human histone 3. ... Deutsches Krebsforschungszentrum

Diagnostic transcript and splice patterns of hr-hpv in different cervical lesions

The present invention relates to a method for differentiating in a subject with hr-hpv between a severe form of hr-hpv infection and a mild form of hr-hpv infection. It further is concerned with a composition comprising a probe oligonucleotide mixture, a device, and a kit for use in conjunction with the method of the invention.. ... Deutsches Krebsforschungszentrum

Biomarker panel for diagnosing cancer

The present invention pertains to a new method for the diagnosis, prognosis, stratification and/or monitoring of a therapy, of cancer in a patient. The method is based on the determination of the level of a panel of biomarkers selected from cea, areg, il-6, gdf-15, hgf-receptor, cxcl9, erbb4-her4, cxclio, flt3l, vegfr-2, cd69, cxcl5s, psa, emmprin, cathepsin-d, caspase-3, tnf-alpha, and inf-gamma. ... Deutsches Krebsforschungszentrum

Oligonucleotide sequences targeting transcription factortsc22d4 for the treatment of insulin resistance

The present invention relates to oligonucleotide inhibitors of the tsc22d4 activity or expression and their uses for the prevention, treatment, and/or regulation of insulin resistance, metabolic syndrome and/or diabetes and/or for improving insulin sensitivity in a mammal.. . ... Deutsches Krebsforschungszentrum

Binding molecules, especially antibodies, binding to l1cam (cd171)

The present disclosure relates to a binding molecule binding to l1, which is capable of binding to the same l1 epitope recognized by the monoclonal antibody l1-ov52.24, and/or which competes with the monoclonal antibody l1-ov52.24 for binding to l1, wherein the variable part of the light chain of l1-ov52.24 comprises the sequence according to seq id no: 1 or wherein the light chain is encoded by seq id no: 3, and wherein the variable part of the heavy chain of l1-ov52.24 comprises the sequence according to seq id no: 2 or wherein the heavy chain is encoded by seq id no: 4, nucleic acids encoding the binding molecules, uses thereof and pharmaceutical compositions comprising the binding molecules.. . ... Deutsches Krebsforschungszentrum

09/07/17 / #20170254803

Method for the detection of antigen presentation

The present invention pertains to a method for detecting antigen presentation via antigen presenting molecules such as major histocompatibility complex (mhc) class i or ii. The invention deploys a first binding agent specific for the antigen epitope and a second binding agent specific for the antigen presenting molecule. ... Deutsches Krebsforschungszentrum

07/13/17 / #20170198018

Hcbi, msbi, mssi and cmi sequences as an early marker for the future development of cancer and diseases of the cns and as a target for the treatment and prevention of these diseases

Described are hcbi (healthy cattle blood isolate), msbi (multiple sclerosis brain isolate), mssi (multiple sclerosis serum isolate) and cmi (cow milk isolate) nucleotide sequences as well as probes and primers comprising part of said nucleotide sequences and antibodies against polypeptides encoded by said nucleotide sequences. Said compounds are useful as early markers for the future development of cancer and diseases of the cns (multiple sclerosis ms, prion-linked diseases, amyotrophic lateral sclerosis, transmissible spongiforme encephalitis, parkinson's disease, alzheimer disease) and should represent targets for treatment and prevention.. ... Deutsches Krebsforschungszentrum

06/01/17 / #20170153246

Receptors of rspo2 and rspo3

The present invention relates to the finding that syndecans (sdc) are receptors of rspondin-2 (rspo2) and rspondin-3 (rspo3). Thus, the present invention relates to the identification of rspo2, rspo3 and/or sdc activity modulators by determining if a test compound has the ability to modulate the binding of an rspo2 and/or rspo3 polypeptide to an sdc polypeptide. ... Deutsches Krebsforschungszentrum

05/11/17 / #20170128532

Methods for the prediction of a personalized esa-dose in the treatment of anemia

The present invention pertains to the use of an integrative pharmacokinetic/pharmacodynamic (pk/pd) esa-epor mathematical model for calculating the binding behaviour of erythropoiesis stimulating agents (esa). The invention provides methods for the determining of esa binding sites in cells or patients suffering from anemia. ... Deutsches Krebsforschungszentrum

02/02/17 / #20170030912

S100p and hyaluronic acid as biomarkers for metastatic breast cancer

The present invention pertains to a new method for the diagnosis, prognosis, stratification and/or monitoring of a therapy, of breast cancer in a patient. The method is based on the use of hyaluronic acid and s100p as combined biomarkers in the plasma of breast cancer patients. ... Deutsches Krebsforschungszentrum

01/05/17 / #20170002352

Inhibitors of thioredoxin-interacting protein (txnip) for therapy

Described is a compound capable of reducing or inhibiting (a) the biological activity of thioredoxin-interacting protein (txnip) or (b) the expression of the gene encoding txnip for treating a condition where improving the resistance towards oxidative stress has a beneficial effect, e.g., for improving female fertiliy or extending healthy lifespan.. . ... Deutsches Krebsforschungszentrum








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