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Duke University patents (2018 archive)


Recent patent applications related to Duke University. Duke University is listed as an Agent/Assignee. Note: Duke University may have other listings under different names/spellings. We're not affiliated with Duke University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Duke University-related inventors


Hsf-like transcription factor, tbf1, is a major molecular switch for growth-to-defense transition in plants

The present invention relates to new methods to study and control the expression of plant genes, particularly nucleotide sequences located downstream from regions comprising binding sites for transcription factors, such as the cis-element translocon 1 (tl1) comprising gaagaagaa and similar sequences. The invention relates to isolated nucleotide sequences comprising a regulatory region comprising a promoter operably-linked to one or more upstream open reading frames (uorfs) and one or more downstream open reading frames (dorfs) encoding one or more functional polypeptides, including transcription factors such as tbf1, reporter polypeptides, and polypeptides conferring resistance to drugs, resistance of plants viral, bacterial, or fungal pathogens, and polypeptides involved in the growth of plants. ... Duke University

Compositions and methods for identifying and treating dystonia disorders

The present disclosure provides methods and compositions for the treatment, identification, diagnosis, and prognosis of dystonia, or dystonia related disorders.. . ... Duke University

Compact telescope configurations for light scanning systems and methods of using the same

Compact telescope configurations for light scanning systems and related methods are disclosed. According to an aspect, a system for imaging or relaying an image of an object includes a first optical element having a first focal length f1 for imaging or relaying an image of an object at the distance f1 from the first optical element. ... Duke University

Tumor infiltrating lymphocytes for treatment of cancer

Tumor infiltrating lymphocytes (tils) are white blood cells that are actively recruited to the tumor site to mount an immune response against tumor growth and metastasis. The disclosure provides methods for treating cancer that comprise steps of isolating cd8+ t cells from a sample derived from a subject, expanding the cd8+ t cells in the presence of interleukin-10, and administering the expanded cd8+ t cells to the subject. ... Duke University

Breathing training device adapters and associated methods

Breathing training device adapters and associated methods are disclosed herein. According to an aspect, a breathing training device adapter includes a housing comprising a first end and a second end that each define an opening. ... Duke University

Tetanus toxoid and ccl3 improve dc vaccines

Pre-conditioning a vaccine site with a potent recall antigen such as tetanus/diphtheria (td) toxoid can significantly improve the lymph node homing and efficacy of tumor antigen-specific dc vaccines. Patients given td had enhanced dc migration bilaterally and significantly improved survival. ... Duke University

Nanoprobe compositions and methods of use thereof

Gold nanorattle probes are provided that are highly tunable, physiologically stable, and ultra-bright raman probes for in vitro and in vivo surface-enhanced raman scattering (sers) applications. The nanorattles contain an essentially uniform gap between core and shell that is tunable and can range from 2nm to 10nm in width. ... Duke University

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin

The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.. ... Duke University

Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same

Provided herein are conjugates including a polypeptide and one or more drug molecules. The polypeptide includes one or more charged motifs, and may further include one or more uncharged motifs. ... Duke University

Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates

A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.. ... Duke University

Systems and methods for utilizing deep brain stimulation local evoked potentials for the treatment of neurological disorders

Systems, methods, and devices are disclosed for the use of evoked potentials from the deep brain stimulation (dbs) electrode as a feedback signal to indicate lead/contact placement relative to brain targets and to enable selection or modulation of effective stimulation parameters. In some embodiments, the brain signals are recorded using specialized equipment and used to determine characteristics of the electrode position and response to stimulation. ... Duke University

Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates

Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the c-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the c-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.. ... Duke University

Lasofoxifene treatment of breast cancer

The disclosure provides methods for treating estrogen receptor positive (er+) cancer in women with an effective amount of lasofoxifene, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The disclosure also includes the detection of the estrogen receptor 1 (esr1) gene mutations that lead to endocrine resistance and treatment of endocrine resistant er+ cancers.. ... Duke University

Flexible biopsy device

A device for taking a core biopsy sample comprising a flexible catheter assembly and a needle is provided. The flexible catheter assembly comprises a first flexible catheter and a second flexible catheter partially received within the first catheter, and the first flexible catheter and second flexible catheter are coupled to a spring.. ... Duke University

08/02/18 / #20180214691

Neuromodulation device

The present invention provides improved devices, systems and methods to provide for control of bladder function. Aspects of the present disclosure relate to an apparatus, system and/or a method for modulating the neural activity of afferent fibres of the pelvic nerve to bladder function. ... Duke University

07/26/18 / #20180207193

Compositions and methods for improving enzyme replacement therapy for lysosomal storage diseases

The present disclosure provides compositions and methods for improving the efficacy of enzyme replacement therapy for lysosomal storage diseases.. . ... Duke University

07/19/18 / #20180203086

Systems and methods for phase-sensitive inversion recovery mr imaging with reduced sensitivity to cardiac motion

A magnetic resonance imaging system and method are provided for improved phase-sensitive magnetic resonance imaging of tissues affected by cardiovascular pulsatile motion. A magnetically-prepared image dataset and corresponding reference image dataset (for phase sensitivity) are obtained within the duration of a single cardiac cycle. ... Duke University

07/19/18 / #20180201951

Compositions, systems and methods for cell therapy

Disclosed herein are compositions and methods for cell therapy comprising an engineered cell. The present invention is directed to a composition for treating a subject having or suspected of having a disease, the composition comprising a modified cell comprising a modified endogenous gene, wherein an endogenous gene or fragment thereof is replaced with a transgene using a crispr/cas9 system to generate the modified endogenous gene, the modified cell having an altered response to a cell signal or stimulus.. ... Duke University

07/19/18 / #20180200183

2' fluoro-modified rnas as immunostimulators

Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5′ triphosphate, 2′ fluoro-modified pyrimidine non-linear single stranded rna at least 17 nucleotides long with a least 3 base pairings or a 5′ triphosphate, 2′ fluoro-modified double stranded rna at least 17 base pairs long in an amount effective to inhibit cell growth, induce cell death or induce cytokine production by the cells. The methods also include administration of the compositions to a subject. ... Duke University

07/12/18 / #20180195132

Oligodendroglioma drive genes

Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. ... Duke University

07/12/18 / #20180194778

Antimicrobial prochelators to target drug-resistant bacteria and methods of making and using the same

The present disclosure provides antibacterial prodrugs and methods of making and using the same.. . ... Duke University

07/05/18 / #20180185457

Treatment of glycogen storage disease type ii

Methods of treating glycogen storage disease type ii, by administering acid α-glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type ii.. . ... Duke University

06/21/18 / #20180174490

Methods and systems for generating fluid simulation models

. . Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2d) image data are provided. Data is segmented from 2d images of a sample having a biological structure with fluid flow therethrough. ... Duke University

06/21/18 / #20180170130

Non-regular electrical stimulation patterns for treating neurological disorders

Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. ... Duke University

06/14/18 / #20180161423

Liposome-peptide conjugate and method of using same to induce production of anti-hiv antibodies

The present invention relates, in general, to human immunodeficiency virus (hiv), and, in particular, to a method of inducing neutralizing antibodies to hiv and to compounds and compositions suitable for use in such a method.. . ... Duke University

06/07/18 / #20180156804

Methods of developing a prognosis for pancreatic cancer and predicting responsiveness to cancer therapeutics

Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a vegf targeting agent are provided herein. The methods include detecting the expression level of at least one biomarker selected from ang-2, sdf-1 and vegf-d in a sample from the subject and using the expression levels to determine whether the vegf targeting agent will be effective to treat the cancer in the subject. ... Duke University

06/07/18 / #20180155763

Non-fouling polymeric surface modification and signal amplification method for biomolecular detection

An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) coupled to the brush molecules. ... Duke University

06/07/18 / #20180155423

Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor and an antigen expressed by a cell infected by a virus and uses thereof

The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accomplished using bispecific molecules that are immunoreactive with an activating receptor of an immune effector cell and to an antigen expressed by a cell infected with a virus wherein the antigen is detectably present on the cell infected with the virus at a level that is greater than the level at which the antigen is detected on the virus by the bispecific molecules, and to the use of such bispecific molecules in the treatment of latent viral infections.. ... Duke University

06/07/18 / #20180154178

Phosphor-containing drug activator activatable by a monte carlo derived x-ray exposure, system containing the activator, and methods for use

A phosphor-containing drug activator activatable from a monte carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a monte carlo derived x-ray dose. ... Duke University

06/07/18 / #20180153982

Compositions, methods and kits for eliciting an immune response

The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one cmv antigen expressed by a cancer cell, in particular for treating and preventing cancer. Cmv determination methods, compositions, and kits also are provided.. ... Duke University

06/07/18 / #20180153952

Compositions and methods for treating post operative cognitive dysfunction and neuroinflammation with annexin a1 (anxa1) peptides

The present disclosure provides compositions and methods for treating post-operative cognitive dysfunction with annexin a1 (anxa1) peptides.. . ... Duke University

06/07/18 / #20180153504

3d ultrasound imaging, associated methods, devices, and systems

Methods, system, and devices that are adapted to restrict the movement of an ultrasound transducer about at least one axis or point, and tag a plurality of frames of electronic signals indicative of information received by the ultrasound transducer with information sensed by an orientation sensor. The methods, system, and devices can generate a 3d ultrasound volume image of the patient by positioning the plurality of tagged frames of electronic signals at their respective orientations relative to the axis or point.. ... Duke University

05/31/18 / #20180149719

Circuits for magnetic resonance imaging systems for integrated parallel reception, excitation, and shimming

Systems, methods and devices are configured for integrated parallel reception, excitation, and shimming (ipres). Parallel transmit/receive (which can include b1 shimming and/or parallel imaging capabilities) and b0 shimming employ the same set of localized coils or transverse electromagnetic (tem) coil elements, with each coil or tem element working in both an rf mode (for transmit/receive and b1 shimming) and a direct current (dc) mode (for b0 shimming) simultaneously. ... Duke University

05/24/18 / #20180143276

Magnetic resonance imaging (mri) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses

Magnetic resonance imaging (mri) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses are disclosed. According to an aspect, a system includes a signal generator configured to generate a pulse sequence for on-resonance magnetization transfer preparation. ... Duke University

05/24/18 / #20180142243

A method of regulating gene expression

The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.. . ... Duke University

05/24/18 / #20180140720

Compositions and methods for tissue regeneration

The present disclosure relates to compositions and methods for tissue regeneration.. . ... Duke University

05/17/18 / #20180136296

Rf coil elements with split dc loops for magnetic resonance imaging systems for integrated parallel reception, excitation, and shimming and related methods and devices

Systems, methods and devices are configured for integrated parallel reception, excitation, and shimming (ipres) with rf coil elements with split dc loops. Parallel transmit/receive (which can include b1 shimming and/or parallel imaging capabilities) and b0 shimming employ the same set of localized coils or transverse electromagnetic (tem) coil elements, with each coil or tem element working in both an rf mode (for transmit/receive and b1 shimming) and a direct current (dc) mode (for b0 shimming) simultaneously. ... Duke University

05/17/18 / #20180133319

Synergistic nanotherapy systems and methods of use thereof

The presently disclosed subject matter is directed to a method of treating cancer, such as (but not limited to) metastatic bladder and breast cancer. The disclosed method comprises using two treatment modalities to synergistically treat primary and secondary tumor cells in a subject. ... Duke University

05/17/18 / #20180133186

Preventative treatment of alzheimer's disease

The present disclosure provides methods and formulations for the treatment of alzheimer's disease in a subject in need thereof. The methods comprise administering to the subject an ornithine decarboxylase inhibitor such as alpha-difluoromethylornithine or a pharmaceutically acceptable salt in an amount effective to treat the disease.. ... Duke University

05/10/18 / #20180125869

Bisphosphonate compositions and methods for treating heart failure

The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.. . ... Duke University

05/03/18 / #20180120307

Acoustically responsive particles

Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast acoustic particles, wherein the particles can contain a functional group available for covalent modification.. ... Duke University

05/03/18 / #20180118743

Composition and methods for the treatment of camkk2-mediated disorders

The present disclosure provides compositions and methods for treating ocular disorders in mammals especially in and not limited to humans and mice. The present disclosure further provides methods of treating cancer and appetite suppression using the compositions which are novel small molecule inhibitors of camkk2. ... Duke University

05/03/18 / #20180117182

Thrombus imaging aptamers and methods of using same

Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. ... Duke University

05/03/18 / #20180117111

Method of reducing titers of antibodies specific for a therapeutic agent

The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ert) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral or viral vectors, or other therapeutic modality or modalities, used alone or in combination, which involve the administration of exogenous substances for potential therapeutic benefit, including, but not limited to dna vaccines, sirna, splice-site switching oligomers (ssos) as well as rna-based nanoparticles (rnps) and nanovaccines. The invention further relates to compounds and compositions suitable for use in such methods.. ... Duke University

05/03/18 / #20180116992

Modulators of prostate-specific g-protein receptor (psgr/or51e2) and methods of using same

The present disclosure provides, in part, modulators of prostate-specific g-protein receptor (or51e2/psgr) and methods of treating, preventing, and diagnosing prostate cancer using the same.. . ... Duke University

04/19/18 / #20180105814

A method of regulating gene expression

The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.. . ... Duke University

04/19/18 / #20180105500

Novel inhibitors of transforming growth factor kinase and methods of use thereof

The present invention provides novel inhibitors of tak1 and methods of using such compounds to treat various diseases.. . ... Duke University

04/19/18 / #20180104479

Systems and methods for utilizing model-based optimization of spinal cord stimulation parameters

Systems, methods, and devices are disclosed for optimizing patient-specific stimulation parameters for spinal cord stimulation. A patient-specific anatomical model is developed based on a pre-operative image, and a patient-specific electrical model is developed based on the anatomical model. ... Duke University

04/19/18 / #20180104309

Compositions and methods for spinal cord regeneration

The invention provides pharmaceutical compositions and methods of use thereof for ameliorating injuries and conditions of the central nervous system. More specifically, the invention provides pharmaceutical compositions that when administered promote spinal cord regeneration.. ... Duke University

04/12/18 / #20180099044

Lymph node-targeting nanoparticles

Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. A cytokine. ... Duke University

04/12/18 / #20180098963

Lasofoxifene treatment of breast cancer

The disclosure provides methods for treating estrogen receptor positive (er+) cancer in women with an effective amount of lasofoxifene, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The disclosure also includes the detection of the estrogen receptor 1 (esr1) gene mutations that lead to endocrine resistance and treatment of endocrine resistant er+ cancers.. ... Duke University

04/12/18 / #20180098752

Systems and methods for determining viscoelastic properties in soft tissue using ultrasound

Systems and methods for determining viscoelastic properties in soft tissue using ultrasound are disclosed. According to an aspect, a method includes using an ultrasound probe to acquire soft tissue data. ... Duke University

04/12/18 / #20180098722

Modulating the aryl hydrocarbon receptor system to treat major depressive disorder

Materials and methods for treating major depressive disorder by modulating the aryl hydrocarbon receptor system are provided herein.. . ... Duke University

04/05/18 / #20180095129

Software-based self-test and diagnosis using on-chip memory

Embedded processor-based self-test and diagnosis using the compressed test data is described for ics having on-chip memory. Techniques for compressing the test data before the compressed test data is transferred to a device under test (dut) are also described. ... Duke University

04/05/18 / #20180095128

Software-based self-test and diagnosis using on-chip memory

Embedded processor-based self-test and diagnosis using the compressed test data is described for ics having on-chip memory. Techniques for compressing the test data before the compressed test data is transferred to a device under test (dut) are also described. ... Duke University

04/05/18 / #20180094238

Compositions and methods for the induction and tuning of gene expression

Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.. . ... Duke University

04/05/18 / #20180094050

Vaccines against her3 antigens and methods of using the same

The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to antigenic polypeptides and their use in cancer vaccines that may be used, in part, to treat cancer types dependent upon her2-mediated signaling.. ... Duke University

04/05/18 / #20180092989

Mitochondrial antiviral signaling (mavs) protein compositions and methods of using the same

The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to mavs compositions and their use in cancer therapeutics that may be used to treat various cancers alone or in combination with other anti-cancer therapeutic agents.. ... Duke University

03/22/18 / #20180079801

Hiv-1 neutralizing antibodies and uses thereof (cd4bs antibodies)

The invention relates to the identification of monoclonal hiv-1 neutralizing antibodies, such as, but not limited to, antibodies that bind to the cd4 binding site (cd4bs) of hiv-1 gp120, their recombinant expression and purification and uses. In certain aspects, the invention provides a pharmaceutical composition comprising anyone of the antibodies of the invention or fragments thereof or any combination thereof. ... Duke University

03/15/18 / #20180073003

Method of treating glycogen storage disease

The disclosure relates, in general, to glycogen storage disease and, in particular, to a method of treating glycogen storage disease and to compounds and compositions suitable for use in such a method.. . ... Duke University

03/15/18 / #20180072797

Hiv-1 neutralizing antibodies and uses thereof (v3 antibodies)

The invention is directed to hiv-1 neutralizing antibodies, cd4 binding site and v3 glycan antibodies, and methods for their uses.. . ... Duke University

03/15/18 / #20180071410

Contrast agents for magnetic resonance imaging

Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (mri) image of a body or body region such as an organ or organ region in a subject. The method is carried out by parenterally administering ascorbate or a pharmaceutically acceptable salt thereof to the subject in an mri image-enhancing amount; and then generating, by mri of the subject, an image of the body or body region. ... Duke University

03/08/18 / #20180069318

Metamaterials for surfaces and waveguides

Complementary metamaterial elements provide an effective permittivity and/or permeability for surface structures and/or waveguide structures. The complementary metamaterial resonant elements may include babinet complements of “split ring resonator” (srr) and “electric lc” (elc) metamaterial elements. ... Duke University

03/08/18 / #20180067137

Compositions and methods for metabolic profiling in subjects with heart failure with preserved ejection fraction

Disclosed herein are compositions and methods for targeted metabolomics profiling to provide absolute quantification of a broad array of metabolic intermediates of fatty acids, amino acids, and carbohydrate metabolism for hfpef. In an aspect, the disclosure relates to a method for assessing risk of death or a major adverse cardiac event (mace) in a subject diagnosed with heart failure with preserved ejection fraction (hfpef). ... Duke University

03/08/18 / #20180067129

Compositions and methods for identifying and modulating metabolic health

This invention provides reagents, methods and biochemical markers for identifying and providing therapeutic intervention for individuals with metabolic dysfunction, or individuals at risk for metabolic dysfunction.. . ... Duke University

03/08/18 / #20180064944

Non-regular electrical stimulation patterns for improved efficiency in treating parkinson's disease

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency. ... Duke University

03/08/18 / #20180064943

Systems and methods for spinal cord stimulation

Delivering stimulation includes delivering temporal patterns of stimulation pulses to respective transducers of an array of transducers, wherein the delivery of the pattern to a particular transducer of the array is different from at least some of the deliveries of the patterns to the other transducers of the array at least according to a time delay. The patterns delivered may include regular temporal patterns each having a respective constant inter-pulse interval. ... Duke University

02/22/18 / #20180050077

Plasmonics-active metal nanostar compositions and methods of use

Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated drug, which is activated by the photo-response of the nanostar to electromagnetic stimulation; a thermally-activated drug, which is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which may directly or indirectly cause the death of an undesirable cell. ... Duke University

02/15/18 / #20180045846

Electromagnetic (em) well logging tools and related methods

An electromagnetic well logging tool for a wireline logging process, includes a shaft, a transmitter coil mounted on the shaft and configured to generate primary magnetic fields for propagation into a well formation, upon excitation by a first current, a receiver coil mounted on the shaft at a predefined distance from the transmitter coil and configured to receive secondary magnetic fields generated from the well formation, and a bucking coil mounted on the shaft in a concentric arrangement with the receiver coil, wherein the bucking coil is configured to generate magnetic fields at the receiver coil upon excitation by a second current, for cancelling the magnetic fields generated at the receiver coil due to direct coupling between the transmitter and receiver coils.. . ... Duke University

02/15/18 / #20180044736

Biomarker based prognostic model for predicting overall survival in patients with metastatic clear cell kidney cancer

The present invention describes a method of using a molecular prognostic signature, to predict overall survival in patients with metastatic clear cell renal cell carcinoma. The present invention also describes a method of selecting therapy and a process for patient risk stratification based on the molecular prognostic signature analysis.. ... Duke University

02/15/18 / #20180043184

Automatic determination of radiation beam configurations for patient-specific radiation therapy planning

Systems and methods for efficient and automatic determination of radiation beam configurations for patient-specific radiation therapy planning are disclosed. According to an aspect, a method includes receiving data based on patient information and geometric characterization of one or more organs at risk proximate to a target volume of a patient. ... Duke University

02/15/18 / #20180043182

Systems and methods for automated radiation treatment planning with decision support

Systems and methods for automated radiation treatment planning with decision support are disclosed. According to an aspect, a method includes receiving data based on patient information and geometric characterization of one or more organs at risk and a cancer target of a patient. ... Duke University

02/15/18 / #20180042969

Compositions and methods for the reprogramming of cells into cardiomyocytes

The present disclosure provides compositions and methods for the reprogramming of cells such as fibroblasts into cardiomyocytes. The invention provided herein features a chemically defined media and methods of reprogramming cells to increase cardiac gene and protein expression in cardiac fibroblasts and other fibroblasts, e.g. ... Duke University

02/08/18 / #20180037928

Glucose/galactose biosensors and methods of using same

. . Provided herein are glucose and galactose biosensors and methods of making and using the same.. . ... Duke University

02/08/18 / #20180037609

Phase transition biopolymers and methods of use

The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. ... Duke University

02/08/18 / #20180036400

Double engineered hiv-1 envelopes

In certain aspects the invention provides hiv-1 engineered envelope proteins and their uses. The engineered envelopes comprise a sequence that prevents cleavage of the envelope associated with recombinant expression in a cell line, and n-terminal deletion which improves envelope expression as a monomer.. ... Duke University

01/25/18 / #20180023065

Fusion molecules of rationally-designed dna-binding proteins and effector domains

Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. ... Duke University

01/25/18 / #20180023064

Compositions and methods for epigenome editing

Disclosed herein are crispr/cas9-based gene activation systems that include a fusion protein of a cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.. . ... Duke University

01/11/18 / #20180008718

Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure

Controlled release dosage formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the active agent, such as eca or a derivative thereof, for an effective period of time.. ... Duke University

01/11/18 / #20180008147

Systems and methods for endoscopic angle-resolved low coherence interferometry

A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. ... Duke University

01/11/18 / #20180008140

Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope

Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope are disclosed herein. According to an aspect, a system includes first and second eyepieces. ... Duke University

01/04/18 / #20180001472

Specialized robot motion planning hardware and methods of making and using same

Specialized robot motion planning hardware and methods of making and using same are provided. A robot-specific hardware can be designed using a tool that receives a robot description comprising a collision geometry of a robot, degrees of freedom for each joint of the robot, and joint limits of the robot; receives a scenario description; generates a probabilistic roadmap (prm) using the robot description and the scenario description; and for each edge of prm, produces a collision detection unit comprising a circuit indicating all parts of obstacles that collide with that edge. ... Duke University








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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