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Duke University patents


Recent patent applications related to Duke University. Duke University is listed as an Agent/Assignee. Note: Duke University may have other listings under different names/spellings. We're not affiliated with Duke University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Duke University-related inventors


Hsf-like transcription factor, tbf1, is a major molecular switch for growth-to-defense transition in plants

The present invention relates to new methods to study and control the expression of plant genes, particularly nucleotide sequences located downstream from regions comprising binding sites for transcription factors, such as the cis-element translocon 1 (tl1) comprising gaagaagaa and similar sequences. The invention relates to isolated nucleotide sequences comprising a regulatory region comprising a promoter operably-linked to one or more upstream open reading frames (uorfs) and one or more downstream open reading frames (dorfs) encoding one or more functional polypeptides, including transcription factors such as tbf1, reporter polypeptides, and polypeptides conferring resistance to drugs, resistance of plants viral, bacterial, or fungal pathogens, and polypeptides involved in the growth of plants. ... Duke University

Compositions and methods for identifying and treating dystonia disorders

The present disclosure provides methods and compositions for the treatment, identification, diagnosis, and prognosis of dystonia, or dystonia related disorders.. . ... Duke University

Compact telescope configurations for light scanning systems and methods of using the same

Compact telescope configurations for light scanning systems and related methods are disclosed. According to an aspect, a system for imaging or relaying an image of an object includes a first optical element having a first focal length f1 for imaging or relaying an image of an object at the distance f1 from the first optical element. ... Duke University

Tumor infiltrating lymphocytes for treatment of cancer

Tumor infiltrating lymphocytes (tils) are white blood cells that are actively recruited to the tumor site to mount an immune response against tumor growth and metastasis. The disclosure provides methods for treating cancer that comprise steps of isolating cd8+ t cells from a sample derived from a subject, expanding the cd8+ t cells in the presence of interleukin-10, and administering the expanded cd8+ t cells to the subject. ... Duke University

Breathing training device adapters and associated methods

Breathing training device adapters and associated methods are disclosed herein. According to an aspect, a breathing training device adapter includes a housing comprising a first end and a second end that each define an opening. ... Duke University

Tetanus toxoid and ccl3 improve dc vaccines

Pre-conditioning a vaccine site with a potent recall antigen such as tetanus/diphtheria (td) toxoid can significantly improve the lymph node homing and efficacy of tumor antigen-specific dc vaccines. Patients given td had enhanced dc migration bilaterally and significantly improved survival. ... Duke University

Nanoprobe compositions and methods of use thereof

Gold nanorattle probes are provided that are highly tunable, physiologically stable, and ultra-bright raman probes for in vitro and in vivo surface-enhanced raman scattering (sers) applications. The nanorattles contain an essentially uniform gap between core and shell that is tunable and can range from 2nm to 10nm in width. ... Duke University

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin

The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.. ... Duke University

Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same

Provided herein are conjugates including a polypeptide and one or more drug molecules. The polypeptide includes one or more charged motifs, and may further include one or more uncharged motifs. ... Duke University

Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates

A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.. ... Duke University

Systems and methods for utilizing deep brain stimulation local evoked potentials for the treatment of neurological disorders

Systems, methods, and devices are disclosed for the use of evoked potentials from the deep brain stimulation (dbs) electrode as a feedback signal to indicate lead/contact placement relative to brain targets and to enable selection or modulation of effective stimulation parameters. In some embodiments, the brain signals are recorded using specialized equipment and used to determine characteristics of the electrode position and response to stimulation. ... Duke University

Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates

Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the c-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the c-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.. ... Duke University

Lasofoxifene treatment of breast cancer

The disclosure provides methods for treating estrogen receptor positive (er+) cancer in women with an effective amount of lasofoxifene, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The disclosure also includes the detection of the estrogen receptor 1 (esr1) gene mutations that lead to endocrine resistance and treatment of endocrine resistant er+ cancers.. ... Duke University

Flexible biopsy device

A device for taking a core biopsy sample comprising a flexible catheter assembly and a needle is provided. The flexible catheter assembly comprises a first flexible catheter and a second flexible catheter partially received within the first catheter, and the first flexible catheter and second flexible catheter are coupled to a spring.. ... Duke University

08/02/18 / #20180214691

Neuromodulation device

The present invention provides improved devices, systems and methods to provide for control of bladder function. Aspects of the present disclosure relate to an apparatus, system and/or a method for modulating the neural activity of afferent fibres of the pelvic nerve to bladder function. ... Duke University

07/26/18 / #20180207193

Compositions and methods for improving enzyme replacement therapy for lysosomal storage diseases

The present disclosure provides compositions and methods for improving the efficacy of enzyme replacement therapy for lysosomal storage diseases.. . ... Duke University

07/19/18 / #20180203086

Systems and methods for phase-sensitive inversion recovery mr imaging with reduced sensitivity to cardiac motion

A magnetic resonance imaging system and method are provided for improved phase-sensitive magnetic resonance imaging of tissues affected by cardiovascular pulsatile motion. A magnetically-prepared image dataset and corresponding reference image dataset (for phase sensitivity) are obtained within the duration of a single cardiac cycle. ... Duke University

07/19/18 / #20180201951

Compositions, systems and methods for cell therapy

Disclosed herein are compositions and methods for cell therapy comprising an engineered cell. The present invention is directed to a composition for treating a subject having or suspected of having a disease, the composition comprising a modified cell comprising a modified endogenous gene, wherein an endogenous gene or fragment thereof is replaced with a transgene using a crispr/cas9 system to generate the modified endogenous gene, the modified cell having an altered response to a cell signal or stimulus.. ... Duke University

07/19/18 / #20180200183

2' fluoro-modified rnas as immunostimulators

Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5′ triphosphate, 2′ fluoro-modified pyrimidine non-linear single stranded rna at least 17 nucleotides long with a least 3 base pairings or a 5′ triphosphate, 2′ fluoro-modified double stranded rna at least 17 base pairs long in an amount effective to inhibit cell growth, induce cell death or induce cytokine production by the cells. The methods also include administration of the compositions to a subject. ... Duke University

07/12/18 / #20180195132

Oligodendroglioma drive genes

Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. ... Duke University

07/12/18 / #20180194778

Antimicrobial prochelators to target drug-resistant bacteria and methods of making and using the same

The present disclosure provides antibacterial prodrugs and methods of making and using the same.. . ... Duke University

07/05/18 / #20180185457

Treatment of glycogen storage disease type ii

Methods of treating glycogen storage disease type ii, by administering acid α-glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type ii.. . ... Duke University

06/21/18 / #20180174490

Methods and systems for generating fluid simulation models

. . Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2d) image data are provided. Data is segmented from 2d images of a sample having a biological structure with fluid flow therethrough. ... Duke University

06/21/18 / #20180170130

Non-regular electrical stimulation patterns for treating neurological disorders

Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. ... Duke University

06/14/18 / #20180161423

Liposome-peptide conjugate and method of using same to induce production of anti-hiv antibodies

The present invention relates, in general, to human immunodeficiency virus (hiv), and, in particular, to a method of inducing neutralizing antibodies to hiv and to compounds and compositions suitable for use in such a method.. . ... Duke University

06/07/18 / #20180156804

Methods of developing a prognosis for pancreatic cancer and predicting responsiveness to cancer therapeutics

Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a vegf targeting agent are provided herein. The methods include detecting the expression level of at least one biomarker selected from ang-2, sdf-1 and vegf-d in a sample from the subject and using the expression levels to determine whether the vegf targeting agent will be effective to treat the cancer in the subject. ... Duke University

06/07/18 / #20180155763

Non-fouling polymeric surface modification and signal amplification method for biomolecular detection

An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) coupled to the brush molecules. ... Duke University

06/07/18 / #20180155423

Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor and an antigen expressed by a cell infected by a virus and uses thereof

The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accomplished using bispecific molecules that are immunoreactive with an activating receptor of an immune effector cell and to an antigen expressed by a cell infected with a virus wherein the antigen is detectably present on the cell infected with the virus at a level that is greater than the level at which the antigen is detected on the virus by the bispecific molecules, and to the use of such bispecific molecules in the treatment of latent viral infections.. ... Duke University

06/07/18 / #20180154178

Phosphor-containing drug activator activatable by a monte carlo derived x-ray exposure, system containing the activator, and methods for use

A phosphor-containing drug activator activatable from a monte carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a monte carlo derived x-ray dose. ... Duke University

06/07/18 / #20180153982

Compositions, methods and kits for eliciting an immune response

The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one cmv antigen expressed by a cancer cell, in particular for treating and preventing cancer. Cmv determination methods, compositions, and kits also are provided.. ... Duke University

06/07/18 / #20180153952

Compositions and methods for treating post operative cognitive dysfunction and neuroinflammation with annexin a1 (anxa1) peptides

The present disclosure provides compositions and methods for treating post-operative cognitive dysfunction with annexin a1 (anxa1) peptides.. . ... Duke University

06/07/18 / #20180153504

3d ultrasound imaging, associated methods, devices, and systems

Methods, system, and devices that are adapted to restrict the movement of an ultrasound transducer about at least one axis or point, and tag a plurality of frames of electronic signals indicative of information received by the ultrasound transducer with information sensed by an orientation sensor. The methods, system, and devices can generate a 3d ultrasound volume image of the patient by positioning the plurality of tagged frames of electronic signals at their respective orientations relative to the axis or point.. ... Duke University

05/31/18 / #20180149719

Circuits for magnetic resonance imaging systems for integrated parallel reception, excitation, and shimming

Systems, methods and devices are configured for integrated parallel reception, excitation, and shimming (ipres). Parallel transmit/receive (which can include b1 shimming and/or parallel imaging capabilities) and b0 shimming employ the same set of localized coils or transverse electromagnetic (tem) coil elements, with each coil or tem element working in both an rf mode (for transmit/receive and b1 shimming) and a direct current (dc) mode (for b0 shimming) simultaneously. ... Duke University

05/24/18 / #20180143276

Magnetic resonance imaging (mri) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses

Magnetic resonance imaging (mri) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses are disclosed. According to an aspect, a system includes a signal generator configured to generate a pulse sequence for on-resonance magnetization transfer preparation. ... Duke University

05/24/18 / #20180142243

A method of regulating gene expression

The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.. . ... Duke University

05/24/18 / #20180140720

Compositions and methods for tissue regeneration

The present disclosure relates to compositions and methods for tissue regeneration.. . ... Duke University

05/17/18 / #20180136296

Rf coil elements with split dc loops for magnetic resonance imaging systems for integrated parallel reception, excitation, and shimming and related methods and devices

Systems, methods and devices are configured for integrated parallel reception, excitation, and shimming (ipres) with rf coil elements with split dc loops. Parallel transmit/receive (which can include b1 shimming and/or parallel imaging capabilities) and b0 shimming employ the same set of localized coils or transverse electromagnetic (tem) coil elements, with each coil or tem element working in both an rf mode (for transmit/receive and b1 shimming) and a direct current (dc) mode (for b0 shimming) simultaneously. ... Duke University

05/17/18 / #20180133319

Synergistic nanotherapy systems and methods of use thereof

The presently disclosed subject matter is directed to a method of treating cancer, such as (but not limited to) metastatic bladder and breast cancer. The disclosed method comprises using two treatment modalities to synergistically treat primary and secondary tumor cells in a subject. ... Duke University

05/17/18 / #20180133186

Preventative treatment of alzheimer's disease

The present disclosure provides methods and formulations for the treatment of alzheimer's disease in a subject in need thereof. The methods comprise administering to the subject an ornithine decarboxylase inhibitor such as alpha-difluoromethylornithine or a pharmaceutically acceptable salt in an amount effective to treat the disease.. ... Duke University

05/10/18 / #20180125869

Bisphosphonate compositions and methods for treating heart failure

The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.. . ... Duke University

05/03/18 / #20180120307

Acoustically responsive particles

Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast acoustic particles, wherein the particles can contain a functional group available for covalent modification.. ... Duke University

05/03/18 / #20180118743

Composition and methods for the treatment of camkk2-mediated disorders

The present disclosure provides compositions and methods for treating ocular disorders in mammals especially in and not limited to humans and mice. The present disclosure further provides methods of treating cancer and appetite suppression using the compositions which are novel small molecule inhibitors of camkk2. ... Duke University

05/03/18 / #20180117182

Thrombus imaging aptamers and methods of using same

Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. ... Duke University

05/03/18 / #20180117111

Method of reducing titers of antibodies specific for a therapeutic agent

The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ert) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral or viral vectors, or other therapeutic modality or modalities, used alone or in combination, which involve the administration of exogenous substances for potential therapeutic benefit, including, but not limited to dna vaccines, sirna, splice-site switching oligomers (ssos) as well as rna-based nanoparticles (rnps) and nanovaccines. The invention further relates to compounds and compositions suitable for use in such methods.. ... Duke University

05/03/18 / #20180116992

Modulators of prostate-specific g-protein receptor (psgr/or51e2) and methods of using same

The present disclosure provides, in part, modulators of prostate-specific g-protein receptor (or51e2/psgr) and methods of treating, preventing, and diagnosing prostate cancer using the same.. . ... Duke University

04/19/18 / #20180105814

A method of regulating gene expression

The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.. . ... Duke University

04/19/18 / #20180105500

Novel inhibitors of transforming growth factor kinase and methods of use thereof

The present invention provides novel inhibitors of tak1 and methods of using such compounds to treat various diseases.. . ... Duke University

04/19/18 / #20180104479

Systems and methods for utilizing model-based optimization of spinal cord stimulation parameters

Systems, methods, and devices are disclosed for optimizing patient-specific stimulation parameters for spinal cord stimulation. A patient-specific anatomical model is developed based on a pre-operative image, and a patient-specific electrical model is developed based on the anatomical model. ... Duke University

04/19/18 / #20180104309

Compositions and methods for spinal cord regeneration

The invention provides pharmaceutical compositions and methods of use thereof for ameliorating injuries and conditions of the central nervous system. More specifically, the invention provides pharmaceutical compositions that when administered promote spinal cord regeneration.. ... Duke University

04/12/18 / #20180099044

Lymph node-targeting nanoparticles

Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. A cytokine. ... Duke University

04/12/18 / #20180098963

Lasofoxifene treatment of breast cancer

The disclosure provides methods for treating estrogen receptor positive (er+) cancer in women with an effective amount of lasofoxifene, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The disclosure also includes the detection of the estrogen receptor 1 (esr1) gene mutations that lead to endocrine resistance and treatment of endocrine resistant er+ cancers.. ... Duke University

04/12/18 / #20180098752

Systems and methods for determining viscoelastic properties in soft tissue using ultrasound

Systems and methods for determining viscoelastic properties in soft tissue using ultrasound are disclosed. According to an aspect, a method includes using an ultrasound probe to acquire soft tissue data. ... Duke University

04/12/18 / #20180098722

Modulating the aryl hydrocarbon receptor system to treat major depressive disorder

Materials and methods for treating major depressive disorder by modulating the aryl hydrocarbon receptor system are provided herein.. . ... Duke University

04/05/18 / #20180095129

Software-based self-test and diagnosis using on-chip memory

Embedded processor-based self-test and diagnosis using the compressed test data is described for ics having on-chip memory. Techniques for compressing the test data before the compressed test data is transferred to a device under test (dut) are also described. ... Duke University

04/05/18 / #20180095128

Software-based self-test and diagnosis using on-chip memory

Embedded processor-based self-test and diagnosis using the compressed test data is described for ics having on-chip memory. Techniques for compressing the test data before the compressed test data is transferred to a device under test (dut) are also described. ... Duke University

04/05/18 / #20180094238

Compositions and methods for the induction and tuning of gene expression

Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.. . ... Duke University

04/05/18 / #20180094050

Vaccines against her3 antigens and methods of using the same

The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to antigenic polypeptides and their use in cancer vaccines that may be used, in part, to treat cancer types dependent upon her2-mediated signaling.. ... Duke University

04/05/18 / #20180092989

Mitochondrial antiviral signaling (mavs) protein compositions and methods of using the same

The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to mavs compositions and their use in cancer therapeutics that may be used to treat various cancers alone or in combination with other anti-cancer therapeutic agents.. ... Duke University

03/22/18 / #20180079801

Hiv-1 neutralizing antibodies and uses thereof (cd4bs antibodies)

The invention relates to the identification of monoclonal hiv-1 neutralizing antibodies, such as, but not limited to, antibodies that bind to the cd4 binding site (cd4bs) of hiv-1 gp120, their recombinant expression and purification and uses. In certain aspects, the invention provides a pharmaceutical composition comprising anyone of the antibodies of the invention or fragments thereof or any combination thereof. ... Duke University

03/15/18 / #20180073003

Method of treating glycogen storage disease

The disclosure relates, in general, to glycogen storage disease and, in particular, to a method of treating glycogen storage disease and to compounds and compositions suitable for use in such a method.. . ... Duke University

03/15/18 / #20180072797

Hiv-1 neutralizing antibodies and uses thereof (v3 antibodies)

The invention is directed to hiv-1 neutralizing antibodies, cd4 binding site and v3 glycan antibodies, and methods for their uses.. . ... Duke University

03/15/18 / #20180071410

Contrast agents for magnetic resonance imaging

Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (mri) image of a body or body region such as an organ or organ region in a subject. The method is carried out by parenterally administering ascorbate or a pharmaceutically acceptable salt thereof to the subject in an mri image-enhancing amount; and then generating, by mri of the subject, an image of the body or body region. ... Duke University

03/08/18 / #20180069318

Metamaterials for surfaces and waveguides

Complementary metamaterial elements provide an effective permittivity and/or permeability for surface structures and/or waveguide structures. The complementary metamaterial resonant elements may include babinet complements of “split ring resonator” (srr) and “electric lc” (elc) metamaterial elements. ... Duke University

03/08/18 / #20180067137

Compositions and methods for metabolic profiling in subjects with heart failure with preserved ejection fraction

Disclosed herein are compositions and methods for targeted metabolomics profiling to provide absolute quantification of a broad array of metabolic intermediates of fatty acids, amino acids, and carbohydrate metabolism for hfpef. In an aspect, the disclosure relates to a method for assessing risk of death or a major adverse cardiac event (mace) in a subject diagnosed with heart failure with preserved ejection fraction (hfpef). ... Duke University

03/08/18 / #20180067129

Compositions and methods for identifying and modulating metabolic health

This invention provides reagents, methods and biochemical markers for identifying and providing therapeutic intervention for individuals with metabolic dysfunction, or individuals at risk for metabolic dysfunction.. . ... Duke University

03/08/18 / #20180064944

Non-regular electrical stimulation patterns for improved efficiency in treating parkinson's disease

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency. ... Duke University

03/08/18 / #20180064943

Systems and methods for spinal cord stimulation

Delivering stimulation includes delivering temporal patterns of stimulation pulses to respective transducers of an array of transducers, wherein the delivery of the pattern to a particular transducer of the array is different from at least some of the deliveries of the patterns to the other transducers of the array at least according to a time delay. The patterns delivered may include regular temporal patterns each having a respective constant inter-pulse interval. ... Duke University

02/22/18 / #20180050077

Plasmonics-active metal nanostar compositions and methods of use

Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated drug, which is activated by the photo-response of the nanostar to electromagnetic stimulation; a thermally-activated drug, which is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which may directly or indirectly cause the death of an undesirable cell. ... Duke University

02/15/18 / #20180045846

Electromagnetic (em) well logging tools and related methods

An electromagnetic well logging tool for a wireline logging process, includes a shaft, a transmitter coil mounted on the shaft and configured to generate primary magnetic fields for propagation into a well formation, upon excitation by a first current, a receiver coil mounted on the shaft at a predefined distance from the transmitter coil and configured to receive secondary magnetic fields generated from the well formation, and a bucking coil mounted on the shaft in a concentric arrangement with the receiver coil, wherein the bucking coil is configured to generate magnetic fields at the receiver coil upon excitation by a second current, for cancelling the magnetic fields generated at the receiver coil due to direct coupling between the transmitter and receiver coils.. . ... Duke University

02/15/18 / #20180044736

Biomarker based prognostic model for predicting overall survival in patients with metastatic clear cell kidney cancer

The present invention describes a method of using a molecular prognostic signature, to predict overall survival in patients with metastatic clear cell renal cell carcinoma. The present invention also describes a method of selecting therapy and a process for patient risk stratification based on the molecular prognostic signature analysis.. ... Duke University

02/15/18 / #20180043184

Automatic determination of radiation beam configurations for patient-specific radiation therapy planning

Systems and methods for efficient and automatic determination of radiation beam configurations for patient-specific radiation therapy planning are disclosed. According to an aspect, a method includes receiving data based on patient information and geometric characterization of one or more organs at risk proximate to a target volume of a patient. ... Duke University

02/15/18 / #20180043182

Systems and methods for automated radiation treatment planning with decision support

Systems and methods for automated radiation treatment planning with decision support are disclosed. According to an aspect, a method includes receiving data based on patient information and geometric characterization of one or more organs at risk and a cancer target of a patient. ... Duke University

02/15/18 / #20180042969

Compositions and methods for the reprogramming of cells into cardiomyocytes

The present disclosure provides compositions and methods for the reprogramming of cells such as fibroblasts into cardiomyocytes. The invention provided herein features a chemically defined media and methods of reprogramming cells to increase cardiac gene and protein expression in cardiac fibroblasts and other fibroblasts, e.g. ... Duke University

02/08/18 / #20180037928

Glucose/galactose biosensors and methods of using same

. . Provided herein are glucose and galactose biosensors and methods of making and using the same.. . ... Duke University

02/08/18 / #20180037609

Phase transition biopolymers and methods of use

The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. ... Duke University

02/08/18 / #20180036400

Double engineered hiv-1 envelopes

In certain aspects the invention provides hiv-1 engineered envelope proteins and their uses. The engineered envelopes comprise a sequence that prevents cleavage of the envelope associated with recombinant expression in a cell line, and n-terminal deletion which improves envelope expression as a monomer.. ... Duke University

01/25/18 / #20180023065

Fusion molecules of rationally-designed dna-binding proteins and effector domains

Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. ... Duke University

01/25/18 / #20180023064

Compositions and methods for epigenome editing

Disclosed herein are crispr/cas9-based gene activation systems that include a fusion protein of a cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.. . ... Duke University

01/11/18 / #20180008718

Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure

Controlled release dosage formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the active agent, such as eca or a derivative thereof, for an effective period of time.. ... Duke University

01/11/18 / #20180008147

Systems and methods for endoscopic angle-resolved low coherence interferometry

A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. ... Duke University

01/11/18 / #20180008140

Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope

Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope are disclosed herein. According to an aspect, a system includes first and second eyepieces. ... Duke University

01/04/18 / #20180001472

Specialized robot motion planning hardware and methods of making and using same

Specialized robot motion planning hardware and methods of making and using same are provided. A robot-specific hardware can be designed using a tool that receives a robot description comprising a collision geometry of a robot, degrees of freedom for each joint of the robot, and joint limits of the robot; receives a scenario description; generates a probabilistic roadmap (prm) using the robot description and the scenario description; and for each edge of prm, produces a collision detection unit comprising a circuit indicating all parts of obstacles that collide with that edge. ... Duke University

12/28/17 / #20170369491

Compounds and methods for targeting hsp90

Described herein are compounds that may selectively bind to hsp90, methods of using the compounds, and kits including the compounds. The compounds may include detection moieties such as fluorophores that may allow for selective detection of hsp90 in a sample.. ... Duke University

12/28/17 / #20170368050

Compositions and methods for the prevention and treatment of mast cell-induced vascular leakage

Disclosed herein are methods of diagnosing and treating infectious disease characterized by a pathology that involves hemorrhaging or pathological vascular leakage.. . ... Duke University

12/21/17 / #20170360946

Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates

Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the c-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the c-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.. ... Duke University

12/14/17 / #20170357139

Apparatus and method for providing a selectively absorbing structure

An apparatus is described that selectively absorbs electromagnetic radiation. The apparatus includes a conducting surface, a dielectric layer formed on the conducting surface, and a plurality of conducting particles distributed on the dielectric layer. ... Duke University

12/14/17 / #20170355992

Factor v/va-targeting aptamer compositons and methods of using the same

Provided herein are factor v/factor va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are also provided.. ... Duke University

12/07/17 / #20170349544

Ethynylbenzene derivatives

Disclosed are compounds of formulae (i), (ii), and (ii)i: and pharmaceutically acceptable salts thereof, wherein the variables, r, r1, r2, r3, r101, l, d, q, y, x, and z are defined herein. These compounds are useful for treating gram-negative bacteria infections.. ... Duke University

12/07/17 / #20170348531

Non-regular electrical stimulation patterns for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.. ... Duke University

12/07/17 / #20170348214

Compositions and methods for treating hair loss using non-naturally occurring prostaglandins

A method for treating hair loss in mammals uses compositions containing prostaglandin f analogs. The compositions can be applied topically to the skin. ... Duke University

11/30/17 / #20170347460

Stretchable electrically conductive layer formation by aerosol jet printing on flexible substrate

Methods of forming an electrically conductive layer on a flexible substrate, such as a stretchable electrode, by aerosol jet printing on the flexible substrate while the substrate is strained. In general, a stretchable substrate is initially deformed so that a first surface thereof is under tension. ... Duke University

11/30/17 / #20170343603

Multi-layer integrated circuits having isolation cells for layer testing and related methods

Multi-layer integrated circuits having isolation cells for layer testing and related methods are disclosed. According to an aspect, an integrated circuit includes first and second layers that each have one or more electronic components. ... Duke University

11/23/17 / #20170335299

Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity

Rationally-designed laglidadg meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired dna sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.. ... Duke University

11/23/17 / #20170332939

Self-gated interleaved radial mri for abdominothoracic imaging

The present disclosure provides, in part, methods for high spatiotemporal resolution self-sorted 4d mri. These methods can be used to improve resolution of abdominothoracic mri during breathing by facilitating the sorting of information corresponding to individual mri pulse sequences according to phase within the respiratory cycle. ... Duke University

11/16/17 / #20170327866

Methods for in vivo identification of endogenous mrna targets of micrornas

A method of generating a gene expression profile of noncoding regulatory rna (ncrna; e.g. A microrna) in a cell in vivo, is carried out by: (a) partitioning from a cell at least one mrna-protein (rnp) complex, the rnp complex comprising: (i) an rna binding protein (rnabp) or rna associated protein, (ii) at least one mrna bound to or associated with said protein, and (iii) at least one ncrna bound to or associated with said protein, and then (b) identifying at least one ncrna in at least one rnp complex, thereby to produce a gene expression profile comprising the identity of an ncrna in an rnp complex.. ... Duke University

11/16/17 / #20170326258

Contrast agents based on long-lived nuclear singlet states and related methods

Methods are described for preparing magnetic resonance imaging (mri) and/or magnetic resonance spectroscopy contrast agents where the contrast agents are prepared from precursor molecules having at least four non-zero-spin nuclei that form two pairs of chemically equivalent or effectively equivalent nuclei, e.g., diphenylacetylene or diethyl oxalate. The precursor molecule is hyperpolarized and a sequence of one or more radiofrequency pulses is applied to transfer spin state population between the first and second pair of nuclei, thereby providing a non-equilibrium single state nuclear spin population. ... Duke University

11/16/17 / #20170326199

Use of caspase-2 inhibitors to treat and prevent the metabolic syndrome

Methods and compositions for treatment of obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease are discloses. The methods and compositions relate to inhibition of caspase-2.. ... Duke University

11/16/17 / #20170326127

Composition and method for treatment of neuropsychiatric disorders

The present invention relates to a composition and method for combinative therapy, capable of temporarily regulating inherent dysfunctional neural processes and reducing symptoms and/or signs of neuropsychiatric disorders including, but not limited to, psychostimulant use disorder (pud) and other substance-related additive disorders, post-traumatic stress disorder (ptsd) and other trauma- and stress-related disorders, and levodopa-induced dyskinesia (lid) and other types of dyskinesias. The present specification shows specific examples of a dosage form.. ... Duke University

11/09/17 / #20170322273

Magnetic resonance imaging of neuro-electro-magnetic oscillations

In vivo methods of non-invasively imaging neuro-electro-magnetic oscillations (nemo) are carried out by electronically transmitting a pulse sequence to a subject. The pulse sequence has a first excitation pulse, typically applied along an x-axis, followed by a spin-lock pulse applied along a different axis, typically a y-axis, and having a defined frequency, followed by a second rf excitation pulse. ... Duke University

11/09/17 / #20170322209

Biosensor

Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bpbp). Upon binding of ligand to the biosensor, there is a change in the signal transduced by the reporter group.. ... Duke University

11/09/17 / #20170321280

Nano-plasmonic molecular probes for plasmonics coupling interference

Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include rna, dna, mrna, microrna, and small nucleotide polymorphisms (snps). ... Duke University

11/09/17 / #20170319868

Phosphors and scintillators for light stimulation within a medium

A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kvp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. ... Duke University

11/09/17 / #20170319591

Methods of treating hemoglobinopathies

Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin h disease are provided. In some embodiments, the methods comprise administering an inhibitor selected from an erk inhibitor, a mek inhibitor, and, a raf inhibitor. ... Duke University

10/26/17 / #20170307349

Non-invasive thickness measurement using capacitance measurement

Methods of measuring thickness of a material using cross-capacitance. The method generally includes applying a time-varying signal to a first pad and monitoring a response of a capacitor formed by the first pad, a spaced apart second pad, and the material. ... Duke University

10/26/17 / #20170306321

Systems and methods for genetic analysis of intractable microbes

Embodiments of the present disclosure relate generally to the genetic analysis of intractable microbes. More particularly, the present disclosure provides materials and methods that incorporate chemical mutagenesis, phenotypic selection, suppression analysis, and genomic sequencing-based mutational mapping, to identify novel genetic regulators in previously intractable organisms, such as microbes that constitute the human microbiome. ... Duke University

10/26/17 / #20170304652

Systems and methods for the verification of source placement for brachytherapy radiation procedures using real time radiation detectors

The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via real-time measurement. In an embodiment, a radiation detector may be disposed proximate to a radiotherapy target. ... Duke University

10/26/17 / #20170304488

Compositions and methods for the prevention and/or reduction of scarring

The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.. . ... Duke University

10/26/17 / #20170304162

Compositions, systems and methods for the encapsulation and delivery of a substance

A composition and method is provided for synthesizing silicone particles with narrow size distributions and tunable degrees of crosslinking for encapsulation of an active ingredient or multiple active ingredients in the matrix of the particles for controlled release. The method comprises agitating at least one type of silane monomer having two, three or four siloxane bonds in an acidic aqueous solution under conditions sufficient to allow for hydrolysis of the monomers, adding a catalyst and a solution comprising a co-solvent and the active ingredient(s) to the acidic aqueous solution, and continuing to agitate the combined solution to allow for a condensation reaction and formation of silicone particles with a narrow size distribution encapsulating at least a portion of the active ingredient(s). ... Duke University

10/26/17 / #20170303820

Systems, compositions and devices for in vivo magnetic resonance imaging of lungs using perfluorinated gas mixtures

Systems and methods for generating mri images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The images are generated using acquired 19f magnetic resonance image (mri) signal data associated with the perfluorinated gas and oxygen mixture.. ... Duke University

10/12/17 / #20170294248

Noble metal-coated nanostructures and related methods

Noble metal-coated nanostructures and related methods are disclosed. According to an aspect, a nanostructure may include a structure comprising a base metal. ... Duke University

10/12/17 / #20170290650

Implantable mesh and method of use

An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the first end of the mesh extension is integrated into or part of the mesh body. ... Duke University

10/05/17 / #20170283882

Methods and therapeutics relating to mrna biomarkers for clinical prognosis of cancer

This disclosure provides methods and compositions of matter relating to the monitoring of relative concentrations of pairs of isoforms of mrna or downstream expression products thereof. The methods can include measuring a relative expression level of a pair of mrna isoforms or downstream expression products thereof and comparing the relative expression level to relative historical or cohort expression levels of the same pair of mrna isoforms. ... Duke University

10/05/17 / #20170283872

Compositions and methods for enhancing odorant receptor activity

The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor m3) capable of enhancing odorant receptor activation. ... Duke University

10/05/17 / #20170282214

Methods and systems for deposition of blended polymer films

Methods and systems for deposition of blended polymer films are disclosed. According to an aspect a method of producing a film on a substrate includes combining a guest material, a host matrix, and a solvent having one or more hydroxyl (o—h) bonds to form a target emulsion. ... Duke University

09/28/17 / #20170274037

Peptides for suppressing inflammation

Provided herein are peptides that exhibit apoe biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.. ... Duke University

09/14/17 / #20170259067

Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.. ... Duke University

09/07/17 / #20170254999

Multiscale telescopic imaging system

A multiscale telescopic imaging system is disclosed. The system includes an objective lens, having a wide field of view, which forms an intermediate image of a scene at a substantially spherical image surface. ... Duke University

09/07/17 / #20170254634

Non-invasive thickness measurement using resonant frequency shift

A method of measuring thickness of a material generally includes transmitting an oscillating signal from a first pad, through the material, to a second pad, and measuring the signal reflected back to the first pad. The material may be homogenous or heterogeneous, and has dielectric properties. ... Duke University

08/31/17 / #20170250805

Reconfigurable free-space quantum cryptography system

A system, and methods, for transmitting encrypted information as a quantum transmission between a first node and a second node, or among more than two nodes. Each node is characterized by an instantaneous spatial position, and the instantaneous spatial position of the second node is repositionable within a frame of reference associated with the first node. ... Duke University

08/31/17 / #20170247765

Methods for rapid and sensitive detection of hotspot mutations

Methods that rapidly, sensitively, and specifically detect mutations in idh1/2 and the tert promoter employ amplification of particular portions of the genes that experience frequent and exquisitely localized mutations. The ability to distinguish between sequences that differ only by one nucleotide and which may be present in very low ratios is essential for such an assay.. ... Duke University

08/24/17 / #20170239363

Polymer conjugates having reduced antigenicity and methods of using the same

Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. ... Duke University

08/24/17 / #20170239352

Combination drug therapy for the treatment of solid tumors

The present invention relates to a pharmaceutical combination that comprises an igf1r inhibitor and an mtor inhibitor for the treatment of cancer in a subject; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of medicament for the treatment of cancer; a kit comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and a method of treating cancer in a subject, especially a human.. . ... Duke University

08/24/17 / #20170239160

Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. ... Duke University

08/17/17 / #20170233714

Polymer conjugates having reduced antigenicity and methods of using the same

Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. ... Duke University

08/10/17 / #20170227553

Compositions and methods for identifying and treating conditions involving hsf1 activity

Provided herein are methods for identifying and treating subjects having conditions involving reduced hsf1 activity (e.g., diminished hsf1 activity, diminished hsf1 protein levels, increased hsf1 ser303 phosphorylation, increased hsf1 ser307 phosphorylation) or conditions that benefit from increasing hsf1 abundance or activity beyond physiological levels.. . ... Duke University

08/10/17 / #20170224712

Prochelators as broad-spectrum antimicrobial agents and methods of use

The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.. ... Duke University

08/03/17 / #20170216808

Programmable liquid, gel and biohybrid compartments and methods of use

Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. ... Duke University

08/03/17 / #20170216426

Compositions and methods for transient immune response modulation during vaccination

In certain aspects the invention provides a selection of hiv-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. ... Duke University

08/03/17 / #20170216382

Oncolytic poliovirus for human tumors

Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. ... Duke University

08/03/17 / #20170216289

Compositions and methods for the treatment of cancer

The present disclosure provides compositions and methods for the treatment of cancer, relating to the specific inhibition of abelson (abl) kinases.. . ... Duke University

07/27/17 / #20170212195

Magnetic resonance imaging (mri) systems and methods for determining and adjusting inversion time (ti) using single-line acquisition and automatic compartment detection

Magnetic resonance imaging (mri) systems and methods for determining and adjusting ti using single-line acquisition and automatic compartment detection. A method includes positioning a readout line of the mri scanner through a compartment of interest of a region of interest in a subject. ... Duke University

07/20/17 / #20170202823

Method of treating cancer using selective estrogen receptor modulators

Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (serm). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a serm.. ... Duke University

07/13/17 / #20170197206

Disposable pipette tip and methods of use

A kit for detection of an analyte of interest in a liquid sample, and methods of using, are provided. The kit may include a pipette and a disposable pipette tip configured to engage the pipette. ... Duke University

07/13/17 / #20170196953

Vaccines against an oncogenic isoform of her2 (erbb2) and methods of using the same

Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. ... Duke University

07/13/17 / #20170196952

Vaccines against an oncogenic isoform of esr1 and methods of using the same

Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. ... Duke University

07/13/17 / #20170196892

Compositions and methods for the repair of myelin

Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.. . ... Duke University

07/06/17 / #20170190675

Chemical modulators of immune checkpoints and therapeutic use

Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as pd-1, pd-l1 and ctla-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as pd-1, pd-l1 and ctla-4. ... Duke University

07/06/17 / #20170189562

Metal complexes with bisphosphonate or pyrophosphate useful as imaging agents

Provided herein are magnetic resonance imaging (mri) contrast agents comprising a compound having a structure represented by: y—x—z, wherein, x is: fe(iii) or mn(ii), and y and z are each independently selected from pyrophosphate and bisphosphonate (e.g., 1-hydroxybisphosphonate), or a pharmaceutically acceptable hydrate and/or salt thereof. Methods of use of the mri contrast agent are also provided.. ... Duke University

07/06/17 / #20170189561

Ascorbate formulations and methods of use as contrast agents

A sterile aqueous composition suitable for use as an mri contrast agent includes 100 to 600 mm ascorbate; and 100-600 mm sodium, meglumine, or a combination thereof. The composition preferably has an osmolarity of 200 to 1400 mosm/l.. ... Duke University

07/06/17 / #20170189559

Contrast agents for magnetic resonance imaging

Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (mri) image of a body or body region such as an organ or organ region in a subject. The method is carried out by parenterally administering ascorbate or a pharmaceutically acceptable salt thereof to the subject in an mri image-enhancing amount; and then generating, by mri of the subject, an image of the body or body region. ... Duke University

07/06/17 / #20170189357

Methods of limiting morbidity in hemoglobinopathies

Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin h disease are provided. In some embodiments, the methods comprise administering an agent to the subject if the subject has increased expression or activation of at least one of erk, ras, braf, raf1 mek, β-arrest1/2, syk, p60-c-src, or grk2. ... Duke University

06/29/17 / #20170186195

Spectral estimation and poly-energetic reconstruction methods and x-ray systems

Spectral estimation and poly-energetic reconstructions methods and x-ray systems are disclosed. According to an aspect, a spectral estimation method includes using multiple, poly-energetic x-ray sources to generate x-rays and to direct the x-rays towards a target object. ... Duke University

06/29/17 / #20170184729

Linear-response nanocrystal scintillators and methods of using the same

Systems and devices incorporating radiation detection, and techniques and materials for improved radiation detection are provided that involve a nano-scintillator exhibiting a linear luminescent emission response to stimulating electromagnetic radiation. The nano-scintillator can include at least one nanocrystal comprising a rare earth element, a lanthanide dopant, and a spectator dopant, wherein the nanocrystal exhibits a linear luminescent emission response to stimulating electromagnetic radiation of wavelengths less than 100 nm. ... Duke University

06/29/17 / #20170182322

Systems and methods for spinal cord stimulation

Optimizing temporal pulse patterns for stimulation delivery to a subject includes: generating a first generation pulse pattern; delivering stimulation according to the first generation pattern to a subject; measuring efficacy, efficiency and side-effect parameters affected by the delivered stimulation; determining a fitness of the first generation pattern using the measured parameters; generating a second generation pattern using the first generation pattern according to the determined fitness of the first generation temporal pattern; and delivering stimulation according to the second generation pattern. Iterative further optimization may include crossing any particular generation temporal pulse pattern with at least one other temporal pulse pattern to generate offspring patterns for further use and optimization. ... Duke University

06/22/17 / #20170176559

Systems and methods for assessing pulmonary gas transfer using hyperpolarized 129xe mri

Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one mri image and/or image data of 129xe dissolved in the red blood cells (rbc) in the gas exchange regions of the lungs of a patient. The image is sufficiently sensitive to allow a clinician or image recognition program to assess at least one of pulmonary gas exchange, barrier thickness or barrier function based on the 129xe mri rbc image.. ... Duke University

06/22/17 / #20170174660

Heat shock protein 70 (hsp-70) receptor ligands

Inducible hsp70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of small molecule inhibitors of hsp70 pose a new therapy to cancer treatment. ... Duke University

06/22/17 / #20170173350

Plasmonic assisted systems and methods for interior energy-activation from an exterior source

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. ... Duke University

06/22/17 / #20170173252

Arteriovenous graft for hemodialysis with puncture-resistant posterior and side walls

An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet and an outlet, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; and a self-sealing material extending across the cannulation port. ... Duke University

06/15/17 / #20170165316

Method of reducing titers of antibodies specific for a therapeutic agent

The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ert) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral or viral vectors, or other therapeutic modality or modalities, used alone or in combination, which involve the administration of exogenous substances for potential therapeutic benefit, including, but not limited to dna vaccines, sirna, splice-site switching oligomers (ssos) as well as rna-based nanoparticles (rnps) and nanovaccines. The invention further relates to compounds and compositions suitable for use in such methods.. ... Duke University

06/15/17 / #20170165216

Methods and compositions for treatment of acute lung injury

A method of treating acute lung injury (ali) in a patient suspected of having ali is disclosed. The method includes administering to the patient a therapeutically effective amount of an inducible nitric oxide synthase (inos) inhibitor.. ... Duke University








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