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Duke University patents (2015 archive)


Recent patent applications related to Duke University. Duke University is listed as an Agent/Assignee. Note: Duke University may have other listings under different names/spellings. We're not affiliated with Duke University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Duke University-related inventors


12/31/15 / #20150376259

Compositions and methods for enhancing odorant receptor activity

The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor m3) capable of enhancing odorant receptor activation. ... Duke University

12/24/15 / #20150371400

Segmentation and identification of closed-contour features in images using graph theory and quasi-polar transform

Segmentation and identification of closed-contour features in images using graph theory and quasi-polar transform are disclosed. According to an aspect, a method includes representing, in a rectangular domain, an image including a feature of interest. ... Duke University

12/17/15 / #20150359874

Vaccine formulation

The present invention relates, in general, to a method of inducing an immune response to hiv-1 in a mammal and, in particular, to a vaccine formulation suitable for use in such a method comprising an hiv-1 envelope (env) immunogen comprising recombinant envs with some degree of high-mannose glycan residues and a toll-like receptor (tlr) agonist-supplemented squalene-based adjuvant.. . ... Duke University

12/17/15 / #20150359512

Synthetic aperture ultrasound system

A synthetic aperture ultrasound system includes an ultrasound probe, and an ultrasound signal processor configured to communicate with the ultrasound probe to receive phase and amplitude information from a plurality of ultrasonic echo signals from a corresponding plurality of ultrasound pulses. The synthetic aperture ultrasound system also includes a positioning system configured to communicate with the ultrasound signal processor to provide probe position information. ... Duke University

12/10/15 / #20150352358

Systems and methods for optimizing cardiac resynchronization therapy (crt)

Systems and methods for optimizing crt are disclosed. According to an aspect, a method includes receiving, during at least two time periods of a cardiac cycle, electrical signals communicated by two or more electrodes of a crt device positioned one or more of on a surface of a body, within a thorax of the body, a heart of the body, a surrounding venous structure of the body, and a surrounding subcutaneous structure of the body. ... Duke University

12/10/15 / #20150351705

System for improved compressive tomography and method therefor

A method and system for forming tomographic images of an object using discrete, non-continuous illumination rays is disclosed. In some embodiments, coded apertures, collimation filters, or reference structures are used to filter the set of illumination rays from a two- or three-dimensional radiation signal, wherein the set of illumination rays are then used to interrogate the object. ... Duke University

12/03/15 / #20150346205

Methods of subclassification of ductal carcinoma in situ of the breast

Provided herein are methods of determining the aggressiveness or indolence of a ductal carcinoma in situ lesion. Also provided are methods of development treatment plans for subjects with a ductal carcinoma in situ lesion based on the aggressiveness of the lesion.. ... Duke University

12/03/15 / #20150344509

Substituted porphyrins

Substituted metalloporphyrin compounds are described, along with pharmaceutical compositions containing the same, and methods of use thereof in protecting cells from oxidant-induced toxicity and pathological conditions such as inflammatory lung disease, neurodegenerative conditions, radiation injury, cancer, diabetes, cardiac conditions and sickle cell disease. Mn(iii) porphyrins bearing oxygen atoms within side chains are particularly described.. ... Duke University

12/03/15 / #20150342460

Imaging and visualization systems, instruments, and methods using optical coherence tomography

Imaging and visualization systems, instruments, and methods using optical coherence tomography (oct) are disclosed. A method for oct image capture includes determining a location of a feature of interest within an operative field. ... Duke University

11/26/15 / #20150336098

Apparatuses and methods for manipulating droplets

Apparatuses and methods for manipulating droplets are disclosed. In one embodiment, an apparatus for manipulating droplets is provided, the apparatus including a substrate, multiple arrays of electrodes disposed on the substrate, wherein corresponding electrodes in each array are connected to a common electrical signal, and a dielectric layer disposed on the substrate first side surface and patterned to cover the electrodes.. ... Duke University

11/26/15 / #20150335732

Compositions, methods, and kits for eliciting an immune response

The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one cmv antigen expressed by a cancer cell, in particular for treating and preventing cancer. Cmv determination methods, compositions, and kits also are provided.. ... Duke University

11/19/15 / #20150329497

Small molecule agonists of neurotensin receptor 1

Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.. . ... Duke University

11/12/15 / #20150322514

Diagnostic markers for platelet function and methods of use

Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to anti-platelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.. ... Duke University

11/12/15 / #20150322425

Rna aptamers and methods for identifying the same

Rna aptamers and methods for identifying the same are disclosed. The rna aptamers selectively bind coagulation factors, e2f family members, ang1 or ang2, and therapeutic and other uses for the rna aptamers are also disclosed.. ... Duke University

11/12/15 / #20150320726

Method for treating obesity

The present invention relates generally to methods of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight loss-promoting anti-convulsant either alone or in combination with bupropion or metabolites thereof or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism.. . ... Duke University

11/05/15 / #20150316605

Software-based self-test and diagnosis using on-chip memory

Embedded processor-based self-test and diagnosis using the compressed test data is described for ics having on-chip memory. Techniques for compressing the test data before the compressed test data is transferred to a device under test (dut) are also described. ... Duke University

11/05/15 / #20150315556

Fusion molecules of rationally-designed dna-binding proteins and effector domains

Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. ... Duke University

10/29/15 / #20150307614

Enhanced immunological responses

Cancers and other diseases can be treated with two or three types of agents: an agent which induces lymphodepletion or lymphopenia; an inhibitory antibody to a surface marker on treg cells; and optionally a specific antigen. This combination may lead to enhanced immune responses despite lymphodepletion or lymphopenia.. ... Duke University

10/29/15 / #20150305717

Methods, systems and computer program products for multi-resolution imaging and analysis

Methods for determining a mechanical parameter for a sample having a target region include generating a tissue displacement in the target region; transmitting tracking pulses in the target region; receiving corresponding echo signals for the tracking pulses in the target region at a plurality of positions; analyzing the echo signals at one or more multi-resolution pairs of the positions and/or acquisition times; and determining at least one mechanical parameter of the target region based on the echo signals at the one or more multi-resolution pairs of positions and/or acquisition times.. . ... Duke University

10/22/15 / #20150297611

Inhibition of histone methyltransferase for cardiac reprogramming

A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.. . ... Duke University

10/22/15 / #20150297591

Methods of treating pulmonary fibrosis

A method of treating ionizing radiation injury, or pulmonary fibrosis, or pulmonary hypertension due to any cause, such as idiopathic, autoimmune, or environmental, in a mammalian subject in need thereof, comprises administering the subject a gastrin-releasing peptide (grp) blocking agent or inhibitor in a treatment effective amount.. . ... Duke University

10/01/15 / #20150281910

Unsupervised indoor localization and heading directions estimation

Systems and methods for unsupervised indoor localization are provided. Sensor data obtained from a device carried by a user can be used to simultaneously estimate the indoor location of a user and identify landmarks within the indoor environment based on their signatures. ... Duke University

10/01/15 / #20150274640

Method of treating cancer using selective estrogen receptor modulators

Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (serm). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a serm.. ... Duke University

09/24/15 / #20150265684

Methods of treating hemoglobinopathies

Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin h disease are provided. In some embodiments, the methods comprise administering an inhibitor selected from a β-arrestin1/2 inhibitor and/or a grk2 inhibitor to the subject. ... Duke University

09/24/15 / #20150265245

Pmut array for ultrasonic imaging, and related apparatuses, systems, and methods

Piezoelectric micromachined ultrasound transducer (pmut) arrays for ultrasonic imaging, and related apparatuses, systems, and methods are disclosed. In one embodiment, an ultrasonic imaging assembly comprises a substrate and a plurality of array elements arranged on the substrate in an array. ... Duke University

09/17/15 / #20150258220

Magnetic resonance imaging and/or spectroscopy contrast agents and methods of use thereof

The presently disclosed subject matter demonstrates that a spin state which has zero magnetic resonance signal, but an extremely long lifetime, can be used to store magnetization, which can then be recovered into an observable transition. Coupled with hyperpolarization techniques, this permits the preparation of a wide range of contrast agent molecules for use in magnetic resonance imaging (mri) techniques that have long effective relaxation time.. ... Duke University

09/17/15 / #20150258044

Methods of treatment using arylcyclopropylamine compounds

Described herein are methods of treating parkinson's disease using arylcyclopropylamine compounds.. . ... Duke University

09/10/15 / #20150252417

Signatures of radiation response

The present invention relates, in general, to gene expression profiles, and in particular, to a gene expression profile of an environmental exposure, ionizing radiation. The invention further relates to methods of screening patients for radiation exposure based on gene expression profiling and to kits suitable for use in such methods.. ... Duke University

09/10/15 / #20150251016

Non-invasive energy upconversion methods and systems

Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. ... Duke University

09/10/15 / #20150250847

Peptides for suppressing inflammation

Provided herein are peptides that exhibit apoe biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.. ... Duke University

09/03/15 / #20150248325

Systems for and methods of extending lifetime of non-volatile memory

Systems and methods are provided for increasing the number of writes to a page of non-volatile memory before the page must be erased. According to an embodiment, instead of writing a dataword directly to memory, a codeword is written to the memory location. ... Duke University

09/03/15 / #20150246521

Adhesive bonding composition and method of use

A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically x-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. ... Duke University

08/27/15 / #20150238469

Compositions and methods for treating hair loss using non-naturally occurring prostaglandins

A method for treating hair loss in mammals uses compositions containing prostaglandin f analogs. The compositions can be applied topically to the skin. ... Duke University

08/27/15 / #20150237837

Non-human model for wound healing

The present disclosure provides a rodent scar contracture model to study scar contractures and methods of using such a model. Such uses may include, but are not limited to, testing mechanisms or action or developing new anti-scar contracture compounds.. ... Duke University

08/20/15 / #20150231205

Compositions and methods for the treatment of myocardial ischemia/reperfusion injury with annexin a1 short peptide

The present invention provides a method of treating, ameliorating or preventing myocardial ischemia/reperfusion injury in a subject in need thereof, by administering to the subject a therapeutically effective amount of an anxa1short peptide (anxa1sp).. . ... Duke University

08/20/15 / #20150231150

Substituted porphyrins

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.. ... Duke University

08/13/15 / #20150229133

Subscription based miso and mimo wireless energy transfer

Subscription based multiple-in-put-single-output and multiple-input-multiple-output wireless energy transfer enables selective charging and powering of mobile devices using a plurality of spatially distributed transmitters that are synchronized under the control of a transmitter controller. Amplitude, phase, and frequency of each transmitter is controlled to promote or deny the transfer of energy to particular mobile devices or positions through optimization techniques based on the incident power level at each mobile device subscribing to the system. ... Duke University

08/06/15 / #20150216933

Hematopoietic stem cell growth factor

The present invention relates, in general, to stem cells and, in particular, to a hematopoietic stem cell (hsc) growth factor and to methods of using same.. . ... Duke University

08/06/15 / #20150216416

System and method for large field of view, single cell analysis

A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical receptor is employed that is configured to receive the light from the object. ... Duke University

07/30/15 / #20150211066

Methods and compositions for correlating genetic markers with sudden cardiac death risk

The present invention provides a method of identifying a subject as having an increased risk of sudden cardiac death or cardiac arrhythmia by detecting in the subject the presence of various polymorphisms associated with an increased risk of sudden cardiac death or cardiac arrhythmia.. . ... Duke University

07/23/15 / #20150202294

Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders

Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a dna cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.. . ... Duke University

07/09/15 / #20150191471

Compounds and methods for targeting hsp90

Described herein are compounds that may selectively bind to hsp90, methods of using the compounds, and kits including the compounds. The compounds may include detection moieties such as fluorophores that may allow for selective detection of hsp90 in a sample.. ... Duke University

06/25/15 / #20150180133

Metamaterial waveguide lens

A metamaterial waveguide structure is disclosed. In some approaches the metamaterial waveguide structure is compressed along an optical axis using transformation optics techniques. ... Duke University

06/25/15 / #20150177496

Apparatus comprising a compact telescope

A camera system for a mobile device includes an array of compact catadioptric telescopes wherein at least some of the telescopes have a portion of their aperture truncated. At least some of the catadioptric telescopes in the array are tilted with respect to the system optical axis.. ... Duke University

06/25/15 / #20150177344

Magnetic resonance imaging systems for integrated parallel reception, excitation and shimming and related methods and devices

Systems, methods and devices are configured for integrated parallel reception, excitation, and shimming (ipres). Parallel transmit/receive (which can include b?1#191 shimming and/or parallel imaging capabilities) and b1 shimming employ the same set of localized coils or transverse electromagnetic (tem) coil elements, with each coil or tem element working in both an rf mode (for transmit/receive and b1 shimming) and a direct current (dc) mode (for b0 shimming) simultaneously. ... Duke University

06/25/15 / #20150174577

Filler fluids for droplet operations

The present invention relates to filler fluids for droplet operations. According to one embodiment of this aspect, a droplet microactuator is provided and includes: (a) a first substrate comprising electrodes configured for conducting droplet operations on a surface of the substrate; (b) a second substrate spaced from the surface of the substrate by a distance sufficient to define an interior volume between the first substrate and second substrate, wherein the distance is sufficient to contain a droplet disposed in the space on the first substrate; and (c) a droplet arranged in the interior volume and arranged with respect to the electrodes in a manner which permits droplet operations to be effected on the droplet using the electrodes.. ... Duke University

06/25/15 / #20150174408

Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.. ... Duke University

06/18/15 / #20150166509

Smoothened modulators and methods of use thereof

Compounds of general formulas (i), (ia), (ib) are described, along with compositions containing the same and methods of use thereof, inhibiting the hedgehog pathway in a cell or inhibiting unwanted proliferation of a cell.. . ... Duke University

06/11/15 / #20150160240

Host biomarkers for dengue fever (df) and methods thereof

The present invention provides methods of determining whether a subject has a dengue virus infection that is likely to develop into a life-threatening dengue disease and methods of selecting a treatment regimen for a subject in need thereof who has been infected with a dengue virus. The invention further provides a prognostic kit for distinguishing a subject who is likely to develop a mild dengue disease from a subject who is likely to develop a life-threatening dengue disease. ... Duke University

06/04/15 / #20150154741

Multi-shot scan protocols for high-resolution mri incorporating multiplexed sensitivity-encoding (muse)

Multi-shot dwi with multiplexed sensitivity-encoding (muse) inherently corrects nonlinear shot-to-shot phase variations without requiring the use of navigator echoes. The multi-shot dwi can use interleaved echo-planar imaging or other scan protocols. ... Duke University

06/04/15 / #20150150941

Chronic lymphocytic leukemia prognosis and treatment

Provided herein are methods for identifying a subject afflicted with chronic lymphocytic leukemia who is responsive to treatment with a chemotherapeutic agent by detecting the presence or absence of at least one apoe4 allele in the subject, the presence of an apoe4 allele identifying the subject as responsive to the treatment. Also provided are methods of treating a subject afflicted with chronic lymphocytic leukemia, including administering an estrogenic agent, an androgen withdrawal agent, an apoe4 peptide or mimetic thereof, and/or a chemotherapeutic agent in an amount effective to treat said chronic lymphocytic leukemia. ... Duke University

05/28/15 / #20150148238

Droplet-based surface modification and washing

The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one or more beads. ... Duke University

05/28/15 / #20150147387

Method of inducing antibodies to human immunodeficiency virus involving the administration of mper peptide-liposome conjugates

The present invention relates to a method of inducing the production in a patient of anti-hiv antibodies. The method comprises administering to a patient in need thereof an amount of at least one liposome-peptide conjugate in an amount sufficient to effect that induction. ... Duke University

05/07/15 / #20150127066

Non-regular electrical stimulation patterns for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.. ... Duke University

04/30/15 / #20150118692

Acoustically responsive particles

Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast acoustic particles, wherein the particles can contain a functional group available for covalent modification.. ... Duke University

04/30/15 / #20150118181

Concurrent chemotherapy and immunotherapy

The concurrent administration of chemotherapy and immunotherapy has been considered a contraindication because of the concern that the induced lymphopenia would ablate therapeutic efficacy of immunotherapy. Temozolomide has been shown to be an effective chemotherapeutic for patients with malignant gliomas and to deprive patients with glioblastoma (gbm) patients of this agent in order to treat with immunotherapy is controversial. ... Duke University

04/30/15 / #20150116187

Metamaterials for surfaces and waveguides

Complementary metamaterial elements provide an effective permittivity and/or permeability for surface structures and/or waveguide structures. The complementary metamaterial resonant elements may include babinet complements of “split ring resonator” (srr) and “electric lc” (elc) metamaterial elements. ... Duke University

04/23/15 / #20150113685

Hsf-like transcription factor, tbf1, is a major molecular switch for growth-to-defense transition in plants

The present invention relates to new methods to study and control the expression of plant genes, particularly nucleotide sequences located downstream from regions comprising binding sites for transcription factors, such as the cis-element translocon 1 (tl1) comprising gaagaagaa and similar sequences. The invention relates to isolated nucleotide sequences comprising a regulatory region comprising a promoter operably-linked to one or more upstream open reading frames (uorfs) and one or more downstream open reading frames (dorfs) encoding one or more functional polypeptides, including transcription factors such as tbf1, reporter polypeptides, and polypeptides conferring resistance to drugs, resistance of plants viral, bacterial, or fungal pathogens, and polypeptides involved in the growth of plants. ... Duke University

04/23/15 / #20150112022

Phase transition biopolymers and methods of use

The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. ... Duke University

04/23/15 / #20150111830

Methods and compositions for activation of sirtuins with annexin a1 peptides

The present invention provides a method of treating, ameliorating or inhibiting sirtuin-associated disorders and/or conditions in a subject in need thereof, by administering to the subject an effective amount of an anxa1 peptide.. . ... Duke University

04/02/15 / #20150096065

Method of regulating gene expression

The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.. . ... Duke University

03/26/15 / #20150083923

Linear-response nanocrystal scintillators and methods of using the same

Systems and devices incorporating radiation detection, and techniques and materials for improved radiation detection are provided that involve a nano-scintillator exhibiting a linear luminescent emission response to stimulating electromagnetic radiation. The nano-scintillator can include at least one nanocrystal comprising a rare earth element, a lanthanide dopant, and a spectator dopant, wherein the nanocrystal exhibits a linear luminescent emission response to stimulating electromagnetic radiation of wavelengths less than 100 nm. ... Duke University

03/19/15 / #20150080306

Therapeutic agents comprising elastic peptides

The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible, extended conformation. ... Duke University

03/19/15 / #20150079064

Genetic correction of mutated genes

Disclosed herein are transcription activator-like effector nuclease (talen)-related compositions and methods of using said talens for correcting mutant genes.. . ... Duke University

03/19/15 / #20150077855

Finite-embedded coordinate designed transformation-optical devices

The design method for complex electromagnetic materials is expanded from form-invariant coordinate transformations of maxwell's equations to finite embedded coordinate transformations. Embedded transformations allow the transfer of electromagnetic field manipulations from the transformation-optical medium to another medium, thereby allowing the design of structures that are not exclusively invisible. ... Duke University

03/19/15 / #20150077535

Systems and methods for structured illumination super-resolution phase microscopy

Systems and methods for structured illumination super-resolution phase microscopy are disclosed. According to an aspect, an imaging system includes a light source configured to generate light. ... Duke University

03/12/15 / #20150073495

Non-regular electrical stimulation patterns for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.. ... Duke University

03/05/15 / #20150064113

Contrast agents based on long-lived nuclear singlet states and related methods

Methods are described for preparing magnetic resonance imaging (mri) and/or magnetic resonance spectroscopy contrast agents where the contrast agents are prepared from precursor molecules having at least four non-zero-spin nuclei that form two pairs of chemically equivalent or effectively equivalent nuclei, e.g., diphenylacetylene or diethyl oxalate. The precursor molecule is hyperpolarized and a sequence of one or more radiofrequency pulses is applied to transfer spin state population between the first and second pair of nuclei, thereby providing a non-equilibrium single state nuclear spin population. ... Duke University

03/05/15 / #20150062686

Apparatus and method for providing a selectively absorbing structure

An apparatus is described that selectively absorbs electromagnetic radiation. The apparatus includes a conducting surface, a dielectric layer formed on the conducting surface, and a plurality of conducting particles distributed on the dielectric layer. ... Duke University

03/05/15 / #20150062591

Apparatuses, systems, and methods for low-coherence interferometry (lci)

Embodiments described herein involve low-coherence interferometry (lci) techniques which enable acquisition of structural and depth information regarding a sample of interest. In one embodiment, a “swept-source” (ss) light source is used in lci to obtain structural and depth information about a sample. ... Duke University

03/05/15 / #20150060284

Apparatuses and methods for manipulating droplets

Apparatuses and methods for manipulating droplets are disclosed. In one embodiment, an apparatus for manipulating droplets is provided, the apparatus including a substrate, multiple arrays of electrodes disposed on the substrate, wherein corresponding electrodes in each array are connected to a common electrical signal, and a dielectric layer disposed on the substrate first side surface and patterned to cover the electrodes.. ... Duke University

02/26/15 / #20150057689

Ophthalmic drug delivery device and methods of use

The present disclosure provides an elastomeric material for the delivery of an ophthalmic agent to the eye of a subject and methods of using such material.. . ... Duke University

02/26/15 / #20150057165

Microrna and use thereof in identification of b cell malignancies

Disclosed are nucleic acid sequences, including microrna sequences and cdna sequences, as well as vectors, dna libraries, microarrays, and recombinant cells comprising the nucleic acid sequences described herein. Methods of determining the b cell stage from which a b cell malignancy is derived. ... Duke University

02/19/15 / #20150051557

Devices and methods of administering opthalmic medications

A system for administering medication to an eye. The system includes a siphon tube in fluid communication with a medication reservoir, a dispensing nozzle connected to the siphon tube, and a shield coupled to the dispensing nozzle for movement relative thereto between an opened position and a closed position. ... Duke University

02/19/15 / #20150050734

Carbon nanotubes and methods of use

The present disclosure provides carbon nanotube substrates, and methods of using those substrates, for the treatment and/or amelioration of neurological conditions associated with elevated levels of neural chloride. One aspect of the present disclosure provides a substrate comprising, consisting of or consisting essentially of high-conductivity few-walled cnts dispersed thereon, wherein the cnts comprise an intrinsic electrical conductivity of at least 2,500 s/cm. ... Duke University

02/12/15 / #20150045677

Systems and methods for endoscopic angle-resolved low coherence interferometry

A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. ... Duke University

02/12/15 / #20150044223

Combination drug therapy for the treatment of solid tumors

The present invention relates to a pharmaceutical combination that comprises an igf1r inhibitor and an mtor inhibitor for the treatment of cancer in a subject; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of medicament for the treatment of cancer; a kit comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and a method of treating cancer in a subject, especially a human.. . ... Duke University

02/05/15 / #20150038530

Compositions and methods for the prevention and treatment of mast cell-induced vascular leakage

Disclosed herein are methods of diagnosing and treating infectious disease characterized by a pathology that involves hemorrhaging or pathological vascular leakage.. . ... Duke University

02/05/15 / #20150037329

Method of reducing titers of antibodies specific for a therapeutic agent

The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ert) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral or viral vectors, or other therapeutic modality or modalities, used alone or in combination, which involve the administration of exogenous substances for potential therapeutic benefit, including, but not limited to dna vaccines, sirna, splice-site switching oligomers (ssos) as well as rna-based nanoparticles (rnps) and nanovaccines. The invention further relates to compounds and compositions suitable for use in such methods.. ... Duke University

01/29/15 / #20150030256

Multi-sensor compressive imaging

Multi-sensor compressive imaging systems can include an imaging component (such an an rf, microwave, or mmw metamaterial surface antenna) and an auxialiary sensing component (such as an eo/ir sensor). In some approaches, the auxiliary sensing component includes a structured light sensor configured to identify the location or posture of an imaging target within a field of view of the imaging component. ... Duke University

01/22/15 / #20150025063

Antiparkinsonian action of phenylisopropylamines

A method of treating a subject for parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of parkinson's disease.. ... Duke University

01/22/15 / #20150023909

Lymph node-targeting nanoparticles

Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. A cytokine. ... Duke University

01/15/15 / #20150018281

Compositions and methods for uncoupling trkb receptor from plc gamma 1 for the treatment of epilepsy and anxiety-like disorder

The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides that when administered disrupt the physical interaction of trkb with its signaling effector, phospholipase cγ1 (plcγ1). ... Duke University

01/15/15 / #20150017261

Methods of treating and preventing cancer by disrupting the binding of copper in the map kinase pathway

The present disclosure provides methods of treating and/or preventing cancer in a subject comprising administering to the subject a copper-reduced diet by itself or as a supplement along with a regular diet to create a copper-reduced melieu, maintain a reduced-copper melieu, or both, thereby treating and/or preventing the development of the cancer. Methods also comprise further adding a copper chelator, mek inhibitor, or combinations thereof.. ... Duke University

01/01/15 / #20150004152

Treatment of glycogen storage disease type ii

Methods of treating glycogen storage disease type ii, by administering acid α-glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type ii.. . ... Duke University








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