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Dh Technologies Development Pte Ltd patents

Recent patent applications related to Dh Technologies Development Pte Ltd. Dh Technologies Development Pte Ltd is listed as an Agent/Assignee. Note: Dh Technologies Development Pte Ltd may have other listings under different names/spellings. We're not affiliated with Dh Technologies Development Pte Ltd, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Dh Technologies Development Pte Ltd-related inventors

Method for removing trapped ions from a multipole device

A method and apparatus for clearing ions from a multipole ion transmission device which includes introducing a dc or rf clear out pulse to one or more of the rods of the multipole device. The dc pulse is selected so as to supply sufficient kinetic energy to the ions to overcome a pseudo-potential trapping well generated by the rf potentials of the ion transmission device. ... Dh Technologies Development Pte Ltd

Method of increasing quality of tandem mass spectra

A method and apparatus for improving the quality of spectra of a sample obtained from a tandem mass spectrometer system containing an ion trap. The method and apparatus includes the setting of an upper and lower threshold limit on peak intensity and only triggering an enhanced product ion scan when a detected intensity of a peak in an initial scan falls between the upper and lower threshold limits. ... Dh Technologies Development Pte Ltd

Rf/dc filter to enhance mass spectrometer robustness

Systems and methods described herein utilize a multipole ion guide that can receive ions from an ion source for transmission to downstream mass analyzers, while preventing unwanted/interfering/contaminating ions from being transmitted into the high-vacuum chambers of mass spectrometer systems. In various aspects, rf and/or dc signals can be provided to auxiliary electrodes interposed within a quadrupole rod set so as to control or manipulate the transmission of ions from the multipole ion guide.. ... Dh Technologies Development Pte Ltd

Top down protein identification method

Systems and methods described herein can provide for “top down” mass spectrometric analysis of proteins or peptides in a sample using exd, in some aspects via direct infusion of the sample to the ion source without on-line lc separation, while deconvoluting the ambiguity in the exd spectra generated by impure samples. For example, methods and systems in accordance with various aspects of the present teachings can utilize patterns in charge-reduced species following exd to correlate the exd fragments with their precursor ions in order to more confidently identify the precursor ion from which the detected product ions originated.. ... Dh Technologies Development Pte Ltd

Electron induced dissociation devices and methods

A method and apparatus for conducting reactions between precursor ions and reagent ions, for example, a reaction between a precursor cation and an electron, such as ecd, are disclosed. The apparatus comprises first, second, and third pathways, each of which extends at least partially along a central axis, and wherein the second central axis is orthogonal to the first and third central axes. ... Dh Technologies Development Pte Ltd

Differential mobility spectrometry method

Methods and systems are provided herein for varying the cov about a nominal cov-apex while monitoring the ion of interest corresponding to the nominal cov-apex as it is transmitted by a dms. In various aspects, the cov can be swept or stepped across a series of values during the injection of ions into the dms such that a composite spectra of the ion of interest transmitted by the dms (or its product ions following one or more stages of fragmentation) can be generated so as to include the transmission of the particular ion at a cov with optimum sensitivity (i.e., if distinct from the cov-apex), thereby improving the robustness, accuracy, and/or selectivity during experimental conditions relative to known dms techniques, which typically used a fixed cov value for each ion of interest.. ... Dh Technologies Development Pte Ltd

Methods and systems for selecting ions for ion fragmentation

The present teachings are directed to methods and systems for the selection of ions for subsequent ion fragmentation in the analysis of a sample. Rather than select the most intense subset of precursor ions for further analysis in an attempt to maximize the number of high quality, identifiable ms/ms spectra, in some settings, systems and methods for analyzing and 5 identifying precursor ions for further processing can benefit from a discovery approach in which precursor ions are selected randomly/stochastically.. ... Dh Technologies Development Pte Ltd

Methods and systems for cross-talk elimination in continuous beam mobility-based spectrometers

A sample analysis system having a continuous beam ion mobility filter incorporates an ion removal mechanism for removing residual ions from the ion mobility filter to reduce cross-talk. A sample to be analyzed by the sample analysis system can be entered into the continuous beam ion mobility filter, which filters the ions of the sample and passes the filtered group of ions to a detector or a mass analyzer (e.g., via an ion optics assembly disposed between the mass analyzer and the ion mobility filter), where some or all of the ions in the group are detected. ... Dh Technologies Development Pte Ltd

Methods for detection in differential mobility spectrometer using a peptide metal complex

Methods and systems for separating and/or quantifying peptides using differential mobility spectrometry (dms) are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can provide for the separation of one or more peptides, for example, peptides that may be difficult to separate with conventional techniques, such as mass spectrometry (ms), by complexing the peptides with a metal cation (e.g., ca2+) prior to dms. ... Dh Technologies Development Pte Ltd

Band pass extraction from an ion trapping device and tof mass spectrometer sensitivity enhancement

A multipole rod set of an ion guide is adapted to receive a radial rf trapping voltage and a radial dipole direct current dc voltage. A lens electrode of the ion guide is positioned at one end of the multipole rod set to extract ions from the multipole rod set and adapted to receive an axial trapping ac voltage and a dc voltage. ... Dh Technologies Development Pte Ltd

Ion mobility method and apparatus

A method and system for performing an ion mobility based analysis that ionizes the components of a sample into ions; provides a field asymmetric waveform ion mobility or differential mobility spectrometry ion mobility based filter that comprises at least two electrodes, the at least two electrodes being spaced apart such that a constant sized gap is formed there between, through which a drift gas flows; introducing said ions into the drift gas, wherein said drift gas also comprises a mixture of liquid modifiers.. . ... Dh Technologies Development Pte Ltd

Methods for analysis of lipids using mass spectrometry

A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ecd, eid, or eieio. ... Dh Technologies Development Pte Ltd

Magnetic elements for processing fluids

Methods and apparatus for processing fluids on a macro- or micro-scale are described. In various aspects, a fluid may have a plurality of elongated (i.e., substantially rod-shaped) magnetic elements disposed therein within a fluid container. ... Dh Technologies Development Pte Ltd

Fluid transfer from digital microfluidic device

Methods and systems for processing fluids utilizing a digital microfluidic device and transferring droplets from the digital microfluidic device to a downstream analyzer are described herein. Methods and systems in accordance with the present teachings can allow for the withdrawal of fluid from a digital microfluidic device, and can in some aspects enable the integration of a digital microfluidic device as a direct, in-line sample processing platform from which a droplet can be transferred to a downstream analyzer.. ... Dh Technologies Development Pte Ltd

02/02/17 / #20170032953

Mass spectrometer

Methods and apparatus for operating a mass spectrometer are described. In various aspects, ions of a mass range of interest may be mass-selectively ejected from an accumulation ion trap into a multi-ion trap structure. ... Dh Technologies Development Pte Ltd

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