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Emory University patents


Recent patent applications related to Emory University. Emory University is listed as an Agent/Assignee. Note: Emory University may have other listings under different names/spellings. We're not affiliated with Emory University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "E" | Emory University-related inventors


Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as cdk inhibitors and their therapeutic use

Certain pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds that inhibit cycline dependent kinase (cdk) (e.g., cdk1, cdk2, cdk4, cdk5, cdk6, cdk7, cdk8, cdk9, cdk10, cdk11, cdk12, cdk13, etc.) are disclosed. Pharmaceutical compositions comprising these compounds, and the use of these compounds and compositions to inhibit cdk; to treat disorders associated with cdk such as those arising from an inappropriate activity, mutation, overexpression, or upstream pathway activation of cdk; or disorders that are ameliorated by the inhibition of cdk; proliferative disorders; cancer; viral infections; neurodegenerative disorders; ischaemia; renal diseases; and cardiovascular disorders are also disclosed. ... Emory University

Jaml specific binding agents, antibodies, and uses related thereto

Certain embodiments of the disclosure relate to targeted binding agents that specifically bind to jam-like protein and therein inhibit epithelial damage. Although it is not intended that embodiments of the disclosure be limited by any particular mechanism, it is believed that a possible mechanism by which this can be achieved may include, but are not limited to, either inhibition of binding of jaml to the car, inhibition of jaml induced car signaling, or increased clearance of jaml from the body of a subject, therein reducing the effective concentration of soluble jaml. ... Emory University

Use of kinase inhibitors to manage tuberculosis and other infectious diseases

This disclosure relates to the use of kinase inhibitor to treat or prevent infectious diseases such as tuberculosis. In certain embodiments, this disclosure relates to treating or preventing an infectious disease comprising administering an effective amount of a kinase inhibitor or other compound disclosed herein to a subject in need thereof. ... Emory University

Optogenetic inhibition of overactive neuronal activity

This disclosure relates to recombinant proteins, vectors, and methods of treating neurological conditions by exposing neurons to an opsin and luciferase in the presence of a luciferin. In certain embodiments, the disclosure relates to treating or preventing epilepsy or seizures comprising administering an effective amount of a vector that encodes an opsin and luciferase in combination with a luciferin to a subject in need thereof.. ... Emory University

Methylsulfonamide derivatives and uses related thereto

This disclosure relates to methylsulfonamide derivatives and uses as imaging agents and other uses related to cxcr4 inhibition. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein, derivatives, or pharmaceutically acceptable salts or prodrugs thereof. ... Emory University

Steroid analogues for neuroprotection

Provided are steroid analogues functionalized with polar substituents at the c3 and/or c20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.. ... Emory University

7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto

In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to bdnf and trkb activity, such as psychiatric disorders, depression, post-traumatic stress disorder, and autism spectrum disorders, stroke, rett syndrome, parkinson's disease, and alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof. ... Emory University

Growth and survival compositions for cells capable of producing antibodies and methods related thereto

This disclosure relates to growth media and environments for in vitro culturing of cells that produce or are capable of producing antibodies. In certain embodiments, the media comprises il-6, fibronectin, and typically a saccharide. ... Emory University

Methods of measuring cell purity for making quality control determinations and related compositions

This disclosure relates to methods of detecting and quantifying low concentrations of cells in a sample with targeted nanoparticles having raman reporters using surface-enhanced raman scattering for detection. In certain embodiments, the sample is a group of cells derived from stem cells that have been differentiated into specific cell types and one is detecting residual stem cells or other progeny in order to quantify the purity of the sample. ... Emory University

Multivalent enterovirus vaccine compositions and uses related thereto

This disclosure relates to multivalent enterovirus vaccine compositions and uses related thereto. In certain embodiments, the disclosure relates to vaccine compositions comprising multivalent, mixtures of enterovirus (for example hrv) serotypes or recombinantly produced variants or recombinantly produced viral capsid proteins. ... Emory University

Systems, methods and computer readable storage media storing instructions for generating planning images based on hdr applicators

Systems, methods, and computer-readable storage media relate to generate an integrated image based on one or more applicators inserted into a target of a patient. The method may include receiving ultrasound image data and planning image data of the target. ... Emory University

Oligosaccharide libraries and methods of production

This disclosure relates to libraries of oligosaccharides comprising multiple individual oligosaccharides derived from cells that contain a tag or detectable marker. In certain embodiments, the tag or detectable marker is an oxygen linked to the oligosaccharides through the first carbon of a sugar ring. ... Emory University

3-(phenyl)-n-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide compounds for the management of cftr protein mediated diseases

This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (cftr) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 3-(phenyl)-n-(4-phenoxybenzyl)-1,2,4-oxa-diazole-5-carboxamide compound, salt, or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-n-benzylidene-acetohydrazide compound is 3-(3,5-dibromo-4-hydroxyphenyl)-n-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide.. ... Emory University

Compositions and methods for detecting staphylococcous infections

Provided herein are compositions and methods for detecting and/or diagnosing a staphylococcus aureus (s. Aureus) infection in a subject. ... Emory University

05/10/18 / #20180128833

Methods of treating with tumor membrane vesicle-based immunotherapy and predicting therapeutic response thereto

Disclosed herein is a method for treating a subject having, or at risk of having, a triple negative breast cancer, comprising administering to the subject a therapeutically effective amount of an immunotherapeutic agent and a tumor membrane vesicle (tmv), wherein the tmv comprises a lipid membrane, and a b7-1 and/or il-12 molecule anchored to the lipid membrane. Also disclosed is method for predicting the likelihood a human subject having a cancer will respond therapeutically to a tmv immunotherapy, wherein the method comprises obtaining a blood or serum sample from the subject; measuring the amount of a set of biomarkers in the sample, wherein the biomarkers include at least ifn-gamma, tnf-alpha, and il-2, and wherein an increase in the level of the biomarkers as compared to a control indicates an increased likelihood the subject will respond therapeutically to the tmv immunotherapy.. ... Emory University

05/10/18 / #20180125967

Hiv immune stimulating compositions comprising recombinantly expressed pili on bacteria and methods related thereto

This disclosure relates to recombinant bacteria, e.g. L. ... Emory University

05/10/18 / #20180125812

Dehydroacetic acid (dhaa) and derivative for uses in treating cancer

This disclosure relates to methods of managing or treating cancer with agents that lower circulating acetoacetate levels, such as hypolipidemic agents, or other agents that antagonize acetoacetate-braf v600 mutant binding to attenuate braf v600 mutant tumor growth. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of an agent to a subject in need thereof, wherein the agent is dehydroacetic acid, derivative, prodrug, or salt thereof.. ... Emory University

05/03/18 / #20180121600

Methods, systems and computer readable storage media for generating accurate nucleotide sequences

Methods, systems and computer-readable storage media relate to generating one or more consensus sequences. The methods may include determining a group of one or more reads with each main position without diversity from a group of one or more aligned reads based on diversity status of each main position, each group including sequence data disposed at a plurality of main positions and a plurality of secondary position regions disposed adjacent to the main positions. ... Emory University

05/03/18 / #20180117145

Immunostimulatory compositions, particles, and uses related thereto

In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition or tumor vaccine defined herein. ... Emory University

04/19/18 / #20180104243

Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction

The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.. . ... Emory University

04/05/18 / #20180094018

Progesterone phosphate analogs and uses related thereto

This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.. ... Emory University

04/05/18 / #20180092876

Treating or preventing nephrogenic diabetes insipidus

In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount of a ampk activator to a subject in need thereof, wherein in certain embodiments, the ampk activator is metformin or salt thereof. In certain embodiments, the subject has been diagnosed with nephrogenic diabetes insipidus.. ... Emory University

03/08/18 / #20180066323

Biomarkers in cancer, methods, and systems related thereto

This disclosure relates biomarkers of cancer, e.g. Prostate cancer. ... Emory University

03/01/18 / #20180057817

Particle-nucleic acid conjugates and therapeutic uses related thereto

This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically cleaves rna, e.g., dnazyme or rnazyme. ... Emory University

03/01/18 / #20180057517

Metal tricarbonyl complexes comprising substituted iminodiactic acid ligands and uses as radioisotope tracers

This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as radioisotope tracers such as renal tracers. ... Emory University

02/22/18 / #20180052161

Biomarkers for malaria diagnosis

Disclosed herein are methods of detecting plasmodium in a subject (for example, presence of plasmodium parasite) by detecting the presence and/or amount of one or more metabolites in a sample from the subject. In some embodiments, the methods include detecting in the sample one or more metabolites listed in table 1, table 2, and/or tables 5-8. ... Emory University

02/15/18 / #20180042985

Methods of improving behavioral therapies

This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of psychotherapeutic or social disorders such as autism, and in particular the use of these compounds as an adjunct to psychotherapeutic counseling or behavioral therapy.. . ... Emory University

02/15/18 / #20180042956

Glutamate dehydrogenase 1 inhibitors and methods of treating cancer

This disclosure relates to methods of treating or preventing cancer comprising administering an effective amount of a glutamate dehydrogenase 1 inhibitor to a subject in need thereof.. . ... Emory University

12/28/17 / #20170369417

Tak1 kinase inhibitors, compositions, and uses related thereto

The disclosure relates to tak1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula i, pharmaceutical compositions having a compound of formula i, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula i to a subject in need thereof.. ... Emory University

11/30/17 / #20170343561

Diagnostic and therapeutic methods and products related to anxiety disorders

The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (pacap) expression levels in tissue collected from female subjects.. ... Emory University

11/23/17 / #20170334941

2',2'-dihalo nucleoside analogs for treatment of the flaviviridae family of viruses and cancer

The present invention is directed to compounds, compositions and methods for treating or preventing flaviviridae family of viruses (including hcv, yellow fever, dengue, chikungunya ebola and west nile virus), rsv, hev, and influenza infection and cancer in human subjects or other animal hosts.. . ... Emory University

11/23/17 / #20170333366

Casein coated drug-loaded iron oxide nanoparticles

This disclosure relates to nanoparticle drug delivery systems composed of casein (cn) coated nanoparticles, e.g., iron oxide nanoparticles coated with an inner layer and an out layer comprising the milk protein casein. In certain embodiments, drug molecules are incorporated into an inner polymeric layer coating the nanoparticles, which are subsequently coated with a casein containing outer layer, i.e., a layer-by-layer (lbl) construction. ... Emory University

11/09/17 / #20170322275

Magnetic resonance method and apparatus for quantitative simultaneous multi-slice assessment of tissue displacement, deformation, and related biomarker parameters

Embodiments relate to a magnetic resonance imaging (mri) technique in which the two-dimensional (2d) displacement encoding with stimulated echoes (dense) imaging technique and the multiband technique are combined to provide a 2d multi-slice quantitative assessment of displacement, deformation, and mechanics indices of tissue. The scan time is equivalent to the short scan time of the conventional single slice 2d imaging while providing spatial volumetric coverage similar to three-dimensional (3d) imaging. ... Emory University

09/28/17 / #20170273827

Apparatus and methods for drug delivery using microneedles

. . A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication with the cartridge. ... Emory University

09/28/17 / #20170273555

Internet-based cognitive diagnostics using visual paired comparison task

Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for diagnosing dementia such as mild cognitive impairment and alzheimer's disease.. ... Emory University

09/14/17 / #20170260575

Devices and methods useful for detecting mechanical forces of ligand receptor interactions

This disclosure related to methods of detecting mechanical forces required to separate ligand and receptor interactions. In certain embodiments, this disclosure relates to methods of detecting mechanical forces between a ligand and receptor, where the ligand is immobilized on a surface using weaker forces. ... Emory University

09/14/17 / #20170258904

Antagonism of the vip signaling pathway

Inhibition of the vip signaling pathway with vip antagonist is contemplated. In certain embodiments, the disclosure relates to methods of enhancing the immune response to a cell therapy comprising administering a vip antagonist to a subject in combination with a cell. ... Emory University

09/07/17 / #20170252411

Compositions derived from platelet lysates and uses in vascularization

This disclosure relates to compositions comprising a fibrin polymer produced by mixing platelet lysates with a minimal essential medium and thrombin. Typically, an optimized concentration of a calcium salt is utilized. ... Emory University

08/17/17 / #20170233428

Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer

The present invention is directed to compounds, compositions and methods for treating or preventing flaviviridae family of viruses (including hcv, yellow fever, dengue, chikungunya and west nile virus), rsv, hev, and influenza infection and cancer in human subjects or other animal hosts.. . ... Emory University

08/17/17 / #20170231522

Magnetic resonance method and apparatus for quantitative time-resolved assessment of tissue displacement and related biomarker parameters with blood suppression in the whole cardiac cycle

Embodiments relate to acquiring magnetic resonance (mr) images with suppressed residual blood signal in the early cardiac phases, leading to images with a preferred dark-blood appearance throughout the entire cardiac cycle, which improves accuracy of subsequent post-processing algorithms. The acquisition of the desired blood suppressed tissue images is achieved through a double inversion recovery pulse in dense sequences. ... Emory University

08/10/17 / #20170224322

Sternal retractor

Devices and methods for sternal retraction that reduces bleeding from the cut edges of a sternum and reduces fracturing of the sternum during retraction. The devices and methods involve the use of sternal retractor blades having a certain geometry and inserts placed inside the sternal retractor blades during retraction of the sternotomy incision. ... Emory University

08/03/17 / #20170216561

Delivery devices, systems and methods for delivering therapeutic materials

Delivery devices, systems, and methods may be configured to define a barrier region at a treatment site to deliver one or more therapeutic materials. A device for delivering one or more therapeutic materials to a treatment site may include a body; one or more members that are movable with respect to the body and that are configured to define a barrier region at the treatment site; and one or more delivery lumens configured to deliver one or more therapeutic materials to the barrier region.. ... Emory University

08/03/17 / #20170216319

Treating various disorders using trkb agonists

Novel compounds and methods for activating the trkb receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four six-membered rings and a substituted or unsubstituted c5 or c6 heteroaryl or heterocycloalkyl ring and pharmaceutically acceptable salts, prodrugs, and derivatives thereof. ... Emory University

07/27/17 / #20170209572

Classifiers of nf-kb pathway activation, devices, and methods of use thereof

This disclosure relates to classifiers of nf-κb pathway activation, devices, and methods of use thereof. In certain embodiments, the disclosure relates to methods comprising measuring changes in expression of genes controlled by p105 in a sample providing a detected p105 controlled gene expression pattern. ... Emory University

07/13/17 / #20170196885

Use of gabaa receptor antagonists for the treatment of excessive sleepiness and disorders associated with excessive sleepiness

Gabaa receptor mediated hypersomnia can be treated by administering a gabaa receptor antagonist (e.g., flumazenil; clarithromycin; picrotoxin; bicuculline; cicutoxin; and oenanthotoxin). In some embodiments, the gabaa receptor antagonist is flumazenil or clarithromycin. ... Emory University

06/22/17 / #20170173306

Spittable needle

Splittable needles for use in catheterizations are described. The splittable needles are formed of equal or unequal longitudinal parts that precisely align and lock for secure access to subject's vessels. ... Emory University

06/15/17 / #20170166569

Asparagine endopeptidase (aep) inhibitors for managing cancer and compositions related thereto

This disclosure relates to asparagine endopeptidase inhibitors for managing cancer and compositions related thereto. In certain embodiments, the asparagine endopeptidase inhibitors are substituted 3,7-dihydropurine-2,6-dione derivatives useful for treating or preventing metastasis, tumor growth, and/or cancer. ... Emory University

06/15/17 / #20170165225

Heterocyclic flavone derivatives, compositions, and methods related thereto

In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to bdnf and trkb activity, such as depression, stroke, rett syndrome, parkinson's disease, and alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein.. ... Emory University

06/08/17 / #20170157178

Cellular compositions used to restore stem cell or progenitor cell function and methods related thereto

This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered cells comprising mixing isolated cells with compositions disclosed herein under conditions such that epigenetically altered cells are formed. ... Emory University

05/18/17 / #20170137401

Chemokine cxcr4 and ccr5 receptor modulators and uses related thereto

The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. ... Emory University

04/27/17 / #20170118634

Methods and systems for determining protected location information based on temporal correlations

The systems and methods can provide location privacy protection by incorporating temporal correlations of a user's locations. The method may include obtaining a first location of a user of a mobile user device. ... Emory University

04/27/17 / #20170114400

Polynucleotide based movement, kits and methods related thereto

This disclosure relates dna based movement of objects. In certain embodiments, particles, pairs of particles, or a rods are conjugated with single stranded dna that hybridizes to a single stranded rna that is conjugated to a substrate. ... Emory University

04/20/17 / #20170107489

Therapeutic use of cd31 expressing cells

The present invention features compositions and methods related to the isolation, culture and therapeutic use of cd31-expressing cells.. . ... Emory University

04/20/17 / #20170106359

Water oxidation catalysts and methods of use thereof

Homogeneous water oxidation catalysts (wocs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred embodiment, the woc is a polyoxometalate woc which is hydrolytically stable, oxidatively stable, and thermally stable. ... Emory University

04/13/17 / #20170100477

Methods of immunizing a subject and compositions related thereto

This disclosure relates to methods of immunization comprising administering an effective amount of an immunogenic composition comprising an antigen or vaccine and an adjuvant disclosed herein to a subject in need thereof. In certain embodiments, the adjuvant is 1,8-dihydroxy-9,10-dihydroanthracen-9-one or derivative thereof. ... Emory University

03/23/17 / #20170082623

Methods of diagnosing and treating tuberculosis

This disclosure relates to methods of treating and diagnosing a tuberculosis infection as pulmonary active or latent based on biomarkers expressed on pools of cd4+ cells. In certain embodiments, the disclosure relates to methods of treatment of a subject diagnosed with tuberculosis comprising the steps of, measuring a pool of cd4+ifn-γ cells for cells that also express cd38, hla-dr, and/or ki-67 providing a measurement; associating an increased measurement of cd4+ifn-γ cells that also express cd38, hla-dr, ki-67, compared to a control, as an indication that the subject has active tuberculosis; and treating the subject with an aggressive tuberculosis treatment.. ... Emory University

03/23/17 / #20170081385

Variable lymphocyte receptors (vlr) modifications and compositions and uses related thereto

This disclosure relates to variable lymphocyte receptors (vlrs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and uses related thereto. In certain embodiments, the disclosure relates to recombinant polypeptide vlrs disclosed herein and variants thereof. ... Emory University

03/23/17 / #20170081314

Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto

The disclosure relates to prostaglandin receptor ep2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which ep2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.. ... Emory University

03/23/17 / #20170079971

Chemokine cxcr4 receptor modulators and uses related thereto

The disclosure relates to chemokine cxcr4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. ... Emory University

03/23/17 / #20170079950

Methods of managing graft versus host disease (gvhd) using indole carboxyaldehydes or derivatives thereof

In certain embodiments, this disclosure relates to methods of treating or preventing hvgd comprising administering an effective amount of indole-2-carboxyaldehyde, indole-3-carboxyaldehyde, or derivative to a subject in need thereof. In certain embodiments, this disclosure relates to methods of treating a subject with a hematological malignancy or other cancer comprising transplanting allogenic bone marrow or stem cells in combination with administering an effective amount of an indole-2-carboxyaldehyde, indole-3-carboxyaldehyde, or derivative thereof to a subject in need thereof.. ... Emory University

03/23/17 / #20170079864

Surgical support devices and systems

These systems and devices can be placed on top of any commercially available standard operating table and therefore can provide a portable and inexpensive alternative to commercially available specialized operating tables. The system may include a frame body having a first end, a second end, and a length therebetween. ... Emory University

03/09/17 / #20170065615

Steroid analogues for neuroprotection

Provided are steroid analogues functionalized with polar substituents at the c3 and/or c20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.. ... Emory University

02/23/17 / #20170051284

Manipulating microrna for the management of neurological diseases or conditions and compositions related thereto

This disclosure relates to manipulating microrna for the management of neurological disorders and compositions related thereto. In certain embodiments, the disclosure contemplates inhibition of mir324 or mir324-5p, e.g., the use of nucleobase polymers for antisense disruptions or rna interference of mir-324 expression or for mir324-5p binding in order to increase kv4.2 expression. ... Emory University

02/23/17 / #20170049909

Compositions for the inactivation of virus replication and methods of making and using the same

Provided herein are recombinant constructs, vectors and expression cassettes including a first promoter which is suitably a trna promoter operably connected to a first polynucleotide encoding a first single guide rna and a second promoter operably connected to a second polynucleotide encoding a cas9 polypeptide. The first single guide rna includes a first portion complementary to a strand of a target sequence of a dna virus and a second portion capable of interacting with the cas9 polypeptide. ... Emory University

02/23/17 / #20170049815

Selective chemotherapy treatments and diagnostic methods related thereto

This disclosure relates to methods of identifying subjects that have an increased likelihood of responding to a combination of a poly (adp) ribose polymerase enzyme inhibitor and a platinum based reagent and optionally other anticancer agents in the course of chemotherapy. In certain embodiments, the disclosure relates to methods of treating cancer comprising administering an effective amount of a poly (adp) ribose polymerase enzyme inhibitor and a platinum based reagent to the subject in need thereof, wherein the subject is in need thereof because measuring a quantity of rna isolated from a cancer cell from the subject indicates an increased quantity of the rna compared to a normal sample, wherein the rna is associated with one or more of the following genes/pseudogenes gls, ubec2, hacl1, msi2, and loc100129585.. ... Emory University

02/23/17 / #20170049468

Systems and methods for tissue treatment

Systems and methods are configured to treat a tissue by automatically linearly oscillating an instrument into a target site. A system may include a body having a length and configured to receive a portion of the instrument guide member having an exposed end and/or an instrument. ... Emory University

02/16/17 / #20170042905

Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto

The disclosure relates to prostaglandin receptor ep2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which ep2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflamation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.. ... Emory University

02/02/17 / #20170029407

Potent and selective inhibitors of hepatitis c virus

The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis c virus (hcv) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment or prevention of hcv infection.. ... Emory University

01/12/17 / #20170007652

Botanical extracts and compounds from schinus plants and methods of use

This disclosure relates to extracts from the anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a schinus plant. ... Emory University

01/05/17 / #20170000818

Nylon-3 polymers active against clostridium difficile

A method and corresponding composition to inhibit outgrowth of c. Difficile spores and/or to inhibit growth of c. ... Emory University

01/05/17 / #20170000508

Devices and methods for stabilizing tissue

The devices and methods relate to devices for stabilizing and/or positioning tissue (e.g., heart) within a surgical area. The device may include an articulating arm and a tissue stabilizing member. ... Emory University








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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