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Editas Medicine Inc patents


Recent patent applications related to Editas Medicine Inc. Editas Medicine Inc is listed as an Agent/Assignee. Note: Editas Medicine Inc may have other listings under different names/spellings. We're not affiliated with Editas Medicine Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "E" | Editas Medicine Inc-related inventors


Use of exonucleases to improve crispr/cas-mediated genome editing

The present disclosure is directed to methods of producing a modified nucleic acid comprising a precise deletion in a target nucleic acid in a cell comprising generating, within the cell, a first single strand break on a first strand of the target nucleic acid and a second single strand break on a second strand of the target nucleic acid, thereby forming a double strand break in the target nucleic acid having a first 3′ overhang and a second 3′ overhang; processing the first 3′ overhang and the second 3′ overhang with an exonuclease molecule, thereby deleting the segment of the target nucleic acid that was located between the first single strand break and the second single strand break, and forming a processed double strand break; and allowing the processed double strand break to be repaired by at least one dna repair pathway, thereby producing the modified nucleic acid comprising the precise deletion in the target nucleic acid in the cell. Gene editing systems, vectors, polynucleotides, and methods of treatment are also disclosed herein.. ... Editas Medicine Inc

Systems and methods for one-shot guide rna (ogrna) targeting of endogenous and source dna

Engineered nucleic acids encoding genome editing system components are provided, as are engineered rna-guided nucleases that include inserts encoded in part by cellular genomic or other sequences recognized by guide rnas.. . ... Editas Medicine Inc

Crispr/cas-related methods and compositions for treating herpes simplex virus

Crispr/cas-related systems, compositions and methods for editing rs1, rl2, and/or lat genes in human cells are described, as are cells and compositions including cells edited according to the same.. . ... Editas Medicine Inc

Compositions and methods for promoting homology directed repair

This application provides improved methods of genome editing. Cas9 molecules can be used to create a break in a genomic region of interest. ... Editas Medicine Inc

Crispr/cas-related methods and compositions for treating hepatitis b virus

Crispr/cas-related genome editing systems, compositions and methods for preventing and/or treating hbv infection are disclosed.. . ... Editas Medicine Inc

Systems and methods for one-shot guide rna (ogrna) targeting of endogenous and source dna

Engineered nucleic acids encoding genome editing system components are provided, as are engineered rna-guided nucleases that include inserts encoded in part by cellular genomic or other sequences recognized by guide rnas.. . ... Editas Medicine Inc

Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)

Crispr/cas-related compositions and methods for treatment of leber's congenital amaurosis 10 (lca10) are disclosed.. . ... Editas Medicine Inc

Compositions and methods for treating cep290-associated disease

Compositions and methods for treatment of cep290 related diseases are disclosed.. . ... Editas Medicine Inc

Evaluation of cas9 molecule/guide rna molecule complexes

Disclosed herein are methods for evaluation, selection, optimization, and design of cas9 molecule/grna molecule complexes.. . ... Editas Medicine Inc

Crispr/cas-related methods and compositions for treating hiv infection and aids

Crispr/cas-related systems, compositions and methods for editing ccr5 and/or cxcr4 genes in human cells are described, as are cells and compositions including cells edited according to the same.. . ... Editas Medicine Inc

Crispr-cas-related methods, compositions and components for cancer immunotherapy

Crispr/cas-related composition and methods for treatment of cancer, in particular by using grna molecules comprising a targeting domain which is complementary with a target domain from the fas, bid, ctla4, pdcd1, cblb, ptpn6, trac or trbc gene. In some embodiments, grnas are used with cas9 enzymes to cause a cleavage event in said genes within engineered chimeric antigen receptor (car) t cells. ... Editas Medicine Inc

Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1)

Crispr/cas-related compositions and methods for treatment of hsv-1 are disclosed.. . ... Editas Medicine Inc

Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa

Crispr/cas-related compositions and methods for treatment of usher syndrome and/or retinitis pigmentosa are disclosed herein.. . ... Editas Medicine Inc

Crispr/cas-related methods and compositions for treating primary open angle glaucoma

Crispr/cas-related compositions and methods for treatment of primary open angle glaucoma (poag) are disclosed.. . ... Editas Medicine Inc

01/26/17 / #20170022507

Crispr/cas-related methods and compositions for treating cystic fibrosis

Crispr/cas-related compositions and methods for treatment of cystic fibrosis (cf).. . ... Editas Medicine Inc

01/12/17 / #20170007679

Crispr/cas-related methods and compositions for treating hiv infection and aids

Crispr/cas-related compositions and methods for treatment of a subject at risk for or having a hiv infection or aids are disclosed.. . ... Editas Medicine Inc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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