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Fred Hutchinson Cancer Research Center patents (2015 archive)


Recent patent applications related to Fred Hutchinson Cancer Research Center. Fred Hutchinson Cancer Research Center is listed as an Agent/Assignee. Note: Fred Hutchinson Cancer Research Center may have other listings under different names/spellings. We're not affiliated with Fred Hutchinson Cancer Research Center, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "F" | Fred Hutchinson Cancer Research Center-related inventors


12/24/15 / #20150368646

Compositions and methods for treating pancreatic cancer

The present disclosure provides compositions and methods for treating or reducing the risk of pancreatic cancer by administering compounds capable of inhibiting the expression or activity of runx3.. . ... Fred Hutchinson Cancer Research Center

12/10/15 / #20150353890

Compositions and methods for expansion of embryonic hematopoietic stem cells

The present invention relates to methods, kits and compositions for expansion of embryonic hematopoietic stem cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a notch agonist, one or more growth factors, and, optionally, an inhibitor of the tgfp pathway. ... Fred Hutchinson Cancer Research Center

11/26/15 / #20150337041

Methods and compositions for treating autoimmune diseases or conditions

The present invention relates to methods of treating immune disorders, particularly autoimmune and inflammatory disorders such as rheumatoid arthritis, and methods of producing antibodies for use in therapeutic strategies for treating such disorders. Generally, the present methods involve the use of antibodies that specifically bind to nkg2d receptors present on the surface of cells underlying the disorders.. ... Fred Hutchinson Cancer Research Center

11/12/15 / #20150322123

Lipocalin fusion partners

Methods and systems for producing fusion proteins and peptides are disclosed. Fusion proteins and peptides created using the methods are also provided. ... Fred Hutchinson Cancer Research Center

11/05/15 / #20150316536

Methods for screening

Methods and systems for discovering drug candidates are disclosed. Methods and systems can include generating libraries of potential drug candidates (e.g., libraries of peptides) that can be screened to identify sub-libraries of potential drug candidates (e.g., sub-libraries of peptides) having selected pharmacological properties. ... Fred Hutchinson Cancer Research Center

10/29/15 / #20150309037

Treatment-induced damage to the tumor micro-environment promotes cancer therapy resistance through extracellular proteins

The present disclosure provides methods for determining the effectiveness of a cancer therapy, as well as methods for increasing the effectiveness of that therapy and determining a prognosis for a patient receiving that therapy.. . ... Fred Hutchinson Cancer Research Center

10/29/15 / #20150307923

Megasphaera cerevisiae system process control (spc) primers, probes, and methods

Provided are system process control (spc) compositions and methods for confirming dna extraction and pcr amplification of a patient sample through the detection of an introduced control organism, such as megasphaera cerevisiae, which is not otherwise present in a patient sample. Compositions of the present disclosure include primers, primer sets, and probes for specifically detecting a control organism introduced into a patient sample.. ... Fred Hutchinson Cancer Research Center

10/22/15 / #20150299785

Method of measuring adaptive immunity

Compositions and methods for measuring adaptive immune receptor (t cell receptor and immunoglobulin) diversity are described, and find uses for assessing immunocompetence and other purposes. Means are provided for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. ... Fred Hutchinson Cancer Research Center

08/20/15 / #20150232476

Compounds and methods for preventing, treating and/or protecting against sensory hair cell death

Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair cell death. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.. ... Fred Hutchinson Cancer Research Center

07/30/15 / #20150212084

Specific removal of activated immune cells

The present invention provides a method of detecting an immune response in a mammalian subject by: (a) withdrawing blood or a blood fraction containing immune cells from the subject; (b) contacting the blood or blood fraction to an antibody (e.g., a monoclonal antibody) that specifically binds to the cell surface hla-f histocompatibility protein of activated mammalian immune cells, which antibody does not bind to the cell surface of non-activated mammalian immune cells; and then (c) detecting the presence or absence of binding of the immune cells to the antibody, the presence of binding indicating the presence of an immune response in the subject. A further aspect of the invention is a composition comprising, consisting of or consisting essentially of a solid support having an antibody (e.g., a monoclonal antibody) coupled thereto, which antibody specifically binds to the cell surface hla-f histocompatibility protein of activated mammalian t-lymphocytes, and which antibody does not bind to the—cell surface of non-activated mammalian t-lymphocytes. ... Fred Hutchinson Cancer Research Center

07/02/15 / #20150183851

Compositions, methods and uses for alpha-1 antitrypsin or derivatives thereof as radioprotectants

Embodiments herein report methods and compositions for treating or preventing adverse effects of radiation therapies. In certain embodiments, compositions and methods relate to reducing or inhibiting damage due to acute, periodic or chronic radiation exposure.. ... Fred Hutchinson Cancer Research Center

06/18/15 / #20150166969

Compositions and methods for the treatment of hemoglobinopathies

Provided are compositions and methods for the treatment of hemoglobinopathies such as thalassemias and sickle cell disease. Compositions and methods include one or more endonuclease(s) or endonuclease fusion protein(s), including one or more homing endonuclease(s) and/or homing endonuclease fusion protein(s) and/or crispr endonuclease(s) ad/or crispr endonuclease fusion protein(s): (a) to disrupt a bcl11a coding region; (b) to disrupt a bcl11a gene regulatory region; (c) to modify an adult human β-globin locus; (d) to disrupt a hbp silencing dna regulatory element or pathway, such as a bcl11a-regulated hbp silencing region; (e) to mutate one or more γ-globin gene promoter(s) to achieve increased expression of a γ-globin gene; (f) to mutate one or more δ-globin gene promoter(s) to achieve increased expression of a δ-globin gene; and/or (g) to correct one or more β-globin gene mutation(s).. ... Fred Hutchinson Cancer Research Center

06/18/15 / #20150166961

Ex vivo expansion of myogenic stem cells by notch activation

Activating notch signaling in cultured canine muscle derived cells inhibited myogenic differentiation, and increased the number of myogenic progenitor cells that were similar to quiescent or newly activated satellite cells. Importantly, cells expanded in the presence of notch activation maintained engraftment potential, indicating the potential for therapeutic benefit. ... Fred Hutchinson Cancer Research Center

06/18/15 / #20150164942

Liquid chalcogenide compositions and methods of manufacturing and using the same

The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.. ... Fred Hutchinson Cancer Research Center

06/18/15 / #20150164064

Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms

The present invention concerns the use of oxygen antagonists for inducing stasis in cells, tissues, and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. ... Fred Hutchinson Cancer Research Center

06/11/15 / #20150159220

Methods for predicting and detecting cancer risk

Disclosed herein are methods for predicting and detecting cancer risk using genetic markers such as somatic genomic alterations (sga) that are associated with cancer risk. Also disclosed herein are methods for predicting and detecting a risk of esophageal adenocarcinoma (ea) based on the use of sga that are associated with a risk of ea.. ... Fred Hutchinson Cancer Research Center

05/28/15 / #20150148254

Diffuse large b-cell lymphoma markers and uses therefor

The present invention provides methods and compositions for prognosing treatment outcome in dlbcl patients, diagnosing dlbcl and monitoring efficacy of dlbcl treatment.. . ... Fred Hutchinson Cancer Research Center

05/07/15 / #20150126376

Compositions and methods for sensitive mutation detection in nucleic acid molecules

The present disclosure provides methods for detecting mutations in a target nucleic acid molecule by rolling circle amplification of a library of double-stranded circular bar-coded template molecules. Also provided herein are methods for enriching a target nucleic acid molecule.. ... Fred Hutchinson Cancer Research Center

04/30/15 / #20150118208

Enhanced affinity t cell receptors and methods for making the same

The present disclosure provides methods for generating enhanced affinity t cell receptors by agonist selection of hematopoietic progenitor cells expressing an antigen specific tcrα cultured with stromal cells expressing delta-like-1 or delta-like-4, compositions prepared from such methods, and uses of thereof.. . ... Fred Hutchinson Cancer Research Center

02/12/15 / #20150044257

Baculovirus-based enterovirus 71 vlp as a vaccine

An optimized baculovirus/insect cell-mediated system is provided for the production of enterovirus 71 virus-like particles to produce a vaccine against recent ev71 virus outbreaks. Co-expression of the viral capsid polyprotein p1 orf derived from a fatal case in the fuyang province of the people's republic of china plus the 3 cd protease of ev71 prototype strain brcr resulted in the formation of vlps. ... Fred Hutchinson Cancer Research Center

01/29/15 / #20150032019

End-tidal gas monitoring apparatus

A non-invasive monitoring apparatus for end-tidal gas concentrations, and a method of use thereof, is described for the detection of endogenous gas concentrations, including respiratory gases, in exhaled breath.. . ... Fred Hutchinson Cancer Research Center

01/22/15 / #20150025017

Compositions and methods for treating cancer

The present disclosure provides compositions and methods for treating cellular hyperproliferative disorders with a phf5α inhibitor, such as sirna, shrna, antisense oligonucleotides, or pharmaceutical compounds. Exemplary cellular hyperproliferative disorders that can be treated with the phf5α antagonists of the present disclosure include cancers, such as gliomas, adenocarcinomas, cervical cancer or prostate cancer.. ... Fred Hutchinson Cancer Research Center

01/22/15 / #20150024950

Compositions and methods for accurately identifying mutations

The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.. . ... Fred Hutchinson Cancer Research Center

01/22/15 / #20150024391

Compositions and methods for detecting allogeneic matter in a subject

The present disclosure provides a panel of nucleic acid molecule primers specific for hla-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious disease, allograft rejection, or pregnancy-related pathologies.. . ... Fred Hutchinson Cancer Research Center

01/22/15 / #20150023938

Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens

Methods for preparing ex vivo t cell cultures using il-21 compositions for use in adoptive immunotherapy are described. Addition of il-21 to cultures of non-terminally differentiated t cells population, either isolated or present in peripheral blood mononuclear cells are exposed to one or more tumor antigens, and in the presence of il-21 compositions and antigen presenting cells (apcs), the resulting t cell population has an enhanced antigen-specificity, and can be reintroduced into the patient. ... Fred Hutchinson Cancer Research Center

01/15/15 / #20150018233

Methods and g proteins for screening and identifying ligands of g protein-coupled receptors

Abstract of the disclosure disclosed herein are methods and compounds for screening and identifying ligands of g protein-coupled receptors (gpcrs). Also disclosed are chimeric g proteins and methods for detecting the activation or inhibition of gpcrs.. ... Fred Hutchinson Cancer Research Center








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