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Duke University patents (2016 archive)


Recent patent applications related to Duke University. Duke University is listed as an Agent/Assignee. Note: Duke University may have other listings under different names/spellings. We're not affiliated with Duke University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Duke University-related inventors


Immune monitoring to predict and prevent infection

Methods of evaluating the risk of infection after transplantation or immunosuppression in a subject are provided. Methods of determining whether a subject should be treated prophylactically with an anti-microbial agent are also provided herein. ... Duke University

Trpc6 involved in glomerulonephritis

Focal and segmental glomerulosclerosis (fsgs) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary fsgs carries a missense mutation in the trpc6 gene on chromosome 11q, encoding the ion channel protein transient receptor potential cation channel 6. ... Duke University

Regulatory b cells and their uses

The present invention relates to a phenotypically distinct cd1dhighcd5+ b cell subset that regulates t cell mediated inflammatory responses through the secretion of interleukin-10 (il-10). The invention also relates to the use of these il-10 producing regulatory b cells in the manipulation of immune and inflammatory responses, and in the treatment of disease. ... Duke University

Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies

The present invention concerns the treatment of serotonergic dysregulation disordersand/or augmentation of serotonin levels in the brain by add-on treatments to serotonin enhancers, and slow-release formulations of 5-hydroxytryptophan (5-htp) therefor.. . ... Duke University

Ultrasound device and method for estimating tissue stiffness

An ultrasound device and method for calculating an estimated tissue stiffness based on peak on-axis tissue displacement propagating along the axis of an acoustic radiation force (arf) excitation region are disclosed. Embodiments estimate stiffness by measuring time-to-peak tissue displacement directly along the acoustic radiation force axis. ... Duke University

Systems and devices for protease detection based on engineered polymers and biopolymers and methods of use

The presently disclosed subject matter relates to modular peptide-substrate protease assays, in particular low cost and reliable methodology for measurement of protease and other enzyme activity that may be detected by optical turbidimetry or visual observation. The presently disclosed subject matter also relates to methods of using the disclosed assays within methods of detecting and monitoring diseases, methods of drug discovery, as well as in detection devices and systems.. ... Duke University

System for accurate measurement of dynamics and kinematics

A sensor insert is provided for measuring head dynamics and kinematics. The sensor insert includes at least one sensor embedded in the insert. ... Duke University

Mutations define clinical subgroups of gliomas

Genetic signatures capable of distinguishing among several types of gliomas provide clinically relevant information that can serve as an adjunct to histopathological diagnosis. For example, mutations in the tert promoter occurred in 74.2% of glioblastomas (gbm), but occurred in a minority of grade ii-iii astrocytomas (18.2%). ... Duke University

Hiv-1 mother-to-child transmission correlates of protection and vaccine

The invention provides compositions and methods to induce and boost antibody response, including but not limited to igg responses binding to hiv-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example v3 and/or cd4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (mtct) of hiv-1.. . ... Duke University

Systems and methods for eye tracking for motion corrected ophthalmic optical coherenece tomography

Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography (oct) are disclosed. According to an aspect, an imaging system includes an eye tracking device configured to determine movement of an eye. ... Duke University

Non-fouling polymeric surface modification and signal amplification method for biomolecular detection

An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) coupled to the brush molecules. ... Duke University

Use of caspase-2 inhibitors to treat and prevent the metabolic syndrome

Methods and compositions for treatment of obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease are discloses. The methods and compositions relate to inhibition of caspase-2.. ... Duke University

Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders

Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a dna cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.. . ... Duke University

Non-invasive systems and methods for in-situ photobiomodulation

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. ... Duke University

11/10/16 / #20160324808

Method of treating cancer using selective estrogen receptor modulators

Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (serm). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a serm.. ... Duke University

10/27/16 / #20160314602

Multi-sensor compressive imaging

Multi-sensor compressive imaging systems can include an imaging component (such an an rf, microwave, or mmw metamaterial surface antenna) and an auxialiary sensing component (such as an eo/ir sensor). In some approaches, the auxiliary sensing component includes a structured light sensor configured to identify the location or posture of an imaging target within a field of view of the imaging component. ... Duke University

10/27/16 / #20160311893

Inhibitors of complement factor h

Disclosed herein are complement factor h (cfh) inhibitors, such as anti-cfh antibodies and small molecules, and methods of using said inhibitors.. . ... Duke University

10/06/16 / #20160290867

Multiple window processing schemes for spectroscopic optical coherence tomography (oct) and fourier domain low coherence interferometry

Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (soct) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (dw) apparatuses and methods for reconstructing time-frequency distributions (tfds) that applies two windows that independently determine the optical and temporal resolution is provided. ... Duke University

10/06/16 / #20160289297

Reversible platelet inhibition

The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein iib/iiia (gpiib/iiia), and to aptamers suitable for use in such a method. The invention also relates to antidotes to antiplatelet agents and to methods of using such antidotes to reverse aptamer-induced platelet inhibition. ... Duke University

10/06/16 / #20160287575

Compositions and methods for the treatment of diseases involving hippo pathway

Provided herein are interfering molecules and pharmaceutical combinations comprising such interfering molecules that modulate the hippo signaling pathway. Also provided are methods of treating and preventing a disease or condition associated disruption of a hippo signaling pathway component, such as skeletal muscle disorders and cancers, where the method comprises administering to a subject in need thereof an interfering molecule or pharmaceutical composition described herein.. ... Duke University

10/06/16 / #20160287123

Method and system for evaluating stability of cardiac propagation reserve

A method of determining the susceptibility to ventricular arrhythmias in a subject, the method including determining a reserve of refractoriness (ror) and a reserve of memory (rom) and combining the reserve of refractoriness (ror) and the reserve of memory (rom) to produce a metric of stability-of-propagation reserve (sopr) in the subject, a higher value of sopr indicating lower susceptibility to ventricular arrhythmias in the subject. Systems and apparatus for carrying out the method are also described.. ... Duke University

10/06/16 / #20160287063

Colposcopes having light emitters and image capture devices and associated methods

Colposcopes having light emitters and image capture devices and associated methods are disclosed. According to an aspect, a colposcope includes an elongate body having a distal end, a proximate end, and an axis extending between the distal end and the proximate end. ... Duke University

09/29/16 / #20160286137

Method for combining multiple image fields

Methods for stitching multiple sub-images together to form a substantially seamless composite image are disclosed. Overlap regions formed by each pair of neighboring sub-images are periodically examined and key features common to the overlap regions in each sub-image of the pair are identified. ... Duke University

09/29/16 / #20160281107

Synthetic regulation of gene expression

Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. ... Duke University

09/22/16 / #20160271262

Hydrogels formed from polypeptide micelles and methods of use thereof

The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of micro- and macro-hydrogels that are formed from polypeptide micelles. The systems have enhanced mechanical properties that can be useful in a wide variety of applications, can be used for controlled release of drug-loaded micelles, and can be designed to reversibly assemble and disassemble on demand.. ... Duke University

09/22/16 / #20160271244

Method of inducing the production of protective anti-hiv-1 antibodies

The present invention relates, in general, to an immunogen for hiv vaccination and, in particular, to a method of inducing the production of protective anti-hiv antibodies by targeting b cell germline and clone intermediates using a combination of hiv envelope and non-hiv immunogens. The invention also relates to compositions suitable for use in such a method.. ... Duke University

09/22/16 / #20160271240

Tetanus toxoid and ccl3 improve dc vaccines

Pre-conditioning a vaccine site with a potent recall antigen such as tetanus/diphtheria (td) toxoid can significantly improve the lymph node homing and efficacy of tumor antigen-specific dc vaccines. Patients given td had enhanced dc migration bilaterally and significantly improved survival. ... Duke University

09/15/16 / #20160266248

Metamaterial devices and methods of using the same

Compressive imaging captures images in compressed form, where each sensor does not directly correspond with a pixel, as opposed to standard image capture techniques. This can lead to faster image capture rates due to lower i/o bandwidth requirements, and avoids the need for image compression hardware, as the image is captured in compressed form. ... Duke University

09/15/16 / #20160265049

Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms

Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise. ... Duke University

09/15/16 / #20160263393

Non-invasive energy upconversion methods and systems for in-situ photobiomodulation

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. ... Duke University

09/01/16 / #20160250165

Method of modulating the activity of a nucleic acid molecule

The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic acid molecules in a sequence independent manner and modulate (e.g., inhibit or reverse) their activity. The invention also relates to compositions comprising such agents and to methods of using same.. ... Duke University

08/25/16 / #20160244510

Human monoclonal antibodies

The present invention relates, in general, to hiv-1-reactive antibodies and, in at least certain specific embodiments, to broadly neutralizing antibodies (bnabs) (and fragments and derivatives thereof) and to compositions comprising same. The invention further relates to methods of using such bnabs (and fragments and derivatives thereof) and compositions in immunotherapy regimens (e.g., passive immunotherapy regimens). ... Duke University

08/25/16 / #20160244507

Peptide compounds for suppressing inflammation

Provided herein are peptides that exhibit apoe biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.. ... Duke University

08/25/16 / #20160243151

Co-releasing compounds & formulations thereof useful for inducing mitochondrial biogenesis and tissue repair

Provided are pharmacological methods of inducing through a unified set of molecular mechanisms the maturation of stem cells, methods of promoting mitochondrial biogenesis in a cell and tissue, methods of reducing pluripotency in a stem cell, and methods of promoting differentiation of a stem cell. In particular, the invention relates to methods for promoting tissue growth and/or tissue repair and/or improving tissue survival, preventing and treating fibrotic lesions and disorders.. ... Duke University

08/25/16 / #20160243150

Compositions and methods for treating cancer with jak2 activity

Methods and compositions for diagnosing and treating jak2 inhibitor resistant cancers are disclosed. In the disclosed methods, akt and/or pi3k inhibitors, erk/mek inhibitors, bcl-xl protein inhibitors, or combinations thereof are administered to a subject to reverse jak2 inhibitor resistance. ... Duke University

08/18/16 / #20160237492

Diagnostic and prognostic test for sturge-weber syndrome, klippel-trenaunay-weber syndrome, and port-wine stains (pwss)

The present invention relates to the fields of neurological and skin disorders. More specifically, the present invention provides methods and compositions for diagnosing and prognosing sturge-weber syndrome (sws), klippel-trenaunay-weber syndrome (ktws), and port wine stains (pws). ... Duke University

08/18/16 / #20160237153

Nav1.7 antibodies and methods of using the same

Disclosed herein is an antibody that binds to a voltage sensor paddle (vsp) of nav1.7. Also disclosed herein are methods of treating pain, itch, neurogenic inflammation, or cough in a subject in need thereof. ... Duke University

08/18/16 / #20160235292

Method and system for improving aiming during optical coherence tomography on young children by synchronization with retinal bifringence scanning

The present invention is directed to a method and system for improved aiming during optical coherence tomography (oct) on young children and those unable to cooperate with oct imaging by synchronization with retinal birefringence scanning (rbs). Oct is performed without knowing whether or not the subject is looking at the intended target. ... Duke University

08/11/16 / #20160231268

Droplet-based surface modification and washing

The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one or more beads. ... Duke University

08/11/16 / #20160229846

Composition and methods for the treatment of camkk2-mediated disorders

The present disclosure provides compositions and methods for treating ocular disorders in mammals especially in and not limited to humans and mice. The present disclosure further provides methods of treating cancer and appetite suppression using the compositions which are novel small molecule inhibitors of camkk2. ... Duke University

08/11/16 / #20160229811

Tetra-aryl cyclobutane inhibitors of androgen receptor action for the treatment of hormone refractory cancer

The present disclosure provides tetra-substituted cyclobutane inhibitors of androgen receptor action, and methods of using such inhibitors, for the treatment of hormone-refractory cancers.. . ... Duke University

08/04/16 / #20160222218

Tunable nonfouling surface of oligoethylene glycol

An article having a nonfouling surface thereon is comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer, preferably by the process of surface-initiated polymerization of monomeric units thereon, with each of the monomeric units comprising a monomer core group having at least one protein-resistant head group coupled thereto, to thereby form a brush molecule on the surface portion. The brush molecule comprising a stem formed from the polymerization of the monomer core groups, and a plurality of branches formed from the hydrophilic head group projecting from the stem. ... Duke University

08/04/16 / #20160221934

Substituted hydroxamic acid compounds

Disclosed are compounds of formulae: (i), and (ii) and pharmaceutically acceptable salts thereof, wherein the variables, r, r1, r2, r3, r21, r22, r23, r34, r37, r33, r39, d, q, y, x, x1, x3, and x4 are defined herein. These compounds are useful for treating gram-negative bacteria infections.. ... Duke University

08/04/16 / #20160220592

Prochelators as broad-spectrum antimicrobial agents and methods of use

The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.. ... Duke University

08/04/16 / #20160220467

Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. ... Duke University

07/28/16 / #20160213771

Compositions, methods and kits for eliciting an immune response

The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one cmv antigen expressed by a cancer cell, in particular for treating and preventing cancer. Cmv determination methods, compositions, and kits also are provided.. ... Duke University

07/14/16 / #20160204515

Discrete-dipole methods and systems for applications to complementary metamaterials

Discrete-dipole methods and systems for applications to complementary metamaterials are disclosed. According to an aspect, a method includes identifying a discrete dipole interaction matrix for a plurality of discrete dipoles corresponding to a plurality of scattering elements of a surface scattering antenna.. ... Duke University

07/14/16 / #20160201089

Rna-guided gene editing and gene regulation

Disclosed herein are clustered regularly interspaced short palindromic repeats (crispr)/crispr-associated (cas) 9-based system related compositions and methods of using said crispr/cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.. ... Duke University

07/14/16 / #20160200682

2-piperidinyl substituted n,3-dihydroxybutanamides

Disclosed are compounds of formulae: (i) and pharmaceutically acceptable salts thereof, wherein the variables, r1, r2, y, and z are defined herein. These compounds are useful for treating gram-negative bacteria infections.. ... Duke University

07/14/16 / #20160200673

Antibacterial compounds

Disclosed are compounds of formulae (i) and (ii) and pharmaceutically acceptable salts thereof, wherein the variables, r, r1, r2, r3, y, z, x, r12, r17, r18, r19, y1, z1, x1, and x2 are defined herein. These compounds are useful for treating gram-negative bacteria infections, such as neisseria gonorrhoeae bacterial infections.. ... Duke University

07/14/16 / #20160199363

Trpa1 and trpv4 inhibitors and methods of using the same for organ-specific inflammation and itch

Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. ... Duke University

07/07/16 / #20160195543

Predicting coronary artery disease and risk of cardiovascular events

Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. ... Duke University

07/07/16 / #20160194715

Molecular predictors of fungal infection

Methods for identifying fungal infection, assays for identifying genomic and protein markers of fungal infection, and methods for diagnosing the fungal infection. In one aspect, the method of identifying fungal infection by proteomic assay involves measuring the protein levels of proteins listed in table 2a in a peripheral blood cell sample and comparing the determined protein levels to standard protein levels. ... Duke University

06/16/16 / #20160171688

Segmentation and identification of layered structures in images

Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. ... Duke University

06/09/16 / #20160158555

Non-regular electrical stimulation patterns for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.. ... Duke University

06/02/16 / #20160154102

Systems and methods for using time of flight measurements for imaging target objects

An imaging system as disclosed can include multiple bistatic radar sensors configured to transmit electromagnetic waves towards a surface of a target object and configured to measure the electromagnetic waves reflected from the surface of the target object. The imaging system includes a computing device that determines time of flight estimates based on the measured waves. ... Duke University

06/02/16 / #20160152980

Method of regulating gene expression

The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.. . ... Duke University

05/26/16 / #20160146822

Methods of developing a prognosis for pancreatic cancer and predicting responsiveness to cancer therapeutics

Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a vegf targeting agent are provided herein. The methods include detecting the expression level of at least one biomarker selected from ang-2, sdf-1 and vegf-d in a sample from the subject and using the expression levels to determine whether the vegf targeting agent will be effective to treat the cancer in the subject. ... Duke University

05/26/16 / #20160143884

Use of tetrahydroindazolylbenzamide and tetrahydroindolylbenzamide derivatives for the treatment of human immunodeficiency virus (hiv) and acquired immune deficiency syndrome (aids)

Provided are methods of treating or inhibiting human immunodeficiency virus (hiv) infection, or treating or inhibiting acquired human immunodeficiency syndrome (aids) in a subject in need thereof, comprising administering an hsp90 inhibitor in a therapeutically effective amount.. . ... Duke University

05/19/16 / #20160142646

Monocentric lens-based multi-scale optical systems and methods of use

A monocentric lens-based multi-scale imaging system is disclosed. Embodiments of the present invention comprise a monocentric lens as an objective lens that collects light from a scene. ... Duke University

05/19/16 / #20160136431

Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.. ... Duke University

05/19/16 / #20160135790

Systems and methods for ultrasound motion display and analysis

A method of generating an image of a scanned subject includes: emitting, by multiple ultrasonic elements of an array, multiple respective ultrasonic signals into a subject, the multiple respective ultrasonic signals defining at least two beam portions traveling in different directions; receiving, by the multiple ultrasonic elements, multiple respective ultrasonic echo signals; and generating at least one image of a portion of the subject from the received multiple ultrasonic echo signals. A negatively focused wavefront including the at least two beam portions traveling in the different directions may be emitted. ... Duke University

05/12/16 / #20160129282

Systems and methods for specifying treatment criteria and treatment parameters for patient specific radiation therapy planning

Disclosed herein are systems and methods for specifying treatment criteria and treatment planning parameters for patient specific radiation therapy planning. According to an aspect, a method includes receiving data about a patient, computing geometric characterization of one or more organs at risk proximate to a target volume of a patient or vice versa, and selecting relevant treatment knowledge and experience. ... Duke University

05/12/16 / #20160129258

Waveform shapes for treating neurological disorders optimized for energy efficiency

Systems and methods for stimulation of neurological tissue apply a stimulation waveform that is derived by a developed genetic algorithm (ga), which may be coupled to a computational model of extracellular stimulation of a mammalian myelinated axon. The waveform is optimized for energy efficiency.. ... Duke University

05/05/16 / #20160122733

Method of treating glycogen storage disease

The disclosure relates, in general, to glycogen storage disease and, in particular, to a method of treating glycogen storage disease and to compounds and compositions suitable for use in such a method.. . ... Duke University

05/05/16 / #20160122451

Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates

Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the c-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the c-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.. ... Duke University

05/05/16 / #20160120952

Therapeutic agents comprising elastin-like peptides

The present invention provides therapeutic agents and compositions comprising elastin-like peptides (elps) and therapeutic proteins. In some embodiments, the therapeutic protein is a glp-1 receptor agonist, insulin, or factor vii/viia, including functional analogs. ... Duke University

04/28/16 / #20160116556

Rf coil elements with split dc loops for magnetic resonance imaging systems for integrated parallel reception, excitation, and shimming and related methods and devices

Systems, methods and devices are configured for integrated parallel reception, excitation, and shimming (ipres) with rf coil elements with split dc loops. Parallel transmit/receive (which can include b1 shimming and/or parallel imaging capabilities) and b0 shimming employ the same set of localized coils or transverse electromagnetic (tem) coil elements, with each coil or tem element working in both an rf mode (for transmit/receive and b1 shimming) and a direct current (dc) mode (for b0 shimming) simultaneously. ... Duke University

04/28/16 / #20160114320

Droplet manipulation device

Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. ... Duke University

04/28/16 / #20160114053

Methods and compositions for delivering active agents with enhanced pharmacological properties

Provided herein are methods of enhancing in vivo efficacy of an active agent, comprising: administering to a subject an active agent that is coupled to a bioelastic polymer or elastin-like peptide, wherein the in vivo efficacy of the active agent is enhanced as compared to the same active agent when administered to the subject not coupled to (or not associated with) a bioelastic polymer or elp.. . ... Duke University

04/28/16 / #20160113548

Systems, methods, compositions and devices for in vivo magnetic resonance imaging of lungs using perfluorinated gas mixtures

Systems and methods for generating mri images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The images are generated using acquired 19f magnetic resonance image (mri) signal data associated with the perfluorinated gas and oxygen mixture.. ... Duke University

04/07/16 / #20160097099

Biomarkers for the molecular classification of bacterial infection

Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.. . ... Duke University

03/24/16 / #20160084948

Systems, methods and computer program products for doppler spatial coherence imaging

Methods, systems and computer program products for imaging fluid in a sample include acquiring a plurality of echo signals for a region of interest in the sample from a plurality of ultrasound transducer elements in an ultrasound transducer array; applying a stationary echo cancellation to the plurality of echo signals to reduce or remove echo signals that are associated with stationary and/or slower moving features to provide a corresponding plurality of filtered signals; extracting coherence information from the plurality of filtered signals; and imaging the region of interest in response to the coherence information from the plurality of filtered signals.. . ... Duke University

03/24/16 / #20160082035

Immunomodulating gene therapy

The present invention relates, in general, to pompe disease and, in particular, to a methods of treating pompe disease and to compounds/constructs suitable for use in such methods.. . ... Duke University

03/24/16 / #20160081858

Compositions and methods for the prevention of scarring and/or promotion of wound healing

The present disclosure provides methods of preventing and/or reducing scar contracture and methods of promoting wound healing by utilizing an electrospun biocompatible scaffold.. . ... Duke University

03/17/16 / #20160077097

Method of isolating circulating tumor cells

Provided are methods for detecting or isolating circulating tumor cells (ctcs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (emt) biomarker. ... Duke University

03/17/16 / #20160076086

Nano-plasmonic molecular probes and methods of use

Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include rna, dna, mrna, microrna, and small nucleotide polymorphisms (snps). ... Duke University

03/17/16 / #20160074541

Prosthetic compounds for labeling internalizing biomolecules

Prosthetic compounds are disclosed that are effective for radiolabeling biomolecules with 18f. Representative biomolecules include antibodies (e.g., monoclonal antibodies (mabs) and nanobodies (sdabs)), antibody fragments, and peptides that may have an affinity for particular types of cells, such as cancer cells. ... Duke University

03/17/16 / #20160074405

Compositions and methods for the treatment of drug-induced hand-foot syndrome

The present invention provides methods of treating, ameliorating or preventing hand-foot syndrome in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a phosphodiesterase inhibitor.. . ... Duke University

03/10/16 / #20160068610

Glutamate dehydrogenase in idh1- and idh2-mutated cancers

Expression of glud1, glud2, or both is tested in gliomas, leukemias, or suspected gliomas and leukemias. Up-regulation of expression is found in idh1/idh2 mutant cancers. ... Duke University

02/18/16 / #20160047859

Signal tracing using on-chip memory for in-system post-fabrication debug

A post-fabrication debug and on-line error checking framework for 2d- and 3d-ics with integrated memories is described. A design-for-debug (dfd) architecture can include, for an ic with on-chip memory, a debug module connected to a functional bus of the ic. ... Duke University

02/11/16 / #20160039885

Recombinant production of hiv-1 envelope glycoproteins

The present invention relates, in general, to hiv-1 and, in particular, to methods of producing hiv-1 envelope (env) proteins, and subunits thereof, and to constructs suitable for use in such methods.. . ... Duke University

02/11/16 / #20160038740

Systems and methods for administering spinal cord stimulation based on temporal patterns of electrical stimulation

Systems and methods for administering spinal cord stimulation (scs) based on temporal patterns of electrical stimulation are disclosed. According to an aspect, a method includes using a computational model of a wide-dynamic range (wdr) neuron to determine one or more non-regular temporal patterns that results in predetermined wdr neuronal output and stimulation activity for one of efficacy optimization and efficiency optimization. ... Duke University

02/04/16 / #20160032007

Human antibody fragments against chondroitin sulfate proteoglycan 4 (cspg4)

Human antibody fragments against chrondroitin sulfate proteoglycan 4 can be used to deliver cytotoxic agents to cells which express cspg4. The agents can be diagnostic or therapeutic moieties. ... Duke University

02/04/16 / #20160030521

Therapeutic agents comprising elastin-like peptides

The present invention provides therapeutic agents and compositions comprising elastin-like peptides (elps) and therapeutic proteins. In some embodiments, the therapeutic protein is a glp-1 receptor agonist, insulin, or factor vii/viia, including functional analogs. ... Duke University

02/04/16 / #20160030497

Oncolytic poliovirus for human tumors

Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. ... Duke University

02/04/16 / #20160030332

2-fluoro-modified rnas as immunostimulators

Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5′ triphosphate, 2′ fluoro-modified pyrimidine non-linear single stranded rna at least 17 nucleotides long with a least 3 base pairings or a 5′ triphosphate, 2′ fluoro-modified double stranded rna at least 17 base pairs long in an amount effective to inhibit cell growth, induce cell death or induce cytokine production by the cells. The methods also include administration of the compositions to a subject. ... Duke University

01/28/16 / #20160024585

Methods of predicting responsiveness of a cancer to an agent and methods of determining a prognosis for a cancer patient

The present disclosure provides biomarkers, and methods of using such biomarkers, that are predictive for efficacy of and resistance to an egfr targeting agent, such as cetuximab, or prognostic with respect to cancer survival.. . ... Duke University

01/28/16 / #20160022993

Systems and methods for applying electrical stimulation for optimizing spinal cord stimulation

Systems and methods for applying electrical stimulation to different sub-populations of targeted neurological tissue for optimizing spinal cord stimulation are disclosed. According to an aspect, a method includes applying a first pattern of electrical stimulation to a first sub-population of targeted neurological tissue of a subject. ... Duke University

01/28/16 / #20160022772

Cytokine receptors as targets for hypertension therapy and methods of use

The present disclosure provides methods of treating or ameliorating hypertension in a subject comprising administering a therapeutically effective amount of an il-1 receptor antagonist.. . ... Duke University

01/21/16 / #20160018364

Methods, systems and computer program products for estimating shear wave speed using statistical inference

Methods, systems and computer program products for determining a mechanical parameter for a sample having a target region, include determining a prior probability density function that characterizes at least one physical property of the target region; generating a displacement of the sample in the target region to form a shear wave that propagates orthogonal to a direction of the displacement; transmitting tracking pulses in the target region; receiving corresponding echo signals for the tracking pulses in the target region at a plurality of lateral positions; estimating a propagation parameter of the shear wave in response to the echo signals and the prior probability density function using statistical inference; and determining at least one mechanical parameter of the target region based on the estimated propagation parameter.. . ... Duke University

01/21/16 / #20160016180

Devices, systems, and methods for acoustically-enhanced magnetophoresis

The present disclosure provides systems and devices for the sorting of objects using acoustic waves and magnetic forces as well as methods of using the systems and devices.. . ... Duke University

01/07/16 / #20160005503

Plasmonic assisted systems and methods for interior energy-activation from an exterior source

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. ... Duke University

01/07/16 / #20160003928

Mri with repeated k-t -sub-sampling and artifact minimization allowing for free breathing abdominal mri

Methods of processing mri image data to reduce or eliminate motion-related artifacts in mri images includes: electronically repeatedly acquiring sets of 2d or 3d k-space data of a target region of a subject using at least one mri pulse sequence; electronically applying a bootstrapping procedure to produce a large number of images from the acquired k-space data; then electronically evaluating the images produced by the bootstrapping procedure; and electronically identifying an image with a minimal motion-related artifact level from the evaluation of the images produced by the boot-strapping procedure.. . ... Duke University

01/07/16 / #20160003837

Biomarkers for the prediction of preterm birth

The present disclosure provides biomarkers useful for determining the risk of, prognosis of, and/or diagnosis of conditions such as preterm birth in a subject.. . ... Duke University

01/07/16 / #20160002629

Diagnostic and treatment for chronic and acute phase myeloid leukemia

Disclosed are methods of predicting responsiveness of a cancer cell to a tyrosine kinase inhibitor, and methods of predicting the risk of progression of a cancer cell to a more aggressive form. Also provided are methods of reducing proliferation or promoting differentiation of a cancer cell having reduced level of numb or increased level of msi. ... Duke University








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