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Duke University patents (2017 archive)


Recent patent applications related to Duke University. Duke University is listed as an Agent/Assignee. Note: Duke University may have other listings under different names/spellings. We're not affiliated with Duke University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Duke University-related inventors


Compounds and methods for targeting hsp90

Described herein are compounds that may selectively bind to hsp90, methods of using the compounds, and kits including the compounds. The compounds may include detection moieties such as fluorophores that may allow for selective detection of hsp90 in a sample.. ... Duke University

Compositions and methods for the prevention and treatment of mast cell-induced vascular leakage

Disclosed herein are methods of diagnosing and treating infectious disease characterized by a pathology that involves hemorrhaging or pathological vascular leakage.. . ... Duke University

Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates

Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the c-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the c-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.. ... Duke University

Apparatus and method for providing a selectively absorbing structure

An apparatus is described that selectively absorbs electromagnetic radiation. The apparatus includes a conducting surface, a dielectric layer formed on the conducting surface, and a plurality of conducting particles distributed on the dielectric layer. ... Duke University

Factor v/va-targeting aptamer compositons and methods of using the same

Provided herein are factor v/factor va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are also provided.. ... Duke University

Ethynylbenzene derivatives

Disclosed are compounds of formulae (i), (ii), and (ii)i: and pharmaceutically acceptable salts thereof, wherein the variables, r, r1, r2, r3, r101, l, d, q, y, x, and z are defined herein. These compounds are useful for treating gram-negative bacteria infections.. ... Duke University

Non-regular electrical stimulation patterns for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.. ... Duke University

Compositions and methods for treating hair loss using non-naturally occurring prostaglandins

A method for treating hair loss in mammals uses compositions containing prostaglandin f analogs. The compositions can be applied topically to the skin. ... Duke University

Stretchable electrically conductive layer formation by aerosol jet printing on flexible substrate

Methods of forming an electrically conductive layer on a flexible substrate, such as a stretchable electrode, by aerosol jet printing on the flexible substrate while the substrate is strained. In general, a stretchable substrate is initially deformed so that a first surface thereof is under tension. ... Duke University

Multi-layer integrated circuits having isolation cells for layer testing and related methods

Multi-layer integrated circuits having isolation cells for layer testing and related methods are disclosed. According to an aspect, an integrated circuit includes first and second layers that each have one or more electronic components. ... Duke University

Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity

Rationally-designed laglidadg meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired dna sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.. ... Duke University

Self-gated interleaved radial mri for abdominothoracic imaging

The present disclosure provides, in part, methods for high spatiotemporal resolution self-sorted 4d mri. These methods can be used to improve resolution of abdominothoracic mri during breathing by facilitating the sorting of information corresponding to individual mri pulse sequences according to phase within the respiratory cycle. ... Duke University

Methods for in vivo identification of endogenous mrna targets of micrornas

A method of generating a gene expression profile of noncoding regulatory rna (ncrna; e.g. A microrna) in a cell in vivo, is carried out by: (a) partitioning from a cell at least one mrna-protein (rnp) complex, the rnp complex comprising: (i) an rna binding protein (rnabp) or rna associated protein, (ii) at least one mrna bound to or associated with said protein, and (iii) at least one ncrna bound to or associated with said protein, and then (b) identifying at least one ncrna in at least one rnp complex, thereby to produce a gene expression profile comprising the identity of an ncrna in an rnp complex.. ... Duke University

Contrast agents based on long-lived nuclear singlet states and related methods

Methods are described for preparing magnetic resonance imaging (mri) and/or magnetic resonance spectroscopy contrast agents where the contrast agents are prepared from precursor molecules having at least four non-zero-spin nuclei that form two pairs of chemically equivalent or effectively equivalent nuclei, e.g., diphenylacetylene or diethyl oxalate. The precursor molecule is hyperpolarized and a sequence of one or more radiofrequency pulses is applied to transfer spin state population between the first and second pair of nuclei, thereby providing a non-equilibrium single state nuclear spin population. ... Duke University

11/16/17 / #20170326199

Use of caspase-2 inhibitors to treat and prevent the metabolic syndrome

Methods and compositions for treatment of obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease are discloses. The methods and compositions relate to inhibition of caspase-2.. ... Duke University

11/16/17 / #20170326127

Composition and method for treatment of neuropsychiatric disorders

The present invention relates to a composition and method for combinative therapy, capable of temporarily regulating inherent dysfunctional neural processes and reducing symptoms and/or signs of neuropsychiatric disorders including, but not limited to, psychostimulant use disorder (pud) and other substance-related additive disorders, post-traumatic stress disorder (ptsd) and other trauma- and stress-related disorders, and levodopa-induced dyskinesia (lid) and other types of dyskinesias. The present specification shows specific examples of a dosage form.. ... Duke University

11/09/17 / #20170322273

Magnetic resonance imaging of neuro-electro-magnetic oscillations

In vivo methods of non-invasively imaging neuro-electro-magnetic oscillations (nemo) are carried out by electronically transmitting a pulse sequence to a subject. The pulse sequence has a first excitation pulse, typically applied along an x-axis, followed by a spin-lock pulse applied along a different axis, typically a y-axis, and having a defined frequency, followed by a second rf excitation pulse. ... Duke University

11/09/17 / #20170322209

Biosensor

Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bpbp). Upon binding of ligand to the biosensor, there is a change in the signal transduced by the reporter group.. ... Duke University

11/09/17 / #20170321280

Nano-plasmonic molecular probes for plasmonics coupling interference

Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include rna, dna, mrna, microrna, and small nucleotide polymorphisms (snps). ... Duke University

11/09/17 / #20170319868

Phosphors and scintillators for light stimulation within a medium

A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kvp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. ... Duke University

11/09/17 / #20170319591

Methods of treating hemoglobinopathies

Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin h disease are provided. In some embodiments, the methods comprise administering an inhibitor selected from an erk inhibitor, a mek inhibitor, and, a raf inhibitor. ... Duke University

10/26/17 / #20170307349

Non-invasive thickness measurement using capacitance measurement

Methods of measuring thickness of a material using cross-capacitance. The method generally includes applying a time-varying signal to a first pad and monitoring a response of a capacitor formed by the first pad, a spaced apart second pad, and the material. ... Duke University

10/26/17 / #20170306321

Systems and methods for genetic analysis of intractable microbes

Embodiments of the present disclosure relate generally to the genetic analysis of intractable microbes. More particularly, the present disclosure provides materials and methods that incorporate chemical mutagenesis, phenotypic selection, suppression analysis, and genomic sequencing-based mutational mapping, to identify novel genetic regulators in previously intractable organisms, such as microbes that constitute the human microbiome. ... Duke University

10/26/17 / #20170304652

Systems and methods for the verification of source placement for brachytherapy radiation procedures using real time radiation detectors

The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via real-time measurement. In an embodiment, a radiation detector may be disposed proximate to a radiotherapy target. ... Duke University

10/26/17 / #20170304488

Compositions and methods for the prevention and/or reduction of scarring

The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.. . ... Duke University

10/26/17 / #20170304162

Compositions, systems and methods for the encapsulation and delivery of a substance

A composition and method is provided for synthesizing silicone particles with narrow size distributions and tunable degrees of crosslinking for encapsulation of an active ingredient or multiple active ingredients in the matrix of the particles for controlled release. The method comprises agitating at least one type of silane monomer having two, three or four siloxane bonds in an acidic aqueous solution under conditions sufficient to allow for hydrolysis of the monomers, adding a catalyst and a solution comprising a co-solvent and the active ingredient(s) to the acidic aqueous solution, and continuing to agitate the combined solution to allow for a condensation reaction and formation of silicone particles with a narrow size distribution encapsulating at least a portion of the active ingredient(s). ... Duke University

10/26/17 / #20170303820

Systems, compositions and devices for in vivo magnetic resonance imaging of lungs using perfluorinated gas mixtures

Systems and methods for generating mri images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The images are generated using acquired 19f magnetic resonance image (mri) signal data associated with the perfluorinated gas and oxygen mixture.. ... Duke University

10/12/17 / #20170294248

Noble metal-coated nanostructures and related methods

Noble metal-coated nanostructures and related methods are disclosed. According to an aspect, a nanostructure may include a structure comprising a base metal. ... Duke University

10/12/17 / #20170290650

Implantable mesh and method of use

An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the first end of the mesh extension is integrated into or part of the mesh body. ... Duke University

10/05/17 / #20170283882

Methods and therapeutics relating to mrna biomarkers for clinical prognosis of cancer

This disclosure provides methods and compositions of matter relating to the monitoring of relative concentrations of pairs of isoforms of mrna or downstream expression products thereof. The methods can include measuring a relative expression level of a pair of mrna isoforms or downstream expression products thereof and comparing the relative expression level to relative historical or cohort expression levels of the same pair of mrna isoforms. ... Duke University

10/05/17 / #20170283872

Compositions and methods for enhancing odorant receptor activity

The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor m3) capable of enhancing odorant receptor activation. ... Duke University

10/05/17 / #20170282214

Methods and systems for deposition of blended polymer films

Methods and systems for deposition of blended polymer films are disclosed. According to an aspect a method of producing a film on a substrate includes combining a guest material, a host matrix, and a solvent having one or more hydroxyl (o—h) bonds to form a target emulsion. ... Duke University

09/28/17 / #20170274037

Peptides for suppressing inflammation

Provided herein are peptides that exhibit apoe biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.. ... Duke University

09/14/17 / #20170259067

Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.. ... Duke University

09/07/17 / #20170254999

Multiscale telescopic imaging system

A multiscale telescopic imaging system is disclosed. The system includes an objective lens, having a wide field of view, which forms an intermediate image of a scene at a substantially spherical image surface. ... Duke University

09/07/17 / #20170254634

Non-invasive thickness measurement using resonant frequency shift

A method of measuring thickness of a material generally includes transmitting an oscillating signal from a first pad, through the material, to a second pad, and measuring the signal reflected back to the first pad. The material may be homogenous or heterogeneous, and has dielectric properties. ... Duke University

08/31/17 / #20170250805

Reconfigurable free-space quantum cryptography system

A system, and methods, for transmitting encrypted information as a quantum transmission between a first node and a second node, or among more than two nodes. Each node is characterized by an instantaneous spatial position, and the instantaneous spatial position of the second node is repositionable within a frame of reference associated with the first node. ... Duke University

08/31/17 / #20170247765

Methods for rapid and sensitive detection of hotspot mutations

Methods that rapidly, sensitively, and specifically detect mutations in idh1/2 and the tert promoter employ amplification of particular portions of the genes that experience frequent and exquisitely localized mutations. The ability to distinguish between sequences that differ only by one nucleotide and which may be present in very low ratios is essential for such an assay.. ... Duke University

08/24/17 / #20170239363

Polymer conjugates having reduced antigenicity and methods of using the same

Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. ... Duke University

08/24/17 / #20170239352

Combination drug therapy for the treatment of solid tumors

The present invention relates to a pharmaceutical combination that comprises an igf1r inhibitor and an mtor inhibitor for the treatment of cancer in a subject; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of medicament for the treatment of cancer; a kit comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and a method of treating cancer in a subject, especially a human.. . ... Duke University

08/24/17 / #20170239160

Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. ... Duke University

08/17/17 / #20170233714

Polymer conjugates having reduced antigenicity and methods of using the same

Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. ... Duke University

08/10/17 / #20170227553

Compositions and methods for identifying and treating conditions involving hsf1 activity

Provided herein are methods for identifying and treating subjects having conditions involving reduced hsf1 activity (e.g., diminished hsf1 activity, diminished hsf1 protein levels, increased hsf1 ser303 phosphorylation, increased hsf1 ser307 phosphorylation) or conditions that benefit from increasing hsf1 abundance or activity beyond physiological levels.. . ... Duke University

08/10/17 / #20170224712

Prochelators as broad-spectrum antimicrobial agents and methods of use

The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.. ... Duke University

08/03/17 / #20170216808

Programmable liquid, gel and biohybrid compartments and methods of use

Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. ... Duke University

08/03/17 / #20170216426

Compositions and methods for transient immune response modulation during vaccination

In certain aspects the invention provides a selection of hiv-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. ... Duke University

08/03/17 / #20170216382

Oncolytic poliovirus for human tumors

Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. ... Duke University

08/03/17 / #20170216289

Compositions and methods for the treatment of cancer

The present disclosure provides compositions and methods for the treatment of cancer, relating to the specific inhibition of abelson (abl) kinases.. . ... Duke University

07/27/17 / #20170212195

Magnetic resonance imaging (mri) systems and methods for determining and adjusting inversion time (ti) using single-line acquisition and automatic compartment detection

Magnetic resonance imaging (mri) systems and methods for determining and adjusting ti using single-line acquisition and automatic compartment detection. A method includes positioning a readout line of the mri scanner through a compartment of interest of a region of interest in a subject. ... Duke University

07/20/17 / #20170202823

Method of treating cancer using selective estrogen receptor modulators

Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (serm). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a serm.. ... Duke University

07/13/17 / #20170197206

Disposable pipette tip and methods of use

A kit for detection of an analyte of interest in a liquid sample, and methods of using, are provided. The kit may include a pipette and a disposable pipette tip configured to engage the pipette. ... Duke University

07/13/17 / #20170196953

Vaccines against an oncogenic isoform of her2 (erbb2) and methods of using the same

Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. ... Duke University

07/13/17 / #20170196952

Vaccines against an oncogenic isoform of esr1 and methods of using the same

Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. ... Duke University

07/13/17 / #20170196892

Compositions and methods for the repair of myelin

Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.. . ... Duke University

07/06/17 / #20170190675

Chemical modulators of immune checkpoints and therapeutic use

Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as pd-1, pd-l1 and ctla-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as pd-1, pd-l1 and ctla-4. ... Duke University

07/06/17 / #20170189562

Metal complexes with bisphosphonate or pyrophosphate useful as imaging agents

Provided herein are magnetic resonance imaging (mri) contrast agents comprising a compound having a structure represented by: y—x—z, wherein, x is: fe(iii) or mn(ii), and y and z are each independently selected from pyrophosphate and bisphosphonate (e.g., 1-hydroxybisphosphonate), or a pharmaceutically acceptable hydrate and/or salt thereof. Methods of use of the mri contrast agent are also provided.. ... Duke University

07/06/17 / #20170189561

Ascorbate formulations and methods of use as contrast agents

A sterile aqueous composition suitable for use as an mri contrast agent includes 100 to 600 mm ascorbate; and 100-600 mm sodium, meglumine, or a combination thereof. The composition preferably has an osmolarity of 200 to 1400 mosm/l.. ... Duke University

07/06/17 / #20170189559

Contrast agents for magnetic resonance imaging

Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (mri) image of a body or body region such as an organ or organ region in a subject. The method is carried out by parenterally administering ascorbate or a pharmaceutically acceptable salt thereof to the subject in an mri image-enhancing amount; and then generating, by mri of the subject, an image of the body or body region. ... Duke University

07/06/17 / #20170189357

Methods of limiting morbidity in hemoglobinopathies

Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin h disease are provided. In some embodiments, the methods comprise administering an agent to the subject if the subject has increased expression or activation of at least one of erk, ras, braf, raf1 mek, β-arrest1/2, syk, p60-c-src, or grk2. ... Duke University

06/29/17 / #20170186195

Spectral estimation and poly-energetic reconstruction methods and x-ray systems

Spectral estimation and poly-energetic reconstructions methods and x-ray systems are disclosed. According to an aspect, a spectral estimation method includes using multiple, poly-energetic x-ray sources to generate x-rays and to direct the x-rays towards a target object. ... Duke University

06/29/17 / #20170184729

Linear-response nanocrystal scintillators and methods of using the same

Systems and devices incorporating radiation detection, and techniques and materials for improved radiation detection are provided that involve a nano-scintillator exhibiting a linear luminescent emission response to stimulating electromagnetic radiation. The nano-scintillator can include at least one nanocrystal comprising a rare earth element, a lanthanide dopant, and a spectator dopant, wherein the nanocrystal exhibits a linear luminescent emission response to stimulating electromagnetic radiation of wavelengths less than 100 nm. ... Duke University

06/29/17 / #20170182322

Systems and methods for spinal cord stimulation

Optimizing temporal pulse patterns for stimulation delivery to a subject includes: generating a first generation pulse pattern; delivering stimulation according to the first generation pattern to a subject; measuring efficacy, efficiency and side-effect parameters affected by the delivered stimulation; determining a fitness of the first generation pattern using the measured parameters; generating a second generation pattern using the first generation pattern according to the determined fitness of the first generation temporal pattern; and delivering stimulation according to the second generation pattern. Iterative further optimization may include crossing any particular generation temporal pulse pattern with at least one other temporal pulse pattern to generate offspring patterns for further use and optimization. ... Duke University

06/22/17 / #20170176559

Systems and methods for assessing pulmonary gas transfer using hyperpolarized 129xe mri

Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one mri image and/or image data of 129xe dissolved in the red blood cells (rbc) in the gas exchange regions of the lungs of a patient. The image is sufficiently sensitive to allow a clinician or image recognition program to assess at least one of pulmonary gas exchange, barrier thickness or barrier function based on the 129xe mri rbc image.. ... Duke University

06/22/17 / #20170174660

Heat shock protein 70 (hsp-70) receptor ligands

Inducible hsp70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of small molecule inhibitors of hsp70 pose a new therapy to cancer treatment. ... Duke University

06/22/17 / #20170173350

Plasmonic assisted systems and methods for interior energy-activation from an exterior source

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. ... Duke University

06/22/17 / #20170173252

Arteriovenous graft for hemodialysis with puncture-resistant posterior and side walls

An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet and an outlet, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; and a self-sealing material extending across the cannulation port. ... Duke University

06/15/17 / #20170165316

Method of reducing titers of antibodies specific for a therapeutic agent

The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ert) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral or viral vectors, or other therapeutic modality or modalities, used alone or in combination, which involve the administration of exogenous substances for potential therapeutic benefit, including, but not limited to dna vaccines, sirna, splice-site switching oligomers (ssos) as well as rna-based nanoparticles (rnps) and nanovaccines. The invention further relates to compounds and compositions suitable for use in such methods.. ... Duke University

06/15/17 / #20170165216

Methods and compositions for treatment of acute lung injury

A method of treating acute lung injury (ali) in a patient suspected of having ali is disclosed. The method includes administering to the patient a therapeutically effective amount of an inducible nitric oxide synthase (inos) inhibitor.. ... Duke University

06/08/17 / #20170161454

Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices

Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices are disclosed. According to an aspect a method includes providing a patient-specific electroanatomical model including the spine, spinal cord, and a map of target neural elements and non-target neural elements. ... Duke University

06/08/17 / #20170157418

X-ray psoralen activated cancer therapy (x-pact)

A system for treating a diseased site in a human or animal body. The system includes a pharmaceutical carrier including one or more phosphors which are capable of emitting light into the diseased site upon interaction, a photoactivatable drug for intercalating into dna of cells at the diseased site, one or more devices which infuse the diseased sited with the photoactivatable drug and the pharmaceutical carrier, an x-ray or high energy electron source, and a processor programmed to control a dose of x-rays or electrons to the diseased site for production of light inside the tumor to activate the photoactivatable drug.. ... Duke University

06/08/17 / #20170157218

Methods of treating fragile x syndrome and related disorders

Disclosed herein are novel methodologies of treating fragile x syndrome and related disorders by inhibiting mg1u5-relevant signaling pathways via the reduction of β-arrestin2 protein levels or the diminution of mg1u5 and β-arrestin2 protein interactions.. . ... Duke University

06/01/17 / #20170151331

Nanostars and nanoconstructs for detection, imaging, and therapy

A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. ... Duke University

05/18/17 / #20170140544

Segmentation and identification of layered structures in images

Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. ... Duke University

05/18/17 / #20170138967

Metabolics biomarker for nafld and methods of use

The present disclosure provides metabolomics biomarkers for nafld and indicative of liver fibrosis and methods of using same.. . ... Duke University

05/11/17 / #20170132804

System and method for improved computational imaging

A system and method for computing a digital image of a scene, where the digital image contains enhanced depth information are disclosed. Embodiments of the present invention form a light distribution on a focal-plane array, where the light distribution is based on an optical image of the scene formed by a lens system. ... Duke University

05/11/17 / #20170128526

Stem cell derived factors for treating pathologic conditions

A purified paracrine factor of a mesenchymal stem cell, such as a secreted frizzled related protein (sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.. . ... Duke University

05/11/17 / #20170127938

Systems and methods for obtaining low-angle circumferential optical access to the eye

A system for obtaining low-angle circumferential optical access to an eye of a subject. The system includes a light source to generate a beam of light; a beam steering mechanism to steer the beam of light a focusing lens to focus the beam of light; and a contact lens to direct the beam of light into the eye of the subject, the contact lens including a tapered reflective surface to direct the beam of light into the eye of the subject.. ... Duke University

05/04/17 / #20170121707

Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves

This invention relates to metabolically engineered microorganisms, such as bacterial and or fungal strains, and bioprocesses utilizing such strains. These strains enable the dynamic control of metabolic pathways, which can be used to optimize production. ... Duke University

05/04/17 / #20170121472

Plasmonic assisted systems and methods for interior energy-activation from an exterior source

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. ... Duke University

04/27/17 / #20170115293

Methods for predicting the radiosensitivity of a cancer tumor and methods of treating cancer

Methods for predicting the radiosensitivity of a cancer tumor and treating cancer in a subject are provided. In another aspect, methods of treating cancer in a subject are also provided. ... Duke University

04/27/17 / #20170113061

Methods and systems for treating cell proliferation disorders with psoralen derivatives

Psoralen compounds of compounds having formulae 1a-10a, 1b-10b, 1c-10c, 1d-10d, 1e-10e, 1f-10f, 1g-10g, and 1h-5h as shown in fig. 1, and pharmaceutically acceptable salts thereof; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an auto vaccine effect in a subject using the method.. ... Duke University

04/20/17 / #20170107197

Phenyl-substituted nicotinic ligands, and methods of use thereof

Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety, alzheimer's disease, learning deficit, cognition deficit, attention deficit, memory loss, lewy body dementia, attention deficit hyperactivity disorder (adhd), parkinson's disease, huntington's disease, tourette's syndrome, amyotrophic lateral sclerosis, inflammation, stroke, spinal cord injury, dyskinesias, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, ganser's syndrome, migraine pain, bulimia, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, autism, mutism, trichotillomania, hypothermia, and disorders of sleep.. . ... Duke University

04/20/17 / #20170106080

Liposome-peptide conjugate and method of using same to induce production of anti-hiv antibodies

The present invention relates, in general, to human immunodeficiency virus (hiv), and, in particular, to a method of inducing neutralizing antibodies to hiv and to compounds and compositions suitable for use in such a method.. . ... Duke University

04/06/17 / #20170095503

Inhibition of endosomal toll-like receptor activation

The present invention relates, in general, to pattern-recognition receptors (prrs), including toll-like receptors (tlrs), and, in particular, to a method of inhibiting nucleic acid-induced activation of, for example, endosomal tlrs using an agent that binds to the nucleic acid (“nucleic acid binding agent”), preferably, in a manner that is independent of the nucleotide sequence, the chemistry (e.g., dna or rna, with or without base or sugar modifications) and/or the structure (e.g., double-stranded or single-stranded, complexed or uncomplexed with, for example protein) of the nucleic acid(s) responsible for inducing tlr activation. The invention also relates to methods of identifying nucleic acid binding agents suitable for use in such methods.. ... Duke University

04/06/17 / #20170095223

Systems and methods for estimating irradiation dose for patient application based on a radiation field model and a patient anatomy model

Systems and methods for estimating irradiation dose for patient application based on a radiation field model and a patient anatomy model are disclosed. According to an aspect, a method includes providing a database of patient anatomy models. ... Duke University

03/30/17 / #20170088883

Electronic platform for sensing and control of electrochemical reactions

A sensor comprising a semiconductor layer having a two dimensional electron gas (2deg) and an oxide layer in electronic contact with the semiconductor layer is provided. A method of detecting an analyte molecule using such sensor is also provided.. ... Duke University

03/30/17 / #20170088625

Cd-20-specific antibodies and methods of employing same

The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to cd20, as well as pharmaceutical compositions comprising the same. The invention further provides methods of using the monoclonal antibodies, antigen-binding fragments, and pharmaceutical compositions, for example, in methods of depleting b cells or in treating b cell disorders. ... Duke University

03/23/17 / #20170081730

Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma

We found mutations of the r132 residue of isocitrate dehydrogenase 1 (idh1) in the majority of grade ii and iii astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in idh1 often had mutations at the analogous r172 residue of the closely related idh2 gene. ... Duke University

03/23/17 / #20170080428

Device for conducting biochemical or chemical reactions

Methods and devices for conducting chemical or biochemical reactions that require multiple reaction temperatures are described. The methods involve moving one or more reaction droplets or reaction volumes through various reaction zones having different temperatures on a microfluidics apparatus. ... Duke University

03/16/17 / #20170076143

Systems and methods for large scale face identification and verification

Methods and systems for large-scale face recognition. The system includes an electronic processor to receive at least one image of a subject of interest and apply at least one subspace model as a splitting binary decision function on the at least one image of the subject of interest. ... Duke University

03/09/17 / #20170065568

Methods and compounds for calcium ion channel regulation

The present invention generally relates to methods of modulating cav1.2 channels and cav1.2 channel activators.. . ... Duke University

03/02/17 / #20170064204

Systems and methods for burst image delurring

System and method for automatically removing blur and noise in a plurality of digital images. The system comprises an electronic processor configured to receive the plurality of digital images, perform motion estimation and motion compensation to align the plurality of digital images, determine an alignment of the plurality of digital images with respect to a reference frame, generate a consistency map based on the alignment of the plurality of digital images with respect to the reference frame, combine the plurality of digital images aligned with respect to the reference frame in the fourier domain using a quality of alignment information from the consistency map to generate an aggregated frame, and apply a post-processing filter to enhance the quality of the aggregated frame.. ... Duke University

03/02/17 / #20170062895

Rapid radio frequency (rf) waveguide components and related methods

Rapid radio frequency (rf) microwave devices and methods are disclosed. According to an aspect, a waveguide includes a body having first and second components that are attachable together to form an interior having a surface. ... Duke University

03/02/17 / #20170059829

Quasi-monocentric-lens-based multi-scale optical system

Optical systems based on an objective lens comprising one or more plastic lens elements are disclosed. The inclusion of plastic lens element reduces one or more of system cost, size, weight, and/or complexity. ... Duke University

03/02/17 / #20170056532

Hyperpolarized noble gas production systems with nanocluster suppression, detection and/or filtering and related methods and devices

Systems, methods and related devices used to produce and collect polarized noble gas to inhibit, suppress, detect or filter alkali metal nanoclusters to preserve or increase a polarization level thereof. The systems can include a pre-sat chamber that has an area ratio between 20 and 500.. ... Duke University

02/16/17 / #20170043178

Non-invasive energy upconversion methods and systems

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. ... Duke University

02/09/17 / #20170037544

Electrospun cationic nanofibers and methods of making and using the same

Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition, methods of using the polycationic nanofibers to reduce inflammation, to adsorb anionic compounds such as heparin or nucleic acids, to inhibit the growth of microbes or inhibit the formation of a biofilm are also provided. ... Duke University

02/09/17 / #20170037471

Methods for diagnosing & treating copper-dependent diseases

Described are methods and materials for diagnosing a subject's predisposition for cardiovascular disease by detecting a copper deficiency genetic marker, as well as methods of alleviating cu transport impairment. Specifically, the cu deficiency genetic marker may be within the gene encoding a transmembrane cu transporter protein (ctri) or its regulatory sequences.. ... Duke University

02/09/17 / #20170035743

2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof

Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including alzheimer's disease, parkinson's disease, dyskinesias, tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.. ... Duke University

02/02/17 / #20170027928

Camkk-beta as a target for treating cancer

Provided herein are compounds, compositions, including pharmaceutical compositions, having anti-cancer activity. Also provided are methods for diagnosing, detecting, and treating cancer in a subject, as well as a method for evaluating cancer stage in a subject, wherein the methods include determining the amount of a ca2+/calmodulin dependent kinase kinase (camkk) in a sample. ... Duke University

01/26/17 / #20170022498

Method of regulating gene expression

The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.. . ... Duke University

01/26/17 / #20170020828

Use of disulfiram for inflammatory breast cancer therapy

Methods, compositions of matter, and kits for treatment of breast cancer, and in particular for inflammatory breast cancer, in a patient are disclosed. The methods can include administering a redox modulating agent to the patient. ... Duke University

01/19/17 / #20170016915

Screening targets and compositions and methods for treatment of ciliopathy disorders

The present disclosure provides methods of screening and compositions and methods for treating ciliopathy diseases. Methods are provided for screening for molecules to treat ciliopathy disorders by measuring the activity of ubiquitin-proteasome system (ups)-mediated protein degradation in the presence and the absence of a candidate molecule, wherein an increase of the activity in the presence of the candidate molecule identifies the molecule as a potential therapeutic. ... Duke University

01/19/17 / #20170015758

Compositions and methods for modulating and redirecting immune responses

Provided herein are methods of modulating and redirecting an immune response. Compositions and methods for killing targeted cells in a cell population are also provided wherein, a cell population containing target cells expressing a target associated antigen and t cells are contacted with 1, 2, or more immune checkpoint antagonists and a multispecific t cell-redirecting agent that specifically binds the target associated antigen expressed on the target cells and specifically binds a t cell surface antigen.. ... Duke University

01/19/17 / #20170014402

Methods and compositions for treating cancer through inhibition of pi3k

Provided herein are methods for treating cancer relating to inhibition of pi3k, as pharmaceutical compositions comprising a pi3k inhibitor and a pak1 inhibitor.. . ... Duke University

01/19/17 / #20170014108

Systems and methods for extracting prognostic image features

Described herein are systems and methods for extracting image features from magnetic resonance imaging scans. These methods and systems are useful for both determining cancer lesion severity and disease prognosis. ... Duke University

01/05/17 / #20170003389

Metamaterial devices and methods of using the same

Compressive imaging captures images in compressed form, where each sensor does not directly correspond with a pixel, as opposed to standard image capture techniques. This can lead to faster image capture rates due to lower i/o bandwidth requirements, and avoids the need for image compression hardware, as the image is captured in compressed form. ... Duke University

01/05/17 / #20170003340

Non-invasive pre-bond tsv using ring oscillators and multiple voltage levels

A design for test (dft) architecture is provided that enables pre-bond parametric testing of through-silicon vias (tsvs). A grouping of n number of input/output (i/o) segments are configured to receive a test signal in a feedback loop, where each i/o segment includes one or more buffers (or inverters) and a tsv connected at one end to the one or more buffers. ... Duke University

01/05/17 / #20170002417

Compositions and methods for identifying altered effectiveness of beta blocker therapy

The present invention provides a method of identifying a human subject as having an increased risk of altered effectiveness of beta blocker therapy, comprising detecting in the subject one or more single nucleotide polymorphism associated with increased risk of altered effectiveness of beta blocker therapy.. . ... Duke University








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