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Fred Hutchinson Cancer Research Center patents


Recent patent applications related to Fred Hutchinson Cancer Research Center. Fred Hutchinson Cancer Research Center is listed as an Agent/Assignee. Note: Fred Hutchinson Cancer Research Center may have other listings under different names/spellings. We're not affiliated with Fred Hutchinson Cancer Research Center, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "F" | Fred Hutchinson Cancer Research Center-related inventors


Compounds and methods for modulation of dux4

The present disclosure pertains generally to double-stranded small interfering rnas that modulate gene expression for use in research, diagnostics, and/or therapeutics. In certain embodiments, the present disclosure provides double-stranded small interfering rnas that modulate dux4 gene expression. ... Fred Hutchinson Cancer Research Center

Needle array assembly and method for delivering therapeutic agents

A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. ... Fred Hutchinson Cancer Research Center

Methods for colon hyperproliferative disorder detection, prognosis, and diagnosis

The present disclosure provides methods of using certain biomarker expression profiles in the detection, diagnosis, prognosis, or development of treatment regimens for various cellular hyperproliferative disorders of the bowel. For example, pre-diagnostic methods comprise detecting whether the concentration of at least bag4 in a test biological sample from a subject is elevated as compared to a control.. ... Fred Hutchinson Cancer Research Center

Compositions and methods for expansion of embryonic hematopoietic stem cells

The present invention relates to methods, kits and compositions for expansion of embryonic hematopoietic stem cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a notch agonist, one or more growth factors, and, optionally, an inhibitor of the tgfβ pathway. ... Fred Hutchinson Cancer Research Center

Compounds and methods for enhancing viral gene transfer to human hematopoietic cells

Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are based on the use of pyrimido[4,5-b]indole derivatives. ... Fred Hutchinson Cancer Research Center

Chlorotoxin variants, conjugates, and methods for their use

Chlorotoxin variants, chlorotoxin variant conjugates, compositions that include the chlorotoxin variants or conjugates, and methods for using the chlorotoxin variants, conjugates, and compositions.. . ... Fred Hutchinson Cancer Research Center

Point-of-care and/or portable platform for gene therapy

A platform for ex vivo isolation, production, and formulation of genetically-modified cells is described. The platform utilizes a software-enabled point-of-care and/or portable device making gene therapy more widely available.. ... Fred Hutchinson Cancer Research Center

Compositions for cellular immunotherapy

The present disclosure relates to compositions and methods for using cells having cellular immunotherapies comprising a composition of chimeric antigen receptor (car)-modified cd4+ t cells and a composition of cd8+ t cells modified with a distinct car in that the intracellular signaling component of the each car is different, wherein the modified cd4+ and cd8+ t cells have enhanced helper and effector functions, respectively, and together more effectively augment the immune response. Such cellular immunotherapies are useful in treating disease, such as cancer.. ... Fred Hutchinson Cancer Research Center

Methods for identifying and using inhibitors of casein kinase 1 epsilon isoform for inhibiting the growth and/or proliferation of myc-driven tumor cells

In one aspect, the invention provides a method for inhibiting the growth and/or proliferation of a myc-driven tumor cell comprising the step of contacting the tumor cells with a csnk1ε inhibitor. In another aspect, the invention provides a method of treating a subject suffering from a tumor comprising myc-driven tumor cells, comprising administering to the subject an amount of a composition comprising a csnk1ε inhibitor effective to inhibit the growth and/or proliferation of the tumor cells.. ... Fred Hutchinson Cancer Research Center

Biomarkers and uses thereof for selecting pancreas cancer intervention

The instant disclosure provides methods for using biomarkers for identifying therapeutic regimens to treat pancreas cancer, or to reduce the risk of pancreas cancer, pancreas cancer metastasis, pancreas cancer proliferation, or pancreas cancer recurrence. For example, such therapeutic regimens can be based on the level of runx3 expression in the context of a particular dpc4 genotype, or based on the level of runx3 expression in combination with the level of col6a1 expression, spp1 expression or both. ... Fred Hutchinson Cancer Research Center

Modified stem cells and uses thereof

Stem cells are modified to express an extracellular component including a tag cassette. The tag cassette can be used to detect, enrich, isolate, activate, track, deplete, or eliminate modified cells. ... Fred Hutchinson Cancer Research Center

Cocal envelope pseudotyped retroviral vector producer cells

Producer cell lines that produce cocal envelope pseudotyped retroviral vectors are described. The producer cells can be grown and can produce the cocal envelope pseudotyped retroviral vectors in large scale serum-free suspensions.. ... Fred Hutchinson Cancer Research Center

Compositions and methods for target nucleic acid molecule enrichment

The present disclosure relates to methods of detecting mutations in a target nucleic acid molecule by amplifying a target sequence to contain adaptor sequences and allowed for the product to be directly sequenced using high throughput dna sequencing technology.. . ... Fred Hutchinson Cancer Research Center

Engineered and multimerized human immunodeficiency virus envelope glycoproteins and uses thereof

Multimerized human immunodeficiency virus (hiv) envelope glycoproteins are described. The envelope glycoproteins are multimerized engineered and multimerized human immunodeficiency virus (hiv) envelope glycoproteins are described. ... Fred Hutchinson Cancer Research Center

03/29/18 / #20180085406

Compositions and methods for providing hematopoietic function without hla matching

The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the hla-type of the expanded human cord blood stem/progenitor sample or the hla-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.. ... Fred Hutchinson Cancer Research Center

03/22/18 / #20180080078

Method of identifying human compatible t cell receptors specific for an antigenic target

Methods are provided for identifying t cell receptors that specifically bind a particular antigenic target and can be used as therapeutics against disease.. . ... Fred Hutchinson Cancer Research Center

03/15/18 / #20180073015

Method of measuring adaptive immunity

A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. ... Fred Hutchinson Cancer Research Center

03/08/18 / #20180066282

Cocal vesiculovirus envelope pseudotyped retroviral vectors

Provided herein are cocal vesiculovirus envelope pseudotyped retroviral vectors that exhibit high titers, broad species and cell-type tropism, and improved serum stability. Disclosed cocal vesiculovirus envelope pseudotyped retroviral vectors may be suitably employed for gene therapy applications and, in particular, for the ex vivo and in vivo delivery of a gene of interest to a wide variety of target cells.. ... Fred Hutchinson Cancer Research Center

02/15/18 / #20180044404

Immunomodulatory fusion proteins and uses thereof

The present disclosure relates to immunomodulatory fusion proteins containing an extracellular binding domain and an intracellular signaling domain, wherein binding of a target can generate a modulatory signal in a host cell, such as a t cell. The present disclosure also relates to uses of immune cells expressing such immunomodulatory fusion proteins to treat certain diseases, such as cancer or infectious disease.. ... Fred Hutchinson Cancer Research Center

02/08/18 / #20180037953

Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing

Methods are provided for predicting a subject's infection status using high-throughput t cell receptor sequencing to match the subject's tcr repertoire to a known set of disease-associated t cell receptor sequences. The methods of the present invention may be used to predict the status of several infectious agents in a single sample from a subject. ... Fred Hutchinson Cancer Research Center

02/01/18 / #20180030153

Compositions and methods to modify cells for therapeutic objectives

The present disclosure provides compositions and methods that rapidly and selectively modify cells of the immune system to achieve therapeutic objectives. The methods can be practiced in vivo and any cell type that expresses a known marker can be targeted for a therapeutic objective.. ... Fred Hutchinson Cancer Research Center

01/11/18 / #20180008684

Compositions, methods and uses for alpha-1 antitrypsin or derivatives thereof

Embodiments herein report methods and compositions for treating or preventing adverse effects of radiation therapies. In certain embodiments, compositions and methods relate to reducing or inhibiting damage due to acute, periodic or chronic radiation exposure.. ... Fred Hutchinson Cancer Research Center

12/21/17 / #20170362653

Characterization of adaptive immune response to vaccination or infection using immunosequencing

Methods of monitoring and measuring dynamic adaptive immune cell responses are provided. High-throughput sequencing of t cell receptor and immunoglobulin loci is used to characterize the breadth of an effector cell response to a stimulus, such as a vaccine or infection. ... Fred Hutchinson Cancer Research Center

12/21/17 / #20170362298

Enhanced affinity t cell receptors and methods for making the same

The present disclosure provides methods for generating enhanced affinity t cell receptors by agonist selection of hematopoietic progenitor cells expressing an antigen specific tcrα cultured with stromal cells expressing delta-like-1 or delta-like-4, compositions prepared from such methods, and uses of thereof.. . ... Fred Hutchinson Cancer Research Center

11/23/17 / #20170335391

Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples

The invention is directed to methods for highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune heterodimers from a large number of biological samples containing lymphocytes of interest. Methods of the invention comprise performing a single pairing assay on a pool of source samples to determine nucleic acids encoding paired cognate receptor heterodimer chains in the combined pool. ... Fred Hutchinson Cancer Research Center

11/23/17 / #20170335386

Method of measuring adaptive immunity

Compositions and methods for measuring adaptive immune receptor (t cell receptor and immunoglobulin) diversity are described, and find uses for assessing immunocompetence and other purposes. Means are provided for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. ... Fred Hutchinson Cancer Research Center

11/09/17 / #20170322216

Pancreatic cancer diagnostic

The present disclosure provides methods of using certain biomarker expression profiles in the detection, diagnosis, prognosis, or development of treatment regimens for various cellular hyperproliferative disorders of the pancreas. For example, methods comprise detecting whether the concentration of erbb2, esr1, and tnc in a test biological sample from a subject is elevated as compared to a control.. ... Fred Hutchinson Cancer Research Center

09/21/17 / #20170267756

Tagged chimeric effector molecules and receptors thereof

The present disclosure relates to tagged chimeric effector molecules and receptor molecules thereof for genetically engineering a host cell, wherein the recombinant host cell can be identified, isolated, sorted, induced to proliferate, tracked or eliminated using the tag. An exemplary receptor molecule is a chimeric antigen receptors (cars) having an extracellular domain comprising a binding domain for a target, a hinge region and a tag cassette, a hydrophobic portion as a transmembrane domain and, an intracellular part with an effector domain. ... Fred Hutchinson Cancer Research Center

09/14/17 / #20170260584

Cell population analysis using single nucleotide polymorphisms from single cell transcriptomes

The disclosure provides methods and systems for producing single cell rna sequencing data. Single nucleotide polymorphisms (snps) identified in such data can be used to distinguish subpopulations of cells within a mixed population.. ... Fred Hutchinson Cancer Research Center

08/31/17 / #20170246279

Compositions and methods for boosting the efficacy of adoptive cellular immunotherapy

The present disclosure provides compositions and methods for boosting, augmenting or enhancing the efficacy of the adoptive cellular immunotherapy by using modified t cells expressing an antigen binding protein in conjunction with modified cells (such as hematopoietic progenitor cells, modified human immune system cells or a combination thereof) expressing the antigen specifically bound by the antigen binding protein of the modified t cells.. . ... Fred Hutchinson Cancer Research Center

04/27/17 / #20170112869

Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers

The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin b12 and, optionally, agents that impact heme protein metabolism.. ... Fred Hutchinson Cancer Research Center

04/20/17 / #20170107493

Expansion and engraftment of stem cells using notch 1 and/or notch 2 agonists

The present disclosure provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, the methods comprising culturing the precursor cells in the presence of a notch 1 agonist, notch 2 agonist or notch 1 agonist and notch 2 agonist (and, in particular embodiments, one or more growth factors) that support the proliferation but not differentiation of the non-terminally differentiated cells. The present disclosure further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a notch 1 agonist, notch 2 agonist or notch 1 agonist and notch 2 agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. ... Fred Hutchinson Cancer Research Center

02/23/17 / #20170049809

Compositions and methods to modulate angiogenesis

The present invention provides methods of stimulating angiogenesis and the growth or migration of cells associated with angiogenesis, by contacting animals, tissues, or cells with sulfide, alone or in combination with nitric oxide. These methods may be used for a variety or purposes, including promoting wound healings, increasing blood flow, and for the treatment and prevention of diseases and disorders associated with decreased blood flow, including ischemic or hypoxic injury.. ... Fred Hutchinson Cancer Research Center








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